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Random Assignment in Experiments | Introduction & Examples

Published on March 8, 2021 by Pritha Bhandari . Revised on June 22, 2023.

In experimental research, random assignment is a way of placing participants from your sample into different treatment groups using randomization.

With simple random assignment, every member of the sample has a known or equal chance of being placed in a control group or an experimental group. Studies that use simple random assignment are also called completely randomized designs .

Random assignment is a key part of experimental design . It helps you ensure that all groups are comparable at the start of a study: any differences between them are due to random factors, not research biases like sampling bias or selection bias .

Table of contents

Why does random assignment matter, random sampling vs random assignment, how do you use random assignment, when is random assignment not used, other interesting articles, frequently asked questions about random assignment.

Random assignment is an important part of control in experimental research, because it helps strengthen the internal validity of an experiment and avoid biases.

In experiments, researchers manipulate an independent variable to assess its effect on a dependent variable, while controlling for other variables. To do so, they often use different levels of an independent variable for different groups of participants.

This is called a between-groups or independent measures design.

You use three groups of participants that are each given a different level of the independent variable:

  • a control group that’s given a placebo (no dosage, to control for a placebo effect ),
  • an experimental group that’s given a low dosage,
  • a second experimental group that’s given a high dosage.

Random assignment to helps you make sure that the treatment groups don’t differ in systematic ways at the start of the experiment, as this can seriously affect (and even invalidate) your work.

If you don’t use random assignment, you may not be able to rule out alternative explanations for your results.

  • participants recruited from cafes are placed in the control group ,
  • participants recruited from local community centers are placed in the low dosage experimental group,
  • participants recruited from gyms are placed in the high dosage group.

With this type of assignment, it’s hard to tell whether the participant characteristics are the same across all groups at the start of the study. Gym-users may tend to engage in more healthy behaviors than people who frequent cafes or community centers, and this would introduce a healthy user bias in your study.

Although random assignment helps even out baseline differences between groups, it doesn’t always make them completely equivalent. There may still be extraneous variables that differ between groups, and there will always be some group differences that arise from chance.

Most of the time, the random variation between groups is low, and, therefore, it’s acceptable for further analysis. This is especially true when you have a large sample. In general, you should always use random assignment in experiments when it is ethically possible and makes sense for your study topic.

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Random sampling and random assignment are both important concepts in research, but it’s important to understand the difference between them.

Random sampling (also called probability sampling or random selection) is a way of selecting members of a population to be included in your study. In contrast, random assignment is a way of sorting the sample participants into control and experimental groups.

While random sampling is used in many types of studies, random assignment is only used in between-subjects experimental designs.

Some studies use both random sampling and random assignment, while others use only one or the other.

Random sample vs random assignment

Random sampling enhances the external validity or generalizability of your results, because it helps ensure that your sample is unbiased and representative of the whole population. This allows you to make stronger statistical inferences .

You use a simple random sample to collect data. Because you have access to the whole population (all employees), you can assign all 8000 employees a number and use a random number generator to select 300 employees. These 300 employees are your full sample.

Random assignment enhances the internal validity of the study, because it ensures that there are no systematic differences between the participants in each group. This helps you conclude that the outcomes can be attributed to the independent variable .

  • a control group that receives no intervention.
  • an experimental group that has a remote team-building intervention every week for a month.

You use random assignment to place participants into the control or experimental group. To do so, you take your list of participants and assign each participant a number. Again, you use a random number generator to place each participant in one of the two groups.

To use simple random assignment, you start by giving every member of the sample a unique number. Then, you can use computer programs or manual methods to randomly assign each participant to a group.

  • Random number generator: Use a computer program to generate random numbers from the list for each group.
  • Lottery method: Place all numbers individually in a hat or a bucket, and draw numbers at random for each group.
  • Flip a coin: When you only have two groups, for each number on the list, flip a coin to decide if they’ll be in the control or the experimental group.
  • Use a dice: When you have three groups, for each number on the list, roll a dice to decide which of the groups they will be in. For example, assume that rolling 1 or 2 lands them in a control group; 3 or 4 in an experimental group; and 5 or 6 in a second control or experimental group.

This type of random assignment is the most powerful method of placing participants in conditions, because each individual has an equal chance of being placed in any one of your treatment groups.

Random assignment in block designs

In more complicated experimental designs, random assignment is only used after participants are grouped into blocks based on some characteristic (e.g., test score or demographic variable). These groupings mean that you need a larger sample to achieve high statistical power .

For example, a randomized block design involves placing participants into blocks based on a shared characteristic (e.g., college students versus graduates), and then using random assignment within each block to assign participants to every treatment condition. This helps you assess whether the characteristic affects the outcomes of your treatment.

In an experimental matched design , you use blocking and then match up individual participants from each block based on specific characteristics. Within each matched pair or group, you randomly assign each participant to one of the conditions in the experiment and compare their outcomes.

Sometimes, it’s not relevant or ethical to use simple random assignment, so groups are assigned in a different way.

When comparing different groups

Sometimes, differences between participants are the main focus of a study, for example, when comparing men and women or people with and without health conditions. Participants are not randomly assigned to different groups, but instead assigned based on their characteristics.

In this type of study, the characteristic of interest (e.g., gender) is an independent variable, and the groups differ based on the different levels (e.g., men, women, etc.). All participants are tested the same way, and then their group-level outcomes are compared.

When it’s not ethically permissible

When studying unhealthy or dangerous behaviors, it’s not possible to use random assignment. For example, if you’re studying heavy drinkers and social drinkers, it’s unethical to randomly assign participants to one of the two groups and ask them to drink large amounts of alcohol for your experiment.

When you can’t assign participants to groups, you can also conduct a quasi-experimental study . In a quasi-experiment, you study the outcomes of pre-existing groups who receive treatments that you may not have any control over (e.g., heavy drinkers and social drinkers). These groups aren’t randomly assigned, but may be considered comparable when some other variables (e.g., age or socioeconomic status) are controlled for.

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random assignment benefits

If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples.

  • Student’s  t -distribution
  • Normal distribution
  • Null and Alternative Hypotheses
  • Chi square tests
  • Confidence interval
  • Quartiles & Quantiles
  • Cluster sampling
  • Stratified sampling
  • Data cleansing
  • Reproducibility vs Replicability
  • Peer review
  • Prospective cohort study

Research bias

  • Implicit bias
  • Cognitive bias
  • Placebo effect
  • Hawthorne effect
  • Hindsight bias
  • Affect heuristic
  • Social desirability bias

In experimental research, random assignment is a way of placing participants from your sample into different groups using randomization. With this method, every member of the sample has a known or equal chance of being placed in a control group or an experimental group.

Random selection, or random sampling , is a way of selecting members of a population for your study’s sample.

In contrast, random assignment is a way of sorting the sample into control and experimental groups.

Random sampling enhances the external validity or generalizability of your results, while random assignment improves the internal validity of your study.

Random assignment is used in experiments with a between-groups or independent measures design. In this research design, there’s usually a control group and one or more experimental groups. Random assignment helps ensure that the groups are comparable.

In general, you should always use random assignment in this type of experimental design when it is ethically possible and makes sense for your study topic.

To implement random assignment , assign a unique number to every member of your study’s sample .

Then, you can use a random number generator or a lottery method to randomly assign each number to a control or experimental group. You can also do so manually, by flipping a coin or rolling a dice to randomly assign participants to groups.

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Random Assignment in Psychology: Definition & Examples

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Editor at Simply Psychology

BA (Hons) Psychology, Princeton University

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In psychology, random assignment refers to the practice of allocating participants to different experimental groups in a study in a completely unbiased way, ensuring each participant has an equal chance of being assigned to any group.

In experimental research, random assignment, or random placement, organizes participants from your sample into different groups using randomization. 

Random assignment uses chance procedures to ensure that each participant has an equal opportunity of being assigned to either a control or experimental group.

The control group does not receive the treatment in question, whereas the experimental group does receive the treatment.

When using random assignment, neither the researcher nor the participant can choose the group to which the participant is assigned. This ensures that any differences between and within the groups are not systematic at the onset of the study. 

In a study to test the success of a weight-loss program, investigators randomly assigned a pool of participants to one of two groups.

Group A participants participated in the weight-loss program for 10 weeks and took a class where they learned about the benefits of healthy eating and exercise.

Group B participants read a 200-page book that explains the benefits of weight loss. The investigator randomly assigned participants to one of the two groups.

The researchers found that those who participated in the program and took the class were more likely to lose weight than those in the other group that received only the book.

Importance 

Random assignment ensures that each group in the experiment is identical before applying the independent variable.

In experiments , researchers will manipulate an independent variable to assess its effect on a dependent variable, while controlling for other variables. Random assignment increases the likelihood that the treatment groups are the same at the onset of a study.

Thus, any changes that result from the independent variable can be assumed to be a result of the treatment of interest. This is particularly important for eliminating sources of bias and strengthening the internal validity of an experiment.

Random assignment is the best method for inferring a causal relationship between a treatment and an outcome.

Random Selection vs. Random Assignment 

Random selection (also called probability sampling or random sampling) is a way of randomly selecting members of a population to be included in your study.

On the other hand, random assignment is a way of sorting the sample participants into control and treatment groups. 

Random selection ensures that everyone in the population has an equal chance of being selected for the study. Once the pool of participants has been chosen, experimenters use random assignment to assign participants into groups. 

Random assignment is only used in between-subjects experimental designs, while random selection can be used in a variety of study designs.

Random Assignment vs Random Sampling

Random sampling refers to selecting participants from a population so that each individual has an equal chance of being chosen. This method enhances the representativeness of the sample.

Random assignment, on the other hand, is used in experimental designs once participants are selected. It involves allocating these participants to different experimental groups or conditions randomly.

This helps ensure that any differences in results across groups are due to manipulating the independent variable, not preexisting differences among participants.

When to Use Random Assignment

Random assignment is used in experiments with a between-groups or independent measures design.

In these research designs, researchers will manipulate an independent variable to assess its effect on a dependent variable, while controlling for other variables.

There is usually a control group and one or more experimental groups. Random assignment helps ensure that the groups are comparable at the onset of the study.

How to Use Random Assignment

There are a variety of ways to assign participants into study groups randomly. Here are a handful of popular methods: 

  • Random Number Generator : Give each member of the sample a unique number; use a computer program to randomly generate a number from the list for each group.
  • Lottery : Give each member of the sample a unique number. Place all numbers in a hat or bucket and draw numbers at random for each group.
  • Flipping a Coin : Flip a coin for each participant to decide if they will be in the control group or experimental group (this method can only be used when you have just two groups) 
  • Roll a Die : For each number on the list, roll a dice to decide which of the groups they will be in. For example, assume that rolling 1, 2, or 3 places them in a control group and rolling 3, 4, 5 lands them in an experimental group.

When is Random Assignment not used?

  • When it is not ethically permissible: Randomization is only ethical if the researcher has no evidence that one treatment is superior to the other or that one treatment might have harmful side effects. 
  • When answering non-causal questions : If the researcher is just interested in predicting the probability of an event, the causal relationship between the variables is not important and observational designs would be more suitable than random assignment. 
  • When studying the effect of variables that cannot be manipulated: Some risk factors cannot be manipulated and so it would not make any sense to study them in a randomized trial. For example, we cannot randomly assign participants into categories based on age, gender, or genetic factors.

Drawbacks of Random Assignment

While randomization assures an unbiased assignment of participants to groups, it does not guarantee the equality of these groups. There could still be extraneous variables that differ between groups or group differences that arise from chance. Additionally, there is still an element of luck with random assignments.

Thus, researchers can not produce perfectly equal groups for each specific study. Differences between the treatment group and control group might still exist, and the results of a randomized trial may sometimes be wrong, but this is absolutely okay.

Scientific evidence is a long and continuous process, and the groups will tend to be equal in the long run when data is aggregated in a meta-analysis.

Additionally, external validity (i.e., the extent to which the researcher can use the results of the study to generalize to the larger population) is compromised with random assignment.

Random assignment is challenging to implement outside of controlled laboratory conditions and might not represent what would happen in the real world at the population level. 

Random assignment can also be more costly than simple observational studies, where an investigator is just observing events without intervening with the population.

Randomization also can be time-consuming and challenging, especially when participants refuse to receive the assigned treatment or do not adhere to recommendations. 

What is the difference between random sampling and random assignment?

Random sampling refers to randomly selecting a sample of participants from a population. Random assignment refers to randomly assigning participants to treatment groups from the selected sample.

Does random assignment increase internal validity?

Yes, random assignment ensures that there are no systematic differences between the participants in each group, enhancing the study’s internal validity .

Does random assignment reduce sampling error?

Yes, with random assignment, participants have an equal chance of being assigned to either a control group or an experimental group, resulting in a sample that is, in theory, representative of the population.

Random assignment does not completely eliminate sampling error because a sample only approximates the population from which it is drawn. However, random sampling is a way to minimize sampling errors. 

When is random assignment not possible?

Random assignment is not possible when the experimenters cannot control the treatment or independent variable.

For example, if you want to compare how men and women perform on a test, you cannot randomly assign subjects to these groups.

Participants are not randomly assigned to different groups in this study, but instead assigned based on their characteristics.

Does random assignment eliminate confounding variables?

Yes, random assignment eliminates the influence of any confounding variables on the treatment because it distributes them at random among the study groups. Randomization invalidates any relationship between a confounding variable and the treatment.

Why is random assignment of participants to treatment conditions in an experiment used?

Random assignment is used to ensure that all groups are comparable at the start of a study. This allows researchers to conclude that the outcomes of the study can be attributed to the intervention at hand and to rule out alternative explanations for study results.

Further Reading

  • Bogomolnaia, A., & Moulin, H. (2001). A new solution to the random assignment problem .  Journal of Economic theory ,  100 (2), 295-328.
  • Krause, M. S., & Howard, K. I. (2003). What random assignment does and does not do .  Journal of Clinical Psychology ,  59 (7), 751-766.

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The Definition of Random Assignment According to Psychology

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Random assignment refers to the use of chance procedures in psychology experiments to ensure that each participant has the same opportunity to be assigned to any given group in a study to eliminate any potential bias in the experiment at the outset. Participants are randomly assigned to different groups, such as the treatment group versus the control group. In clinical research, randomized clinical trials are known as the gold standard for meaningful results.

Simple random assignment techniques might involve tactics such as flipping a coin, drawing names out of a hat, rolling dice, or assigning random numbers to a list of participants. It is important to note that random assignment differs from random selection .

While random selection refers to how participants are randomly chosen from a target population as representatives of that population, random assignment refers to how those chosen participants are then assigned to experimental groups.

Random Assignment In Research

To determine if changes in one variable will cause changes in another variable, psychologists must perform an experiment. Random assignment is a critical part of the experimental design that helps ensure the reliability of the study outcomes.

Researchers often begin by forming a testable hypothesis predicting that one variable of interest will have some predictable impact on another variable.

The variable that the experimenters will manipulate in the experiment is known as the independent variable , while the variable that they will then measure for different outcomes is known as the dependent variable. While there are different ways to look at relationships between variables, an experiment is the best way to get a clear idea if there is a cause-and-effect relationship between two or more variables.

Once researchers have formulated a hypothesis, conducted background research, and chosen an experimental design, it is time to find participants for their experiment. How exactly do researchers decide who will be part of an experiment? As mentioned previously, this is often accomplished through something known as random selection.

Random Selection

In order to generalize the results of an experiment to a larger group, it is important to choose a sample that is representative of the qualities found in that population. For example, if the total population is 60% female and 40% male, then the sample should reflect those same percentages.

Choosing a representative sample is often accomplished by randomly picking people from the population to be participants in a study. Random selection means that everyone in the group stands an equal chance of being chosen to minimize any bias. Once a pool of participants has been selected, it is time to assign them to groups.

By randomly assigning the participants into groups, the experimenters can be fairly sure that each group will have the same characteristics before the independent variable is applied.

Participants might be randomly assigned to the control group , which does not receive the treatment in question. The control group may receive a placebo or receive the standard treatment. Participants may also be randomly assigned to the experimental group , which receives the treatment of interest. In larger studies, there can be multiple treatment groups for comparison.

There are simple methods of random assignment, like rolling the die. However, there are more complex techniques that involve random number generators to remove any human error.

There can also be random assignment to groups with pre-established rules or parameters. For example, if you want to have an equal number of men and women in each of your study groups, you might separate your sample into two groups (by sex) before randomly assigning each of those groups into the treatment group and control group.

Random assignment is essential because it increases the likelihood that the groups are the same at the outset. With all characteristics being equal between groups, other than the application of the independent variable, any differences found between group outcomes can be more confidently attributed to the effect of the intervention.

Example of Random Assignment

Imagine that a researcher is interested in learning whether or not drinking caffeinated beverages prior to an exam will improve test performance. After randomly selecting a pool of participants, each person is randomly assigned to either the control group or the experimental group.

The participants in the control group consume a placebo drink prior to the exam that does not contain any caffeine. Those in the experimental group, on the other hand, consume a caffeinated beverage before taking the test.

Participants in both groups then take the test, and the researcher compares the results to determine if the caffeinated beverage had any impact on test performance.

A Word From Verywell

Random assignment plays an important role in the psychology research process. Not only does this process help eliminate possible sources of bias, but it also makes it easier to generalize the results of a tested sample of participants to a larger population.

Random assignment helps ensure that members of each group in the experiment are the same, which means that the groups are also likely more representative of what is present in the larger population of interest. Through the use of this technique, psychology researchers are able to study complex phenomena and contribute to our understanding of the human mind and behavior.

Lin Y, Zhu M, Su Z. The pursuit of balance: An overview of covariate-adaptive randomization techniques in clinical trials . Contemp Clin Trials. 2015;45(Pt A):21-25. doi:10.1016/j.cct.2015.07.011

Sullivan L. Random assignment versus random selection . In: The SAGE Glossary of the Social and Behavioral Sciences. SAGE Publications, Inc.; 2009. doi:10.4135/9781412972024.n2108

Alferes VR. Methods of Randomization in Experimental Design . SAGE Publications, Inc.; 2012. doi:10.4135/9781452270012

Nestor PG, Schutt RK. Research Methods in Psychology: Investigating Human Behavior. (2nd Ed.). SAGE Publications, Inc.; 2015.

By Kendra Cherry, MSEd Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the "Everything Psychology Book."

Random Assignment in Psychology (Definition + 40 Examples)

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Have you ever wondered how researchers discover new ways to help people learn, make decisions, or overcome challenges? A hidden hero in this adventure of discovery is a method called random assignment, a cornerstone in psychological research that helps scientists uncover the truths about the human mind and behavior.

Random Assignment is a process used in research where each participant has an equal chance of being placed in any group within the study. This technique is essential in experiments as it helps to eliminate biases, ensuring that the different groups being compared are similar in all important aspects.

By doing so, researchers can be confident that any differences observed are likely due to the variable being tested, rather than other factors.

In this article, we’ll explore the intriguing world of random assignment, diving into its history, principles, real-world examples, and the impact it has had on the field of psychology.

History of Random Assignment

two women in different conditions

Stepping back in time, we delve into the origins of random assignment, which finds its roots in the early 20th century.

The pioneering mind behind this innovative technique was Sir Ronald A. Fisher , a British statistician and biologist. Fisher introduced the concept of random assignment in the 1920s, aiming to improve the quality and reliability of experimental research .

His contributions laid the groundwork for the method's evolution and its widespread adoption in various fields, particularly in psychology.

Fisher’s groundbreaking work on random assignment was motivated by his desire to control for confounding variables – those pesky factors that could muddy the waters of research findings.

By assigning participants to different groups purely by chance, he realized that the influence of these confounding variables could be minimized, paving the way for more accurate and trustworthy results.

Early Studies Utilizing Random Assignment

Following Fisher's initial development, random assignment started to gain traction in the research community. Early studies adopting this methodology focused on a variety of topics, from agriculture (which was Fisher’s primary field of interest) to medicine and psychology.

The approach allowed researchers to draw stronger conclusions from their experiments, bolstering the development of new theories and practices.

One notable early study utilizing random assignment was conducted in the field of educational psychology. Researchers were keen to understand the impact of different teaching methods on student outcomes.

By randomly assigning students to various instructional approaches, they were able to isolate the effects of the teaching methods, leading to valuable insights and recommendations for educators.

Evolution of the Methodology

As the decades rolled on, random assignment continued to evolve and adapt to the changing landscape of research.

Advances in technology introduced new tools and techniques for implementing randomization, such as computerized random number generators, which offered greater precision and ease of use.

The application of random assignment expanded beyond the confines of the laboratory, finding its way into field studies and large-scale surveys.

Researchers across diverse disciplines embraced the methodology, recognizing its potential to enhance the validity of their findings and contribute to the advancement of knowledge.

From its humble beginnings in the early 20th century to its widespread use today, random assignment has proven to be a cornerstone of scientific inquiry.

Its development and evolution have played a pivotal role in shaping the landscape of psychological research, driving discoveries that have improved lives and deepened our understanding of the human experience.

Principles of Random Assignment

Delving into the heart of random assignment, we uncover the theories and principles that form its foundation.

The method is steeped in the basics of probability theory and statistical inference, ensuring that each participant has an equal chance of being placed in any group, thus fostering fair and unbiased results.

Basic Principles of Random Assignment

Understanding the core principles of random assignment is key to grasping its significance in research. There are three principles: equal probability of selection, reduction of bias, and ensuring representativeness.

The first principle, equal probability of selection , ensures that every participant has an identical chance of being assigned to any group in the study. This randomness is crucial as it mitigates the risk of bias and establishes a level playing field.

The second principle focuses on the reduction of bias . Random assignment acts as a safeguard, ensuring that the groups being compared are alike in all essential aspects before the experiment begins.

This similarity between groups allows researchers to attribute any differences observed in the outcomes directly to the independent variable being studied.

Lastly, ensuring representativeness is a vital principle. When participants are assigned randomly, the resulting groups are more likely to be representative of the larger population.

This characteristic is crucial for the generalizability of the study’s findings, allowing researchers to apply their insights broadly.

Theoretical Foundation

The theoretical foundation of random assignment lies in probability theory and statistical inference .

Probability theory deals with the likelihood of different outcomes, providing a mathematical framework for analyzing random phenomena. In the context of random assignment, it helps in ensuring that each participant has an equal chance of being placed in any group.

Statistical inference, on the other hand, allows researchers to draw conclusions about a population based on a sample of data drawn from that population. It is the mechanism through which the results of a study can be generalized to a broader context.

Random assignment enhances the reliability of statistical inferences by reducing biases and ensuring that the sample is representative.

Differentiating Random Assignment from Random Selection

It’s essential to distinguish between random assignment and random selection, as the two terms, while related, have distinct meanings in the realm of research.

Random assignment refers to how participants are placed into different groups in an experiment, aiming to control for confounding variables and help determine causes.

In contrast, random selection pertains to how individuals are chosen to participate in a study. This method is used to ensure that the sample of participants is representative of the larger population, which is vital for the external validity of the research.

While both methods are rooted in randomness and probability, they serve different purposes in the research process.

Understanding the theories, principles, and distinctions of random assignment illuminates its pivotal role in psychological research.

This method, anchored in probability theory and statistical inference, serves as a beacon of reliability, guiding researchers in their quest for knowledge and ensuring that their findings stand the test of validity and applicability.

Methodology of Random Assignment

woman sleeping with a brain monitor

Implementing random assignment in a study is a meticulous process that involves several crucial steps.

The initial step is participant selection, where individuals are chosen to partake in the study. This stage is critical to ensure that the pool of participants is diverse and representative of the population the study aims to generalize to.

Once the pool of participants has been established, the actual assignment process begins. In this step, each participant is allocated randomly to one of the groups in the study.

Researchers use various tools, such as random number generators or computerized methods, to ensure that this assignment is genuinely random and free from biases.

Monitoring and adjusting form the final step in the implementation of random assignment. Researchers need to continuously observe the groups to ensure that they remain comparable in all essential aspects throughout the study.

If any significant discrepancies arise, adjustments might be necessary to maintain the study’s integrity and validity.

Tools and Techniques Used

The evolution of technology has introduced a variety of tools and techniques to facilitate random assignment.

Random number generators, both manual and computerized, are commonly used to assign participants to different groups. These generators ensure that each individual has an equal chance of being placed in any group, upholding the principle of equal probability of selection.

In addition to random number generators, researchers often use specialized computer software designed for statistical analysis and experimental design.

These software programs offer advanced features that allow for precise and efficient random assignment, minimizing the risk of human error and enhancing the study’s reliability.

Ethical Considerations

The implementation of random assignment is not devoid of ethical considerations. Informed consent is a fundamental ethical principle that researchers must uphold.

Informed consent means that every participant should be fully informed about the nature of the study, the procedures involved, and any potential risks or benefits, ensuring that they voluntarily agree to participate.

Beyond informed consent, researchers must conduct a thorough risk and benefit analysis. The potential benefits of the study should outweigh any risks or harms to the participants.

Safeguarding the well-being of participants is paramount, and any study employing random assignment must adhere to established ethical guidelines and standards.

Conclusion of Methodology

The methodology of random assignment, while seemingly straightforward, is a multifaceted process that demands precision, fairness, and ethical integrity. From participant selection to assignment and monitoring, each step is crucial to ensure the validity of the study’s findings.

The tools and techniques employed, coupled with a steadfast commitment to ethical principles, underscore the significance of random assignment as a cornerstone of robust psychological research.

Benefits of Random Assignment in Psychological Research

The impact and importance of random assignment in psychological research cannot be overstated. It is fundamental for ensuring the study is accurate, allowing the researchers to determine if their study actually caused the results they saw, and making sure the findings can be applied to the real world.

Facilitating Causal Inferences

When participants are randomly assigned to different groups, researchers can be more confident that the observed effects are due to the independent variable being changed, and not other factors.

This ability to determine the cause is called causal inference .

This confidence allows for the drawing of causal relationships, which are foundational for theory development and application in psychology.

Ensuring Internal Validity

One of the foremost impacts of random assignment is its ability to enhance the internal validity of an experiment.

Internal validity refers to the extent to which a researcher can assert that changes in the dependent variable are solely due to manipulations of the independent variable , and not due to confounding variables.

By ensuring that each participant has an equal chance of being in any condition of the experiment, random assignment helps control for participant characteristics that could otherwise complicate the results.

Enhancing Generalizability

Beyond internal validity, random assignment also plays a crucial role in enhancing the generalizability of research findings.

When done correctly, it ensures that the sample groups are representative of the larger population, so can allow researchers to apply their findings more broadly.

This representative nature is essential for the practical application of research, impacting policy, interventions, and psychological therapies.

Limitations of Random Assignment

Potential for implementation issues.

While the principles of random assignment are robust, the method can face implementation issues.

One of the most common problems is logistical constraints. Some studies, due to their nature or the specific population being studied, find it challenging to implement random assignment effectively.

For instance, in educational settings, logistical issues such as class schedules and school policies might stop the random allocation of students to different teaching methods .

Ethical Dilemmas

Random assignment, while methodologically sound, can also present ethical dilemmas.

In some cases, withholding a potentially beneficial treatment from one of the groups of participants can raise serious ethical questions, especially in medical or clinical research where participants' well-being might be directly affected.

Researchers must navigate these ethical waters carefully, balancing the pursuit of knowledge with the well-being of participants.

Generalizability Concerns

Even when implemented correctly, random assignment does not always guarantee generalizable results.

The types of people in the participant pool, the specific context of the study, and the nature of the variables being studied can all influence the extent to which the findings can be applied to the broader population.

Researchers must be cautious in making broad generalizations from studies, even those employing strict random assignment.

Practical and Real-World Limitations

In the real world, many variables cannot be manipulated for ethical or practical reasons, limiting the applicability of random assignment.

For instance, researchers cannot randomly assign individuals to different levels of intelligence, socioeconomic status, or cultural backgrounds.

This limitation necessitates the use of other research designs, such as correlational or observational studies , when exploring relationships involving such variables.

Response to Critiques

In response to these critiques, people in favor of random assignment argue that the method, despite its limitations, remains one of the most reliable ways to establish cause and effect in experimental research.

They acknowledge the challenges and ethical considerations but emphasize the rigorous frameworks in place to address them.

The ongoing discussion around the limitations and critiques of random assignment contributes to the evolution of the method, making sure it is continuously relevant and applicable in psychological research.

While random assignment is a powerful tool in experimental research, it is not without its critiques and limitations. Implementation issues, ethical dilemmas, generalizability concerns, and real-world limitations can pose significant challenges.

However, the continued discourse and refinement around these issues underline the method's enduring significance in the pursuit of knowledge in psychology.

By being careful with how we do things and doing what's right, random assignment stays a really important part of studying how people act and think.

Real-World Applications and Examples

man on a treadmill

Random assignment has been employed in many studies across various fields of psychology, leading to significant discoveries and advancements.

Here are some real-world applications and examples illustrating the diversity and impact of this method:

  • Medicine and Health Psychology: Randomized Controlled Trials (RCTs) are the gold standard in medical research. In these studies, participants are randomly assigned to either the treatment or control group to test the efficacy of new medications or interventions.
  • Educational Psychology: Studies in this field have used random assignment to explore the effects of different teaching methods, classroom environments, and educational technologies on student learning and outcomes.
  • Cognitive Psychology: Researchers have employed random assignment to investigate various aspects of human cognition, including memory, attention, and problem-solving, leading to a deeper understanding of how the mind works.
  • Social Psychology: Random assignment has been instrumental in studying social phenomena, such as conformity, aggression, and prosocial behavior, shedding light on the intricate dynamics of human interaction.

Let's get into some specific examples. You'll need to know one term though, and that is "control group." A control group is a set of participants in a study who do not receive the treatment or intervention being tested , serving as a baseline to compare with the group that does, in order to assess the effectiveness of the treatment.

  • Smoking Cessation Study: Researchers used random assignment to put participants into two groups. One group received a new anti-smoking program, while the other did not. This helped determine if the program was effective in helping people quit smoking.
  • Math Tutoring Program: A study on students used random assignment to place them into two groups. One group received additional math tutoring, while the other continued with regular classes, to see if the extra help improved their grades.
  • Exercise and Mental Health: Adults were randomly assigned to either an exercise group or a control group to study the impact of physical activity on mental health and mood.
  • Diet and Weight Loss: A study randomly assigned participants to different diet plans to compare their effectiveness in promoting weight loss and improving health markers.
  • Sleep and Learning: Researchers randomly assigned students to either a sleep extension group or a regular sleep group to study the impact of sleep on learning and memory.
  • Classroom Seating Arrangement: Teachers used random assignment to place students in different seating arrangements to examine the effect on focus and academic performance.
  • Music and Productivity: Employees were randomly assigned to listen to music or work in silence to investigate the effect of music on workplace productivity.
  • Medication for ADHD: Children with ADHD were randomly assigned to receive either medication, behavioral therapy, or a placebo to compare treatment effectiveness.
  • Mindfulness Meditation for Stress: Adults were randomly assigned to a mindfulness meditation group or a waitlist control group to study the impact on stress levels.
  • Video Games and Aggression: A study randomly assigned participants to play either violent or non-violent video games and then measured their aggression levels.
  • Online Learning Platforms: Students were randomly assigned to use different online learning platforms to evaluate their effectiveness in enhancing learning outcomes.
  • Hand Sanitizers in Schools: Schools were randomly assigned to use hand sanitizers or not to study the impact on student illness and absenteeism.
  • Caffeine and Alertness: Participants were randomly assigned to consume caffeinated or decaffeinated beverages to measure the effects on alertness and cognitive performance.
  • Green Spaces and Well-being: Neighborhoods were randomly assigned to receive green space interventions to study the impact on residents’ well-being and community connections.
  • Pet Therapy for Hospital Patients: Patients were randomly assigned to receive pet therapy or standard care to assess the impact on recovery and mood.
  • Yoga for Chronic Pain: Individuals with chronic pain were randomly assigned to a yoga intervention group or a control group to study the effect on pain levels and quality of life.
  • Flu Vaccines Effectiveness: Different groups of people were randomly assigned to receive either the flu vaccine or a placebo to determine the vaccine’s effectiveness.
  • Reading Strategies for Dyslexia: Children with dyslexia were randomly assigned to different reading intervention strategies to compare their effectiveness.
  • Physical Environment and Creativity: Participants were randomly assigned to different room setups to study the impact of physical environment on creative thinking.
  • Laughter Therapy for Depression: Individuals with depression were randomly assigned to laughter therapy sessions or control groups to assess the impact on mood.
  • Financial Incentives for Exercise: Participants were randomly assigned to receive financial incentives for exercising to study the impact on physical activity levels.
  • Art Therapy for Anxiety: Individuals with anxiety were randomly assigned to art therapy sessions or a waitlist control group to measure the effect on anxiety levels.
  • Natural Light in Offices: Employees were randomly assigned to workspaces with natural or artificial light to study the impact on productivity and job satisfaction.
  • School Start Times and Academic Performance: Schools were randomly assigned different start times to study the effect on student academic performance and well-being.
  • Horticulture Therapy for Seniors: Older adults were randomly assigned to participate in horticulture therapy or traditional activities to study the impact on cognitive function and life satisfaction.
  • Hydration and Cognitive Function: Participants were randomly assigned to different hydration levels to measure the impact on cognitive function and alertness.
  • Intergenerational Programs: Seniors and young people were randomly assigned to intergenerational programs to study the effects on well-being and cross-generational understanding.
  • Therapeutic Horseback Riding for Autism: Children with autism were randomly assigned to therapeutic horseback riding or traditional therapy to study the impact on social communication skills.
  • Active Commuting and Health: Employees were randomly assigned to active commuting (cycling, walking) or passive commuting to study the effect on physical health.
  • Mindful Eating for Weight Management: Individuals were randomly assigned to mindful eating workshops or control groups to study the impact on weight management and eating habits.
  • Noise Levels and Learning: Students were randomly assigned to classrooms with different noise levels to study the effect on learning and concentration.
  • Bilingual Education Methods: Schools were randomly assigned different bilingual education methods to compare their effectiveness in language acquisition.
  • Outdoor Play and Child Development: Children were randomly assigned to different amounts of outdoor playtime to study the impact on physical and cognitive development.
  • Social Media Detox: Participants were randomly assigned to a social media detox or regular usage to study the impact on mental health and well-being.
  • Therapeutic Writing for Trauma Survivors: Individuals who experienced trauma were randomly assigned to therapeutic writing sessions or control groups to study the impact on psychological well-being.
  • Mentoring Programs for At-risk Youth: At-risk youth were randomly assigned to mentoring programs or control groups to assess the impact on academic achievement and behavior.
  • Dance Therapy for Parkinson’s Disease: Individuals with Parkinson’s disease were randomly assigned to dance therapy or traditional exercise to study the effect on motor function and quality of life.
  • Aquaponics in Schools: Schools were randomly assigned to implement aquaponics programs to study the impact on student engagement and environmental awareness.
  • Virtual Reality for Phobia Treatment: Individuals with phobias were randomly assigned to virtual reality exposure therapy or traditional therapy to compare effectiveness.
  • Gardening and Mental Health: Participants were randomly assigned to engage in gardening or other leisure activities to study the impact on mental health and stress reduction.

Each of these studies exemplifies how random assignment is utilized in various fields and settings, shedding light on the multitude of ways it can be applied to glean valuable insights and knowledge.

Real-world Impact of Random Assignment

old lady gardening

Random assignment is like a key tool in the world of learning about people's minds and behaviors. It’s super important and helps in many different areas of our everyday lives. It helps make better rules, creates new ways to help people, and is used in lots of different fields.

Health and Medicine

In health and medicine, random assignment has helped doctors and scientists make lots of discoveries. It’s a big part of tests that help create new medicines and treatments.

By putting people into different groups by chance, scientists can really see if a medicine works.

This has led to new ways to help people with all sorts of health problems, like diabetes, heart disease, and mental health issues like depression and anxiety.

Schools and education have also learned a lot from random assignment. Researchers have used it to look at different ways of teaching, what kind of classrooms are best, and how technology can help learning.

This knowledge has helped make better school rules, develop what we learn in school, and find the best ways to teach students of all ages and backgrounds.

Workplace and Organizational Behavior

Random assignment helps us understand how people act at work and what makes a workplace good or bad.

Studies have looked at different kinds of workplaces, how bosses should act, and how teams should be put together. This has helped companies make better rules and create places to work that are helpful and make people happy.

Environmental and Social Changes

Random assignment is also used to see how changes in the community and environment affect people. Studies have looked at community projects, changes to the environment, and social programs to see how they help or hurt people’s well-being.

This has led to better community projects, efforts to protect the environment, and programs to help people in society.

Technology and Human Interaction

In our world where technology is always changing, studies with random assignment help us see how tech like social media, virtual reality, and online stuff affect how we act and feel.

This has helped make better and safer technology and rules about using it so that everyone can benefit.

The effects of random assignment go far and wide, way beyond just a science lab. It helps us understand lots of different things, leads to new and improved ways to do things, and really makes a difference in the world around us.

From making healthcare and schools better to creating positive changes in communities and the environment, the real-world impact of random assignment shows just how important it is in helping us learn and make the world a better place.

So, what have we learned? Random assignment is like a super tool in learning about how people think and act. It's like a detective helping us find clues and solve mysteries in many parts of our lives.

From creating new medicines to helping kids learn better in school, and from making workplaces happier to protecting the environment, it’s got a big job!

This method isn’t just something scientists use in labs; it reaches out and touches our everyday lives. It helps make positive changes and teaches us valuable lessons.

Whether we are talking about technology, health, education, or the environment, random assignment is there, working behind the scenes, making things better and safer for all of us.

In the end, the simple act of putting people into groups by chance helps us make big discoveries and improvements. It’s like throwing a small stone into a pond and watching the ripples spread out far and wide.

Thanks to random assignment, we are always learning, growing, and finding new ways to make our world a happier and healthier place for everyone!

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Purpose and Limitations of Random Assignment

In an experimental study, random assignment is a process by which participants are assigned, with the same chance, to either a treatment or a control group. The goal is to assure an unbiased assignment of participants to treatment options.

Random assignment is considered the gold standard for achieving comparability across study groups, and therefore is the best method for inferring a causal relationship between a treatment (or intervention or risk factor) and an outcome.

Representation of random assignment in an experimental study

Random assignment of participants produces comparable groups regarding the participants’ initial characteristics, thereby any difference detected in the end between the treatment and the control group will be due to the effect of the treatment alone.

How does random assignment produce comparable groups?

1. random assignment prevents selection bias.

Randomization works by removing the researcher’s and the participant’s influence on the treatment allocation. So the allocation can no longer be biased since it is done at random, i.e. in a non-predictable way.

This is in contrast with the real world, where for example, the sickest people are more likely to receive the treatment.

2. Random assignment prevents confounding

A confounding variable is one that is associated with both the intervention and the outcome, and thus can affect the outcome in 2 ways:

Causal diagram representing how confounding works

Either directly:

Direct influence of confounding on the outcome

Or indirectly through the treatment:

Indirect influence of confounding on the outcome

This indirect relationship between the confounding variable and the outcome can cause the treatment to appear to have an influence on the outcome while in reality the treatment is just a mediator of that effect (as it happens to be on the causal pathway between the confounder and the outcome).

Random assignment eliminates the influence of the confounding variables on the treatment since it distributes them at random between the study groups, therefore, ruling out this alternative path or explanation of the outcome.

How random assignment protects from confounding

3. Random assignment also eliminates other threats to internal validity

By distributing all threats (known and unknown) at random between study groups, participants in both the treatment and the control group become equally subject to the effect of any threat to validity. Therefore, comparing the outcome between the 2 groups will bypass the effect of these threats and will only reflect the effect of the treatment on the outcome.

These threats include:

  • History: This is any event that co-occurs with the treatment and can affect the outcome.
  • Maturation: This is the effect of time on the study participants (e.g. participants becoming wiser, hungrier, or more stressed with time) which might influence the outcome.
  • Regression to the mean: This happens when the participants’ outcome score is exceptionally good on a pre-treatment measurement, so the post-treatment measurement scores will naturally regress toward the mean — in simple terms, regression happens since an exceptional performance is hard to maintain. This effect can bias the study since it represents an alternative explanation of the outcome.

Note that randomization does not prevent these effects from happening, it just allows us to control them by reducing their risk of being associated with the treatment.

What if random assignment produced unequal groups?

Question: What should you do if after randomly assigning participants, it turned out that the 2 groups still differ in participants’ characteristics? More precisely, what if randomization accidentally did not balance risk factors that can be alternative explanations between the 2 groups? (For example, if one group includes more male participants, or sicker, or older people than the other group).

Short answer: This is perfectly normal, since randomization only assures an unbiased assignment of participants to groups, i.e. it produces comparable groups, but it does not guarantee the equality of these groups.

A more complete answer: Randomization will not and cannot create 2 equal groups regarding each and every characteristic. This is because when dealing with randomization there is still an element of luck. If you want 2 perfectly equal groups, you better match them manually as is done in a matched pairs design (for more information see my article on matched pairs design ).

This is similar to throwing a die: If you throw it 10 times, the chance of getting a specific outcome will not be 1/6. But it will approach 1/6 if you repeat the experiment a very large number of times and calculate the average number of times the specific outcome turned up.

So randomization will not produce perfectly equal groups for each specific study, especially if the study has a small sample size. But do not forget that scientific evidence is a long and continuous process, and the groups will tend to be equal in the long run when a meta-analysis aggregates the results of a large number of randomized studies.

So for each individual study, differences between the treatment and control group will exist and will influence the study results. This means that the results of a randomized trial will sometimes be wrong, and this is absolutely okay.

BOTTOM LINE:

Although the results of a particular randomized study are unbiased, they will still be affected by a sampling error due to chance. But the real benefit of random assignment will be when data is aggregated in a meta-analysis.

Limitations of random assignment

Randomized designs can suffer from:

1. Ethical issues:

Randomization is ethical only if the researcher has no evidence that one treatment is superior to the other.

Also, it would be unethical to randomly assign participants to harmful exposures such as smoking or dangerous chemicals.

2. Low external validity:

With random assignment, external validity (i.e. the generalizability of the study results) is compromised because the results of a study that uses random assignment represent what would happen under “ideal” experimental conditions, which is in general very different from what happens at the population level.

In the real world, people who take the treatment might be very different from those who don’t – so the assignment of participants is not a random event, but rather under the influence of all sort of external factors.

External validity can be also jeopardized in cases where not all participants are eligible or willing to accept the terms of the study.

3. Higher cost of implementation:

An experimental design with random assignment is typically more expensive than observational studies where the investigator’s role is just to observe events without intervening.

Experimental designs also typically take a lot of time to implement, and therefore are less practical when a quick answer is needed.

4. Impracticality when answering non-causal questions:

A randomized trial is our best bet when the question is to find the causal effect of a treatment or a risk factor.

Sometimes however, the researcher is just interested in predicting the probability of an event or a disease given some risk factors. In this case, the causal relationship between these variables is not important, making observational designs more suitable for such problems.

5. Impracticality when studying the effect of variables that cannot be manipulated:

The usual objective of studying the effects of risk factors is to propose recommendations that involve changing the level of exposure to these factors.

However, some risk factors cannot be manipulated, and so it does not make any sense to study them in a randomized trial. For example it would be impossible to randomly assign participants to age categories, gender, or genetic factors.

6. Difficulty to control participants:

These difficulties include:

  • Participants refusing to receive the assigned treatment.
  • Participants not adhering to recommendations.
  • Differential loss to follow-up between those who receive the treatment and those who don’t.

All of these issues might occur in a randomized trial, but might not affect an observational study.

  • Shadish WR, Cook TD, Campbell DT. Experimental and Quasi-Experimental Designs for Generalized Causal Inference . 2nd edition. Cengage Learning; 2001.
  • Friedman LM, Furberg CD, DeMets DL, Reboussin DM, Granger CB. Fundamentals of Clinical Trials . 5th ed. 2015 edition. Springer; 2015.

Further reading

  • Posttest-Only Control Group Design
  • Pretest-Posttest Control Group Design
  • Randomized Block Design
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Statistics By Jim

Making statistics intuitive

Random Assignment in Experiments

By Jim Frost 4 Comments

Random assignment uses chance to assign subjects to the control and treatment groups in an experiment. This process helps ensure that the groups are equivalent at the beginning of the study, which makes it safer to assume the treatments caused any differences between groups that the experimenters observe at the end of the study.

photogram of tumbling dice to illustrate a process for random assignment.

Huh? That might be a big surprise! At this point, you might be wondering about all of those studies that use statistics to assess the effects of different treatments. There’s a critical separation between significance and causality:

  • Statistical procedures determine whether an effect is significant.
  • Experimental designs determine how confidently you can assume that a treatment causes the effect.

In this post, learn how using random assignment in experiments can help you identify causal relationships.

Correlation, Causation, and Confounding Variables

Random assignment helps you separate causation from correlation and rule out confounding variables. As a critical component of the scientific method , experiments typically set up contrasts between a control group and one or more treatment groups. The idea is to determine whether the effect, which is the difference between a treatment group and the control group, is statistically significant. If the effect is significant, group assignment correlates with different outcomes.

However, as you have no doubt heard, correlation does not necessarily imply causation. In other words, the experimental groups can have different mean outcomes, but the treatment might not be causing those differences even though the differences are statistically significant.

The difficulty in definitively stating that a treatment caused the difference is due to potential confounding variables or confounders. Confounders are alternative explanations for differences between the experimental groups. Confounding variables correlate with both the experimental groups and the outcome variable. In this situation, confounding variables can be the actual cause for the outcome differences rather than the treatments themselves. As you’ll see, if an experiment does not account for confounding variables, they can bias the results and make them untrustworthy.

Related posts : Understanding Correlation in Statistics , Causation versus Correlation , and Hill’s Criteria for Causation .

Example of Confounding in an Experiment

A photograph of vitamin capsules to represent our experiment.

  • Control group: Does not consume vitamin supplements
  • Treatment group: Regularly consumes vitamin supplements.

Imagine we measure a specific health outcome. After the experiment is complete, we perform a 2-sample t-test to determine whether the mean outcomes for these two groups are different. Assume the test results indicate that the mean health outcome in the treatment group is significantly better than the control group.

Why can’t we assume that the vitamins improved the health outcomes? After all, only the treatment group took the vitamins.

Related post : Confounding Variables in Regression Analysis

Alternative Explanations for Differences in Outcomes

The answer to that question depends on how we assigned the subjects to the experimental groups. If we let the subjects decide which group to join based on their existing vitamin habits, it opens the door to confounding variables. It’s reasonable to assume that people who take vitamins regularly also tend to have other healthy habits. These habits are confounders because they correlate with both vitamin consumption (experimental group) and the health outcome measure.

Random assignment prevents this self sorting of participants and reduces the likelihood that the groups start with systematic differences.

In fact, studies have found that supplement users are more physically active, have healthier diets, have lower blood pressure, and so on compared to those who don’t take supplements. If subjects who already take vitamins regularly join the treatment group voluntarily, they bring these healthy habits disproportionately to the treatment group. Consequently, these habits will be much more prevalent in the treatment group than the control group.

The healthy habits are the confounding variables—the potential alternative explanations for the difference in our study’s health outcome. It’s entirely possible that these systematic differences between groups at the start of the study might cause the difference in the health outcome at the end of the study—and not the vitamin consumption itself!

If our experiment doesn’t account for these confounding variables, we can’t trust the results. While we obtained statistically significant results with the 2-sample t-test for health outcomes, we don’t know for sure whether the vitamins, the systematic difference in habits, or some combination of the two caused the improvements.

Learn why many randomized clinical experiments use a placebo to control for the Placebo Effect .

Experiments Must Account for Confounding Variables

Your experimental design must account for confounding variables to avoid their problems. Scientific studies commonly use the following methods to handle confounders:

  • Use control variables to keep them constant throughout an experiment.
  • Statistically control for them in an observational study.
  • Use random assignment to reduce the likelihood that systematic differences exist between experimental groups when the study begins.

Let’s take a look at how random assignment works in an experimental design.

Random Assignment Can Reduce the Impact of Confounding Variables

Note that random assignment is different than random sampling. Random sampling is a process for obtaining a sample that accurately represents a population .

Photo of a coin toss to represent how we can incorporate random assignment in our experiment.

Random assignment uses a chance process to assign subjects to experimental groups. Using random assignment requires that the experimenters can control the group assignment for all study subjects. For our study, we must be able to assign our participants to either the control group or the supplement group. Clearly, if we don’t have the ability to assign subjects to the groups, we can’t use random assignment!

Additionally, the process must have an equal probability of assigning a subject to any of the groups. For example, in our vitamin supplement study, we can use a coin toss to assign each subject to either the control group or supplement group. For more complex experimental designs, we can use a random number generator or even draw names out of a hat.

Random Assignment Distributes Confounders Equally

The random assignment process distributes confounding properties amongst your experimental groups equally. In other words, randomness helps eliminate systematic differences between groups. For our study, flipping the coin tends to equalize the distribution of subjects with healthier habits between the control and treatment group. Consequently, these two groups should start roughly equal for all confounding variables, including healthy habits!

Random assignment is a simple, elegant solution to a complex problem. For any given study area, there can be a long list of confounding variables that you could worry about. However, using random assignment, you don’t need to know what they are, how to detect them, or even measure them. Instead, use random assignment to equalize them across your experimental groups so they’re not a problem.

Because random assignment helps ensure that the groups are comparable when the experiment begins, you can be more confident that the treatments caused the post-study differences. Random assignment helps increase the internal validity of your study.

Comparing the Vitamin Study With and Without Random Assignment

Let’s compare two scenarios involving our hypothetical vitamin study. We’ll assume that the study obtains statistically significant results in both cases.

Scenario 1: We don’t use random assignment and, unbeknownst to us, subjects with healthier habits disproportionately end up in the supplement treatment group. The experimental groups differ by both healthy habits and vitamin consumption. Consequently, we can’t determine whether it was the habits or vitamins that improved the outcomes.

Scenario 2: We use random assignment and, consequently, the treatment and control groups start with roughly equal levels of healthy habits. The intentional introduction of vitamin supplements in the treatment group is the primary difference between the groups. Consequently, we can more confidently assert that the supplements caused an improvement in health outcomes.

For both scenarios, the statistical results could be identical. However, the methodology behind the second scenario makes a stronger case for a causal relationship between vitamin supplement consumption and health outcomes.

How important is it to use the correct methodology? Well, if the relationship between vitamins and health outcomes is not causal, then consuming vitamins won’t cause your health outcomes to improve regardless of what the study indicates. Instead, it’s probably all the other healthy habits!

Learn more about Randomized Controlled Trials (RCTs) that are the gold standard for identifying causal relationships because they use random assignment.

Drawbacks of Random Assignment

Random assignment helps reduce the chances of systematic differences between the groups at the start of an experiment and, thereby, mitigates the threats of confounding variables and alternative explanations. However, the process does not always equalize all of the confounding variables. Its random nature tends to eliminate systematic differences, but it doesn’t always succeed.

Sometimes random assignment is impossible because the experimenters cannot control the treatment or independent variable. For example, if you want to determine how individuals with and without depression perform on a test, you cannot randomly assign subjects to these groups. The same difficulty occurs when you’re studying differences between genders.

In other cases, there might be ethical issues. For example, in a randomized experiment, the researchers would want to withhold treatment for the control group. However, if the treatments are vaccinations, it might be unethical to withhold the vaccinations.

Other times, random assignment might be possible, but it is very challenging. For example, with vitamin consumption, it’s generally thought that if vitamin supplements cause health improvements, it’s only after very long-term use. It’s hard to enforce random assignment with a strict regimen for usage in one group and non-usage in the other group over the long-run. Or imagine a study about smoking. The researchers would find it difficult to assign subjects to the smoking and non-smoking groups randomly!

Fortunately, if you can’t use random assignment to help reduce the problem of confounding variables, there are different methods available. The other primary approach is to perform an observational study and incorporate the confounders into the statistical model itself. For more information, read my post Observational Studies Explained .

Read About Real Experiments that Used Random Assignment

I’ve written several blog posts about studies that have used random assignment to make causal inferences. Read studies about the following:

  • Flu Vaccinations
  • COVID-19 Vaccinations

Sullivan L.  Random assignment versus random selection . SAGE Glossary of the Social and Behavioral Sciences, SAGE Publications, Inc.; 2009.

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Reader Interactions

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November 13, 2019 at 4:59 am

Hi Jim, I have a question of randomly assigning participants to one of two conditions when it is an ongoing study and you are not sure of how many participants there will be. I am using this random assignment tool for factorial experiments. http://methodologymedia.psu.edu/most/rannumgenerator It asks you for the total number of participants but at this point, I am not sure how many there will be. Thanks for any advice you can give me, Floyd

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May 28, 2019 at 11:34 am

Jim, can you comment on the validity of using the following approach when we can’t use random assignments. I’m in education, we have an ACT prep course that we offer. We can’t force students to take it and we can’t keep them from taking it either. But we want to know if it’s working. Let’s say that by senior year all students who are going to take the ACT have taken it. Let’s also say that I’m only including students who have taking it twice (so I can show growth between first and second time taking it). What I’ve done to address confounders is to go back to say 8th or 9th grade (prior to anyone taking the ACT or the ACT prep course) and run an analysis showing the two groups are not significantly different to start with. Is this valid? If the ACT prep students were higher achievers in 8th or 9th grade, I could not assume my prep course is effecting greater growth, but if they were not significantly different in 8th or 9th grade, I can assume the significant difference in ACT growth (from first to second testing) is due to the prep course. Yes or no?

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May 26, 2019 at 5:37 pm

Nice post! I think the key to understanding scientific research is to understand randomization. And most people don’t get it.

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May 27, 2019 at 9:48 pm

Thank you, Anoop!

I think randomness in an experiment is a funny thing. The issue of confounding factors is a serious problem. You might not even know what they are! But, use random assignment and, voila, the problem usually goes away! If you can’t use random assignment, suddenly you have a whole host of issues to worry about, which I’ll be writing about in more detail in my upcoming post about observational experiments!

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Unraveling the Mystery of Random Assignment in Psychology

random assignment benefits

Random assignment is a crucial concept in psychology research, ensuring the validity and reliability of experiments. But what exactly is random assignment, and why is it so important in the field of psychology?

In this article, we will discuss the difference between random assignment and random sampling, the steps involved in random assignment, and how researchers can effectively implement this technique. We will also explore the benefits and limitations of random assignment, as well as ways to ensure its effectiveness in psychology research.

Join us as we unravel the mystery of random assignment in psychology.

  • Random assignment is a research method used in psychology to eliminate bias and increase internal validity by randomly assigning participants to different groups.
  • Unlike random sampling, which selects participants for a study, random assignment randomly distributes participants into groups to ensure unbiased results.
  • Researchers can ensure effective random assignment by using randomization tables, random number generators, and stratified random assignment to increase the accuracy and generalizability of their findings.
  • 1 What is Random Assignment in Psychology?
  • 2.1 What is the Difference between Random Assignment and Random Sampling?
  • 3.1 What are the Steps Involved in Random Assignment?
  • 4.1 Eliminates Bias
  • 4.2 Increases Internal Validity
  • 4.3 Allows for Generalizability
  • 5.1 Practical Limitations
  • 5.2 Ethical Concerns
  • 6.1 Use a Randomization Table
  • 6.2 Use a Random Number Generator
  • 6.3 Use Stratified Random Assignment
  • 7.1 What is random assignment and why is it important in psychology?
  • 7.2 How is random assignment different from random selection?
  • 7.3 What are some common methods of random assignment in psychology research?
  • 7.4 Are there any limitations to random assignment in psychology research?
  • 7.5 What are the advantages of using random assignment in psychology research?
  • 7.6 Can random assignment be used in all types of psychology research?

What is Random Assignment in Psychology?

Random assignment in psychology refers to the method of placing participants in experimental groups through a random process to ensure unbiased distribution of characteristics.

This method is crucial in research studies as it allows for the elimination of potential biases that could skew results, leading to more accurate and generalizable findings. By randomly assigning participants, researchers can be more confident that any differences observed between groups are due to the treatment or intervention being studied rather than pre-existing individual characteristics.

For example, in a study investigating the effectiveness of a new therapy for anxiety, random assignment would involve randomly assigning participants with similar levels of anxiety to either the treatment group receiving the new therapy or the control group receiving a placebo. Variables such as age, gender, and severity of anxiety are controlled through random assignment to ensure that any differences in outcomes can be attributed to the therapy.

Why is Random Assignment Important in Psychology Experiments?

Random assignment holds paramount importance in psychology experiments as it enhances internal validity, establishes cause-and-effect relationships, and ensures accurate data analysis.

Random assignment involves the objective allocation of participants into different experimental groups without any bias or preconceived notions. This method is crucial in ensuring that researchers can confidently draw conclusions about the causal relationships being examined, rather than attributing any observed effects to other variables.

By randomly assigning participants, researchers can control for potential confounding variables and eliminate the influence of extraneous factors, thus strengthening the internal validity of the study. This process minimizes the likelihood of alternative explanations for the results, allowing for more accurate interpretations and conclusions.

In fields like clinical trials, the use of random assignment is fundamental in evaluating the effectiveness of new treatments or interventions. Test performance studies also rely on random assignment to evenly distribute factors that may impact scores, such as motivation levels or prior knowledge. In behavioral studies, random assignment ensures that participants are evenly distributed across conditions, reducing the risk of bias and increasing the generalizability of findings.

What is the Difference between Random Assignment and Random Sampling?

Random assignment and random sampling are distinct concepts in research methodology; while random assignment involves the allocation of participants to groups, random sampling pertains to the selection of a representative sample from a population.

In research design, random assignment plays a crucial role in ensuring the control and distribution of variables among different experimental groups, thereby minimizing bias and allowing researchers to establish cause-effect relationships. On the other hand, random sampling is essential for obtaining a sample that accurately represents the larger population being studied, increasing the generalizability of research findings.

For instance, in a study investigating the effects of a new medication, researchers may use random assignment to assign participants randomly to either the treatment group receiving the medication or the control group receiving a placebo. This random allocation helps in isolating the impact of the medication from other variables.

Conversely, when employing random sampling, researchers aim to select participants in a way that every individual in the population has an equal chance of being included in the study. This method ensures that the sample closely reflects the characteristics of the entire population under investigation.

How is Random Assignment Used in Psychology Research?

Random assignment is a fundamental component of psychology research, utilized to allocate participants randomly to groups in controlled experiments to investigate the impact of variables on study outcomes.

In experimental design, researchers use random assignment to ensure that participants have equal chances of being assigned to different conditions, reducing bias and increasing the validity of the study results.

This method allows researchers to confidently infer causality between variables, as any differences observed in outcomes can be attributed to the manipulation of independent variables, rather than pre-existing participant characteristics.

Clinical research often relies on random assignment to assess the efficacy of new treatments or interventions, helping to establish evidence-based practices that improve patient outcomes.

What are the Steps Involved in Random Assignment?

The steps in random assignment entail the creation of groups, selection of participants, and the assignment process itself, ensuring a randomized distribution in the experimental design.

The creation of groups involves categorizing the participants based on relevant criteria such as age, gender, or other demographics to form distinct experimental and control groups. Then, the selection of participants requires a systematic approach to avoid bias, ensuring that each individual has an equal chance of inclusion.

Following this, the assignment process involves using randomization methods like coin flipping, random number generators, or computer algorithms to determine which group each participant will be allocated to. By doing this, the randomization helps reduce the impact of confounding variables, making the results more reliable and valid.

What are the Benefits of Using Random Assignment in Psychology?

Using random assignment in psychology offers multiple benefits such as eliminating bias , increasing internal validity, and establishing causal relationships crucial for accurate data analysis in behavioral studies.

Random assignment is a method that involves every participant having an equal chance of being assigned to any condition or group within a study. By implementing this technique, researchers can ensure that potential confounding variables are evenly distributed across groups, leading to more reliable and valid results . This process is integral in psychology research as it not only strengthens the internal validity of a study but also allows researchers to confidently attribute any observed differences to the treatment being studied.

Eliminates Bias

One of the key benefits of random assignment is its ability to eliminate bias by ensuring that participants are equally distributed between the control and treatment groups, mitigating the impact of confounding variables.

Reducing bias in research is crucial as it enhances the internal validity of the study, making the results more reliable and generalizable.

  • Random assignment is particularly vital in experimental studies, where the goal is to determine causality.

For instance, imagine a study on the effectiveness of a new medication for hypertension. If participants with severe hypertension are all placed in the treatment group, and those with mild hypertension in the control group, the results may not accurately reflect the medication’s true impact.

Increases Internal Validity

Random assignment enhances internal validity by ensuring that any observed effects are attributed to the manipulation of the independent variable rather than external factors, strengthening the causal inference between variables.

Control and treatment groups play a crucial role in this process. The control group does not receive the treatment , serving as a baseline comparison to evaluate the impact of the independent variable. On the other hand, the treatment group is exposed to the independent variable. This distinction allows researchers to isolate the effects of the intervention accurately.

The relationship between the independent and dependent variables is key. The independent variable is manipulated by the researcher to observe its effect on the dependent variable. For instance, in a study testing a new drug’s efficacy (independent variable), the patient’s health outcomes (dependent variable) are measured.

Allows for Generalizability

Random assignment enables generalizability by creating samples that represent the broader population, increasing the validity of research findings and supporting the generalization of hypotheses to larger groups.

When researchers use random assignment, it helps to eliminate bias and ensure that participants are equally distributed between different experimental conditions. This method enhances the likelihood that the results are not skewed by pre-existing differences among participants, thus making the findings more reliable and applicable to a wider range of individuals.

By having diverse and representative samples through random assignment, researchers can draw conclusions that are more likely to be valid for the entire population, rather than just a specific subgroup. This approach also enhances the ability to make predictions and recommendations based on the study’s outcomes that can be beneficial for decision-making processes in various fields.

What are the Limitations of Random Assignment in Psychology?

Despite its advantages, random assignment in psychology experiments faces limitations such as practical constraints that may affect the implementation process and ethical considerations related to participant welfare.

One practical challenge encountered with random assignment is the logistical complexity of ensuring a truly random allocation of participants to experimental conditions. Researchers may find it difficult to maintain perfect randomization due to issues like accessibility, time constraints, and resources required. For instance, in a study aiming to investigate the effects of sleep deprivation on cognitive performance, ensuring that participants are randomly assigned to control and experimental groups might be challenging.

Ethical dilemmas arise concerning the well-being of participants. Random assignment can lead to unequal group distributions, potentially exposing some individuals to risks without corresponding benefits. For instance, assigning participants with a history of mental health issues to a placebo group in a study testing the efficacy of a new treatment can raise ethical concerns.

Addressing these challenges requires researchers to adopt measures such as stratified random assignment, where participants are grouped based on specific characteristics to ensure balanced representation across experimental conditions. By predefining strata, researchers can control for variables that may affect outcomes.

Practical Limitations

Practical limitations of random assignment include logistical challenges in participant recruitment, constraints in experimental design, and potential impacts on study outcomes due to practical considerations.

One of the major challenges researchers face is the difficulty of ensuring a truly randomized sample, especially when dealing with complex recruitment processes and limited resources for participant selection. The logistics involved in coordinating experimental procedures for each participant can be overwhelming, leading to delays in data collection and analysis.

These issues can significantly affect the internal validity of a study, as deviations from random assignment may introduce bias and confound the results. To mitigate these challenges, researchers can adopt strategies such as stratified randomization or matching to improve participant allocation and minimize the impact of logistical constraints on the study outcomes.

Ethical Concerns

Ethical concerns in random assignment revolve around participant welfare, equitable treatment in the control and treatment groups, and the ethical implications of manipulating variables that may impact individuals’ well-being.

When conducting a psychology experiment, researchers must ensure that the random assignment of participants to different groups is carried out in a fair and unbiased manner. This is crucial in maintaining the integrity of the study and upholding ethical principles.

Participant welfare is paramount, and researchers have a responsibility to safeguard the well-being of individuals involved in the research.

How Can Researchers Ensure Effective Random Assignment?

Researchers can ensure effective random assignment by utilizing tools such as randomization tables , random number generators , and stratified random assignment methods to enhance the randomness and validity of group allocations.

Randomization tables help match participants to different treatment groups based on a predefined criteria or algorithm, ensuring an unbiased assignment process. Random number generators play a crucial role in allocating participants to groups without any conscious or subconscious bias, fostering transparent and fair treatment allocations.

Implementing stratified assignments involves dividing participants into subgroups based on specific characteristics, such as age, gender, or severity of the condition, to create more homogeneous groups for more accurate results.

Best practices for maintaining the integrity of the random assignment process include double-blinding the study, ensuring proper concealment of allocation mechanisms, and conducting randomization procedures by an independent party to minimize potential biases.

Use a Randomization Table

A randomization table is a valuable tool in research that aids in the allocation of participants to different groups using a predetermined random sequence, ensuring an unbiased distribution in the random assignment process.

By utilizing a randomization table, researchers can avoid selection bias and ensure that each participant has an equal chance of being assigned to any group. This method promotes fairness and helps in achieving comparability among the groups in a study. For example, in a clinical trial testing a new medication, a randomization table can be employed to assign participants either to the treatment group receiving the medication or the control group receiving a placebo.

The benefits of using randomization tables include increased internal validity, reduced confounding variables, and the ability to demonstrate causal relationships with greater confidence. This tool enhances the reliability and replicability of research findings by minimizing systematic errors in group allocations.

Use a Random Number Generator

In research, a random number generator is employed to allocate participants randomly to groups, ensuring an unbiased distribution and enhancing the validity and reliability of study outcomes.

Random number generators play a crucial role in the scientific method by enabling researchers to achieve randomness essential for reliable experiments. They aid in minimizing selection bias, thereby contributing to the integrity of the study design. Random number generators uphold the principle of chance, fostering a fair and equal opportunity for each participant to be assigned to a specific condition. This methodological approach ensures that the treatment and control groups are comparable, leading to more accurate conclusions and interpretations.

Use Stratified Random Assignment

Stratified random assignment involves grouping participants based on specific characteristics before random assignment, allowing for the control of variables and ensuring a balanced representation within groups.

This methodology is particularly useful in research design as it helps minimize the potential biases that can arise in studies. By dividing participants into homogeneous subgroups, such as age, gender, or socio-economic status, researchers can ensure that each subgroup is appropriately represented in the study sample. For example, in a healthcare study, stratified random assignment can ensure that both younger and older age groups are equally represented, providing more comprehensive results that can be generalized to the larger population.

Frequently Asked Questions

What is random assignment and why is it important in psychology.

Random assignment is the process of randomly assigning participants to different groups in a research study. It is important in psychology because it helps to eliminate bias and ensure that the groups being compared are similar, allowing researchers to determine the true effects of a variable.

How is random assignment different from random selection?

Random assignment involves randomly assigning participants to different groups, while random selection involves randomly choosing participants from a larger population. Random assignment is done within the chosen sample, while random selection is done before the sample is chosen.

What are some common methods of random assignment in psychology research?

Some common methods of random assignment include simple random assignment, stratified random assignment, and matched random assignment. Simple random assignment involves randomly assigning participants to groups with no restrictions. Stratified random assignment involves dividing participants into subgroups and then randomly assigning participants from each subgroup to different groups. Matched random assignment involves pairing participants based on certain characteristics and then randomly assigning one of each pair to a group.

Are there any limitations to random assignment in psychology research?

Yes, there are some limitations to random assignment. For example, it may not always be feasible or ethical to randomly assign participants to different groups. Additionally, random assignment does not guarantee that the groups will be exactly equal on all characteristics, which could potentially impact the results of the study.

What are the advantages of using random assignment in psychology research?

The main advantage of using random assignment is that it helps to eliminate bias and ensure that the groups being compared are similar. This allows researchers to make more accurate conclusions about the relationship between variables and determine causality.

Can random assignment be used in all types of psychology research?

Random assignment is commonly used in experimental research, where participants are randomly assigned to different conditions. However, it may not be as useful in other types of research, such as correlational studies, where participants are not manipulated and groups cannot be randomly assigned.

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Lena Nguyen, an industrial-organizational psychologist, specializes in employee engagement, leadership development, and organizational culture. Her consultancy work has helped businesses build stronger teams and create environments that promote innovation and efficiency. Lena’s articles offer a fresh perspective on managing workplace dynamics and harnessing the potential of human capital in achieving business success.

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Elements of Research

                                                                                   

Random assignment is a procedure used in experiments to create multiple study groups that include participants with similar characteristics so that the groups are equivalent at the beginning of the study. The procedure involves assigning individuals to an experimental treatment or program at random, or by chance (like the flip of a coin). This means that each individual has an equal chance of being assigned to either group. Usually in studies that involve random assignment, participants will receive a new treatment or program, will receive nothing at all or will receive an existing treatment. When using random assignment, neither the researcher nor the participant can choose the group to which the participant is assigned.

The benefit of using random assignment is that it “evens the playing field.” This means that the groups will differ only in the program or treatment to which they are assigned. If both groups are equivalent except for the program or treatment that they receive, then any change that is observed after comparing information collected about individuals at the beginning of the study and again at the end of the study can be attributed to the program or treatment. This way, the researcher has more confidence that any changes that might have occurred are due to the treatment under study and not to the characteristics of the group.

A potential problem with random assignment is the temptation to ignore the random assignment procedures. For example, it may be tempting to assign an overweight participant to the treatment group that includes participation in a weight-loss program. Ignoring random assignment procedures in this study limits the ability to determine whether or not the weight loss program is effective because the groups will not be randomized. Research staff must follow random assignment protocol, if that is part of the study design, to maintain the integrity of the research. Failure to follow procedures used for random assignment prevents the study outcomes from being meaningful and applicable to the groups represented.

                                

                                                                                                          

 

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Advancing research • shaping policy • developing leaders, why randomize.

About Randomized Field Experiments Randomized field experiments allow researchers to scientifically measure the impact of an intervention on a particular outcome of interest.

What is a randomized field experiment? In a randomized experiment, a study sample is divided into one group that will receive the intervention being studied (the treatment group) and another group that will not receive the intervention (the control group). For instance, a study sample might consist of all registered voters in a particular city. This sample will then be randomly divided into treatment and control groups. Perhaps 40% of the sample will be on a campaign’s Get-Out-the-Vote (GOTV) mailing list and the other 60% of the sample will not receive the GOTV mailings. The outcome measured –voter turnout– can then be compared in the two groups. The difference in turnout will reflect the effectiveness of the intervention.

What does random assignment mean? The key to randomized experimental research design is in the random assignment of study subjects – for example, individual voters, precincts, media markets or some other group – into treatment or control groups. Randomization has a very specific meaning in this context. It does not refer to haphazard or casual choosing of some and not others. Randomization in this context means that care is taken to ensure that no pattern exists between the assignment of subjects into groups and any characteristics of those subjects. Every subject is as likely as any other to be assigned to the treatment (or control) group. Randomization is generally achieved by employing a computer program containing a random number generator. Randomization procedures differ based upon the research design of the experiment. Individuals or groups may be randomly assigned to treatment or control groups. Some research designs stratify subjects by geographic, demographic or other factors prior to random assignment in order to maximize the statistical power of the estimated effect of the treatment (e.g., GOTV intervention). Information about the randomization procedure is included in each experiment summary on the site.

What are the advantages of randomized experimental designs? Randomized experimental design yields the most accurate analysis of the effect of an intervention (e.g., a voter mobilization phone drive or a visit from a GOTV canvasser, on voter behavior). By randomly assigning subjects to be in the group that receives the treatment or to be in the control group, researchers can measure the effect of the mobilization method regardless of other factors that may make some people or groups more likely to participate in the political process. To provide a simple example, say we are testing the effectiveness of a voter education program on high school seniors. If we allow students from the class to volunteer to participate in the program, and we then compare the volunteers’ voting behavior against those who did not participate, our results will reflect something other than the effects of the voter education intervention. This is because there are, no doubt, qualities about those volunteers that make them different from students who do not volunteer. And, most important for our work, those differences may very well correlate with propensity to vote. Instead of letting students self-select, or even letting teachers select students (as teachers may have biases in who they choose), we could randomly assign all students in a given class to be in either a treatment or control group. This would ensure that those in the treatment and control groups differ solely due to chance. The value of randomization may also be seen in the use of walk lists for door-to-door canvassers. If canvassers choose which houses they will go to and which they will skip, they may choose houses that seem more inviting or they may choose houses that are placed closely together rather than those that are more spread out. These differences could conceivably correlate with voter turnout. Or if house numbers are chosen by selecting those on the first half of a ten page list, they may be clustered in neighborhoods that differ in important ways from neighborhoods in the second half of the list. Random assignment controls for both known and unknown variables that can creep in with other selection processes to confound analyses. Randomized experimental design is a powerful tool for drawing valid inferences about cause and effect. The use of randomized experimental design should allow a degree of certainty that the research findings cited in studies that employ this methodology reflect the effects of the interventions being measured and not some other underlying variable or variables.

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Why is random assignment important in psychology?

random assignment benefits

In the dynamic world of psychology research, understanding the importance of random assignment is essential for conducting rigorous and credible studies. Are you curious about how researchers design experiments to investigate the complexities of human behavior and cognition? Random assignment plays a pivotal role in experimental design, helping researchers avoid bias and ensure the validity and reliability of their findings. In this article, we will delve into the concept of random assignment and its critical significance in psychological research. By exploring the benefits of random assignment, such as eliminating bias, controlling for confounding variables, and enhancing internal and external validity, we will gain a deeper understanding of its impact on producing accurate and meaningful results.

If you are in need of assistance with your psychology assignments, our psychology assignment help service is here to provide expert support and guidance. 

Whether you are a psychology student, a researcher, or someone with a general interest in science, this article will shed light on the transformative power of random assignment and its essential role in unlocking the secrets of the human mind. Join us as we unravel the complexities of experimental design and discover how random assignment paves the way for robust and insightful psychological research.

Random assignment is of utmost importance in psychology experiments as it serves multiple vital purposes within the research process.

  • Firstly, random assignment ensures that each participant has an equal opportunity to be assigned to any given group, such as the experimental or control group. This equal distribution of participants helps to eliminate potential bias and confounding variables, creating groups that are comparable at the start of the study. By creating equivalent groups, researchers can confidently attribute any differences observed between groups to the manipulated independent variable, strengthening the internal validity of the experiment.
  • Secondly, random assignment helps to minimize selection biases, ensuring that participants are not deliberately or systematically assigned to specific groups based on personal traits or preferences. This random allocation of participants increases the likelihood that any observed effects are solely due to the manipulation of the independent variable rather than participant characteristics, enhancing the internal validity of the study.
  • Additionally, random assignment enhances the external validity of research findings by allowing for greater generalization to the larger population. When participants are randomly assigned, it reduces the likelihood of systematic differences between groups, making the results more applicable and representative of the target population.

The Foundation of Experimental Design

In psychology research, experiments are conducted to investigate cause-and-effect relationships between variables. However, it is essential to carefully design these studies to minimize bias and confounding variables that can influence results. This is where random assignment comes into play1. It serves as a fundamental component of experimental design, allowing researchers to create unbiased and reliable studies.

Breaking the Bias Barrier

One of the primary reasons random assignment is essential in psychology research is its ability to eliminate bias. Without random assignment, researchers may unknowingly assign participants with certain characteristics to specific groups, leading to a biased sample. By randomly allocating participants to different experimental conditions, random assignment helps ensure that each group represents the larger population2. This improves the generalizability of the findings and allows researchers to draw accurate conclusions about the broader population.

Minimizing Confounding Variables

Confounding variables can greatly impact the validity of research findings by introducing extraneous factors that may influence the observed effects1. Random assignment acts as a safeguard against confounding variables by distributing their effects equally among different experimental groups. This ensures that any observed differences between groups are solely attributable to the manipulated variables being studied, enhancing the credibility of the findings3.

Enhancing Internal Validity

Internal validity is the extent to which a study accurately measures the cause-and-effect relationship between variables1. Random assignment contributes significantly to enhancing internal validity by ensuring that the groups being compared are equivalent in terms of their characteristics, except for the manipulated variable. This control over potential confounding variables strengthens the internal validity of the study, enabling researchers to make confident conclusions based on their results4.

External Validity and Generalizability

In psychology research, external validity refers to the extent to which study findings can be generalized to real-world settings and other populations1. Random assignment plays a crucial role in improving external validity by creating diverse and representative samples. By randomly assigning participants, researchers increase the likelihood of obtaining a sample that closely mirrors the larger population, enhancing the applicability of the findings to different contexts5.

Random assignment is a powerful tool in psychology research, ensuring the validity and reliability of study findings. By eliminating bias, controlling for confounding variables, and enhancing internal and external validity, random assignment serves as the backbone of experimental design. It allows researchers to accurately investigate cause-and-effect relationships between variables and draw reliable conclusions. So, let's appreciate the significance of random assignment in psychological research, recognizing its role in unlocking accurate and trustworthy findings. Armed with this knowledge, we can navigate the exciting world of psychology research with confidence and curiosity.

In summary, random assignment is crucial in psychology experiments as it eliminates bias, controls for confounding variables, strengthens internal validity, minimizes selection biases, and enhances external validity. By implementing random assignment, researchers can have confidence in the accuracy and generalizability of their research findings.

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  • Random Assignment in Experiments | Introduction & Examples

Random Assignment in Experiments | Introduction & Examples

Published on 6 May 2022 by Pritha Bhandari . Revised on 13 February 2023.

In experimental research, random assignment is a way of placing participants from your sample into different treatment groups using randomisation.

With simple random assignment, every member of the sample has a known or equal chance of being placed in a control group or an experimental group. Studies that use simple random assignment are also called completely randomised designs .

Random assignment is a key part of experimental design . It helps you ensure that all groups are comparable at the start of a study: any differences between them are due to random factors.

Table of contents

Why does random assignment matter, random sampling vs random assignment, how do you use random assignment, when is random assignment not used, frequently asked questions about random assignment.

Random assignment is an important part of control in experimental research, because it helps strengthen the internal validity of an experiment.

In experiments, researchers manipulate an independent variable to assess its effect on a dependent variable, while controlling for other variables. To do so, they often use different levels of an independent variable for different groups of participants.

This is called a between-groups or independent measures design.

You use three groups of participants that are each given a different level of the independent variable:

  • A control group that’s given a placebo (no dosage)
  • An experimental group that’s given a low dosage
  • A second experimental group that’s given a high dosage

Random assignment to helps you make sure that the treatment groups don’t differ in systematic or biased ways at the start of the experiment.

If you don’t use random assignment, you may not be able to rule out alternative explanations for your results.

  • Participants recruited from pubs are placed in the control group
  • Participants recruited from local community centres are placed in the low-dosage experimental group
  • Participants recruited from gyms are placed in the high-dosage group

With this type of assignment, it’s hard to tell whether the participant characteristics are the same across all groups at the start of the study. Gym users may tend to engage in more healthy behaviours than people who frequent pubs or community centres, and this would introduce a healthy user bias in your study.

Although random assignment helps even out baseline differences between groups, it doesn’t always make them completely equivalent. There may still be extraneous variables that differ between groups, and there will always be some group differences that arise from chance.

Most of the time, the random variation between groups is low, and, therefore, it’s acceptable for further analysis. This is especially true when you have a large sample. In general, you should always use random assignment in experiments when it is ethically possible and makes sense for your study topic.

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Random sampling and random assignment are both important concepts in research, but it’s important to understand the difference between them.

Random sampling (also called probability sampling or random selection) is a way of selecting members of a population to be included in your study. In contrast, random assignment is a way of sorting the sample participants into control and experimental groups.

While random sampling is used in many types of studies, random assignment is only used in between-subjects experimental designs.

Some studies use both random sampling and random assignment, while others use only one or the other.

Random sample vs random assignment

Random sampling enhances the external validity or generalisability of your results, because it helps to ensure that your sample is unbiased and representative of the whole population. This allows you to make stronger statistical inferences .

You use a simple random sample to collect data. Because you have access to the whole population (all employees), you can assign all 8,000 employees a number and use a random number generator to select 300 employees. These 300 employees are your full sample.

Random assignment enhances the internal validity of the study, because it ensures that there are no systematic differences between the participants in each group. This helps you conclude that the outcomes can be attributed to the independent variable .

  • A control group that receives no intervention
  • An experimental group that has a remote team-building intervention every week for a month

You use random assignment to place participants into the control or experimental group. To do so, you take your list of participants and assign each participant a number. Again, you use a random number generator to place each participant in one of the two groups.

To use simple random assignment, you start by giving every member of the sample a unique number. Then, you can use computer programs or manual methods to randomly assign each participant to a group.

  • Random number generator: Use a computer program to generate random numbers from the list for each group.
  • Lottery method: Place all numbers individually into a hat or a bucket, and draw numbers at random for each group.
  • Flip a coin: When you only have two groups, for each number on the list, flip a coin to decide if they’ll be in the control or the experimental group.
  • Use a dice: When you have three groups, for each number on the list, roll a die to decide which of the groups they will be in. For example, assume that rolling 1 or 2 lands them in a control group; 3 or 4 in an experimental group; and 5 or 6 in a second control or experimental group.

This type of random assignment is the most powerful method of placing participants in conditions, because each individual has an equal chance of being placed in any one of your treatment groups.

Random assignment in block designs

In more complicated experimental designs, random assignment is only used after participants are grouped into blocks based on some characteristic (e.g., test score or demographic variable). These groupings mean that you need a larger sample to achieve high statistical power .

For example, a randomised block design involves placing participants into blocks based on a shared characteristic (e.g., college students vs graduates), and then using random assignment within each block to assign participants to every treatment condition. This helps you assess whether the characteristic affects the outcomes of your treatment.

In an experimental matched design , you use blocking and then match up individual participants from each block based on specific characteristics. Within each matched pair or group, you randomly assign each participant to one of the conditions in the experiment and compare their outcomes.

Sometimes, it’s not relevant or ethical to use simple random assignment, so groups are assigned in a different way.

When comparing different groups

Sometimes, differences between participants are the main focus of a study, for example, when comparing children and adults or people with and without health conditions. Participants are not randomly assigned to different groups, but instead assigned based on their characteristics.

In this type of study, the characteristic of interest (e.g., gender) is an independent variable, and the groups differ based on the different levels (e.g., men, women). All participants are tested the same way, and then their group-level outcomes are compared.

When it’s not ethically permissible

When studying unhealthy or dangerous behaviours, it’s not possible to use random assignment. For example, if you’re studying heavy drinkers and social drinkers, it’s unethical to randomly assign participants to one of the two groups and ask them to drink large amounts of alcohol for your experiment.

When you can’t assign participants to groups, you can also conduct a quasi-experimental study . In a quasi-experiment, you study the outcomes of pre-existing groups who receive treatments that you may not have any control over (e.g., heavy drinkers and social drinkers).

These groups aren’t randomly assigned, but may be considered comparable when some other variables (e.g., age or socioeconomic status) are controlled for.

In experimental research, random assignment is a way of placing participants from your sample into different groups using randomisation. With this method, every member of the sample has a known or equal chance of being placed in a control group or an experimental group.

Random selection, or random sampling , is a way of selecting members of a population for your study’s sample.

In contrast, random assignment is a way of sorting the sample into control and experimental groups.

Random sampling enhances the external validity or generalisability of your results, while random assignment improves the internal validity of your study.

Random assignment is used in experiments with a between-groups or independent measures design. In this research design, there’s usually a control group and one or more experimental groups. Random assignment helps ensure that the groups are comparable.

In general, you should always use random assignment in this type of experimental design when it is ethically possible and makes sense for your study topic.

To implement random assignment , assign a unique number to every member of your study’s sample .

Then, you can use a random number generator or a lottery method to randomly assign each number to a control or experimental group. You can also do so manually, by flipping a coin or rolling a die to randomly assign participants to groups.

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5.2 Experimental Design

Learning objectives.

  • Explain the difference between between-subjects and within-subjects experiments, list some of the pros and cons of each approach, and decide which approach to use to answer a particular research question.
  • Define random assignment, distinguish it from random sampling, explain its purpose in experimental research, and use some simple strategies to implement it
  • Define several types of carryover effect, give examples of each, and explain how counterbalancing helps to deal with them.

In this section, we look at some different ways to design an experiment. The primary distinction we will make is between approaches in which each participant experiences one level of the independent variable and approaches in which each participant experiences all levels of the independent variable. The former are called between-subjects experiments and the latter are called within-subjects experiments.

Between-Subjects Experiments

In a  between-subjects experiment , each participant is tested in only one condition. For example, a researcher with a sample of 100 university  students might assign half of them to write about a traumatic event and the other half write about a neutral event. Or a researcher with a sample of 60 people with severe agoraphobia (fear of open spaces) might assign 20 of them to receive each of three different treatments for that disorder. It is essential in a between-subjects experiment that the researcher assigns participants to conditions so that the different groups are, on average, highly similar to each other. Those in a trauma condition and a neutral condition, for example, should include a similar proportion of men and women, and they should have similar average intelligence quotients (IQs), similar average levels of motivation, similar average numbers of health problems, and so on. This matching is a matter of controlling these extraneous participant variables across conditions so that they do not become confounding variables.

Random Assignment

The primary way that researchers accomplish this kind of control of extraneous variables across conditions is called  random assignment , which means using a random process to decide which participants are tested in which conditions. Do not confuse random assignment with random sampling. Random sampling is a method for selecting a sample from a population, and it is rarely used in psychological research. Random assignment is a method for assigning participants in a sample to the different conditions, and it is an important element of all experimental research in psychology and other fields too.

In its strictest sense, random assignment should meet two criteria. One is that each participant has an equal chance of being assigned to each condition (e.g., a 50% chance of being assigned to each of two conditions). The second is that each participant is assigned to a condition independently of other participants. Thus one way to assign participants to two conditions would be to flip a coin for each one. If the coin lands heads, the participant is assigned to Condition A, and if it lands tails, the participant is assigned to Condition B. For three conditions, one could use a computer to generate a random integer from 1 to 3 for each participant. If the integer is 1, the participant is assigned to Condition A; if it is 2, the participant is assigned to Condition B; and if it is 3, the participant is assigned to Condition C. In practice, a full sequence of conditions—one for each participant expected to be in the experiment—is usually created ahead of time, and each new participant is assigned to the next condition in the sequence as he or she is tested. When the procedure is computerized, the computer program often handles the random assignment.

One problem with coin flipping and other strict procedures for random assignment is that they are likely to result in unequal sample sizes in the different conditions. Unequal sample sizes are generally not a serious problem, and you should never throw away data you have already collected to achieve equal sample sizes. However, for a fixed number of participants, it is statistically most efficient to divide them into equal-sized groups. It is standard practice, therefore, to use a kind of modified random assignment that keeps the number of participants in each group as similar as possible. One approach is block randomization . In block randomization, all the conditions occur once in the sequence before any of them is repeated. Then they all occur again before any of them is repeated again. Within each of these “blocks,” the conditions occur in a random order. Again, the sequence of conditions is usually generated before any participants are tested, and each new participant is assigned to the next condition in the sequence.  Table 5.2  shows such a sequence for assigning nine participants to three conditions. The Research Randomizer website ( http://www.randomizer.org ) will generate block randomization sequences for any number of participants and conditions. Again, when the procedure is computerized, the computer program often handles the block randomization.

4 B
5 C
6 A

Random assignment is not guaranteed to control all extraneous variables across conditions. The process is random, so it is always possible that just by chance, the participants in one condition might turn out to be substantially older, less tired, more motivated, or less depressed on average than the participants in another condition. However, there are some reasons that this possibility is not a major concern. One is that random assignment works better than one might expect, especially for large samples. Another is that the inferential statistics that researchers use to decide whether a difference between groups reflects a difference in the population takes the “fallibility” of random assignment into account. Yet another reason is that even if random assignment does result in a confounding variable and therefore produces misleading results, this confound is likely to be detected when the experiment is replicated. The upshot is that random assignment to conditions—although not infallible in terms of controlling extraneous variables—is always considered a strength of a research design.

Matched Groups

An alternative to simple random assignment of participants to conditions is the use of a matched-groups design . Using this design, participants in the various conditions are matched on the dependent variable or on some extraneous variable(s) prior the manipulation of the independent variable. This guarantees that these variables will not be confounded across the experimental conditions. For instance, if we want to determine whether expressive writing affects people’s health then we could start by measuring various health-related variables in our prospective research participants. We could then use that information to rank-order participants according to how healthy or unhealthy they are. Next, the two healthiest participants would be randomly assigned to complete different conditions (one would be randomly assigned to the traumatic experiences writing condition and the other to the neutral writing condition). The next two healthiest participants would then be randomly assigned to complete different conditions, and so on until the two least healthy participants. This method would ensure that participants in the traumatic experiences writing condition are matched to participants in the neutral writing condition with respect to health at the beginning of the study. If at the end of the experiment, a difference in health was detected across the two conditions, then we would know that it is due to the writing manipulation and not to pre-existing differences in health.

Within-Subjects Experiments

In a  within-subjects experiment , each participant is tested under all conditions. Consider an experiment on the effect of a defendant’s physical attractiveness on judgments of his guilt. Again, in a between-subjects experiment, one group of participants would be shown an attractive defendant and asked to judge his guilt, and another group of participants would be shown an unattractive defendant and asked to judge his guilt. In a within-subjects experiment, however, the same group of participants would judge the guilt of both an attractive  and  an unattractive defendant.

The primary advantage of this approach is that it provides maximum control of extraneous participant variables. Participants in all conditions have the same mean IQ, same socioeconomic status, same number of siblings, and so on—because they are the very same people. Within-subjects experiments also make it possible to use statistical procedures that remove the effect of these extraneous participant variables on the dependent variable and therefore make the data less “noisy” and the effect of the independent variable easier to detect. We will look more closely at this idea later in the book .  However, not all experiments can use a within-subjects design nor would it be desirable to do so.

One disadvantage of within-subjects experiments is that they make it easier for participants to guess the hypothesis. For example, a participant who is asked to judge the guilt of an attractive defendant and then is asked to judge the guilt of an unattractive defendant is likely to guess that the hypothesis is that defendant attractiveness affects judgments of guilt. This  knowledge could  lead the participant to judge the unattractive defendant more harshly because he thinks this is what he is expected to do. Or it could make participants judge the two defendants similarly in an effort to be “fair.”

Carryover Effects and Counterbalancing

The primary disadvantage of within-subjects designs is that they can result in order effects. An order effect  occurs when participants’ responses in the various conditions are affected by the order of conditions to which they were exposed. One type of order effect is a carryover effect. A  carryover effect  is an effect of being tested in one condition on participants’ behavior in later conditions. One type of carryover effect is a  practice effect , where participants perform a task better in later conditions because they have had a chance to practice it. Another type is a fatigue effect , where participants perform a task worse in later conditions because they become tired or bored. Being tested in one condition can also change how participants perceive stimuli or interpret their task in later conditions. This  type of effect is called a  context effect (or contrast effect) . For example, an average-looking defendant might be judged more harshly when participants have just judged an attractive defendant than when they have just judged an unattractive defendant. Within-subjects experiments also make it easier for participants to guess the hypothesis. For example, a participant who is asked to judge the guilt of an attractive defendant and then is asked to judge the guilt of an unattractive defendant is likely to guess that the hypothesis is that defendant attractiveness affects judgments of guilt. 

Carryover effects can be interesting in their own right. (Does the attractiveness of one person depend on the attractiveness of other people that we have seen recently?) But when they are not the focus of the research, carryover effects can be problematic. Imagine, for example, that participants judge the guilt of an attractive defendant and then judge the guilt of an unattractive defendant. If they judge the unattractive defendant more harshly, this might be because of his unattractiveness. But it could be instead that they judge him more harshly because they are becoming bored or tired. In other words, the order of the conditions is a confounding variable. The attractive condition is always the first condition and the unattractive condition the second. Thus any difference between the conditions in terms of the dependent variable could be caused by the order of the conditions and not the independent variable itself.

There is a solution to the problem of order effects, however, that can be used in many situations. It is  counterbalancing , which means testing different participants in different orders. The best method of counterbalancing is complete counterbalancing  in which an equal number of participants complete each possible order of conditions. For example, half of the participants would be tested in the attractive defendant condition followed by the unattractive defendant condition, and others half would be tested in the unattractive condition followed by the attractive condition. With three conditions, there would be six different orders (ABC, ACB, BAC, BCA, CAB, and CBA), so some participants would be tested in each of the six orders. With four conditions, there would be 24 different orders; with five conditions there would be 120 possible orders. With counterbalancing, participants are assigned to orders randomly, using the techniques we have already discussed. Thus, random assignment plays an important role in within-subjects designs just as in between-subjects designs. Here, instead of randomly assigning to conditions, they are randomly assigned to different orders of conditions. In fact, it can safely be said that if a study does not involve random assignment in one form or another, it is not an experiment.

A more efficient way of counterbalancing is through a Latin square design which randomizes through having equal rows and columns. For example, if you have four treatments, you must have four versions. Like a Sudoku puzzle, no treatment can repeat in a row or column. For four versions of four treatments, the Latin square design would look like:

A B C D
B C D A
C D A B
D A B C

You can see in the diagram above that the square has been constructed to ensure that each condition appears at each ordinal position (A appears first once, second once, third once, and fourth once) and each condition preceded and follows each other condition one time. A Latin square for an experiment with 6 conditions would by 6 x 6 in dimension, one for an experiment with 8 conditions would be 8 x 8 in dimension, and so on. So while complete counterbalancing of 6 conditions would require 720 orders, a Latin square would only require 6 orders.

Finally, when the number of conditions is large experiments can use  random counterbalancing  in which the order of the conditions is randomly determined for each participant. Using this technique every possible order of conditions is determined and then one of these orders is randomly selected for each participant. This is not as powerful a technique as complete counterbalancing or partial counterbalancing using a Latin squares design. Use of random counterbalancing will result in more random error, but if order effects are likely to be small and the number of conditions is large, this is an option available to researchers.

There are two ways to think about what counterbalancing accomplishes. One is that it controls the order of conditions so that it is no longer a confounding variable. Instead of the attractive condition always being first and the unattractive condition always being second, the attractive condition comes first for some participants and second for others. Likewise, the unattractive condition comes first for some participants and second for others. Thus any overall difference in the dependent variable between the two conditions cannot have been caused by the order of conditions. A second way to think about what counterbalancing accomplishes is that if there are carryover effects, it makes it possible to detect them. One can analyze the data separately for each order to see whether it had an effect.

When 9 Is “Larger” Than 221

Researcher Michael Birnbaum has argued that the  lack  of context provided by between-subjects designs is often a bigger problem than the context effects created by within-subjects designs. To demonstrate this problem, he asked participants to rate two numbers on how large they were on a scale of 1-to-10 where 1 was “very very small” and 10 was “very very large”.  One group of participants were asked to rate the number 9 and another group was asked to rate the number 221 (Birnbaum, 1999) [1] . Participants in this between-subjects design gave the number 9 a mean rating of 5.13 and the number 221 a mean rating of 3.10. In other words, they rated 9 as larger than 221! According to Birnbaum, this  difference  is because participants spontaneously compared 9 with other one-digit numbers (in which case it is  relatively large) and compared 221 with other three-digit numbers (in which case it is relatively  small).

Simultaneous Within-Subjects Designs

So far, we have discussed an approach to within-subjects designs in which participants are tested in one condition at a time. There is another approach, however, that is often used when participants make multiple responses in each condition. Imagine, for example, that participants judge the guilt of 10 attractive defendants and 10 unattractive defendants. Instead of having people make judgments about all 10 defendants of one type followed by all 10 defendants of the other type, the researcher could present all 20 defendants in a sequence that mixed the two types. The researcher could then compute each participant’s mean rating for each type of defendant. Or imagine an experiment designed to see whether people with social anxiety disorder remember negative adjectives (e.g., “stupid,” “incompetent”) better than positive ones (e.g., “happy,” “productive”). The researcher could have participants study a single list that includes both kinds of words and then have them try to recall as many words as possible. The researcher could then count the number of each type of word that was recalled. 

Between-Subjects or Within-Subjects?

Almost every experiment can be conducted using either a between-subjects design or a within-subjects design. This possibility means that researchers must choose between the two approaches based on their relative merits for the particular situation.

Between-subjects experiments have the advantage of being conceptually simpler and requiring less testing time per participant. They also avoid carryover effects without the need for counterbalancing. Within-subjects experiments have the advantage of controlling extraneous participant variables, which generally reduces noise in the data and makes it easier to detect a relationship between the independent and dependent variables.

A good rule of thumb, then, is that if it is possible to conduct a within-subjects experiment (with proper counterbalancing) in the time that is available per participant—and you have no serious concerns about carryover effects—this design is probably the best option. If a within-subjects design would be difficult or impossible to carry out, then you should consider a between-subjects design instead. For example, if you were testing participants in a doctor’s waiting room or shoppers in line at a grocery store, you might not have enough time to test each participant in all conditions and therefore would opt for a between-subjects design. Or imagine you were trying to reduce people’s level of prejudice by having them interact with someone of another race. A within-subjects design with counterbalancing would require testing some participants in the treatment condition first and then in a control condition. But if the treatment works and reduces people’s level of prejudice, then they would no longer be suitable for testing in the control condition. This difficulty is true for many designs that involve a treatment meant to produce long-term change in participants’ behavior (e.g., studies testing the effectiveness of psychotherapy). Clearly, a between-subjects design would be necessary here.

Remember also that using one type of design does not preclude using the other type in a different study. There is no reason that a researcher could not use both a between-subjects design and a within-subjects design to answer the same research question. In fact, professional researchers often take exactly this type of mixed methods approach.

Key Takeaways

  • Experiments can be conducted using either between-subjects or within-subjects designs. Deciding which to use in a particular situation requires careful consideration of the pros and cons of each approach.
  • Random assignment to conditions in between-subjects experiments or counterbalancing of orders of conditions in within-subjects experiments is a fundamental element of experimental research. The purpose of these techniques is to control extraneous variables so that they do not become confounding variables.
  • You want to test the relative effectiveness of two training programs for running a marathon.
  • Using photographs of people as stimuli, you want to see if smiling people are perceived as more intelligent than people who are not smiling.
  • In a field experiment, you want to see if the way a panhandler is dressed (neatly vs. sloppily) affects whether or not passersby give him any money.
  • You want to see if concrete nouns (e.g.,  dog ) are recalled better than abstract nouns (e.g.,  truth).
  • Birnbaum, M.H. (1999). How to show that 9>221: Collect judgments in a between-subjects design. Psychological Methods, 4 (3), 243-249. ↵

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  • v.43(2); Mar-Apr 2008

Issues in Outcomes Research: An Overview of Randomization Techniques for Clinical Trials

Minsoo kang.

1 Middle Tennessee State University, Murfreesboro, TN

Brian G Ragan

2 University of Northern Iowa, Cedar Falls, IA

Jae-Hyeon Park

3 Korea National Sport University, Seoul, Korea

To review and describe randomization techniques used in clinical trials, including simple, block, stratified, and covariate adaptive techniques.

Background:

Clinical trials are required to establish treatment efficacy of many athletic training procedures. In the past, we have relied on evidence of questionable scientific merit to aid the determination of treatment choices. Interest in evidence-based practice is growing rapidly within the athletic training profession, placing greater emphasis on the importance of well-conducted clinical trials. One critical component of clinical trials that strengthens results is random assignment of participants to control and treatment groups. Although randomization appears to be a simple concept, issues of balancing sample sizes and controlling the influence of covariates a priori are important. Various techniques have been developed to account for these issues, including block, stratified randomization, and covariate adaptive techniques.

Advantages:

Athletic training researchers and scholarly clinicians can use the information presented in this article to better conduct and interpret the results of clinical trials. Implementing these techniques will increase the power and validity of findings of athletic medicine clinical trials, which will ultimately improve the quality of care provided.

Outcomes research is critical in the evidence-based health care environment because it addresses scientific questions concerning the efficacy of treatments. Clinical trials are considered the “gold standard” for outcomes in biomedical research. In athletic training, calls for more evidence-based medical research, specifically clinical trials, have been issued. 1 , 2

The strength of clinical trials is their superior ability to measure change over time from a treatment. Treatment differences identified from cross-sectional observational designs rather than experimental clinical trials have methodologic weaknesses, including confounding, cohort effects, and selection bias. 3 For example, using a nonrandomized trial to examine the effectiveness of prophylactic knee bracing to prevent medial collateral ligament injuries may suffer from confounders and jeopardize the results. One possible confounder is a history of knee injuries. Participants with a history of knee injuries may be more likely to wear braces than those with no such history. Participants with a history of injury are more likely to suffer additional knee injuries, unbalancing the groups and influencing the results of the study.

The primary goal of comparative clinical trials is to provide comparisons of treatments with maximum precision and validity. 4 One critical component of clinical trials is random assignment of participants into groups. Randomizing participants helps remove the effect of extraneous variables (eg, age, injury history) and minimizes bias associated with treatment assignment. Randomization is considered by most researchers to be the optimal approach for participant assignment in clinical trials because it strengthens the results and data interpretation. 4 – , 9

One potential problem with small clinical trials (n < 100) 7 is that conventional simple randomization methods, such as flipping a coin, may result in imbalanced sample size and baseline characteristics (ie, covariates) among treatment and control groups. 9 , 10 This imbalance of baseline characteristics can influence the comparison between treatment and control groups and introduce potential confounding factors. Many procedures have been proposed for random group assignment of participants in clinical trials. 11 Simple, block, stratified, and covariate adaptive randomizations are some examples. Each technique has advantages and disadvantages, which must be carefully considered before a method is selected. Our purpose is to introduce the concept and significance of randomization and to review several conventional and relatively new randomization techniques to aid in the design and implementation of valid clinical trials.

What Is Randomization?

Randomization is the process of assigning participants to treatment and control groups, assuming that each participant has an equal chance of being assigned to any group. 12 Randomization has evolved into a fundamental aspect of scientific research methodology. Demands have increased for more randomized clinical trials in many areas of biomedical research, such as athletic training. 2 , 13 In fact, in the last 2 decades, internationally recognized major medical journals, such as the Journal of the American Medical Association and the BMJ , have been increasingly interested in publishing studies reporting results from randomized controlled trials. 5

Since Fisher 14 first introduced the idea of randomization in a 1926 agricultural study, the academic community has deemed randomization an essential tool for unbiased comparisons of treatment groups. Five years after Fisher's introductory paper, the first randomized clinical trial involving tuberculosis was conducted. 15 A total of 24 participants were paired (ie, 12 comparable pairs), and by a flip of a coin, each participant within the pair was assigned to either the control or treatment group. By employing randomization, researchers offer each participant an equal chance of being assigned to groups, which makes the groups comparable on the dependent variable by eliminating potential bias. Indeed, randomization of treatments in clinical trials is the only means of avoiding systematic characteristic bias of participants assigned to different treatments. Although randomization may be accomplished with a simple coin toss, more appropriate and better methods are often needed, especially in small clinical trials. These other methods will be discussed in this review.

Why Randomize?

Researchers demand randomization for several reasons. First, participants in various groups should not differ in any systematic way. In a clinical trial, if treatment groups are systematically different, trial results will be biased. Suppose that participants are assigned to control and treatment groups in a study examining the efficacy of a walking intervention. If a greater proportion of older adults is assigned to the treatment group, then the outcome of the walking intervention may be influenced by this imbalance. The effects of the treatment would be indistinguishable from the influence of the imbalance of covariates, thereby requiring the researcher to control for the covariates in the analysis to obtain an unbiased result. 16

Second, proper randomization ensures no a priori knowledge of group assignment (ie, allocation concealment). That is, researchers, participants, and others should not know to which group the participant will be assigned. Knowledge of group assignment creates a layer of potential selection bias that may taint the data. Schulz and Grimes 17 stated that trials with inadequate or unclear randomization tended to overestimate treatment effects up to 40% compared with those that used proper randomization. The outcome of the trial can be negatively influenced by this inadequate randomization.

Statistical techniques such as analysis of covariance (ANCOVA), multivariate ANCOVA, or both, are often used to adjust for covariate imbalance in the analysis stage of the clinical trial. However, the interpretation of this postadjustment approach is often difficult because imbalance of covariates frequently leads to unanticipated interaction effects, such as unequal slopes among subgroups of covariates. 18 , 19 One of the critical assumptions in ANCOVA is that the slopes of regression lines are the same for each group of covariates (ie, homogeneity of regression slopes). The adjustment needed for each covariate group may vary, which is problematic because ANCOVA uses the average slope across the groups to adjust the outcome variable. Thus, the ideal way of balancing covariates among groups is to apply sound randomization in the design stage of a clinical trial (before the adjustment procedure) instead of after data collection. In such instances, random assignment is necessary and guarantees validity for statistical tests of significance that are used to compare treatments.

How To Randomize?

Many procedures have been proposed for the random assignment of participants to treatment groups in clinical trials. In this article, common randomization techniques, including simple randomization, block randomization, stratified randomization, and covariate adaptive randomization, are reviewed. Each method is described along with its advantages and disadvantages. It is very important to select a method that will produce interpretable, valid results for your study.

Simple Randomization

Randomization based on a single sequence of random assignments is known as simple randomization. 10 This technique maintains complete randomness of the assignment of a person to a particular group. The most common and basic method of simple randomization is flipping a coin. For example, with 2 treatment groups (control versus treatment), the side of the coin (ie, heads  =  control, tails  =  treatment) determines the assignment of each participant. Other methods include using a shuffled deck of cards (eg, even  =  control, odd  =  treatment) or throwing a die (eg, below and equal to 3  =  control, over 3  =  treatment). A random number table found in a statistics book or computer-generated random numbers can also be used for simple randomization of participants.

This randomization approach is simple and easy to implement in a clinical trial. In large trials (n > 200), simple randomization can be trusted to generate similar numbers of participants among groups. However, randomization results could be problematic in relatively small sample size clinical trials (n < 100), resulting in an unequal number of participants among groups. For example, using a coin toss with a small sample size (n  =  10) may result in an imbalance such that 7 participants are assigned to the control group and 3 to the treatment group ( Figure 1 ).

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Block Randomization

The block randomization method is designed to randomize participants into groups that result in equal sample sizes. This method is used to ensure a balance in sample size across groups over time. Blocks are small and balanced with predetermined group assignments, which keeps the numbers of participants in each group similar at all times. According to Altman and Bland, 10 the block size is determined by the researcher and should be a multiple of the number of groups (ie, with 2 treatment groups, block size of either 4 or 6). Blocks are best used in smaller increments as researchers can more easily control balance. 7 After block size has been determined, all possible balanced combinations of assignment within the block (ie, equal number for all groups within the block) must be calculated. Blocks are then randomly chosen to determine the participants' assignment into the groups.

For a clinical trial with control and treatment groups involving 40 participants, a randomized block procedure would be as follows: (1) a block size of 4 is chosen, (2) possible balanced combinations with 2 C (control) and 2 T (treatment) subjects are calculated as 6 (TTCC, TCTC, TCCT, CTTC, CTCT, CCTT), and (3) blocks are randomly chosen to determine the assignment of all 40 participants (eg, one random sequence would be [TTCC / TCCT / CTTC / CTTC / TCCT / CCTT / TTCC / TCTC / CTCT / TCTC]). This procedure results in 20 participants in both the control and treatment groups ( Figure 2 ).

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Although balance in sample size may be achieved with this method, groups may be generated that are rarely comparable in terms of certain covariates. 6 For example, one group may have more participants with secondary diseases (eg, diabetes, multiple sclerosis, cancer) that could confound the data and may negatively influence the results of the clinical trial. Pocock and Simon 11 stressed the importance of controlling for these covariates because of serious consequences to the interpretation of the results. Such an imbalance could introduce bias in the statistical analysis and reduce the power of the study. 4 , 6 , 8 Hence, sample size and covariates must be balanced in small clinical trials.

Stratified Randomization

The stratified randomization method addresses the need to control and balance the influence of covariates. This method can be used to achieve balance among groups in terms of participants' baseline characteristics (covariates). Specific covariates must be identified by the researcher who understands the potential influence each covariate has on the dependent variable. Stratified randomization is achieved by generating a separate block for each combination of covariates, and participants are assigned to the appropriate block of covariates. After all participants have been identified and assigned into blocks, simple randomization occurs within each block to assign participants to one of the groups.

The stratified randomization method controls for the possible influence of covariates that would jeopardize the conclusions of the clinical trial. For example, a clinical trial of different rehabilitation techniques after a surgical procedure will have a number of covariates. It is well known that the age of the patient affects the rate of healing. Thus, age could be a confounding variable and influence the outcome of the clinical trial. Stratified randomization can balance the control and treatment groups for age or other identified covariates.

For example, with 2 groups involving 40 participants, the stratified randomization method might be used to control the covariates of sex (2 levels: male, female) and body mass index (3 levels: underweight, normal, overweight) between study arms. With these 2 covariates, possible block combinations total 6 (eg, male, underweight). A simple randomization procedure, such as flipping a coin, is used to assign the participants within each block to one of the treatment groups ( Figure 3 ).

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Although stratified randomization is a relatively simple and useful technique, especially for smaller clinical trials, it becomes complicated to implement if many covariates must be controlled. 20 For example, too many block combinations may lead to imbalances in overall treatment allocations because a large number of blocks can generate small participant numbers within the block. Therneau 21 purported that a balance in covariates begins to fail when the number of blocks approaches half the sample size. If another 4-level covariate was added to the example, the number of block combinations would increase from 6 to 24 (2 × 3 × 4), for an average of fewer than 2 (40 / 24  =  1.7) participants per block, reducing the usefulness of the procedure to balance the covariates and jeopardizing the validity of the clinical trial. In small studies, it may not be feasible to stratify more than 1 or 2 covariates because the number of blocks can quickly approach the number of participants. 10

Stratified randomization has another limitation: it works only when all participants have been identified before group assignment. This method is rarely applicable, however, because clinical trial participants are often enrolled one at a time on a continuous basis. When baseline characteristics of all participants are not available before assignment, using stratified randomization is difficult. 7

Covariate Adaptive Randomization

Covariate adaptive randomization has been recommended by many researchers as a valid alternative randomization method for clinical trials. 9 , 22 In covariate adaptive randomization, a new participant is sequentially assigned to a particular treatment group by taking into account the specific covariates and previous assignments of participants. 9 , 12 , 18 , 23 , 24 Covariate adaptive randomization uses the method of minimization by assessing the imbalance of sample size among several covariates. This covariate adaptive approach was first described by Taves. 23

The Taves covariate adaptive randomization method allows for the examination of previous participant group assignments to make a case-by-case decision on group assignment for each individual who enrolls in the study. Consider again the example of 2 groups involving 40 participants, with sex (2 levels: male, female) and body mass index (3 levels: underweight, normal, overweight) as covariates. Assume the first 9 participants have already been randomly assigned to groups by flipping a coin. The 9 participants' group assignments are broken down by covariate level in Figure 4 . Now the 10th participant, who is male and underweight, needs to be assigned to a group (ie, control versus treatment). Based on the characteristics of the 10th participant, the Taves method adds marginal totals of the corresponding covariate categories for each group and compares the totals. The participant is assigned to the group with the lower covariate total to minimize imbalance. In this example, the appropriate categories are male and underweight, which results in the total of 3 (2 for male category + 1 for underweight category) for the control group and a total of 5 (3 for male category + 2 for underweight category) for the treatment group. Because the sum of marginal totals is lower for the control group (3 < 5), the 10th participant is assigned to the control group ( Figure 5 ).

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The Pocock and Simon method 11 of covariate adaptive randomization is similar to the method Taves 23 described. The difference in this approach is the temporary assignment of participants to both groups. This method uses the absolute difference between groups to determine group assignment. To minimize imbalance, the participant is assigned to the group determined by the lowest sum of the absolute differences among the covariates between the groups. For example, using the previous situation in assigning the 10th participant to a group, the Pocock and Simon method would (1) assign the 10th participant temporarily to the control group, resulting in marginal totals of 3 for male category and 2 for underweight category; (2) calculate the absolute difference between control and treatment group (males: 3 control – 3 treatment  =  0; underweight: 2 control – 2 treatment  =  0) and sum (0 + 0  =  0); (3) temporarily assign the 10th participant to the treatment group, resulting in marginal totals of 4 for male category and 3 for underweight category; (4) calculate the absolute difference between control and treatment group (males: 2 control – 4 treatment  =  2; underweight: 1 control – 3 treatment  =  2) and sum (2 + 2  =  4); and (5) assign the 10th participant to the control group because of the lowest sum of absolute differences (0 < 4).

Pocock and Simon 11 also suggested using a variance approach. Instead of calculating absolute difference among groups, this approach calculates the variance among treatment groups. Although the variance method performs similarly to the absolute difference method, both approaches suffer from the limitation of handling only categorical covariates. 25

Frane 18 introduced a covariate adaptive randomization for both continuous and categorical types. Frane used P values to identify imbalance among treatment groups: a smaller P value represents more imbalance among treatment groups.

The Frane method for assigning participants to either the control or treatment group would include (1) temporarily assigning the participant to both the control and treatment groups; (2) calculating P values for each of the covariates using a t test and analysis of variance (ANOVA) for continuous variables and goodness-of-fit χ 2 test for categorical variables; (3) determining the minimum P value for each control or treatment group, which indicates more imbalance among treatment groups; and (4) assigning the participant to the group with the larger minimum P value (ie, try to avoid more imbalance in groups).

Going back to the previous example of assigning the 10th participant (male and underweight) to a group, the Frane method would result in the assignment to the control group. The steps used to make this decision were calculating P values for each of the covariates using the χ 2 goodness-of-fit test represented in the Table . The t tests and ANOVAs were not used because the covariates in this example were categorical. Based on the Table , the lowest minimum P values were 1.0 for the control group and 0.317 for the treatment group. The 10th participant was assigned to the control group because of the higher minimum P value, which indicates better balance in the control group (1.0 > 0.317).

Probabilities From χ 2 Goodness-of-Fit Tests for the Example Shown in Figure 5 (Frane 18 Method)

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Covariate adaptive randomization produces less imbalance than other conventional randomization methods and can be used successfully to balance important covariates among control and treatment groups. 6 Although the balance of covariates among groups using the stratified randomization method begins to fail when the number of blocks approaches half the sample size, covariate adaptive randomization can better handle the problem of increasing numbers of covariates (ie, increased block combinations). 9

One concern of these covariate adaptive randomization methods is that treatment assignments sometimes become highly predictable. Investigators using covariate adaptive randomization sometimes come to believe that group assignment for the next participant can be readily predicted, going against the basic concept of randomization. 12 , 26 , 27 This predictability stems from the ongoing assignment of participants to groups wherein the current allocation of participants may suggest future participant group assignment. In their review, Scott et al 9 argued that this predictability is also true of other methods, including stratified randomization, and it should not be overly penalized. Zielhuis et al 28 and Frane 18 suggested a practical approach to prevent predictability: a small number of participants should be randomly assigned into the groups before the covariate adaptive randomization technique being applied.

The complicated computation process of covariate adaptive randomization increases the administrative burden, thereby limiting its use in practice. A user-friendly computer program for covariate adaptive randomization is available (free of charge) upon request from the authors (M.K., B.G.R., or J.H.P.). 29

Conclusions

Our purpose was to introduce randomization, including its concept and significance, and to review several randomization techniques to guide athletic training researchers and practitioners to better design their randomized clinical trials. Many factors can affect the results of clinical research, but randomization is considered the gold standard in most clinical trials. It eliminates selection bias, ensures balance of sample size and baseline characteristics, and is an important step in guaranteeing the validity of statistical tests of significance used to compare treatment groups.

Before choosing a randomization method, several factors need to be considered, including the size of the clinical trial; the need for balance in sample size, covariates, or both; and participant enrollment. 16 Figure 6 depicts a flowchart designed to help select an appropriate randomization technique. For example, a power analysis for a clinical trial of different rehabilitation techniques after a surgical procedure indicated a sample size of 80. A well-known covariate for this study is age, which must be balanced among groups. Because of the nature of the study with postsurgical patients, participant recruitment and enrollment will be continuous. Using the flowchart, the appropriate randomization technique is covariate adaptive randomization technique.

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Simple randomization works well for a large trial (eg, n > 200) but not for a small trial (n < 100). 7 To achieve balance in sample size, block randomization is desirable. To achieve balance in baseline characteristics, stratified randomization is widely used. Covariate adaptive randomization, however, can achieve better balance than other randomization methods and can be successfully used for clinical trials in an effective manner.

Acknowledgments

This study was partially supported by a Faculty Grant (FRCAC) from the College of Graduate Studies, at Middle Tennessee State University, Murfreesboro, TN.

Minsoo Kang, PhD; Brian G. Ragan, PhD, ATC; and Jae-Hyeon Park, PhD, contributed to conception and design; acquisition and analysis and interpretation of the data; and drafting, critical revision, and final approval of the article.

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  1. Random Assignment in Experiments

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  2. Random Assignment in Psychology: Definition & Examples

    Random selection (also called probability sampling or random sampling) is a way of randomly selecting members of a population to be included in your study. On the other hand, random assignment is a way of sorting the sample participants into control and treatment groups. Random selection ensures that everyone in the population has an equal ...

  3. The Definition of Random Assignment According to Psychology

    Materio / Getty Images. Random assignment refers to the use of chance procedures in psychology experiments to ensure that each participant has the same opportunity to be assigned to any given group in a study to eliminate any potential bias in the experiment at the outset. Participants are randomly assigned to different groups, such as the ...

  4. Random assignment

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    Benefits of Random Assignment in Psychological Research. The impact and importance of random assignment in psychological research cannot be overstated. It is fundamental for ensuring the study is accurate, allowing the researchers to determine if their study actually caused the results they saw, and making sure the findings can be applied to ...

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  7. Random Assignment in Experiments

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    Random assignment controls for both known and unknown variables that can creep in with other selection processes to confound analyses. Randomized experimental design is a powerful tool for drawing valid inferences about cause and effect. The use of randomized experimental design should allow a degree of certainty that the research findings ...

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    Benefits of Random Assignment. There are several benefits to using random assignment. Ease of assigning participants to the control or experimental group.

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    Randomizing key steps during experimentation for unbiased results. Aside from controlling variables, randomization is likely the most forgotten, most important, and easiest to implement concept related to experimentation. People have a hard time predicting or emulating random events. This is part of the reason that games such as poker, dice or ...

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    Random assignment is of utmost importance in psychology experiments as it serves multiple vital purposes within the research process. Firstly, random assignment ensures that each participant has an equal opportunity to be assigned to any given group, such as the experimental or control group. This equal distribution of participants helps to ...

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    Objective: To review and describe randomization techniques used in clinical trials, including simple, block, stratified, and covariate adaptive techniques. Background: Clinical trials are required to establish treatment efficacy of many athletic training procedures. In the past, we have relied on evidence of questionable scientific merit to aid ...

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    Consideration of challenges encountered in implementing random assignment suggests that 1) researcher communication with program staff improves compliance, but may not overcome the need for learning through experience; 2) in keeping with arguments in favor of random assignment-based research, random assignment may control for diverse selection ...