Purdue Online Writing Lab Purdue OWL® College of Liberal Arts

Writing a Literature Review

OWL logo

Welcome to the Purdue OWL

This page is brought to you by the OWL at Purdue University. When printing this page, you must include the entire legal notice.

Copyright ©1995-2018 by The Writing Lab & The OWL at Purdue and Purdue University. All rights reserved. This material may not be published, reproduced, broadcast, rewritten, or redistributed without permission. Use of this site constitutes acceptance of our terms and conditions of fair use.

A literature review is a document or section of a document that collects key sources on a topic and discusses those sources in conversation with each other (also called synthesis ). The lit review is an important genre in many disciplines, not just literature (i.e., the study of works of literature such as novels and plays). When we say “literature review” or refer to “the literature,” we are talking about the research ( scholarship ) in a given field. You will often see the terms “the research,” “the scholarship,” and “the literature” used mostly interchangeably.

Where, when, and why would I write a lit review?

There are a number of different situations where you might write a literature review, each with slightly different expectations; different disciplines, too, have field-specific expectations for what a literature review is and does. For instance, in the humanities, authors might include more overt argumentation and interpretation of source material in their literature reviews, whereas in the sciences, authors are more likely to report study designs and results in their literature reviews; these differences reflect these disciplines’ purposes and conventions in scholarship. You should always look at examples from your own discipline and talk to professors or mentors in your field to be sure you understand your discipline’s conventions, for literature reviews as well as for any other genre.

A literature review can be a part of a research paper or scholarly article, usually falling after the introduction and before the research methods sections. In these cases, the lit review just needs to cover scholarship that is important to the issue you are writing about; sometimes it will also cover key sources that informed your research methodology.

Lit reviews can also be standalone pieces, either as assignments in a class or as publications. In a class, a lit review may be assigned to help students familiarize themselves with a topic and with scholarship in their field, get an idea of the other researchers working on the topic they’re interested in, find gaps in existing research in order to propose new projects, and/or develop a theoretical framework and methodology for later research. As a publication, a lit review usually is meant to help make other scholars’ lives easier by collecting and summarizing, synthesizing, and analyzing existing research on a topic. This can be especially helpful for students or scholars getting into a new research area, or for directing an entire community of scholars toward questions that have not yet been answered.

What are the parts of a lit review?

Most lit reviews use a basic introduction-body-conclusion structure; if your lit review is part of a larger paper, the introduction and conclusion pieces may be just a few sentences while you focus most of your attention on the body. If your lit review is a standalone piece, the introduction and conclusion take up more space and give you a place to discuss your goals, research methods, and conclusions separately from where you discuss the literature itself.

Introduction:

  • An introductory paragraph that explains what your working topic and thesis is
  • A forecast of key topics or texts that will appear in the review
  • Potentially, a description of how you found sources and how you analyzed them for inclusion and discussion in the review (more often found in published, standalone literature reviews than in lit review sections in an article or research paper)
  • Summarize and synthesize: Give an overview of the main points of each source and combine them into a coherent whole
  • Analyze and interpret: Don’t just paraphrase other researchers – add your own interpretations where possible, discussing the significance of findings in relation to the literature as a whole
  • Critically Evaluate: Mention the strengths and weaknesses of your sources
  • Write in well-structured paragraphs: Use transition words and topic sentence to draw connections, comparisons, and contrasts.

Conclusion:

  • Summarize the key findings you have taken from the literature and emphasize their significance
  • Connect it back to your primary research question

How should I organize my lit review?

Lit reviews can take many different organizational patterns depending on what you are trying to accomplish with the review. Here are some examples:

  • Chronological : The simplest approach is to trace the development of the topic over time, which helps familiarize the audience with the topic (for instance if you are introducing something that is not commonly known in your field). If you choose this strategy, be careful to avoid simply listing and summarizing sources in order. Try to analyze the patterns, turning points, and key debates that have shaped the direction of the field. Give your interpretation of how and why certain developments occurred (as mentioned previously, this may not be appropriate in your discipline — check with a teacher or mentor if you’re unsure).
  • Thematic : If you have found some recurring central themes that you will continue working with throughout your piece, you can organize your literature review into subsections that address different aspects of the topic. For example, if you are reviewing literature about women and religion, key themes can include the role of women in churches and the religious attitude towards women.
  • Qualitative versus quantitative research
  • Empirical versus theoretical scholarship
  • Divide the research by sociological, historical, or cultural sources
  • Theoretical : In many humanities articles, the literature review is the foundation for the theoretical framework. You can use it to discuss various theories, models, and definitions of key concepts. You can argue for the relevance of a specific theoretical approach or combine various theorical concepts to create a framework for your research.

What are some strategies or tips I can use while writing my lit review?

Any lit review is only as good as the research it discusses; make sure your sources are well-chosen and your research is thorough. Don’t be afraid to do more research if you discover a new thread as you’re writing. More info on the research process is available in our "Conducting Research" resources .

As you’re doing your research, create an annotated bibliography ( see our page on the this type of document ). Much of the information used in an annotated bibliography can be used also in a literature review, so you’ll be not only partially drafting your lit review as you research, but also developing your sense of the larger conversation going on among scholars, professionals, and any other stakeholders in your topic.

Usually you will need to synthesize research rather than just summarizing it. This means drawing connections between sources to create a picture of the scholarly conversation on a topic over time. Many student writers struggle to synthesize because they feel they don’t have anything to add to the scholars they are citing; here are some strategies to help you:

  • It often helps to remember that the point of these kinds of syntheses is to show your readers how you understand your research, to help them read the rest of your paper.
  • Writing teachers often say synthesis is like hosting a dinner party: imagine all your sources are together in a room, discussing your topic. What are they saying to each other?
  • Look at the in-text citations in each paragraph. Are you citing just one source for each paragraph? This usually indicates summary only. When you have multiple sources cited in a paragraph, you are more likely to be synthesizing them (not always, but often
  • Read more about synthesis here.

The most interesting literature reviews are often written as arguments (again, as mentioned at the beginning of the page, this is discipline-specific and doesn’t work for all situations). Often, the literature review is where you can establish your research as filling a particular gap or as relevant in a particular way. You have some chance to do this in your introduction in an article, but the literature review section gives a more extended opportunity to establish the conversation in the way you would like your readers to see it. You can choose the intellectual lineage you would like to be part of and whose definitions matter most to your thinking (mostly humanities-specific, but this goes for sciences as well). In addressing these points, you argue for your place in the conversation, which tends to make the lit review more compelling than a simple reporting of other sources.

Have a language expert improve your writing

Run a free plagiarism check in 10 minutes, generate accurate citations for free.

  • Knowledge Base

Methodology

  • How to Write a Literature Review | Guide, Examples, & Templates

How to Write a Literature Review | Guide, Examples, & Templates

Published on January 2, 2023 by Shona McCombes . Revised on September 11, 2023.

What is a literature review? A literature review is a survey of scholarly sources on a specific topic. It provides an overview of current knowledge, allowing you to identify relevant theories, methods, and gaps in the existing research that you can later apply to your paper, thesis, or dissertation topic .

There are five key steps to writing a literature review:

  • Search for relevant literature
  • Evaluate sources
  • Identify themes, debates, and gaps
  • Outline the structure
  • Write your literature review

A good literature review doesn’t just summarize sources—it analyzes, synthesizes , and critically evaluates to give a clear picture of the state of knowledge on the subject.

Instantly correct all language mistakes in your text

Upload your document to correct all your mistakes in minutes

upload-your-document-ai-proofreader

Table of contents

What is the purpose of a literature review, examples of literature reviews, step 1 – search for relevant literature, step 2 – evaluate and select sources, step 3 – identify themes, debates, and gaps, step 4 – outline your literature review’s structure, step 5 – write your literature review, free lecture slides, other interesting articles, frequently asked questions, introduction.

  • Quick Run-through
  • Step 1 & 2

When you write a thesis , dissertation , or research paper , you will likely have to conduct a literature review to situate your research within existing knowledge. The literature review gives you a chance to:

  • Demonstrate your familiarity with the topic and its scholarly context
  • Develop a theoretical framework and methodology for your research
  • Position your work in relation to other researchers and theorists
  • Show how your research addresses a gap or contributes to a debate
  • Evaluate the current state of research and demonstrate your knowledge of the scholarly debates around your topic.

Writing literature reviews is a particularly important skill if you want to apply for graduate school or pursue a career in research. We’ve written a step-by-step guide that you can follow below.

Literature review guide

Receive feedback on language, structure, and formatting

Professional editors proofread and edit your paper by focusing on:

  • Academic style
  • Vague sentences
  • Style consistency

See an example

guidelines in literature review

Writing literature reviews can be quite challenging! A good starting point could be to look at some examples, depending on what kind of literature review you’d like to write.

  • Example literature review #1: “Why Do People Migrate? A Review of the Theoretical Literature” ( Theoretical literature review about the development of economic migration theory from the 1950s to today.)
  • Example literature review #2: “Literature review as a research methodology: An overview and guidelines” ( Methodological literature review about interdisciplinary knowledge acquisition and production.)
  • Example literature review #3: “The Use of Technology in English Language Learning: A Literature Review” ( Thematic literature review about the effects of technology on language acquisition.)
  • Example literature review #4: “Learners’ Listening Comprehension Difficulties in English Language Learning: A Literature Review” ( Chronological literature review about how the concept of listening skills has changed over time.)

You can also check out our templates with literature review examples and sample outlines at the links below.

Download Word doc Download Google doc

Before you begin searching for literature, you need a clearly defined topic .

If you are writing the literature review section of a dissertation or research paper, you will search for literature related to your research problem and questions .

Make a list of keywords

Start by creating a list of keywords related to your research question. Include each of the key concepts or variables you’re interested in, and list any synonyms and related terms. You can add to this list as you discover new keywords in the process of your literature search.

  • Social media, Facebook, Instagram, Twitter, Snapchat, TikTok
  • Body image, self-perception, self-esteem, mental health
  • Generation Z, teenagers, adolescents, youth

Search for relevant sources

Use your keywords to begin searching for sources. Some useful databases to search for journals and articles include:

  • Your university’s library catalogue
  • Google Scholar
  • Project Muse (humanities and social sciences)
  • Medline (life sciences and biomedicine)
  • EconLit (economics)
  • Inspec (physics, engineering and computer science)

You can also use boolean operators to help narrow down your search.

Make sure to read the abstract to find out whether an article is relevant to your question. When you find a useful book or article, you can check the bibliography to find other relevant sources.

You likely won’t be able to read absolutely everything that has been written on your topic, so it will be necessary to evaluate which sources are most relevant to your research question.

For each publication, ask yourself:

  • What question or problem is the author addressing?
  • What are the key concepts and how are they defined?
  • What are the key theories, models, and methods?
  • Does the research use established frameworks or take an innovative approach?
  • What are the results and conclusions of the study?
  • How does the publication relate to other literature in the field? Does it confirm, add to, or challenge established knowledge?
  • What are the strengths and weaknesses of the research?

Make sure the sources you use are credible , and make sure you read any landmark studies and major theories in your field of research.

You can use our template to summarize and evaluate sources you’re thinking about using. Click on either button below to download.

Take notes and cite your sources

As you read, you should also begin the writing process. Take notes that you can later incorporate into the text of your literature review.

It is important to keep track of your sources with citations to avoid plagiarism . It can be helpful to make an annotated bibliography , where you compile full citation information and write a paragraph of summary and analysis for each source. This helps you remember what you read and saves time later in the process.

Prevent plagiarism. Run a free check.

To begin organizing your literature review’s argument and structure, be sure you understand the connections and relationships between the sources you’ve read. Based on your reading and notes, you can look for:

  • Trends and patterns (in theory, method or results): do certain approaches become more or less popular over time?
  • Themes: what questions or concepts recur across the literature?
  • Debates, conflicts and contradictions: where do sources disagree?
  • Pivotal publications: are there any influential theories or studies that changed the direction of the field?
  • Gaps: what is missing from the literature? Are there weaknesses that need to be addressed?

This step will help you work out the structure of your literature review and (if applicable) show how your own research will contribute to existing knowledge.

  • Most research has focused on young women.
  • There is an increasing interest in the visual aspects of social media.
  • But there is still a lack of robust research on highly visual platforms like Instagram and Snapchat—this is a gap that you could address in your own research.

There are various approaches to organizing the body of a literature review. Depending on the length of your literature review, you can combine several of these strategies (for example, your overall structure might be thematic, but each theme is discussed chronologically).

Chronological

The simplest approach is to trace the development of the topic over time. However, if you choose this strategy, be careful to avoid simply listing and summarizing sources in order.

Try to analyze patterns, turning points and key debates that have shaped the direction of the field. Give your interpretation of how and why certain developments occurred.

If you have found some recurring central themes, you can organize your literature review into subsections that address different aspects of the topic.

For example, if you are reviewing literature about inequalities in migrant health outcomes, key themes might include healthcare policy, language barriers, cultural attitudes, legal status, and economic access.

Methodological

If you draw your sources from different disciplines or fields that use a variety of research methods , you might want to compare the results and conclusions that emerge from different approaches. For example:

  • Look at what results have emerged in qualitative versus quantitative research
  • Discuss how the topic has been approached by empirical versus theoretical scholarship
  • Divide the literature into sociological, historical, and cultural sources

Theoretical

A literature review is often the foundation for a theoretical framework . You can use it to discuss various theories, models, and definitions of key concepts.

You might argue for the relevance of a specific theoretical approach, or combine various theoretical concepts to create a framework for your research.

Like any other academic text , your literature review should have an introduction , a main body, and a conclusion . What you include in each depends on the objective of your literature review.

The introduction should clearly establish the focus and purpose of the literature review.

Depending on the length of your literature review, you might want to divide the body into subsections. You can use a subheading for each theme, time period, or methodological approach.

As you write, you can follow these tips:

  • Summarize and synthesize: give an overview of the main points of each source and combine them into a coherent whole
  • Analyze and interpret: don’t just paraphrase other researchers — add your own interpretations where possible, discussing the significance of findings in relation to the literature as a whole
  • Critically evaluate: mention the strengths and weaknesses of your sources
  • Write in well-structured paragraphs: use transition words and topic sentences to draw connections, comparisons and contrasts

In the conclusion, you should summarize the key findings you have taken from the literature and emphasize their significance.

When you’ve finished writing and revising your literature review, don’t forget to proofread thoroughly before submitting. Not a language expert? Check out Scribbr’s professional proofreading services !

This article has been adapted into lecture slides that you can use to teach your students about writing a literature review.

Scribbr slides are free to use, customize, and distribute for educational purposes.

Open Google Slides Download PowerPoint

If you want to know more about the research process , methodology , research bias , or statistics , make sure to check out some of our other articles with explanations and examples.

  • Sampling methods
  • Simple random sampling
  • Stratified sampling
  • Cluster sampling
  • Likert scales
  • Reproducibility

 Statistics

  • Null hypothesis
  • Statistical power
  • Probability distribution
  • Effect size
  • Poisson distribution

Research bias

  • Optimism bias
  • Cognitive bias
  • Implicit bias
  • Hawthorne effect
  • Anchoring bias
  • Explicit bias

A literature review is a survey of scholarly sources (such as books, journal articles, and theses) related to a specific topic or research question .

It is often written as part of a thesis, dissertation , or research paper , in order to situate your work in relation to existing knowledge.

There are several reasons to conduct a literature review at the beginning of a research project:

  • To familiarize yourself with the current state of knowledge on your topic
  • To ensure that you’re not just repeating what others have already done
  • To identify gaps in knowledge and unresolved problems that your research can address
  • To develop your theoretical framework and methodology
  • To provide an overview of the key findings and debates on the topic

Writing the literature review shows your reader how your work relates to existing research and what new insights it will contribute.

The literature review usually comes near the beginning of your thesis or dissertation . After the introduction , it grounds your research in a scholarly field and leads directly to your theoretical framework or methodology .

A literature review is a survey of credible sources on a topic, often used in dissertations , theses, and research papers . Literature reviews give an overview of knowledge on a subject, helping you identify relevant theories and methods, as well as gaps in existing research. Literature reviews are set up similarly to other  academic texts , with an introduction , a main body, and a conclusion .

An  annotated bibliography is a list of  source references that has a short description (called an annotation ) for each of the sources. It is often assigned as part of the research process for a  paper .  

Cite this Scribbr article

If you want to cite this source, you can copy and paste the citation or click the “Cite this Scribbr article” button to automatically add the citation to our free Citation Generator.

McCombes, S. (2023, September 11). How to Write a Literature Review | Guide, Examples, & Templates. Scribbr. Retrieved September 2, 2024, from https://www.scribbr.com/dissertation/literature-review/

Is this article helpful?

Shona McCombes

Shona McCombes

Other students also liked, what is a theoretical framework | guide to organizing, what is a research methodology | steps & tips, how to write a research proposal | examples & templates, what is your plagiarism score.

U.S. flag

An official website of the United States government

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

  • Publications
  • Account settings

Preview improvements coming to the PMC website in October 2024. Learn More or Try it out now .

  • Advanced Search
  • Journal List
  • PLoS Comput Biol
  • v.9(7); 2013 Jul

Logo of ploscomp

Ten Simple Rules for Writing a Literature Review

Marco pautasso.

1 Centre for Functional and Evolutionary Ecology (CEFE), CNRS, Montpellier, France

2 Centre for Biodiversity Synthesis and Analysis (CESAB), FRB, Aix-en-Provence, France

Literature reviews are in great demand in most scientific fields. Their need stems from the ever-increasing output of scientific publications [1] . For example, compared to 1991, in 2008 three, eight, and forty times more papers were indexed in Web of Science on malaria, obesity, and biodiversity, respectively [2] . Given such mountains of papers, scientists cannot be expected to examine in detail every single new paper relevant to their interests [3] . Thus, it is both advantageous and necessary to rely on regular summaries of the recent literature. Although recognition for scientists mainly comes from primary research, timely literature reviews can lead to new synthetic insights and are often widely read [4] . For such summaries to be useful, however, they need to be compiled in a professional way [5] .

When starting from scratch, reviewing the literature can require a titanic amount of work. That is why researchers who have spent their career working on a certain research issue are in a perfect position to review that literature. Some graduate schools are now offering courses in reviewing the literature, given that most research students start their project by producing an overview of what has already been done on their research issue [6] . However, it is likely that most scientists have not thought in detail about how to approach and carry out a literature review.

Reviewing the literature requires the ability to juggle multiple tasks, from finding and evaluating relevant material to synthesising information from various sources, from critical thinking to paraphrasing, evaluating, and citation skills [7] . In this contribution, I share ten simple rules I learned working on about 25 literature reviews as a PhD and postdoctoral student. Ideas and insights also come from discussions with coauthors and colleagues, as well as feedback from reviewers and editors.

Rule 1: Define a Topic and Audience

How to choose which topic to review? There are so many issues in contemporary science that you could spend a lifetime of attending conferences and reading the literature just pondering what to review. On the one hand, if you take several years to choose, several other people may have had the same idea in the meantime. On the other hand, only a well-considered topic is likely to lead to a brilliant literature review [8] . The topic must at least be:

  • interesting to you (ideally, you should have come across a series of recent papers related to your line of work that call for a critical summary),
  • an important aspect of the field (so that many readers will be interested in the review and there will be enough material to write it), and
  • a well-defined issue (otherwise you could potentially include thousands of publications, which would make the review unhelpful).

Ideas for potential reviews may come from papers providing lists of key research questions to be answered [9] , but also from serendipitous moments during desultory reading and discussions. In addition to choosing your topic, you should also select a target audience. In many cases, the topic (e.g., web services in computational biology) will automatically define an audience (e.g., computational biologists), but that same topic may also be of interest to neighbouring fields (e.g., computer science, biology, etc.).

Rule 2: Search and Re-search the Literature

After having chosen your topic and audience, start by checking the literature and downloading relevant papers. Five pieces of advice here:

  • keep track of the search items you use (so that your search can be replicated [10] ),
  • keep a list of papers whose pdfs you cannot access immediately (so as to retrieve them later with alternative strategies),
  • use a paper management system (e.g., Mendeley, Papers, Qiqqa, Sente),
  • define early in the process some criteria for exclusion of irrelevant papers (these criteria can then be described in the review to help define its scope), and
  • do not just look for research papers in the area you wish to review, but also seek previous reviews.

The chances are high that someone will already have published a literature review ( Figure 1 ), if not exactly on the issue you are planning to tackle, at least on a related topic. If there are already a few or several reviews of the literature on your issue, my advice is not to give up, but to carry on with your own literature review,

An external file that holds a picture, illustration, etc.
Object name is pcbi.1003149.g001.jpg

The bottom-right situation (many literature reviews but few research papers) is not just a theoretical situation; it applies, for example, to the study of the impacts of climate change on plant diseases, where there appear to be more literature reviews than research studies [33] .

  • discussing in your review the approaches, limitations, and conclusions of past reviews,
  • trying to find a new angle that has not been covered adequately in the previous reviews, and
  • incorporating new material that has inevitably accumulated since their appearance.

When searching the literature for pertinent papers and reviews, the usual rules apply:

  • be thorough,
  • use different keywords and database sources (e.g., DBLP, Google Scholar, ISI Proceedings, JSTOR Search, Medline, Scopus, Web of Science), and
  • look at who has cited past relevant papers and book chapters.

Rule 3: Take Notes While Reading

If you read the papers first, and only afterwards start writing the review, you will need a very good memory to remember who wrote what, and what your impressions and associations were while reading each single paper. My advice is, while reading, to start writing down interesting pieces of information, insights about how to organize the review, and thoughts on what to write. This way, by the time you have read the literature you selected, you will already have a rough draft of the review.

Of course, this draft will still need much rewriting, restructuring, and rethinking to obtain a text with a coherent argument [11] , but you will have avoided the danger posed by staring at a blank document. Be careful when taking notes to use quotation marks if you are provisionally copying verbatim from the literature. It is advisable then to reformulate such quotes with your own words in the final draft. It is important to be careful in noting the references already at this stage, so as to avoid misattributions. Using referencing software from the very beginning of your endeavour will save you time.

Rule 4: Choose the Type of Review You Wish to Write

After having taken notes while reading the literature, you will have a rough idea of the amount of material available for the review. This is probably a good time to decide whether to go for a mini- or a full review. Some journals are now favouring the publication of rather short reviews focusing on the last few years, with a limit on the number of words and citations. A mini-review is not necessarily a minor review: it may well attract more attention from busy readers, although it will inevitably simplify some issues and leave out some relevant material due to space limitations. A full review will have the advantage of more freedom to cover in detail the complexities of a particular scientific development, but may then be left in the pile of the very important papers “to be read” by readers with little time to spare for major monographs.

There is probably a continuum between mini- and full reviews. The same point applies to the dichotomy of descriptive vs. integrative reviews. While descriptive reviews focus on the methodology, findings, and interpretation of each reviewed study, integrative reviews attempt to find common ideas and concepts from the reviewed material [12] . A similar distinction exists between narrative and systematic reviews: while narrative reviews are qualitative, systematic reviews attempt to test a hypothesis based on the published evidence, which is gathered using a predefined protocol to reduce bias [13] , [14] . When systematic reviews analyse quantitative results in a quantitative way, they become meta-analyses. The choice between different review types will have to be made on a case-by-case basis, depending not just on the nature of the material found and the preferences of the target journal(s), but also on the time available to write the review and the number of coauthors [15] .

Rule 5: Keep the Review Focused, but Make It of Broad Interest

Whether your plan is to write a mini- or a full review, it is good advice to keep it focused 16 , 17 . Including material just for the sake of it can easily lead to reviews that are trying to do too many things at once. The need to keep a review focused can be problematic for interdisciplinary reviews, where the aim is to bridge the gap between fields [18] . If you are writing a review on, for example, how epidemiological approaches are used in modelling the spread of ideas, you may be inclined to include material from both parent fields, epidemiology and the study of cultural diffusion. This may be necessary to some extent, but in this case a focused review would only deal in detail with those studies at the interface between epidemiology and the spread of ideas.

While focus is an important feature of a successful review, this requirement has to be balanced with the need to make the review relevant to a broad audience. This square may be circled by discussing the wider implications of the reviewed topic for other disciplines.

Rule 6: Be Critical and Consistent

Reviewing the literature is not stamp collecting. A good review does not just summarize the literature, but discusses it critically, identifies methodological problems, and points out research gaps [19] . After having read a review of the literature, a reader should have a rough idea of:

  • the major achievements in the reviewed field,
  • the main areas of debate, and
  • the outstanding research questions.

It is challenging to achieve a successful review on all these fronts. A solution can be to involve a set of complementary coauthors: some people are excellent at mapping what has been achieved, some others are very good at identifying dark clouds on the horizon, and some have instead a knack at predicting where solutions are going to come from. If your journal club has exactly this sort of team, then you should definitely write a review of the literature! In addition to critical thinking, a literature review needs consistency, for example in the choice of passive vs. active voice and present vs. past tense.

Rule 7: Find a Logical Structure

Like a well-baked cake, a good review has a number of telling features: it is worth the reader's time, timely, systematic, well written, focused, and critical. It also needs a good structure. With reviews, the usual subdivision of research papers into introduction, methods, results, and discussion does not work or is rarely used. However, a general introduction of the context and, toward the end, a recapitulation of the main points covered and take-home messages make sense also in the case of reviews. For systematic reviews, there is a trend towards including information about how the literature was searched (database, keywords, time limits) [20] .

How can you organize the flow of the main body of the review so that the reader will be drawn into and guided through it? It is generally helpful to draw a conceptual scheme of the review, e.g., with mind-mapping techniques. Such diagrams can help recognize a logical way to order and link the various sections of a review [21] . This is the case not just at the writing stage, but also for readers if the diagram is included in the review as a figure. A careful selection of diagrams and figures relevant to the reviewed topic can be very helpful to structure the text too [22] .

Rule 8: Make Use of Feedback

Reviews of the literature are normally peer-reviewed in the same way as research papers, and rightly so [23] . As a rule, incorporating feedback from reviewers greatly helps improve a review draft. Having read the review with a fresh mind, reviewers may spot inaccuracies, inconsistencies, and ambiguities that had not been noticed by the writers due to rereading the typescript too many times. It is however advisable to reread the draft one more time before submission, as a last-minute correction of typos, leaps, and muddled sentences may enable the reviewers to focus on providing advice on the content rather than the form.

Feedback is vital to writing a good review, and should be sought from a variety of colleagues, so as to obtain a diversity of views on the draft. This may lead in some cases to conflicting views on the merits of the paper, and on how to improve it, but such a situation is better than the absence of feedback. A diversity of feedback perspectives on a literature review can help identify where the consensus view stands in the landscape of the current scientific understanding of an issue [24] .

Rule 9: Include Your Own Relevant Research, but Be Objective

In many cases, reviewers of the literature will have published studies relevant to the review they are writing. This could create a conflict of interest: how can reviewers report objectively on their own work [25] ? Some scientists may be overly enthusiastic about what they have published, and thus risk giving too much importance to their own findings in the review. However, bias could also occur in the other direction: some scientists may be unduly dismissive of their own achievements, so that they will tend to downplay their contribution (if any) to a field when reviewing it.

In general, a review of the literature should neither be a public relations brochure nor an exercise in competitive self-denial. If a reviewer is up to the job of producing a well-organized and methodical review, which flows well and provides a service to the readership, then it should be possible to be objective in reviewing one's own relevant findings. In reviews written by multiple authors, this may be achieved by assigning the review of the results of a coauthor to different coauthors.

Rule 10: Be Up-to-Date, but Do Not Forget Older Studies

Given the progressive acceleration in the publication of scientific papers, today's reviews of the literature need awareness not just of the overall direction and achievements of a field of inquiry, but also of the latest studies, so as not to become out-of-date before they have been published. Ideally, a literature review should not identify as a major research gap an issue that has just been addressed in a series of papers in press (the same applies, of course, to older, overlooked studies (“sleeping beauties” [26] )). This implies that literature reviewers would do well to keep an eye on electronic lists of papers in press, given that it can take months before these appear in scientific databases. Some reviews declare that they have scanned the literature up to a certain point in time, but given that peer review can be a rather lengthy process, a full search for newly appeared literature at the revision stage may be worthwhile. Assessing the contribution of papers that have just appeared is particularly challenging, because there is little perspective with which to gauge their significance and impact on further research and society.

Inevitably, new papers on the reviewed topic (including independently written literature reviews) will appear from all quarters after the review has been published, so that there may soon be the need for an updated review. But this is the nature of science [27] – [32] . I wish everybody good luck with writing a review of the literature.

Acknowledgments

Many thanks to M. Barbosa, K. Dehnen-Schmutz, T. Döring, D. Fontaneto, M. Garbelotto, O. Holdenrieder, M. Jeger, D. Lonsdale, A. MacLeod, P. Mills, M. Moslonka-Lefebvre, G. Stancanelli, P. Weisberg, and X. Xu for insights and discussions, and to P. Bourne, T. Matoni, and D. Smith for helpful comments on a previous draft.

Funding Statement

This work was funded by the French Foundation for Research on Biodiversity (FRB) through its Centre for Synthesis and Analysis of Biodiversity data (CESAB), as part of the NETSEED research project. The funders had no role in the preparation of the manuscript.

  • Resources Home 🏠
  • Try SciSpace Copilot
  • Search research papers
  • Add Copilot Extension
  • Try AI Detector
  • Try Paraphraser
  • Try Citation Generator
  • April Papers
  • June Papers
  • July Papers

SciSpace Resources

How To Write A Literature Review - A Complete Guide

Deeptanshu D

Table of Contents

A literature review is much more than just another section in your research paper. It forms the very foundation of your research. It is a formal piece of writing where you analyze the existing theoretical framework, principles, and assumptions and use that as a base to shape your approach to the research question.

Curating and drafting a solid literature review section not only lends more credibility to your research paper but also makes your research tighter and better focused. But, writing literature reviews is a difficult task. It requires extensive reading, plus you have to consider market trends and technological and political changes, which tend to change in the blink of an eye.

Now streamline your literature review process with the help of SciSpace Copilot. With this AI research assistant, you can efficiently synthesize and analyze a vast amount of information, identify key themes and trends, and uncover gaps in the existing research. Get real-time explanations, summaries, and answers to your questions for the paper you're reviewing, making navigating and understanding the complex literature landscape easier.

Perform Literature reviews using SciSpace Copilot

In this comprehensive guide, we will explore everything from the definition of a literature review, its appropriate length, various types of literature reviews, and how to write one.

What is a literature review?

A literature review is a collation of survey, research, critical evaluation, and assessment of the existing literature in a preferred domain.

Eminent researcher and academic Arlene Fink, in her book Conducting Research Literature Reviews , defines it as the following:

“A literature review surveys books, scholarly articles, and any other sources relevant to a particular issue, area of research, or theory, and by so doing, provides a description, summary, and critical evaluation of these works in relation to the research problem being investigated.

Literature reviews are designed to provide an overview of sources you have explored while researching a particular topic, and to demonstrate to your readers how your research fits within a larger field of study.”

Simply put, a literature review can be defined as a critical discussion of relevant pre-existing research around your research question and carving out a definitive place for your study in the existing body of knowledge. Literature reviews can be presented in multiple ways: a section of an article, the whole research paper itself, or a chapter of your thesis.

A literature review paper

A literature review does function as a summary of sources, but it also allows you to analyze further, interpret, and examine the stated theories, methods, viewpoints, and, of course, the gaps in the existing content.

As an author, you can discuss and interpret the research question and its various aspects and debate your adopted methods to support the claim.

What is the purpose of a literature review?

A literature review is meant to help your readers understand the relevance of your research question and where it fits within the existing body of knowledge. As a researcher, you should use it to set the context, build your argument, and establish the need for your study.

What is the importance of a literature review?

The literature review is a critical part of research papers because it helps you:

  • Gain an in-depth understanding of your research question and the surrounding area
  • Convey that you have a thorough understanding of your research area and are up-to-date with the latest changes and advancements
  • Establish how your research is connected or builds on the existing body of knowledge and how it could contribute to further research
  • Elaborate on the validity and suitability of your theoretical framework and research methodology
  • Identify and highlight gaps and shortcomings in the existing body of knowledge and how things need to change
  • Convey to readers how your study is different or how it contributes to the research area

How long should a literature review be?

Ideally, the literature review should take up 15%-40% of the total length of your manuscript. So, if you have a 10,000-word research paper, the minimum word count could be 1500.

Your literature review format depends heavily on the kind of manuscript you are writing — an entire chapter in case of doctoral theses, a part of the introductory section in a research article, to a full-fledged review article that examines the previously published research on a topic.

Another determining factor is the type of research you are doing. The literature review section tends to be longer for secondary research projects than primary research projects.

What are the different types of literature reviews?

All literature reviews are not the same. There are a variety of possible approaches that you can take. It all depends on the type of research you are pursuing.

Here are the different types of literature reviews:

Argumentative review

It is called an argumentative review when you carefully present literature that only supports or counters a specific argument or premise to establish a viewpoint.

Integrative review

It is a type of literature review focused on building a comprehensive understanding of a topic by combining available theoretical frameworks and empirical evidence.

Methodological review

This approach delves into the ''how'' and the ''what" of the research question —  you cannot look at the outcome in isolation; you should also review the methodology used.

Systematic review

This form consists of an overview of existing evidence pertinent to a clearly formulated research question, which uses pre-specified and standardized methods to identify and critically appraise relevant research and collect, report, and analyze data from the studies included in the review.

Meta-analysis review

Meta-analysis uses statistical methods to summarize the results of independent studies. By combining information from all relevant studies, meta-analysis can provide more precise estimates of the effects than those derived from the individual studies included within a review.

Historical review

Historical literature reviews focus on examining research throughout a period, often starting with the first time an issue, concept, theory, or phenomenon emerged in the literature, then tracing its evolution within the scholarship of a discipline. The purpose is to place research in a historical context to show familiarity with state-of-the-art developments and identify future research's likely directions.

Theoretical Review

This form aims to examine the corpus of theory accumulated regarding an issue, concept, theory, and phenomenon. The theoretical literature review helps to establish what theories exist, the relationships between them, the degree the existing approaches have been investigated, and to develop new hypotheses to be tested.

Scoping Review

The Scoping Review is often used at the beginning of an article, dissertation, or research proposal. It is conducted before the research to highlight gaps in the existing body of knowledge and explains why the project should be greenlit.

State-of-the-Art Review

The State-of-the-Art review is conducted periodically, focusing on the most recent research. It describes what is currently known, understood, or agreed upon regarding the research topic and highlights where there are still disagreements.

Can you use the first person in a literature review?

When writing literature reviews, you should avoid the usage of first-person pronouns. It means that instead of "I argue that" or "we argue that," the appropriate expression would be "this research paper argues that."

Do you need an abstract for a literature review?

Ideally, yes. It is always good to have a condensed summary that is self-contained and independent of the rest of your review. As for how to draft one, you can follow the same fundamental idea when preparing an abstract for a literature review. It should also include:

  • The research topic and your motivation behind selecting it
  • A one-sentence thesis statement
  • An explanation of the kinds of literature featured in the review
  • Summary of what you've learned
  • Conclusions you drew from the literature you reviewed
  • Potential implications and future scope for research

Here's an example of the abstract of a literature review

Abstract-of-a-literature-review

Is a literature review written in the past tense?

Yes, the literature review should ideally be written in the past tense. You should not use the present or future tense when writing one. The exceptions are when you have statements describing events that happened earlier than the literature you are reviewing or events that are currently occurring; then, you can use the past perfect or present perfect tenses.

How many sources for a literature review?

There are multiple approaches to deciding how many sources to include in a literature review section. The first approach would be to look level you are at as a researcher. For instance, a doctoral thesis might need 60+ sources. In contrast, you might only need to refer to 5-15 sources at the undergraduate level.

The second approach is based on the kind of literature review you are doing — whether it is merely a chapter of your paper or if it is a self-contained paper in itself. When it is just a chapter, sources should equal the total number of pages in your article's body. In the second scenario, you need at least three times as many sources as there are pages in your work.

Quick tips on how to write a literature review

To know how to write a literature review, you must clearly understand its impact and role in establishing your work as substantive research material.

You need to follow the below-mentioned steps, to write a literature review:

  • Outline the purpose behind the literature review
  • Search relevant literature
  • Examine and assess the relevant resources
  • Discover connections by drawing deep insights from the resources
  • Structure planning to write a good literature review

1. Outline and identify the purpose of  a literature review

As a first step on how to write a literature review, you must know what the research question or topic is and what shape you want your literature review to take. Ensure you understand the research topic inside out, or else seek clarifications. You must be able to the answer below questions before you start:

  • How many sources do I need to include?
  • What kind of sources should I analyze?
  • How much should I critically evaluate each source?
  • Should I summarize, synthesize or offer a critique of the sources?
  • Do I need to include any background information or definitions?

Additionally, you should know that the narrower your research topic is, the swifter it will be for you to restrict the number of sources to be analyzed.

2. Search relevant literature

Dig deeper into search engines to discover what has already been published around your chosen topic. Make sure you thoroughly go through appropriate reference sources like books, reports, journal articles, government docs, and web-based resources.

You must prepare a list of keywords and their different variations. You can start your search from any library’s catalog, provided you are an active member of that institution. The exact keywords can be extended to widen your research over other databases and academic search engines like:

  • Google Scholar
  • Microsoft Academic
  • Science.gov

Besides, it is not advisable to go through every resource word by word. Alternatively, what you can do is you can start by reading the abstract and then decide whether that source is relevant to your research or not.

Additionally, you must spend surplus time assessing the quality and relevance of resources. It would help if you tried preparing a list of citations to ensure that there lies no repetition of authors, publications, or articles in the literature review.

3. Examine and assess the sources

It is nearly impossible for you to go through every detail in the research article. So rather than trying to fetch every detail, you have to analyze and decide which research sources resemble closest and appear relevant to your chosen domain.

While analyzing the sources, you should look to find out answers to questions like:

  • What question or problem has the author been describing and debating?
  • What is the definition of critical aspects?
  • How well the theories, approach, and methodology have been explained?
  • Whether the research theory used some conventional or new innovative approach?
  • How relevant are the key findings of the work?
  • In what ways does it relate to other sources on the same topic?
  • What challenges does this research paper pose to the existing theory
  • What are the possible contributions or benefits it adds to the subject domain?

Be always mindful that you refer only to credible and authentic resources. It would be best if you always take references from different publications to validate your theory.

Always keep track of important information or data you can present in your literature review right from the beginning. It will help steer your path from any threats of plagiarism and also make it easier to curate an annotated bibliography or reference section.

4. Discover connections

At this stage, you must start deciding on the argument and structure of your literature review. To accomplish this, you must discover and identify the relations and connections between various resources while drafting your abstract.

A few aspects that you should be aware of while writing a literature review include:

  • Rise to prominence: Theories and methods that have gained reputation and supporters over time.
  • Constant scrutiny: Concepts or theories that repeatedly went under examination.
  • Contradictions and conflicts: Theories, both the supporting and the contradictory ones, for the research topic.
  • Knowledge gaps: What exactly does it fail to address, and how to bridge them with further research?
  • Influential resources: Significant research projects available that have been upheld as milestones or perhaps, something that can modify the current trends

Once you join the dots between various past research works, it will be easier for you to draw a conclusion and identify your contribution to the existing knowledge base.

5. Structure planning to write a good literature review

There exist different ways towards planning and executing the structure of a literature review. The format of a literature review varies and depends upon the length of the research.

Like any other research paper, the literature review format must contain three sections: introduction, body, and conclusion. The goals and objectives of the research question determine what goes inside these three sections.

Nevertheless, a good literature review can be structured according to the chronological, thematic, methodological, or theoretical framework approach.

Literature review samples

1. Standalone

Standalone-Literature-Review

2. As a section of a research paper

Literature-review-as-a-section-of-a-research-paper

How SciSpace Discover makes literature review a breeze?

SciSpace Discover is a one-stop solution to do an effective literature search and get barrier-free access to scientific knowledge. It is an excellent repository where you can find millions of only peer-reviewed articles and full-text PDF files. Here’s more on how you can use it:

Find the right information

Find-the-right-information-using-SciSpace

Find what you want quickly and easily with comprehensive search filters that let you narrow down papers according to PDF availability, year of publishing, document type, and affiliated institution. Moreover, you can sort the results based on the publishing date, citation count, and relevance.

Assess credibility of papers quickly

Assess-credibility-of-papers-quickly-using-SciSpace

When doing the literature review, it is critical to establish the quality of your sources. They form the foundation of your research. SciSpace Discover helps you assess the quality of a source by providing an overview of its references, citations, and performance metrics.

Get the complete picture in no time

SciSpace's-personalized-informtion-engine

SciSpace Discover’s personalized suggestion engine helps you stay on course and get the complete picture of the topic from one place. Every time you visit an article page, it provides you links to related papers. Besides that, it helps you understand what’s trending, who are the top authors, and who are the leading publishers on a topic.

Make referring sources super easy

Make-referring-pages-super-easy-with-SciSpace

To ensure you don't lose track of your sources, you must start noting down your references when doing the literature review. SciSpace Discover makes this step effortless. Click the 'cite' button on an article page, and you will receive preloaded citation text in multiple styles — all you've to do is copy-paste it into your manuscript.

Final tips on how to write a literature review

A massive chunk of time and effort is required to write a good literature review. But, if you go about it systematically, you'll be able to save a ton of time and build a solid foundation for your research.

We hope this guide has helped you answer several key questions you have about writing literature reviews.

Would you like to explore SciSpace Discover and kick off your literature search right away? You can get started here .

Frequently Asked Questions (FAQs)

1. how to start a literature review.

• What questions do you want to answer?

• What sources do you need to answer these questions?

• What information do these sources contain?

• How can you use this information to answer your questions?

2. What to include in a literature review?

• A brief background of the problem or issue

• What has previously been done to address the problem or issue

• A description of what you will do in your project

• How this study will contribute to research on the subject

3. Why literature review is important?

The literature review is an important part of any research project because it allows the writer to look at previous studies on a topic and determine existing gaps in the literature, as well as what has already been done. It will also help them to choose the most appropriate method for their own study.

4. How to cite a literature review in APA format?

To cite a literature review in APA style, you need to provide the author's name, the title of the article, and the year of publication. For example: Patel, A. B., & Stokes, G. S. (2012). The relationship between personality and intelligence: A meta-analysis of longitudinal research. Personality and Individual Differences, 53(1), 16-21

5. What are the components of a literature review?

• A brief introduction to the topic, including its background and context. The introduction should also include a rationale for why the study is being conducted and what it will accomplish.

• A description of the methodologies used in the study. This can include information about data collection methods, sample size, and statistical analyses.

• A presentation of the findings in an organized format that helps readers follow along with the author's conclusions.

6. What are common errors in writing literature review?

• Not spending enough time to critically evaluate the relevance of resources, observations and conclusions.

• Totally relying on secondary data while ignoring primary data.

• Letting your personal bias seep into your interpretation of existing literature.

• No detailed explanation of the procedure to discover and identify an appropriate literature review.

7. What are the 5 C's of writing literature review?

• Cite - the sources you utilized and referenced in your research.

• Compare - existing arguments, hypotheses, methodologies, and conclusions found in the knowledge base.

• Contrast - the arguments, topics, methodologies, approaches, and disputes that may be found in the literature.

• Critique - the literature and describe the ideas and opinions you find more convincing and why.

• Connect - the various studies you reviewed in your research.

8. How many sources should a literature review have?

When it is just a chapter, sources should equal the total number of pages in your article's body. if it is a self-contained paper in itself, you need at least three times as many sources as there are pages in your work.

9. Can literature review have diagrams?

• To represent an abstract idea or concept

• To explain the steps of a process or procedure

• To help readers understand the relationships between different concepts

10. How old should sources be in a literature review?

Sources for a literature review should be as current as possible or not older than ten years. The only exception to this rule is if you are reviewing a historical topic and need to use older sources.

11. What are the types of literature review?

• Argumentative review

• Integrative review

• Methodological review

• Systematic review

• Meta-analysis review

• Historical review

• Theoretical review

• Scoping review

• State-of-the-Art review

12. Is a literature review mandatory?

Yes. Literature review is a mandatory part of any research project. It is a critical step in the process that allows you to establish the scope of your research, and provide a background for the rest of your work.

But before you go,

  • Six Online Tools for Easy Literature Review
  • Evaluating literature review: systematic vs. scoping reviews
  • Systematic Approaches to a Successful Literature Review
  • Writing Integrative Literature Reviews: Guidelines and Examples

You might also like

Consensus GPT vs. SciSpace GPT: Choose the Best GPT for Research

Consensus GPT vs. SciSpace GPT: Choose the Best GPT for Research

Sumalatha G

Literature Review and Theoretical Framework: Understanding the Differences

Nikhil Seethi

Types of Essays in Academic Writing - Quick Guide (2024)

The Sheridan Libraries

  • Write a Literature Review
  • Sheridan Libraries
  • Evaluate This link opens in a new window

What Will You Do Differently?

Please help your librarians by filling out this two-minute survey of today's class session..

Professor, this one's for you .

Introduction

Literature reviews take time. here is some general information to know before you start.  .

  •  VIDEO -- This video is a great overview of the entire process.  (2020; North Carolina State University Libraries) --The transcript is included --This is for everyone; ignore the mention of "graduate students" --9.5 minutes, and every second is important  
  • OVERVIEW -- Read this page from Purdue's OWL. It's not long, and gives some tips to fill in what you just learned from the video.  
  • NOT A RESEARCH ARTICLE -- A literature review follows a different style, format, and structure from a research article.  
 
Reports on the work of others. Reports on original research.
To examine and evaluate previous literature.

To test a hypothesis and/or make an argument.

May include a short literature review to introduce the subject.

  • Next: Evaluate >>
  • Last Updated: Jul 30, 2024 1:42 PM
  • URL: https://guides.library.jhu.edu/lit-review
  • UConn Library
  • Literature Review: The What, Why and How-to Guide
  • Introduction

Literature Review: The What, Why and How-to Guide — Introduction

  • Getting Started
  • How to Pick a Topic
  • Strategies to Find Sources
  • Evaluating Sources & Lit. Reviews
  • Tips for Writing Literature Reviews
  • Writing Literature Review: Useful Sites
  • Citation Resources
  • Other Academic Writings

What are Literature Reviews?

So, what is a literature review? "A literature review is an account of what has been published on a topic by accredited scholars and researchers. In writing the literature review, your purpose is to convey to your reader what knowledge and ideas have been established on a topic, and what their strengths and weaknesses are. As a piece of writing, the literature review must be defined by a guiding concept (e.g., your research objective, the problem or issue you are discussing, or your argumentative thesis). It is not just a descriptive list of the material available, or a set of summaries." Taylor, D.  The literature review: A few tips on conducting it . University of Toronto Health Sciences Writing Centre.

Goals of Literature Reviews

What are the goals of creating a Literature Review?  A literature could be written to accomplish different aims:

  • To develop a theory or evaluate an existing theory
  • To summarize the historical or existing state of a research topic
  • Identify a problem in a field of research 

Baumeister, R. F., & Leary, M. R. (1997). Writing narrative literature reviews .  Review of General Psychology , 1 (3), 311-320.

What kinds of sources require a Literature Review?

  • A research paper assigned in a course
  • A thesis or dissertation
  • A grant proposal
  • An article intended for publication in a journal

All these instances require you to collect what has been written about your research topic so that you can demonstrate how your own research sheds new light on the topic.

Types of Literature Reviews

What kinds of literature reviews are written?

Narrative review: The purpose of this type of review is to describe the current state of the research on a specific topic/research and to offer a critical analysis of the literature reviewed. Studies are grouped by research/theoretical categories, and themes and trends, strengths and weakness, and gaps are identified. The review ends with a conclusion section which summarizes the findings regarding the state of the research of the specific study, the gaps identify and if applicable, explains how the author's research will address gaps identify in the review and expand the knowledge on the topic reviewed.

  • Example : Predictors and Outcomes of U.S. Quality Maternity Leave: A Review and Conceptual Framework:  10.1177/08948453211037398  

Systematic review : "The authors of a systematic review use a specific procedure to search the research literature, select the studies to include in their review, and critically evaluate the studies they find." (p. 139). Nelson, L. K. (2013). Research in Communication Sciences and Disorders . Plural Publishing.

  • Example : The effect of leave policies on increasing fertility: a systematic review:  10.1057/s41599-022-01270-w

Meta-analysis : "Meta-analysis is a method of reviewing research findings in a quantitative fashion by transforming the data from individual studies into what is called an effect size and then pooling and analyzing this information. The basic goal in meta-analysis is to explain why different outcomes have occurred in different studies." (p. 197). Roberts, M. C., & Ilardi, S. S. (2003). Handbook of Research Methods in Clinical Psychology . Blackwell Publishing.

  • Example : Employment Instability and Fertility in Europe: A Meta-Analysis:  10.1215/00703370-9164737

Meta-synthesis : "Qualitative meta-synthesis is a type of qualitative study that uses as data the findings from other qualitative studies linked by the same or related topic." (p.312). Zimmer, L. (2006). Qualitative meta-synthesis: A question of dialoguing with texts .  Journal of Advanced Nursing , 53 (3), 311-318.

  • Example : Women’s perspectives on career successes and barriers: A qualitative meta-synthesis:  10.1177/05390184221113735

Literature Reviews in the Health Sciences

  • UConn Health subject guide on systematic reviews Explanation of the different review types used in health sciences literature as well as tools to help you find the right review type
  • << Previous: Getting Started
  • Next: How to Pick a Topic >>
  • Last Updated: Sep 21, 2022 2:16 PM
  • URL: https://guides.lib.uconn.edu/literaturereview

Creative Commons

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • View all journals
  • Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • CAREER FEATURE
  • 04 December 2020
  • Correction 09 December 2020

How to write a superb literature review

Andy Tay is a freelance writer based in Singapore.

You can also search for this author in PubMed   Google Scholar

Literature reviews are important resources for scientists. They provide historical context for a field while offering opinions on its future trajectory. Creating them can provide inspiration for one’s own research, as well as some practice in writing. But few scientists are trained in how to write a review — or in what constitutes an excellent one. Even picking the appropriate software to use can be an involved decision (see ‘Tools and techniques’). So Nature asked editors and working scientists with well-cited reviews for their tips.

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 51 print issues and online access

185,98 € per year

only 3,65 € per issue

Rent or buy this article

Prices vary by article type

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-020-03422-x

Interviews have been edited for length and clarity.

Updates & Corrections

Correction 09 December 2020 : An earlier version of the tables in this article included some incorrect details about the programs Zotero, Endnote and Manubot. These have now been corrected.

Hsing, I.-M., Xu, Y. & Zhao, W. Electroanalysis 19 , 755–768 (2007).

Article   Google Scholar  

Ledesma, H. A. et al. Nature Nanotechnol. 14 , 645–657 (2019).

Article   PubMed   Google Scholar  

Brahlek, M., Koirala, N., Bansal, N. & Oh, S. Solid State Commun. 215–216 , 54–62 (2015).

Choi, Y. & Lee, S. Y. Nature Rev. Chem . https://doi.org/10.1038/s41570-020-00221-w (2020).

Download references

Related Articles

guidelines in literature review

  • Research management

Tales of a migratory marine biologist

Tales of a migratory marine biologist

Career Feature 28 AUG 24

Nail your tech-industry interviews with these six techniques

Nail your tech-industry interviews with these six techniques

Career Column 28 AUG 24

How to harness AI’s potential in research — responsibly and ethically

How to harness AI’s potential in research — responsibly and ethically

Career Feature 23 AUG 24

Binning out-of-date chemicals? Somebody think about the carbon!

Correspondence 27 AUG 24

No more hunting for replication studies: crowdsourced database makes them easy to find

No more hunting for replication studies: crowdsourced database makes them easy to find

Nature Index 27 AUG 24

Partners in drug discovery: how to collaborate with non-governmental organizations

Partners in drug discovery: how to collaborate with non-governmental organizations

How can I publish open access when I can’t afford the fees?

How can I publish open access when I can’t afford the fees?

Career Feature 02 SEP 24

Exclusive: the papers that most heavily cite retracted studies

Exclusive: the papers that most heavily cite retracted studies

News 28 AUG 24

Chain retraction: how to stop bad science propagating through the literature

Chain retraction: how to stop bad science propagating through the literature

Comment 28 AUG 24

Permanent Researcher Positions for Materials Science

NIMS (Tsukuba, Japan) invites international applications from researchers who can conduct research in materials science.

Tsukuba, Ibaraki (JP)

National Institute for Materials Science (NIMS)

guidelines in literature review

Osaka University Immunology Frontier Research Center Postdoctoral Researcher

IFReC, Osaka University in Japan offers Advanced Postdoc Positions for Immunology, Cell Biology, Bioinformatics and Bioimaging.

Suita Campus, Osaka University in Osaka, Japan

Immunology Frontier Research Center, Osaka University

guidelines in literature review

Tenure-track Associate Professor [Female Only]

Seeking tenure-track assoc. professor for interdisciplinary research in nanoprobe life sciences or related fields at WPI Nano Life Science Institute.

Kanazawa, Ishikawa, Japan (JP)

Nano Life Science Institute, Kanazawa University

guidelines in literature review

Assistant/Associate Professor

Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center is seeking Assistant or Associate Professor.

Boston, Massachusetts (US)

Beth Israel Deaconess Medical Center (BIDMC)

guidelines in literature review

OPEN FACULTY POSITION-INSTITUTE OF MOLECULAR BIOLOGY, ACADEMIA SINICA, TAIWAN, ROC

One tenure-track faculty position is open to establish an active research program in all disciplines of molecular and cellular biology.

Taipei (TW)

The Institute of Molecular Biology, Academia Sinica, Taiwan

guidelines in literature review

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Quick links

  • Explore articles by subject
  • Guide to authors
  • Editorial policies

Have a language expert improve your writing

Run a free plagiarism check in 10 minutes, automatically generate references for free.

  • Knowledge Base
  • Dissertation
  • What is a Literature Review? | Guide, Template, & Examples

What is a Literature Review? | Guide, Template, & Examples

Published on 22 February 2022 by Shona McCombes . Revised on 7 June 2022.

What is a literature review? A literature review is a survey of scholarly sources on a specific topic. It provides an overview of current knowledge, allowing you to identify relevant theories, methods, and gaps in the existing research.

There are five key steps to writing a literature review:

  • Search for relevant literature
  • Evaluate sources
  • Identify themes, debates and gaps
  • Outline the structure
  • Write your literature review

A good literature review doesn’t just summarise sources – it analyses, synthesises, and critically evaluates to give a clear picture of the state of knowledge on the subject.

Instantly correct all language mistakes in your text

Be assured that you'll submit flawless writing. Upload your document to correct all your mistakes.

upload-your-document-ai-proofreader

Table of contents

Why write a literature review, examples of literature reviews, step 1: search for relevant literature, step 2: evaluate and select sources, step 3: identify themes, debates and gaps, step 4: outline your literature review’s structure, step 5: write your literature review, frequently asked questions about literature reviews, introduction.

  • Quick Run-through
  • Step 1 & 2

When you write a dissertation or thesis, you will have to conduct a literature review to situate your research within existing knowledge. The literature review gives you a chance to:

  • Demonstrate your familiarity with the topic and scholarly context
  • Develop a theoretical framework and methodology for your research
  • Position yourself in relation to other researchers and theorists
  • Show how your dissertation addresses a gap or contributes to a debate

You might also have to write a literature review as a stand-alone assignment. In this case, the purpose is to evaluate the current state of research and demonstrate your knowledge of scholarly debates around a topic.

The content will look slightly different in each case, but the process of conducting a literature review follows the same steps. We’ve written a step-by-step guide that you can follow below.

Literature review guide

The only proofreading tool specialized in correcting academic writing

The academic proofreading tool has been trained on 1000s of academic texts and by native English editors. Making it the most accurate and reliable proofreading tool for students.

guidelines in literature review

Correct my document today

Writing literature reviews can be quite challenging! A good starting point could be to look at some examples, depending on what kind of literature review you’d like to write.

  • Example literature review #1: “Why Do People Migrate? A Review of the Theoretical Literature” ( Theoretical literature review about the development of economic migration theory from the 1950s to today.)
  • Example literature review #2: “Literature review as a research methodology: An overview and guidelines” ( Methodological literature review about interdisciplinary knowledge acquisition and production.)
  • Example literature review #3: “The Use of Technology in English Language Learning: A Literature Review” ( Thematic literature review about the effects of technology on language acquisition.)
  • Example literature review #4: “Learners’ Listening Comprehension Difficulties in English Language Learning: A Literature Review” ( Chronological literature review about how the concept of listening skills has changed over time.)

You can also check out our templates with literature review examples and sample outlines at the links below.

Download Word doc Download Google doc

Before you begin searching for literature, you need a clearly defined topic .

If you are writing the literature review section of a dissertation or research paper, you will search for literature related to your research objectives and questions .

If you are writing a literature review as a stand-alone assignment, you will have to choose a focus and develop a central question to direct your search. Unlike a dissertation research question, this question has to be answerable without collecting original data. You should be able to answer it based only on a review of existing publications.

Make a list of keywords

Start by creating a list of keywords related to your research topic. Include each of the key concepts or variables you’re interested in, and list any synonyms and related terms. You can add to this list if you discover new keywords in the process of your literature search.

  • Social media, Facebook, Instagram, Twitter, Snapchat, TikTok
  • Body image, self-perception, self-esteem, mental health
  • Generation Z, teenagers, adolescents, youth

Search for relevant sources

Use your keywords to begin searching for sources. Some databases to search for journals and articles include:

  • Your university’s library catalogue
  • Google Scholar
  • Project Muse (humanities and social sciences)
  • Medline (life sciences and biomedicine)
  • EconLit (economics)
  • Inspec (physics, engineering and computer science)

You can use boolean operators to help narrow down your search:

Read the abstract to find out whether an article is relevant to your question. When you find a useful book or article, you can check the bibliography to find other relevant sources.

To identify the most important publications on your topic, take note of recurring citations. If the same authors, books or articles keep appearing in your reading, make sure to seek them out.

You probably won’t be able to read absolutely everything that has been written on the topic – you’ll have to evaluate which sources are most relevant to your questions.

For each publication, ask yourself:

  • What question or problem is the author addressing?
  • What are the key concepts and how are they defined?
  • What are the key theories, models and methods? Does the research use established frameworks or take an innovative approach?
  • What are the results and conclusions of the study?
  • How does the publication relate to other literature in the field? Does it confirm, add to, or challenge established knowledge?
  • How does the publication contribute to your understanding of the topic? What are its key insights and arguments?
  • What are the strengths and weaknesses of the research?

Make sure the sources you use are credible, and make sure you read any landmark studies and major theories in your field of research.

You can find out how many times an article has been cited on Google Scholar – a high citation count means the article has been influential in the field, and should certainly be included in your literature review.

The scope of your review will depend on your topic and discipline: in the sciences you usually only review recent literature, but in the humanities you might take a long historical perspective (for example, to trace how a concept has changed in meaning over time).

Remember that you can use our template to summarise and evaluate sources you’re thinking about using!

Take notes and cite your sources

As you read, you should also begin the writing process. Take notes that you can later incorporate into the text of your literature review.

It’s important to keep track of your sources with references to avoid plagiarism . It can be helpful to make an annotated bibliography, where you compile full reference information and write a paragraph of summary and analysis for each source. This helps you remember what you read and saves time later in the process.

You can use our free APA Reference Generator for quick, correct, consistent citations.

Prevent plagiarism, run a free check.

To begin organising your literature review’s argument and structure, you need to understand the connections and relationships between the sources you’ve read. Based on your reading and notes, you can look for:

  • Trends and patterns (in theory, method or results): do certain approaches become more or less popular over time?
  • Themes: what questions or concepts recur across the literature?
  • Debates, conflicts and contradictions: where do sources disagree?
  • Pivotal publications: are there any influential theories or studies that changed the direction of the field?
  • Gaps: what is missing from the literature? Are there weaknesses that need to be addressed?

This step will help you work out the structure of your literature review and (if applicable) show how your own research will contribute to existing knowledge.

  • Most research has focused on young women.
  • There is an increasing interest in the visual aspects of social media.
  • But there is still a lack of robust research on highly-visual platforms like Instagram and Snapchat – this is a gap that you could address in your own research.

There are various approaches to organising the body of a literature review. You should have a rough idea of your strategy before you start writing.

Depending on the length of your literature review, you can combine several of these strategies (for example, your overall structure might be thematic, but each theme is discussed chronologically).

Chronological

The simplest approach is to trace the development of the topic over time. However, if you choose this strategy, be careful to avoid simply listing and summarising sources in order.

Try to analyse patterns, turning points and key debates that have shaped the direction of the field. Give your interpretation of how and why certain developments occurred.

If you have found some recurring central themes, you can organise your literature review into subsections that address different aspects of the topic.

For example, if you are reviewing literature about inequalities in migrant health outcomes, key themes might include healthcare policy, language barriers, cultural attitudes, legal status, and economic access.

Methodological

If you draw your sources from different disciplines or fields that use a variety of research methods , you might want to compare the results and conclusions that emerge from different approaches. For example:

  • Look at what results have emerged in qualitative versus quantitative research
  • Discuss how the topic has been approached by empirical versus theoretical scholarship
  • Divide the literature into sociological, historical, and cultural sources

Theoretical

A literature review is often the foundation for a theoretical framework . You can use it to discuss various theories, models, and definitions of key concepts.

You might argue for the relevance of a specific theoretical approach, or combine various theoretical concepts to create a framework for your research.

Like any other academic text, your literature review should have an introduction , a main body, and a conclusion . What you include in each depends on the objective of your literature review.

The introduction should clearly establish the focus and purpose of the literature review.

If you are writing the literature review as part of your dissertation or thesis, reiterate your central problem or research question and give a brief summary of the scholarly context. You can emphasise the timeliness of the topic (“many recent studies have focused on the problem of x”) or highlight a gap in the literature (“while there has been much research on x, few researchers have taken y into consideration”).

Depending on the length of your literature review, you might want to divide the body into subsections. You can use a subheading for each theme, time period, or methodological approach.

As you write, make sure to follow these tips:

  • Summarise and synthesise: give an overview of the main points of each source and combine them into a coherent whole.
  • Analyse and interpret: don’t just paraphrase other researchers – add your own interpretations, discussing the significance of findings in relation to the literature as a whole.
  • Critically evaluate: mention the strengths and weaknesses of your sources.
  • Write in well-structured paragraphs: use transitions and topic sentences to draw connections, comparisons and contrasts.

In the conclusion, you should summarise the key findings you have taken from the literature and emphasise their significance.

If the literature review is part of your dissertation or thesis, reiterate how your research addresses gaps and contributes new knowledge, or discuss how you have drawn on existing theories and methods to build a framework for your research. This can lead directly into your methodology section.

A literature review is a survey of scholarly sources (such as books, journal articles, and theses) related to a specific topic or research question .

It is often written as part of a dissertation , thesis, research paper , or proposal .

There are several reasons to conduct a literature review at the beginning of a research project:

  • To familiarise yourself with the current state of knowledge on your topic
  • To ensure that you’re not just repeating what others have already done
  • To identify gaps in knowledge and unresolved problems that your research can address
  • To develop your theoretical framework and methodology
  • To provide an overview of the key findings and debates on the topic

Writing the literature review shows your reader how your work relates to existing research and what new insights it will contribute.

The literature review usually comes near the beginning of your  dissertation . After the introduction , it grounds your research in a scholarly field and leads directly to your theoretical framework or methodology .

Cite this Scribbr article

If you want to cite this source, you can copy and paste the citation or click the ‘Cite this Scribbr article’ button to automatically add the citation to our free Reference Generator.

McCombes, S. (2022, June 07). What is a Literature Review? | Guide, Template, & Examples. Scribbr. Retrieved 2 September 2024, from https://www.scribbr.co.uk/thesis-dissertation/literature-review/

Is this article helpful?

Shona McCombes

Shona McCombes

Other students also liked, how to write a dissertation proposal | a step-by-step guide, what is a theoretical framework | a step-by-step guide, what is a research methodology | steps & tips.

Reference management. Clean and simple.

Literature review

Literature review for thesis

How to write a literature review in 6 steps

How do you write a good literature review? This step-by-step guide on how to write an excellent literature review covers all aspects of planning and writing literature reviews for academic papers and theses.

Systematic literature review

How to write a systematic literature review [9 steps]

How do you write a systematic literature review? What types of systematic literature reviews exist and where do you use them? Learn everything you need to know about a systematic literature review in this guide

Literature review explained

What is a literature review? [with examples]

Not sure what a literature review is? This guide covers the definition, purpose, and format of a literature review.

  • USC Libraries
  • Research Guides

Organizing Your Social Sciences Research Paper

  • 5. The Literature Review
  • Purpose of Guide
  • Design Flaws to Avoid
  • Independent and Dependent Variables
  • Glossary of Research Terms
  • Reading Research Effectively
  • Narrowing a Topic Idea
  • Broadening a Topic Idea
  • Extending the Timeliness of a Topic Idea
  • Academic Writing Style
  • Applying Critical Thinking
  • Choosing a Title
  • Making an Outline
  • Paragraph Development
  • Research Process Video Series
  • Executive Summary
  • The C.A.R.S. Model
  • Background Information
  • The Research Problem/Question
  • Theoretical Framework
  • Citation Tracking
  • Content Alert Services
  • Evaluating Sources
  • Primary Sources
  • Secondary Sources
  • Tiertiary Sources
  • Scholarly vs. Popular Publications
  • Qualitative Methods
  • Quantitative Methods
  • Insiderness
  • Using Non-Textual Elements
  • Limitations of the Study
  • Common Grammar Mistakes
  • Writing Concisely
  • Avoiding Plagiarism
  • Footnotes or Endnotes?
  • Further Readings
  • Generative AI and Writing
  • USC Libraries Tutorials and Other Guides
  • Bibliography

A literature review surveys prior research published in books, scholarly articles, and any other sources relevant to a particular issue, area of research, or theory, and by so doing, provides a description, summary, and critical evaluation of these works in relation to the research problem being investigated. Literature reviews are designed to provide an overview of sources you have used in researching a particular topic and to demonstrate to your readers how your research fits within existing scholarship about the topic.

Fink, Arlene. Conducting Research Literature Reviews: From the Internet to Paper . Fourth edition. Thousand Oaks, CA: SAGE, 2014.

Importance of a Good Literature Review

A literature review may consist of simply a summary of key sources, but in the social sciences, a literature review usually has an organizational pattern and combines both summary and synthesis, often within specific conceptual categories . A summary is a recap of the important information of the source, but a synthesis is a re-organization, or a reshuffling, of that information in a way that informs how you are planning to investigate a research problem. The analytical features of a literature review might:

  • Give a new interpretation of old material or combine new with old interpretations,
  • Trace the intellectual progression of the field, including major debates,
  • Depending on the situation, evaluate the sources and advise the reader on the most pertinent or relevant research, or
  • Usually in the conclusion of a literature review, identify where gaps exist in how a problem has been researched to date.

Given this, the purpose of a literature review is to:

  • Place each work in the context of its contribution to understanding the research problem being studied.
  • Describe the relationship of each work to the others under consideration.
  • Identify new ways to interpret prior research.
  • Reveal any gaps that exist in the literature.
  • Resolve conflicts amongst seemingly contradictory previous studies.
  • Identify areas of prior scholarship to prevent duplication of effort.
  • Point the way in fulfilling a need for additional research.
  • Locate your own research within the context of existing literature [very important].

Fink, Arlene. Conducting Research Literature Reviews: From the Internet to Paper. 2nd ed. Thousand Oaks, CA: Sage, 2005; Hart, Chris. Doing a Literature Review: Releasing the Social Science Research Imagination . Thousand Oaks, CA: Sage Publications, 1998; Jesson, Jill. Doing Your Literature Review: Traditional and Systematic Techniques . Los Angeles, CA: SAGE, 2011; Knopf, Jeffrey W. "Doing a Literature Review." PS: Political Science and Politics 39 (January 2006): 127-132; Ridley, Diana. The Literature Review: A Step-by-Step Guide for Students . 2nd ed. Los Angeles, CA: SAGE, 2012.

Types of Literature Reviews

It is important to think of knowledge in a given field as consisting of three layers. First, there are the primary studies that researchers conduct and publish. Second are the reviews of those studies that summarize and offer new interpretations built from and often extending beyond the primary studies. Third, there are the perceptions, conclusions, opinion, and interpretations that are shared informally among scholars that become part of the body of epistemological traditions within the field.

In composing a literature review, it is important to note that it is often this third layer of knowledge that is cited as "true" even though it often has only a loose relationship to the primary studies and secondary literature reviews. Given this, while literature reviews are designed to provide an overview and synthesis of pertinent sources you have explored, there are a number of approaches you could adopt depending upon the type of analysis underpinning your study.

Argumentative Review This form examines literature selectively in order to support or refute an argument, deeply embedded assumption, or philosophical problem already established in the literature. The purpose is to develop a body of literature that establishes a contrarian viewpoint. Given the value-laden nature of some social science research [e.g., educational reform; immigration control], argumentative approaches to analyzing the literature can be a legitimate and important form of discourse. However, note that they can also introduce problems of bias when they are used to make summary claims of the sort found in systematic reviews [see below].

Integrative Review Considered a form of research that reviews, critiques, and synthesizes representative literature on a topic in an integrated way such that new frameworks and perspectives on the topic are generated. The body of literature includes all studies that address related or identical hypotheses or research problems. A well-done integrative review meets the same standards as primary research in regard to clarity, rigor, and replication. This is the most common form of review in the social sciences.

Historical Review Few things rest in isolation from historical precedent. Historical literature reviews focus on examining research throughout a period of time, often starting with the first time an issue, concept, theory, phenomena emerged in the literature, then tracing its evolution within the scholarship of a discipline. The purpose is to place research in a historical context to show familiarity with state-of-the-art developments and to identify the likely directions for future research.

Methodological Review A review does not always focus on what someone said [findings], but how they came about saying what they say [method of analysis]. Reviewing methods of analysis provides a framework of understanding at different levels [i.e. those of theory, substantive fields, research approaches, and data collection and analysis techniques], how researchers draw upon a wide variety of knowledge ranging from the conceptual level to practical documents for use in fieldwork in the areas of ontological and epistemological consideration, quantitative and qualitative integration, sampling, interviewing, data collection, and data analysis. This approach helps highlight ethical issues which you should be aware of and consider as you go through your own study.

Systematic Review This form consists of an overview of existing evidence pertinent to a clearly formulated research question, which uses pre-specified and standardized methods to identify and critically appraise relevant research, and to collect, report, and analyze data from the studies that are included in the review. The goal is to deliberately document, critically evaluate, and summarize scientifically all of the research about a clearly defined research problem . Typically it focuses on a very specific empirical question, often posed in a cause-and-effect form, such as "To what extent does A contribute to B?" This type of literature review is primarily applied to examining prior research studies in clinical medicine and allied health fields, but it is increasingly being used in the social sciences.

Theoretical Review The purpose of this form is to examine the corpus of theory that has accumulated in regard to an issue, concept, theory, phenomena. The theoretical literature review helps to establish what theories already exist, the relationships between them, to what degree the existing theories have been investigated, and to develop new hypotheses to be tested. Often this form is used to help establish a lack of appropriate theories or reveal that current theories are inadequate for explaining new or emerging research problems. The unit of analysis can focus on a theoretical concept or a whole theory or framework.

NOTE: Most often the literature review will incorporate some combination of types. For example, a review that examines literature supporting or refuting an argument, assumption, or philosophical problem related to the research problem will also need to include writing supported by sources that establish the history of these arguments in the literature.

Baumeister, Roy F. and Mark R. Leary. "Writing Narrative Literature Reviews."  Review of General Psychology 1 (September 1997): 311-320; Mark R. Fink, Arlene. Conducting Research Literature Reviews: From the Internet to Paper . 2nd ed. Thousand Oaks, CA: Sage, 2005; Hart, Chris. Doing a Literature Review: Releasing the Social Science Research Imagination . Thousand Oaks, CA: Sage Publications, 1998; Kennedy, Mary M. "Defining a Literature." Educational Researcher 36 (April 2007): 139-147; Petticrew, Mark and Helen Roberts. Systematic Reviews in the Social Sciences: A Practical Guide . Malden, MA: Blackwell Publishers, 2006; Torracro, Richard. "Writing Integrative Literature Reviews: Guidelines and Examples." Human Resource Development Review 4 (September 2005): 356-367; Rocco, Tonette S. and Maria S. Plakhotnik. "Literature Reviews, Conceptual Frameworks, and Theoretical Frameworks: Terms, Functions, and Distinctions." Human Ressource Development Review 8 (March 2008): 120-130; Sutton, Anthea. Systematic Approaches to a Successful Literature Review . Los Angeles, CA: Sage Publications, 2016.

Structure and Writing Style

I.  Thinking About Your Literature Review

The structure of a literature review should include the following in support of understanding the research problem :

  • An overview of the subject, issue, or theory under consideration, along with the objectives of the literature review,
  • Division of works under review into themes or categories [e.g. works that support a particular position, those against, and those offering alternative approaches entirely],
  • An explanation of how each work is similar to and how it varies from the others,
  • Conclusions as to which pieces are best considered in their argument, are most convincing of their opinions, and make the greatest contribution to the understanding and development of their area of research.

The critical evaluation of each work should consider :

  • Provenance -- what are the author's credentials? Are the author's arguments supported by evidence [e.g. primary historical material, case studies, narratives, statistics, recent scientific findings]?
  • Methodology -- were the techniques used to identify, gather, and analyze the data appropriate to addressing the research problem? Was the sample size appropriate? Were the results effectively interpreted and reported?
  • Objectivity -- is the author's perspective even-handed or prejudicial? Is contrary data considered or is certain pertinent information ignored to prove the author's point?
  • Persuasiveness -- which of the author's theses are most convincing or least convincing?
  • Validity -- are the author's arguments and conclusions convincing? Does the work ultimately contribute in any significant way to an understanding of the subject?

II.  Development of the Literature Review

Four Basic Stages of Writing 1.  Problem formulation -- which topic or field is being examined and what are its component issues? 2.  Literature search -- finding materials relevant to the subject being explored. 3.  Data evaluation -- determining which literature makes a significant contribution to the understanding of the topic. 4.  Analysis and interpretation -- discussing the findings and conclusions of pertinent literature.

Consider the following issues before writing the literature review: Clarify If your assignment is not specific about what form your literature review should take, seek clarification from your professor by asking these questions: 1.  Roughly how many sources would be appropriate to include? 2.  What types of sources should I review (books, journal articles, websites; scholarly versus popular sources)? 3.  Should I summarize, synthesize, or critique sources by discussing a common theme or issue? 4.  Should I evaluate the sources in any way beyond evaluating how they relate to understanding the research problem? 5.  Should I provide subheadings and other background information, such as definitions and/or a history? Find Models Use the exercise of reviewing the literature to examine how authors in your discipline or area of interest have composed their literature review sections. Read them to get a sense of the types of themes you might want to look for in your own research or to identify ways to organize your final review. The bibliography or reference section of sources you've already read, such as required readings in the course syllabus, are also excellent entry points into your own research. Narrow the Topic The narrower your topic, the easier it will be to limit the number of sources you need to read in order to obtain a good survey of relevant resources. Your professor will probably not expect you to read everything that's available about the topic, but you'll make the act of reviewing easier if you first limit scope of the research problem. A good strategy is to begin by searching the USC Libraries Catalog for recent books about the topic and review the table of contents for chapters that focuses on specific issues. You can also review the indexes of books to find references to specific issues that can serve as the focus of your research. For example, a book surveying the history of the Israeli-Palestinian conflict may include a chapter on the role Egypt has played in mediating the conflict, or look in the index for the pages where Egypt is mentioned in the text. Consider Whether Your Sources are Current Some disciplines require that you use information that is as current as possible. This is particularly true in disciplines in medicine and the sciences where research conducted becomes obsolete very quickly as new discoveries are made. However, when writing a review in the social sciences, a survey of the history of the literature may be required. In other words, a complete understanding the research problem requires you to deliberately examine how knowledge and perspectives have changed over time. Sort through other current bibliographies or literature reviews in the field to get a sense of what your discipline expects. You can also use this method to explore what is considered by scholars to be a "hot topic" and what is not.

III.  Ways to Organize Your Literature Review

Chronology of Events If your review follows the chronological method, you could write about the materials according to when they were published. This approach should only be followed if a clear path of research building on previous research can be identified and that these trends follow a clear chronological order of development. For example, a literature review that focuses on continuing research about the emergence of German economic power after the fall of the Soviet Union. By Publication Order your sources by publication chronology, then, only if the order demonstrates a more important trend. For instance, you could order a review of literature on environmental studies of brown fields if the progression revealed, for example, a change in the soil collection practices of the researchers who wrote and/or conducted the studies. Thematic [“conceptual categories”] A thematic literature review is the most common approach to summarizing prior research in the social and behavioral sciences. Thematic reviews are organized around a topic or issue, rather than the progression of time, although the progression of time may still be incorporated into a thematic review. For example, a review of the Internet’s impact on American presidential politics could focus on the development of online political satire. While the study focuses on one topic, the Internet’s impact on American presidential politics, it would still be organized chronologically reflecting technological developments in media. The difference in this example between a "chronological" and a "thematic" approach is what is emphasized the most: themes related to the role of the Internet in presidential politics. Note that more authentic thematic reviews tend to break away from chronological order. A review organized in this manner would shift between time periods within each section according to the point being made. Methodological A methodological approach focuses on the methods utilized by the researcher. For the Internet in American presidential politics project, one methodological approach would be to look at cultural differences between the portrayal of American presidents on American, British, and French websites. Or the review might focus on the fundraising impact of the Internet on a particular political party. A methodological scope will influence either the types of documents in the review or the way in which these documents are discussed.

Other Sections of Your Literature Review Once you've decided on the organizational method for your literature review, the sections you need to include in the paper should be easy to figure out because they arise from your organizational strategy. In other words, a chronological review would have subsections for each vital time period; a thematic review would have subtopics based upon factors that relate to the theme or issue. However, sometimes you may need to add additional sections that are necessary for your study, but do not fit in the organizational strategy of the body. What other sections you include in the body is up to you. However, only include what is necessary for the reader to locate your study within the larger scholarship about the research problem.

Here are examples of other sections, usually in the form of a single paragraph, you may need to include depending on the type of review you write:

  • Current Situation : Information necessary to understand the current topic or focus of the literature review.
  • Sources Used : Describes the methods and resources [e.g., databases] you used to identify the literature you reviewed.
  • History : The chronological progression of the field, the research literature, or an idea that is necessary to understand the literature review, if the body of the literature review is not already a chronology.
  • Selection Methods : Criteria you used to select (and perhaps exclude) sources in your literature review. For instance, you might explain that your review includes only peer-reviewed [i.e., scholarly] sources.
  • Standards : Description of the way in which you present your information.
  • Questions for Further Research : What questions about the field has the review sparked? How will you further your research as a result of the review?

IV.  Writing Your Literature Review

Once you've settled on how to organize your literature review, you're ready to write each section. When writing your review, keep in mind these issues.

Use Evidence A literature review section is, in this sense, just like any other academic research paper. Your interpretation of the available sources must be backed up with evidence [citations] that demonstrates that what you are saying is valid. Be Selective Select only the most important points in each source to highlight in the review. The type of information you choose to mention should relate directly to the research problem, whether it is thematic, methodological, or chronological. Related items that provide additional information, but that are not key to understanding the research problem, can be included in a list of further readings . Use Quotes Sparingly Some short quotes are appropriate if you want to emphasize a point, or if what an author stated cannot be easily paraphrased. Sometimes you may need to quote certain terminology that was coined by the author, is not common knowledge, or taken directly from the study. Do not use extensive quotes as a substitute for using your own words in reviewing the literature. Summarize and Synthesize Remember to summarize and synthesize your sources within each thematic paragraph as well as throughout the review. Recapitulate important features of a research study, but then synthesize it by rephrasing the study's significance and relating it to your own work and the work of others. Keep Your Own Voice While the literature review presents others' ideas, your voice [the writer's] should remain front and center. For example, weave references to other sources into what you are writing but maintain your own voice by starting and ending the paragraph with your own ideas and wording. Use Caution When Paraphrasing When paraphrasing a source that is not your own, be sure to represent the author's information or opinions accurately and in your own words. Even when paraphrasing an author’s work, you still must provide a citation to that work.

V.  Common Mistakes to Avoid

These are the most common mistakes made in reviewing social science research literature.

  • Sources in your literature review do not clearly relate to the research problem;
  • You do not take sufficient time to define and identify the most relevant sources to use in the literature review related to the research problem;
  • Relies exclusively on secondary analytical sources rather than including relevant primary research studies or data;
  • Uncritically accepts another researcher's findings and interpretations as valid, rather than examining critically all aspects of the research design and analysis;
  • Does not describe the search procedures that were used in identifying the literature to review;
  • Reports isolated statistical results rather than synthesizing them in chi-squared or meta-analytic methods; and,
  • Only includes research that validates assumptions and does not consider contrary findings and alternative interpretations found in the literature.

Cook, Kathleen E. and Elise Murowchick. “Do Literature Review Skills Transfer from One Course to Another?” Psychology Learning and Teaching 13 (March 2014): 3-11; Fink, Arlene. Conducting Research Literature Reviews: From the Internet to Paper . 2nd ed. Thousand Oaks, CA: Sage, 2005; Hart, Chris. Doing a Literature Review: Releasing the Social Science Research Imagination . Thousand Oaks, CA: Sage Publications, 1998; Jesson, Jill. Doing Your Literature Review: Traditional and Systematic Techniques . London: SAGE, 2011; Literature Review Handout. Online Writing Center. Liberty University; Literature Reviews. The Writing Center. University of North Carolina; Onwuegbuzie, Anthony J. and Rebecca Frels. Seven Steps to a Comprehensive Literature Review: A Multimodal and Cultural Approach . Los Angeles, CA: SAGE, 2016; Ridley, Diana. The Literature Review: A Step-by-Step Guide for Students . 2nd ed. Los Angeles, CA: SAGE, 2012; Randolph, Justus J. “A Guide to Writing the Dissertation Literature Review." Practical Assessment, Research, and Evaluation. vol. 14, June 2009; Sutton, Anthea. Systematic Approaches to a Successful Literature Review . Los Angeles, CA: Sage Publications, 2016; Taylor, Dena. The Literature Review: A Few Tips On Conducting It. University College Writing Centre. University of Toronto; Writing a Literature Review. Academic Skills Centre. University of Canberra.

Writing Tip

Break Out of Your Disciplinary Box!

Thinking interdisciplinarily about a research problem can be a rewarding exercise in applying new ideas, theories, or concepts to an old problem. For example, what might cultural anthropologists say about the continuing conflict in the Middle East? In what ways might geographers view the need for better distribution of social service agencies in large cities than how social workers might study the issue? You don’t want to substitute a thorough review of core research literature in your discipline for studies conducted in other fields of study. However, particularly in the social sciences, thinking about research problems from multiple vectors is a key strategy for finding new solutions to a problem or gaining a new perspective. Consult with a librarian about identifying research databases in other disciplines; almost every field of study has at least one comprehensive database devoted to indexing its research literature.

Frodeman, Robert. The Oxford Handbook of Interdisciplinarity . New York: Oxford University Press, 2010.

Another Writing Tip

Don't Just Review for Content!

While conducting a review of the literature, maximize the time you devote to writing this part of your paper by thinking broadly about what you should be looking for and evaluating. Review not just what scholars are saying, but how are they saying it. Some questions to ask:

  • How are they organizing their ideas?
  • What methods have they used to study the problem?
  • What theories have been used to explain, predict, or understand their research problem?
  • What sources have they cited to support their conclusions?
  • How have they used non-textual elements [e.g., charts, graphs, figures, etc.] to illustrate key points?

When you begin to write your literature review section, you'll be glad you dug deeper into how the research was designed and constructed because it establishes a means for developing more substantial analysis and interpretation of the research problem.

Hart, Chris. Doing a Literature Review: Releasing the Social Science Research Imagination . Thousand Oaks, CA: Sage Publications, 1 998.

Yet Another Writing Tip

When Do I Know I Can Stop Looking and Move On?

Here are several strategies you can utilize to assess whether you've thoroughly reviewed the literature:

  • Look for repeating patterns in the research findings . If the same thing is being said, just by different people, then this likely demonstrates that the research problem has hit a conceptual dead end. At this point consider: Does your study extend current research?  Does it forge a new path? Or, does is merely add more of the same thing being said?
  • Look at sources the authors cite to in their work . If you begin to see the same researchers cited again and again, then this is often an indication that no new ideas have been generated to address the research problem.
  • Search Google Scholar to identify who has subsequently cited leading scholars already identified in your literature review [see next sub-tab]. This is called citation tracking and there are a number of sources that can help you identify who has cited whom, particularly scholars from outside of your discipline. Here again, if the same authors are being cited again and again, this may indicate no new literature has been written on the topic.

Onwuegbuzie, Anthony J. and Rebecca Frels. Seven Steps to a Comprehensive Literature Review: A Multimodal and Cultural Approach . Los Angeles, CA: Sage, 2016; Sutton, Anthea. Systematic Approaches to a Successful Literature Review . Los Angeles, CA: Sage Publications, 2016.

  • << Previous: Theoretical Framework
  • Next: Citation Tracking >>
  • Last Updated: Aug 30, 2024 10:02 AM
  • URL: https://libguides.usc.edu/writingguide

Harvey Cushing/John Hay Whitney Medical Library

  • Collections
  • Research Help

YSN Doctoral Programs: Steps in Conducting a Literature Review

  • Biomedical Databases
  • Global (Public Health) Databases
  • Soc. Sci., History, and Law Databases
  • Grey Literature
  • Trials Registers
  • Data and Statistics
  • Public Policy
  • Google Tips
  • Recommended Books
  • Steps in Conducting a Literature Review

What is a literature review?

A literature review is an integrated analysis -- not just a summary-- of scholarly writings and other relevant evidence related directly to your research question.  That is, it represents a synthesis of the evidence that provides background information on your topic and shows a association between the evidence and your research question.

A literature review may be a stand alone work or the introduction to a larger research paper, depending on the assignment.  Rely heavily on the guidelines your instructor has given you.

Why is it important?

A literature review is important because it:

  • Explains the background of research on a topic.
  • Demonstrates why a topic is significant to a subject area.
  • Discovers relationships between research studies/ideas.
  • Identifies major themes, concepts, and researchers on a topic.
  • Identifies critical gaps and points of disagreement.
  • Discusses further research questions that logically come out of the previous studies.

APA7 Style resources

Cover Art

APA Style Blog - for those harder to find answers

1. Choose a topic. Define your research question.

Your literature review should be guided by your central research question.  The literature represents background and research developments related to a specific research question, interpreted and analyzed by you in a synthesized way.

  • Make sure your research question is not too broad or too narrow.  Is it manageable?
  • Begin writing down terms that are related to your question. These will be useful for searches later.
  • If you have the opportunity, discuss your topic with your professor and your class mates.

2. Decide on the scope of your review

How many studies do you need to look at? How comprehensive should it be? How many years should it cover? 

  • This may depend on your assignment.  How many sources does the assignment require?

3. Select the databases you will use to conduct your searches.

Make a list of the databases you will search. 

Where to find databases:

  • use the tabs on this guide
  • Find other databases in the Nursing Information Resources web page
  • More on the Medical Library web page
  • ... and more on the Yale University Library web page

4. Conduct your searches to find the evidence. Keep track of your searches.

  • Use the key words in your question, as well as synonyms for those words, as terms in your search. Use the database tutorials for help.
  • Save the searches in the databases. This saves time when you want to redo, or modify, the searches. It is also helpful to use as a guide is the searches are not finding any useful results.
  • Review the abstracts of research studies carefully. This will save you time.
  • Use the bibliographies and references of research studies you find to locate others.
  • Check with your professor, or a subject expert in the field, if you are missing any key works in the field.
  • Ask your librarian for help at any time.
  • Use a citation manager, such as EndNote as the repository for your citations. See the EndNote tutorials for help.

Review the literature

Some questions to help you analyze the research:

  • What was the research question of the study you are reviewing? What were the authors trying to discover?
  • Was the research funded by a source that could influence the findings?
  • What were the research methodologies? Analyze its literature review, the samples and variables used, the results, and the conclusions.
  • Does the research seem to be complete? Could it have been conducted more soundly? What further questions does it raise?
  • If there are conflicting studies, why do you think that is?
  • How are the authors viewed in the field? Has this study been cited? If so, how has it been analyzed?

Tips: 

  • Review the abstracts carefully.  
  • Keep careful notes so that you may track your thought processes during the research process.
  • Create a matrix of the studies for easy analysis, and synthesis, across all of the studies.
  • << Previous: Recommended Books
  • Last Updated: Jun 20, 2024 9:08 AM
  • URL: https://guides.library.yale.edu/YSNDoctoral
  • Skip to main content
  • Skip to primary sidebar
  • Request Info
  • Search Search Site Faculty/Staff
  • Open Navigation Menu Menu Close Navigation Menu
  • Literature Review Guidelines

Making sense of what has been written on your topic.

Goals of a literature review:.

Before doing work in primary sources, historians must know what has been written on their topic.  They must be familiar with theories and arguments–as well as facts–that appear in secondary sources.

Before you proceed with your research project, you too must be familiar with the literature: you do not want to waste time on theories that others have disproved and you want to take full advantage of what others have argued.  You want to be able to discuss and analyze your topic.

Your literature review will demonstrate your familiarity with your topic’s secondary literature.

GUIDELINES FOR A LITERATURE REVIEW:

1) LENGTH:  8-10 pages of text for Senior Theses (485) (consult with your professor for other classes), with either footnotes or endnotes and with a works-consulted bibliography. [See also the  citation guide  on this site.]

2) NUMBER OF WORKS REVIEWED: Depends on the assignment, but for Senior Theses (485), at least ten is typical.

3) CHOOSING WORKS:

Your literature review must include enough works to provide evidence of both the breadth and the depth of the research on your topic or, at least, one important angle of it.  The number of works necessary to do this will depend on your topic. For most topics, AT LEAST TEN works (mostly books but also significant scholarly articles) are necessary, although you will not necessarily give all of them equal treatment in your paper (e.g., some might appear in notes rather than the essay). 4) ORGANIZING/ARRANGING THE LITERATURE:

As you uncover the literature (i.e., secondary writing) on your topic, you should determine how the various pieces relate to each other.  Your ability to do so will demonstrate your understanding of the evolution of literature.

You might determine that the literature makes sense when divided by time period, by methodology, by sources, by discipline, by thematic focus, by race, ethnicity, and/or gender of author, or by political ideology.  This list is not exhaustive.  You might also decide to subdivide categories based on other criteria.  There is no “rule” on divisions—historians wrote the literature without consulting each other and without regard to the goal of fitting into a neat, obvious organization useful to students.

The key step is to FIGURE OUT the most logical, clarifying angle.  Do not arbitrarily choose a categorization; use the one that the literature seems to fall into.  How do you do that?  For every source, you should note its thesis, date, author background, methodology, and sources.  Does a pattern appear when you consider such information from each of your sources?  If so, you have a possible thesis about the literature.  If not, you might still have a thesis.

Consider: Are there missing elements in the literature?  For example, no works published during a particular (usually fairly lengthy) time period?  Or do studies appear after long neglect of a topic?  Do interpretations change at some point?  Does the major methodology being used change?  Do interpretations vary based on sources used?

Follow these links for more help on analyzing  historiography  and  historical perspective .

5) CONTENTS OF LITERATURE REVIEW:

The literature review is a research paper with three ingredients:

a) A brief discussion of the issue (the person, event, idea). [While this section should be brief, it needs to set up the thesis and literature that follow.] b) Your thesis about the literature c) A clear argument, using the works on topic as evidence, i.e., you discuss the sources in relation to your thesis, not as a separate topic.

These ingredients must be presented in an essay with an introduction, body, and conclusion.

6) ARGUING YOUR THESIS:

The thesis of a literature review should not only describe how the literature has evolved, but also provide a clear evaluation of that literature.  You should assess the literature in terms of the quality of either individual works or categories of works.  For instance, you might argue that a certain approach (e.g. social history, cultural history, or another) is better because it deals with a more complex view of the issue or because they use a wider array of source materials more effectively. You should also ensure that you integrate that evaluation throughout your argument.  Doing so might include negative assessments of some works in order to reinforce your argument regarding the positive qualities of other works and approaches to the topic.

Within each group, you should provide essential information about each work: the author’s thesis, the work’s title and date, the author’s supporting arguments and major evidence.

In most cases, arranging the sources chronologically by publication date within each section makes the most sense because earlier works influenced later ones in one way or another.  Reference to publication date also indicates that you are aware of this significant historiographical element.

As you discuss each work, DO NOT FORGET WHY YOU ARE DISCUSSING IT.  YOU ARE PRESENTING AND SUPPORTING A THESIS ABOUT THE LITERATURE.

When discussing a particular work for the first time, you should refer to it by the author’s full name, the work’s title, and year of publication (either in parentheses after the title or worked into the sentence).

For example, “The field of slavery studies has recently been transformed by Ben Johnson’s The New Slave (2001)” and “Joe Doe argues in his 1997 study, Slavery in America, that . . . .”

Your paper should always note secondary sources’ relationship to each other, particularly in terms of your thesis about the literature (e.g., “Unlike Smith’s work, Mary Brown’s analysis reaches the conclusion that . . . .” and “Because of Anderson’s reliance on the president’s personal papers, his interpretation differs from Barry’s”). The various pieces of the literature are “related” to each other, so you need to indicate to the reader some of that relationship.  (It helps the reader follow your thesis, and it convinces the reader that you know what you are talking about.)

7) DOCUMENTATION:

Each source you discuss in your paper must be documented using footnotes/endnotes and a bibliography.  Providing author and title and date in the paper is not sufficient.  Use correct Turabian/Chicago Manual of Style form.  [See  Bibliography  and  Footnotes/Endnotes  pages.]

In addition, further supporting, but less significant, sources should be included in  content foot or endnotes .  (e.g., “For a similar argument to Ben Johnson’s, see John Terry, The Slave Who Was New (New York: W. W. Norton, 1985), 3-45.”)

8 ) CONCLUSION OF LITERATURE REVIEW:

Your conclusion should not only reiterate your argument (thesis), but also discuss questions that remain unanswered by the literature.  What has the literature accomplished?  What has not been studied?  What debates need to be settled?

Additional writing guidelines

History and American Studies

  • About the Department
  • Major Requirements & Courses
  • What courses will I take as an History major?
  • What can I do with my History degree?
  • History 485
  • Methodology
  • Choosing a Topic
  • Book Reviews
  • Historiographic Clues
  • Understanding Historical Perspective
  • Sample Literature Review
  • Using Quotations
  • Ellipses and Brackets
  • Footnotes and Endnotes
  • Content Notes
  • Citation Guide
  • Citing Non-Print Resources
  • How to Annotate
  • Annotated Examples
  • Journals vs. Magazines
  • Understanding Plagiarism
  • Historians Define Plagiarism
  • Plagiarism Tutorial
  • UMW Honor System
  • Presentation Guidelines
  • Tips for Leading Seminars
  • Hints for Class Discussion
  • Speaking Center
  • Guidelines for a Research Paper
  • Library Research Plan
  • How to Use ILL
  • Database Guide
  • Guide to Online Research
  • Writing Guidelines
  • Recognizing Passive Voice
  • Introduction and Conclusion
  • MS Word’s Grammar and Spellcheck
  • Writing Center
  • What You Need to Know
  • Links to Online Primary Sources by Region
  • What will I learn from my American Studies major?
  • What courses will I take as an American Studies major?
  • What can I do with my American Studies degree?
  • American Studies 485
  • For Prospective Students
  • Honors and Award Recipients
  • Internships

Alumni Intros

Alumni Intros

How have History & American Studies majors built careers after earning their degrees? Learn more by clicking the image above.  

Recent Posts

  • History and American Studies Symposium–April 26, 2024
  • Fall 2024 Courses
  • Fall 2023 Symposium – 12/8 – All Welcome!
  • Spring ’24 Course Flyers
  • Internship Opportunity – Chesapeake Gateways Ambassador
  • Congratulations to our Graduates!
  • History and American Studies Symposium–April 21, 2023
  • View umwhistory’s profile on Facebook
  • View umwhistory’s profile on Twitter

Loading metrics

Open Access

Ten Simple Rules for Writing a Literature Review

* E-mail: [email protected]

Affiliations Centre for Functional and Evolutionary Ecology (CEFE), CNRS, Montpellier, France, Centre for Biodiversity Synthesis and Analysis (CESAB), FRB, Aix-en-Provence, France

  • Marco Pautasso

PLOS

Published: July 18, 2013

  • https://doi.org/10.1371/journal.pcbi.1003149
  • Reader Comments

Figure 1

Citation: Pautasso M (2013) Ten Simple Rules for Writing a Literature Review. PLoS Comput Biol 9(7): e1003149. https://doi.org/10.1371/journal.pcbi.1003149

Editor: Philip E. Bourne, University of California San Diego, United States of America

Copyright: © 2013 Marco Pautasso. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: This work was funded by the French Foundation for Research on Biodiversity (FRB) through its Centre for Synthesis and Analysis of Biodiversity data (CESAB), as part of the NETSEED research project. The funders had no role in the preparation of the manuscript.

Competing interests: The author has declared that no competing interests exist.

Literature reviews are in great demand in most scientific fields. Their need stems from the ever-increasing output of scientific publications [1] . For example, compared to 1991, in 2008 three, eight, and forty times more papers were indexed in Web of Science on malaria, obesity, and biodiversity, respectively [2] . Given such mountains of papers, scientists cannot be expected to examine in detail every single new paper relevant to their interests [3] . Thus, it is both advantageous and necessary to rely on regular summaries of the recent literature. Although recognition for scientists mainly comes from primary research, timely literature reviews can lead to new synthetic insights and are often widely read [4] . For such summaries to be useful, however, they need to be compiled in a professional way [5] .

When starting from scratch, reviewing the literature can require a titanic amount of work. That is why researchers who have spent their career working on a certain research issue are in a perfect position to review that literature. Some graduate schools are now offering courses in reviewing the literature, given that most research students start their project by producing an overview of what has already been done on their research issue [6] . However, it is likely that most scientists have not thought in detail about how to approach and carry out a literature review.

Reviewing the literature requires the ability to juggle multiple tasks, from finding and evaluating relevant material to synthesising information from various sources, from critical thinking to paraphrasing, evaluating, and citation skills [7] . In this contribution, I share ten simple rules I learned working on about 25 literature reviews as a PhD and postdoctoral student. Ideas and insights also come from discussions with coauthors and colleagues, as well as feedback from reviewers and editors.

Rule 1: Define a Topic and Audience

How to choose which topic to review? There are so many issues in contemporary science that you could spend a lifetime of attending conferences and reading the literature just pondering what to review. On the one hand, if you take several years to choose, several other people may have had the same idea in the meantime. On the other hand, only a well-considered topic is likely to lead to a brilliant literature review [8] . The topic must at least be:

  • interesting to you (ideally, you should have come across a series of recent papers related to your line of work that call for a critical summary),
  • an important aspect of the field (so that many readers will be interested in the review and there will be enough material to write it), and
  • a well-defined issue (otherwise you could potentially include thousands of publications, which would make the review unhelpful).

Ideas for potential reviews may come from papers providing lists of key research questions to be answered [9] , but also from serendipitous moments during desultory reading and discussions. In addition to choosing your topic, you should also select a target audience. In many cases, the topic (e.g., web services in computational biology) will automatically define an audience (e.g., computational biologists), but that same topic may also be of interest to neighbouring fields (e.g., computer science, biology, etc.).

Rule 2: Search and Re-search the Literature

After having chosen your topic and audience, start by checking the literature and downloading relevant papers. Five pieces of advice here:

  • keep track of the search items you use (so that your search can be replicated [10] ),
  • keep a list of papers whose pdfs you cannot access immediately (so as to retrieve them later with alternative strategies),
  • use a paper management system (e.g., Mendeley, Papers, Qiqqa, Sente),
  • define early in the process some criteria for exclusion of irrelevant papers (these criteria can then be described in the review to help define its scope), and
  • do not just look for research papers in the area you wish to review, but also seek previous reviews.

The chances are high that someone will already have published a literature review ( Figure 1 ), if not exactly on the issue you are planning to tackle, at least on a related topic. If there are already a few or several reviews of the literature on your issue, my advice is not to give up, but to carry on with your own literature review,

thumbnail

  • PPT PowerPoint slide
  • PNG larger image
  • TIFF original image

The bottom-right situation (many literature reviews but few research papers) is not just a theoretical situation; it applies, for example, to the study of the impacts of climate change on plant diseases, where there appear to be more literature reviews than research studies [33] .

https://doi.org/10.1371/journal.pcbi.1003149.g001

  • discussing in your review the approaches, limitations, and conclusions of past reviews,
  • trying to find a new angle that has not been covered adequately in the previous reviews, and
  • incorporating new material that has inevitably accumulated since their appearance.

When searching the literature for pertinent papers and reviews, the usual rules apply:

  • be thorough,
  • use different keywords and database sources (e.g., DBLP, Google Scholar, ISI Proceedings, JSTOR Search, Medline, Scopus, Web of Science), and
  • look at who has cited past relevant papers and book chapters.

Rule 3: Take Notes While Reading

If you read the papers first, and only afterwards start writing the review, you will need a very good memory to remember who wrote what, and what your impressions and associations were while reading each single paper. My advice is, while reading, to start writing down interesting pieces of information, insights about how to organize the review, and thoughts on what to write. This way, by the time you have read the literature you selected, you will already have a rough draft of the review.

Of course, this draft will still need much rewriting, restructuring, and rethinking to obtain a text with a coherent argument [11] , but you will have avoided the danger posed by staring at a blank document. Be careful when taking notes to use quotation marks if you are provisionally copying verbatim from the literature. It is advisable then to reformulate such quotes with your own words in the final draft. It is important to be careful in noting the references already at this stage, so as to avoid misattributions. Using referencing software from the very beginning of your endeavour will save you time.

Rule 4: Choose the Type of Review You Wish to Write

After having taken notes while reading the literature, you will have a rough idea of the amount of material available for the review. This is probably a good time to decide whether to go for a mini- or a full review. Some journals are now favouring the publication of rather short reviews focusing on the last few years, with a limit on the number of words and citations. A mini-review is not necessarily a minor review: it may well attract more attention from busy readers, although it will inevitably simplify some issues and leave out some relevant material due to space limitations. A full review will have the advantage of more freedom to cover in detail the complexities of a particular scientific development, but may then be left in the pile of the very important papers “to be read” by readers with little time to spare for major monographs.

There is probably a continuum between mini- and full reviews. The same point applies to the dichotomy of descriptive vs. integrative reviews. While descriptive reviews focus on the methodology, findings, and interpretation of each reviewed study, integrative reviews attempt to find common ideas and concepts from the reviewed material [12] . A similar distinction exists between narrative and systematic reviews: while narrative reviews are qualitative, systematic reviews attempt to test a hypothesis based on the published evidence, which is gathered using a predefined protocol to reduce bias [13] , [14] . When systematic reviews analyse quantitative results in a quantitative way, they become meta-analyses. The choice between different review types will have to be made on a case-by-case basis, depending not just on the nature of the material found and the preferences of the target journal(s), but also on the time available to write the review and the number of coauthors [15] .

Rule 5: Keep the Review Focused, but Make It of Broad Interest

Whether your plan is to write a mini- or a full review, it is good advice to keep it focused 16 , 17 . Including material just for the sake of it can easily lead to reviews that are trying to do too many things at once. The need to keep a review focused can be problematic for interdisciplinary reviews, where the aim is to bridge the gap between fields [18] . If you are writing a review on, for example, how epidemiological approaches are used in modelling the spread of ideas, you may be inclined to include material from both parent fields, epidemiology and the study of cultural diffusion. This may be necessary to some extent, but in this case a focused review would only deal in detail with those studies at the interface between epidemiology and the spread of ideas.

While focus is an important feature of a successful review, this requirement has to be balanced with the need to make the review relevant to a broad audience. This square may be circled by discussing the wider implications of the reviewed topic for other disciplines.

Rule 6: Be Critical and Consistent

Reviewing the literature is not stamp collecting. A good review does not just summarize the literature, but discusses it critically, identifies methodological problems, and points out research gaps [19] . After having read a review of the literature, a reader should have a rough idea of:

  • the major achievements in the reviewed field,
  • the main areas of debate, and
  • the outstanding research questions.

It is challenging to achieve a successful review on all these fronts. A solution can be to involve a set of complementary coauthors: some people are excellent at mapping what has been achieved, some others are very good at identifying dark clouds on the horizon, and some have instead a knack at predicting where solutions are going to come from. If your journal club has exactly this sort of team, then you should definitely write a review of the literature! In addition to critical thinking, a literature review needs consistency, for example in the choice of passive vs. active voice and present vs. past tense.

Rule 7: Find a Logical Structure

Like a well-baked cake, a good review has a number of telling features: it is worth the reader's time, timely, systematic, well written, focused, and critical. It also needs a good structure. With reviews, the usual subdivision of research papers into introduction, methods, results, and discussion does not work or is rarely used. However, a general introduction of the context and, toward the end, a recapitulation of the main points covered and take-home messages make sense also in the case of reviews. For systematic reviews, there is a trend towards including information about how the literature was searched (database, keywords, time limits) [20] .

How can you organize the flow of the main body of the review so that the reader will be drawn into and guided through it? It is generally helpful to draw a conceptual scheme of the review, e.g., with mind-mapping techniques. Such diagrams can help recognize a logical way to order and link the various sections of a review [21] . This is the case not just at the writing stage, but also for readers if the diagram is included in the review as a figure. A careful selection of diagrams and figures relevant to the reviewed topic can be very helpful to structure the text too [22] .

Rule 8: Make Use of Feedback

Reviews of the literature are normally peer-reviewed in the same way as research papers, and rightly so [23] . As a rule, incorporating feedback from reviewers greatly helps improve a review draft. Having read the review with a fresh mind, reviewers may spot inaccuracies, inconsistencies, and ambiguities that had not been noticed by the writers due to rereading the typescript too many times. It is however advisable to reread the draft one more time before submission, as a last-minute correction of typos, leaps, and muddled sentences may enable the reviewers to focus on providing advice on the content rather than the form.

Feedback is vital to writing a good review, and should be sought from a variety of colleagues, so as to obtain a diversity of views on the draft. This may lead in some cases to conflicting views on the merits of the paper, and on how to improve it, but such a situation is better than the absence of feedback. A diversity of feedback perspectives on a literature review can help identify where the consensus view stands in the landscape of the current scientific understanding of an issue [24] .

Rule 9: Include Your Own Relevant Research, but Be Objective

In many cases, reviewers of the literature will have published studies relevant to the review they are writing. This could create a conflict of interest: how can reviewers report objectively on their own work [25] ? Some scientists may be overly enthusiastic about what they have published, and thus risk giving too much importance to their own findings in the review. However, bias could also occur in the other direction: some scientists may be unduly dismissive of their own achievements, so that they will tend to downplay their contribution (if any) to a field when reviewing it.

In general, a review of the literature should neither be a public relations brochure nor an exercise in competitive self-denial. If a reviewer is up to the job of producing a well-organized and methodical review, which flows well and provides a service to the readership, then it should be possible to be objective in reviewing one's own relevant findings. In reviews written by multiple authors, this may be achieved by assigning the review of the results of a coauthor to different coauthors.

Rule 10: Be Up-to-Date, but Do Not Forget Older Studies

Given the progressive acceleration in the publication of scientific papers, today's reviews of the literature need awareness not just of the overall direction and achievements of a field of inquiry, but also of the latest studies, so as not to become out-of-date before they have been published. Ideally, a literature review should not identify as a major research gap an issue that has just been addressed in a series of papers in press (the same applies, of course, to older, overlooked studies (“sleeping beauties” [26] )). This implies that literature reviewers would do well to keep an eye on electronic lists of papers in press, given that it can take months before these appear in scientific databases. Some reviews declare that they have scanned the literature up to a certain point in time, but given that peer review can be a rather lengthy process, a full search for newly appeared literature at the revision stage may be worthwhile. Assessing the contribution of papers that have just appeared is particularly challenging, because there is little perspective with which to gauge their significance and impact on further research and society.

Inevitably, new papers on the reviewed topic (including independently written literature reviews) will appear from all quarters after the review has been published, so that there may soon be the need for an updated review. But this is the nature of science [27] – [32] . I wish everybody good luck with writing a review of the literature.

Acknowledgments

Many thanks to M. Barbosa, K. Dehnen-Schmutz, T. Döring, D. Fontaneto, M. Garbelotto, O. Holdenrieder, M. Jeger, D. Lonsdale, A. MacLeod, P. Mills, M. Moslonka-Lefebvre, G. Stancanelli, P. Weisberg, and X. Xu for insights and discussions, and to P. Bourne, T. Matoni, and D. Smith for helpful comments on a previous draft.

  • 1. Rapple C (2011) The role of the critical review article in alleviating information overload. Annual Reviews White Paper. Available: http://www.annualreviews.org/userimages/ContentEditor/1300384004941/Annual_Reviews_WhitePaper_Web_2011.pdf . Accessed May 2013.
  • View Article
  • Google Scholar
  • 7. Budgen D, Brereton P (2006) Performing systematic literature reviews in software engineering. Proc 28th Int Conf Software Engineering, ACM New York, NY, USA, pp. 1051–1052. doi: https://doi.org/10.1145/1134285.1134500 .
  • 16. Eco U (1977) Come si fa una tesi di laurea. Milan: Bompiani.
  • 17. Hart C (1998) Doing a literature review: releasing the social science research imagination. London: SAGE.
  • 21. Ridley D (2008) The literature review: a step-by-step guide for students. London: SAGE.

Duke University Libraries

Literature Reviews

  • Getting started

What is a literature review?

Why conduct a literature review, stages of a literature review, lit reviews: an overview (video), check out these books.

  • Types of reviews
  • 1. Define your research question
  • 2. Plan your search
  • 3. Search the literature
  • 4. Organize your results
  • 5. Synthesize your findings
  • 6. Write the review
  • Artificial intelligence (AI) tools
  • Thompson Writing Studio This link opens in a new window
  • Need to write a systematic review? This link opens in a new window

Guide Owner

Profile Photo

Contact a Librarian

Ask a Librarian

Definition: A literature review is a systematic examination and synthesis of existing scholarly research on a specific topic or subject.

Purpose: It serves to provide a comprehensive overview of the current state of knowledge within a particular field.

Analysis: Involves critically evaluating and summarizing key findings, methodologies, and debates found in academic literature.

Identifying Gaps: Aims to pinpoint areas where there is a lack of research or unresolved questions, highlighting opportunities for further investigation.

Contextualization: Enables researchers to understand how their work fits into the broader academic conversation and contributes to the existing body of knowledge.

guidelines in literature review

tl;dr  A literature review critically examines and synthesizes existing scholarly research and publications on a specific topic to provide a comprehensive understanding of the current state of knowledge in the field.

What is a literature review NOT?

❌ An annotated bibliography

❌ Original research

❌ A summary

❌ Something to be conducted at the end of your research

❌ An opinion piece

❌ A chronological compilation of studies

The reason for conducting a literature review is to:

What has been written about your topic?

What is the evidence for your topic?

What methods, key concepts, and theories relate to your topic?

Are there current gaps in knowledge or new questions to be asked?

Bring your reader up to date

Further your reader's understanding of the topic

Provide evidence of...

- your knowledge on the topic's theory

- your understanding of the research process

- your ability to critically evaluate and analyze information

- that you're up to date on the literature

guidelines in literature review

Literature Reviews: An Overview for Graduate Students

While this 9-minute video from NCSU is geared toward graduate students, it is useful for anyone conducting a literature review.

guidelines in literature review

Writing the literature review: A practical guide

Available 3rd floor of Perkins

guidelines in literature review

Writing literature reviews: A guide for students of the social and behavioral sciences

Available online!

guidelines in literature review

So, you have to write a literature review: A guided workbook for engineers

guidelines in literature review

Telling a research story: Writing a literature review

guidelines in literature review

The literature review: Six steps to success

guidelines in literature review

Systematic approaches to a successful literature review

Request from Duke Medical Center Library

guidelines in literature review

Doing a systematic review: A student's guide

  • Next: Types of reviews >>
  • Last Updated: Aug 29, 2024 11:40 AM
  • URL: https://guides.library.duke.edu/litreviews

Duke University Libraries

Services for...

  • Faculty & Instructors
  • Graduate Students
  • Undergraduate Students
  • International Students
  • Patrons with Disabilities

Twitter

  • Harmful Language Statement
  • Re-use & Attribution / Privacy
  • Support the Libraries

Creative Commons License

  • - Google Chrome

Intended for healthcare professionals

  • My email alerts
  • BMA member login
  • Username * Password * Forgot your log in details? Need to activate BMA Member Log In Log in via OpenAthens Log in via your institution

Home

Search form

  • Advanced search
  • Search responses
  • Search blogs
  • The PRISMA 2020...

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

  • Related content
  • Peer review
  • Joanne E McKenzie , associate professor 1 ,
  • Patrick M Bossuyt , professor 2 ,
  • Isabelle Boutron , professor 3 ,
  • Tammy C Hoffmann , professor 4 ,
  • Cynthia D Mulrow , professor 5 ,
  • Larissa Shamseer , doctoral student 6 ,
  • Jennifer M Tetzlaff , research product specialist 7 ,
  • Elie A Akl , professor 8 ,
  • Sue E Brennan , senior research fellow 1 ,
  • Roger Chou , professor 9 ,
  • Julie Glanville , associate director 10 ,
  • Jeremy M Grimshaw , professor 11 ,
  • Asbjørn Hróbjartsson , professor 12 ,
  • Manoj M Lalu , associate scientist and assistant professor 13 ,
  • Tianjing Li , associate professor 14 ,
  • Elizabeth W Loder , professor 15 ,
  • Evan Mayo-Wilson , associate professor 16 ,
  • Steve McDonald , senior research fellow 1 ,
  • Luke A McGuinness , research associate 17 ,
  • Lesley A Stewart , professor and director 18 ,
  • James Thomas , professor 19 ,
  • Andrea C Tricco , scientist and associate professor 20 ,
  • Vivian A Welch , associate professor 21 ,
  • Penny Whiting , associate professor 17 ,
  • David Moher , director and professor 22
  • 1 School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
  • 2 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands
  • 3 Université de Paris, Centre of Epidemiology and Statistics (CRESS), Inserm, F 75004 Paris, France
  • 4 Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia
  • 5 University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA; Annals of Internal Medicine
  • 6 Knowledge Translation Program, Li Ka Shing Knowledge Institute, Toronto, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada
  • 7 Evidence Partners, Ottawa, Canada
  • 8 Clinical Research Institute, American University of Beirut, Beirut, Lebanon; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
  • 9 Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, USA
  • 10 York Health Economics Consortium (YHEC Ltd), University of York, York, UK
  • 11 Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; Department of Medicine, University of Ottawa, Ottawa, Canada
  • 12 Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark
  • 13 Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada; Clinical Epidemiology Program, Blueprint Translational Research Group, Ottawa Hospital Research Institute, Ottawa, Canada; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada
  • 14 Department of Ophthalmology, School of Medicine, University of Colorado Denver, Denver, Colorado, United States; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
  • 15 Division of Headache, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Head of Research, The BMJ , London, UK
  • 16 Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, Indiana, USA
  • 17 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
  • 18 Centre for Reviews and Dissemination, University of York, York, UK
  • 19 EPPI-Centre, UCL Social Research Institute, University College London, London, UK
  • 20 Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, Toronto, Canada; Epidemiology Division of the Dalla Lana School of Public Health and the Institute of Health Management, Policy, and Evaluation, University of Toronto, Toronto, Canada; Queen's Collaboration for Health Care Quality Joanna Briggs Institute Centre of Excellence, Queen's University, Kingston, Canada
  • 21 Methods Centre, Bruyère Research Institute, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada
  • 22 Centre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada
  • Correspondence to: M J Page matthew.page{at}monash.edu
  • Accepted 4 January 2021

The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, published in 2009, was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found. Over the past decade, advances in systematic review methodology and terminology have necessitated an update to the guideline. The PRISMA 2020 statement replaces the 2009 statement and includes new reporting guidance that reflects advances in methods to identify, select, appraise, and synthesise studies. The structure and presentation of the items have been modified to facilitate implementation. In this article, we present the PRISMA 2020 27-item checklist, an expanded checklist that details reporting recommendations for each item, the PRISMA 2020 abstract checklist, and the revised flow diagrams for original and updated reviews.

Systematic reviews serve many critical roles. They can provide syntheses of the state of knowledge in a field, from which future research priorities can be identified; they can address questions that otherwise could not be answered by individual studies; they can identify problems in primary research that should be rectified in future studies; and they can generate or evaluate theories about how or why phenomena occur. Systematic reviews therefore generate various types of knowledge for different users of reviews (such as patients, healthcare providers, researchers, and policy makers). 1 2 To ensure a systematic review is valuable to users, authors should prepare a transparent, complete, and accurate account of why the review was done, what they did (such as how studies were identified and selected) and what they found (such as characteristics of contributing studies and results of meta-analyses). Up-to-date reporting guidance facilitates authors achieving this. 3

The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement published in 2009 (hereafter referred to as PRISMA 2009) 4 5 6 7 8 9 10 is a reporting guideline designed to address poor reporting of systematic reviews. 11 The PRISMA 2009 statement comprised a checklist of 27 items recommended for reporting in systematic reviews and an “explanation and elaboration” paper 12 13 14 15 16 providing additional reporting guidance for each item, along with exemplars of reporting. The recommendations have been widely endorsed and adopted, as evidenced by its co-publication in multiple journals, citation in over 60 000 reports (Scopus, August 2020), endorsement from almost 200 journals and systematic review organisations, and adoption in various disciplines. Evidence from observational studies suggests that use of the PRISMA 2009 statement is associated with more complete reporting of systematic reviews, 17 18 19 20 although more could be done to improve adherence to the guideline. 21

Many innovations in the conduct of systematic reviews have occurred since publication of the PRISMA 2009 statement. For example, technological advances have enabled the use of natural language processing and machine learning to identify relevant evidence, 22 23 24 methods have been proposed to synthesise and present findings when meta-analysis is not possible or appropriate, 25 26 27 and new methods have been developed to assess the risk of bias in results of included studies. 28 29 Evidence on sources of bias in systematic reviews has accrued, culminating in the development of new tools to appraise the conduct of systematic reviews. 30 31 Terminology used to describe particular review processes has also evolved, as in the shift from assessing “quality” to assessing “certainty” in the body of evidence. 32 In addition, the publishing landscape has transformed, with multiple avenues now available for registering and disseminating systematic review protocols, 33 34 disseminating reports of systematic reviews, and sharing data and materials, such as preprint servers and publicly accessible repositories. To capture these advances in the reporting of systematic reviews necessitated an update to the PRISMA 2009 statement.

Summary points

To ensure a systematic review is valuable to users, authors should prepare a transparent, complete, and accurate account of why the review was done, what they did, and what they found

The PRISMA 2020 statement provides updated reporting guidance for systematic reviews that reflects advances in methods to identify, select, appraise, and synthesise studies

The PRISMA 2020 statement consists of a 27-item checklist, an expanded checklist that details reporting recommendations for each item, the PRISMA 2020 abstract checklist, and revised flow diagrams for original and updated reviews

We anticipate that the PRISMA 2020 statement will benefit authors, editors, and peer reviewers of systematic reviews, and different users of reviews, including guideline developers, policy makers, healthcare providers, patients, and other stakeholders

Development of PRISMA 2020

A complete description of the methods used to develop PRISMA 2020 is available elsewhere. 35 We identified PRISMA 2009 items that were often reported incompletely by examining the results of studies investigating the transparency of reporting of published reviews. 17 21 36 37 We identified possible modifications to the PRISMA 2009 statement by reviewing 60 documents providing reporting guidance for systematic reviews (including reporting guidelines, handbooks, tools, and meta-research studies). 38 These reviews of the literature were used to inform the content of a survey with suggested possible modifications to the 27 items in PRISMA 2009 and possible additional items. Respondents were asked whether they believed we should keep each PRISMA 2009 item as is, modify it, or remove it, and whether we should add each additional item. Systematic review methodologists and journal editors were invited to complete the online survey (110 of 220 invited responded). We discussed proposed content and wording of the PRISMA 2020 statement, as informed by the review and survey results, at a 21-member, two-day, in-person meeting in September 2018 in Edinburgh, Scotland. Throughout 2019 and 2020, we circulated an initial draft and five revisions of the checklist and explanation and elaboration paper to co-authors for feedback. In April 2020, we invited 22 systematic reviewers who had expressed interest in providing feedback on the PRISMA 2020 checklist to share their views (via an online survey) on the layout and terminology used in a preliminary version of the checklist. Feedback was received from 15 individuals and considered by the first author, and any revisions deemed necessary were incorporated before the final version was approved and endorsed by all co-authors.

The PRISMA 2020 statement

Scope of the guideline.

The PRISMA 2020 statement has been designed primarily for systematic reviews of studies that evaluate the effects of health interventions, irrespective of the design of the included studies. However, the checklist items are applicable to reports of systematic reviews evaluating other interventions (such as social or educational interventions), and many items are applicable to systematic reviews with objectives other than evaluating interventions (such as evaluating aetiology, prevalence, or prognosis). PRISMA 2020 is intended for use in systematic reviews that include synthesis (such as pairwise meta-analysis or other statistical synthesis methods) or do not include synthesis (for example, because only one eligible study is identified). The PRISMA 2020 items are relevant for mixed-methods systematic reviews (which include quantitative and qualitative studies), but reporting guidelines addressing the presentation and synthesis of qualitative data should also be consulted. 39 40 PRISMA 2020 can be used for original systematic reviews, updated systematic reviews, or continually updated (“living”) systematic reviews. However, for updated and living systematic reviews, there may be some additional considerations that need to be addressed. Where there is relevant content from other reporting guidelines, we reference these guidelines within the items in the explanation and elaboration paper 41 (such as PRISMA-Search 42 in items 6 and 7, Synthesis without meta-analysis (SWiM) reporting guideline 27 in item 13d). Box 1 includes a glossary of terms used throughout the PRISMA 2020 statement.

Glossary of terms

Systematic review —A review that uses explicit, systematic methods to collate and synthesise findings of studies that address a clearly formulated question 43

Statistical synthesis —The combination of quantitative results of two or more studies. This encompasses meta-analysis of effect estimates (described below) and other methods, such as combining P values, calculating the range and distribution of observed effects, and vote counting based on the direction of effect (see McKenzie and Brennan 25 for a description of each method)

Meta-analysis of effect estimates —A statistical technique used to synthesise results when study effect estimates and their variances are available, yielding a quantitative summary of results 25

Outcome —An event or measurement collected for participants in a study (such as quality of life, mortality)

Result —The combination of a point estimate (such as a mean difference, risk ratio, or proportion) and a measure of its precision (such as a confidence/credible interval) for a particular outcome

Report —A document (paper or electronic) supplying information about a particular study. It could be a journal article, preprint, conference abstract, study register entry, clinical study report, dissertation, unpublished manuscript, government report, or any other document providing relevant information

Record —The title or abstract (or both) of a report indexed in a database or website (such as a title or abstract for an article indexed in Medline). Records that refer to the same report (such as the same journal article) are “duplicates”; however, records that refer to reports that are merely similar (such as a similar abstract submitted to two different conferences) should be considered unique.

Study —An investigation, such as a clinical trial, that includes a defined group of participants and one or more interventions and outcomes. A “study” might have multiple reports. For example, reports could include the protocol, statistical analysis plan, baseline characteristics, results for the primary outcome, results for harms, results for secondary outcomes, and results for additional mediator and moderator analyses

PRISMA 2020 is not intended to guide systematic review conduct, for which comprehensive resources are available. 43 44 45 46 However, familiarity with PRISMA 2020 is useful when planning and conducting systematic reviews to ensure that all recommended information is captured. PRISMA 2020 should not be used to assess the conduct or methodological quality of systematic reviews; other tools exist for this purpose. 30 31 Furthermore, PRISMA 2020 is not intended to inform the reporting of systematic review protocols, for which a separate statement is available (PRISMA for Protocols (PRISMA-P) 2015 statement 47 48 ). Finally, extensions to the PRISMA 2009 statement have been developed to guide reporting of network meta-analyses, 49 meta-analyses of individual participant data, 50 systematic reviews of harms, 51 systematic reviews of diagnostic test accuracy studies, 52 and scoping reviews 53 ; for these types of reviews we recommend authors report their review in accordance with the recommendations in PRISMA 2020 along with the guidance specific to the extension.

How to use PRISMA 2020

The PRISMA 2020 statement (including the checklists, explanation and elaboration, and flow diagram) replaces the PRISMA 2009 statement, which should no longer be used. Box 2 summarises noteworthy changes from the PRISMA 2009 statement. The PRISMA 2020 checklist includes seven sections with 27 items, some of which include sub-items ( table 1 ). A checklist for journal and conference abstracts for systematic reviews is included in PRISMA 2020. This abstract checklist is an update of the 2013 PRISMA for Abstracts statement, 54 reflecting new and modified content in PRISMA 2020 ( table 2 ). A template PRISMA flow diagram is provided, which can be modified depending on whether the systematic review is original or updated ( fig 1 ).

Noteworthy changes to the PRISMA 2009 statement

Inclusion of the abstract reporting checklist within PRISMA 2020 (see item #2 and table 2 ).

Movement of the ‘Protocol and registration’ item from the start of the Methods section of the checklist to a new Other section, with addition of a sub-item recommending authors describe amendments to information provided at registration or in the protocol (see item #24a-24c).

Modification of the ‘Search’ item to recommend authors present full search strategies for all databases, registers and websites searched, not just at least one database (see item #7).

Modification of the ‘Study selection’ item in the Methods section to emphasise the reporting of how many reviewers screened each record and each report retrieved, whether they worked independently, and if applicable, details of automation tools used in the process (see item #8).

Addition of a sub-item to the ‘Data items’ item recommending authors report how outcomes were defined, which results were sought, and methods for selecting a subset of results from included studies (see item #10a).

Splitting of the ‘Synthesis of results’ item in the Methods section into six sub-items recommending authors describe: the processes used to decide which studies were eligible for each synthesis; any methods required to prepare the data for synthesis; any methods used to tabulate or visually display results of individual studies and syntheses; any methods used to synthesise results; any methods used to explore possible causes of heterogeneity among study results (such as subgroup analysis, meta-regression); and any sensitivity analyses used to assess robustness of the synthesised results (see item #13a-13f).

Addition of a sub-item to the ‘Study selection’ item in the Results section recommending authors cite studies that might appear to meet the inclusion criteria, but which were excluded, and explain why they were excluded (see item #16b).

Splitting of the ‘Synthesis of results’ item in the Results section into four sub-items recommending authors: briefly summarise the characteristics and risk of bias among studies contributing to the synthesis; present results of all statistical syntheses conducted; present results of any investigations of possible causes of heterogeneity among study results; and present results of any sensitivity analyses (see item #20a-20d).

Addition of new items recommending authors report methods for and results of an assessment of certainty (or confidence) in the body of evidence for an outcome (see items #15 and #22).

Addition of a new item recommending authors declare any competing interests (see item #26).

Addition of a new item recommending authors indicate whether data, analytic code and other materials used in the review are publicly available and if so, where they can be found (see item #27).

PRISMA 2020 item checklist

  • View inline

PRISMA 2020 for Abstracts checklist*

Fig 1

PRISMA 2020 flow diagram template for systematic reviews. The new design is adapted from flow diagrams proposed by Boers, 55 Mayo-Wilson et al. 56 and Stovold et al. 57 The boxes in grey should only be completed if applicable; otherwise they should be removed from the flow diagram. Note that a “report” could be a journal article, preprint, conference abstract, study register entry, clinical study report, dissertation, unpublished manuscript, government report or any other document providing relevant information.

  • Download figure
  • Open in new tab
  • Download powerpoint

We recommend authors refer to PRISMA 2020 early in the writing process, because prospective consideration of the items may help to ensure that all the items are addressed. To help keep track of which items have been reported, the PRISMA statement website ( http://www.prisma-statement.org/ ) includes fillable templates of the checklists to download and complete (also available in the data supplement on bmj.com). We have also created a web application that allows users to complete the checklist via a user-friendly interface 58 (available at https://prisma.shinyapps.io/checklist/ and adapted from the Transparency Checklist app 59 ). The completed checklist can be exported to Word or PDF. Editable templates of the flow diagram can also be downloaded from the PRISMA statement website.

We have prepared an updated explanation and elaboration paper, in which we explain why reporting of each item is recommended and present bullet points that detail the reporting recommendations (which we refer to as elements). 41 The bullet-point structure is new to PRISMA 2020 and has been adopted to facilitate implementation of the guidance. 60 61 An expanded checklist, which comprises an abridged version of the elements presented in the explanation and elaboration paper, with references and some examples removed, is available in the data supplement on bmj.com. Consulting the explanation and elaboration paper is recommended if further clarity or information is required.

Journals and publishers might impose word and section limits, and limits on the number of tables and figures allowed in the main report. In such cases, if the relevant information for some items already appears in a publicly accessible review protocol, referring to the protocol may suffice. Alternatively, placing detailed descriptions of the methods used or additional results (such as for less critical outcomes) in supplementary files is recommended. Ideally, supplementary files should be deposited to a general-purpose or institutional open-access repository that provides free and permanent access to the material (such as Open Science Framework, Dryad, figshare). A reference or link to the additional information should be included in the main report. Finally, although PRISMA 2020 provides a template for where information might be located, the suggested location should not be seen as prescriptive; the guiding principle is to ensure the information is reported.

Use of PRISMA 2020 has the potential to benefit many stakeholders. Complete reporting allows readers to assess the appropriateness of the methods, and therefore the trustworthiness of the findings. Presenting and summarising characteristics of studies contributing to a synthesis allows healthcare providers and policy makers to evaluate the applicability of the findings to their setting. Describing the certainty in the body of evidence for an outcome and the implications of findings should help policy makers, managers, and other decision makers formulate appropriate recommendations for practice or policy. Complete reporting of all PRISMA 2020 items also facilitates replication and review updates, as well as inclusion of systematic reviews in overviews (of systematic reviews) and guidelines, so teams can leverage work that is already done and decrease research waste. 36 62 63

We updated the PRISMA 2009 statement by adapting the EQUATOR Network’s guidance for developing health research reporting guidelines. 64 We evaluated the reporting completeness of published systematic reviews, 17 21 36 37 reviewed the items included in other documents providing guidance for systematic reviews, 38 surveyed systematic review methodologists and journal editors for their views on how to revise the original PRISMA statement, 35 discussed the findings at an in-person meeting, and prepared this document through an iterative process. Our recommendations are informed by the reviews and survey conducted before the in-person meeting, theoretical considerations about which items facilitate replication and help users assess the risk of bias and applicability of systematic reviews, and co-authors’ experience with authoring and using systematic reviews.

Various strategies to increase the use of reporting guidelines and improve reporting have been proposed. They include educators introducing reporting guidelines into graduate curricula to promote good reporting habits of early career scientists 65 ; journal editors and regulators endorsing use of reporting guidelines 18 ; peer reviewers evaluating adherence to reporting guidelines 61 66 ; journals requiring authors to indicate where in their manuscript they have adhered to each reporting item 67 ; and authors using online writing tools that prompt complete reporting at the writing stage. 60 Multi-pronged interventions, where more than one of these strategies are combined, may be more effective (such as completion of checklists coupled with editorial checks). 68 However, of 31 interventions proposed to increase adherence to reporting guidelines, the effects of only 11 have been evaluated, mostly in observational studies at high risk of bias due to confounding. 69 It is therefore unclear which strategies should be used. Future research might explore barriers and facilitators to the use of PRISMA 2020 by authors, editors, and peer reviewers, designing interventions that address the identified barriers, and evaluating those interventions using randomised trials. To inform possible revisions to the guideline, it would also be valuable to conduct think-aloud studies 70 to understand how systematic reviewers interpret the items, and reliability studies to identify items where there is varied interpretation of the items.

We encourage readers to submit evidence that informs any of the recommendations in PRISMA 2020 (via the PRISMA statement website: http://www.prisma-statement.org/ ). To enhance accessibility of PRISMA 2020, several translations of the guideline are under way (see available translations at the PRISMA statement website). We encourage journal editors and publishers to raise awareness of PRISMA 2020 (for example, by referring to it in journal “Instructions to authors”), endorsing its use, advising editors and peer reviewers to evaluate submitted systematic reviews against the PRISMA 2020 checklists, and making changes to journal policies to accommodate the new reporting recommendations. We recommend existing PRISMA extensions 47 49 50 51 52 53 71 72 be updated to reflect PRISMA 2020 and advise developers of new PRISMA extensions to use PRISMA 2020 as the foundation document.

We anticipate that the PRISMA 2020 statement will benefit authors, editors, and peer reviewers of systematic reviews, and different users of reviews, including guideline developers, policy makers, healthcare providers, patients, and other stakeholders. Ultimately, we hope that uptake of the guideline will lead to more transparent, complete, and accurate reporting of systematic reviews, thus facilitating evidence based decision making.

Acknowledgments

We dedicate this paper to the late Douglas G Altman and Alessandro Liberati, whose contributions were fundamental to the development and implementation of the original PRISMA statement.

We thank the following contributors who completed the survey to inform discussions at the development meeting: Xavier Armoiry, Edoardo Aromataris, Ana Patricia Ayala, Ethan M Balk, Virginia Barbour, Elaine Beller, Jesse A Berlin, Lisa Bero, Zhao-Xiang Bian, Jean Joel Bigna, Ferrán Catalá-López, Anna Chaimani, Mike Clarke, Tammy Clifford, Ioana A Cristea, Miranda Cumpston, Sofia Dias, Corinna Dressler, Ivan D Florez, Joel J Gagnier, Chantelle Garritty, Long Ge, Davina Ghersi, Sean Grant, Gordon Guyatt, Neal R Haddaway, Julian PT Higgins, Sally Hopewell, Brian Hutton, Jamie J Kirkham, Jos Kleijnen, Julia Koricheva, Joey SW Kwong, Toby J Lasserson, Julia H Littell, Yoon K Loke, Malcolm R Macleod, Chris G Maher, Ana Marušic, Dimitris Mavridis, Jessie McGowan, Matthew DF McInnes, Philippa Middleton, Karel G Moons, Zachary Munn, Jane Noyes, Barbara Nußbaumer-Streit, Donald L Patrick, Tatiana Pereira-Cenci, Ba’ Pham, Bob Phillips, Dawid Pieper, Michelle Pollock, Daniel S Quintana, Drummond Rennie, Melissa L Rethlefsen, Hannah R Rothstein, Maroeska M Rovers, Rebecca Ryan, Georgia Salanti, Ian J Saldanha, Margaret Sampson, Nancy Santesso, Rafael Sarkis-Onofre, Jelena Savović, Christopher H Schmid, Kenneth F Schulz, Guido Schwarzer, Beverley J Shea, Paul G Shekelle, Farhad Shokraneh, Mark Simmonds, Nicole Skoetz, Sharon E Straus, Anneliese Synnot, Emily E Tanner-Smith, Brett D Thombs, Hilary Thomson, Alexander Tsertsvadze, Peter Tugwell, Tari Turner, Lesley Uttley, Jeffrey C Valentine, Matt Vassar, Areti Angeliki Veroniki, Meera Viswanathan, Cole Wayant, Paul Whaley, and Kehu Yang. We thank the following contributors who provided feedback on a preliminary version of the PRISMA 2020 checklist: Jo Abbott, Fionn Büttner, Patricia Correia-Santos, Victoria Freeman, Emily A Hennessy, Rakibul Islam, Amalia (Emily) Karahalios, Kasper Krommes, Andreas Lundh, Dafne Port Nascimento, Davina Robson, Catherine Schenck-Yglesias, Mary M Scott, Sarah Tanveer and Pavel Zhelnov. We thank Abigail H Goben, Melissa L Rethlefsen, Tanja Rombey, Anna Scott, and Farhad Shokraneh for their helpful comments on the preprints of the PRISMA 2020 papers. We thank Edoardo Aromataris, Stephanie Chang, Toby Lasserson and David Schriger for their helpful peer review comments on the PRISMA 2020 papers.

Contributors: JEM and DM are joint senior authors. MJP, JEM, PMB, IB, TCH, CDM, LS, and DM conceived this paper and designed the literature review and survey conducted to inform the guideline content. MJP conducted the literature review, administered the survey and analysed the data for both. MJP prepared all materials for the development meeting. MJP and JEM presented proposals at the development meeting. All authors except for TCH, JMT, EAA, SEB, and LAM attended the development meeting. MJP and JEM took and consolidated notes from the development meeting. MJP and JEM led the drafting and editing of the article. JEM, PMB, IB, TCH, LS, JMT, EAA, SEB, RC, JG, AH, TL, EMW, SM, LAM, LAS, JT, ACT, PW, and DM drafted particular sections of the article. All authors were involved in revising the article critically for important intellectual content. All authors approved the final version of the article. MJP is the guarantor of this work. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.

Funding: There was no direct funding for this research. MJP is supported by an Australian Research Council Discovery Early Career Researcher Award (DE200101618) and was previously supported by an Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship (1088535) during the conduct of this research. JEM is supported by an Australian NHMRC Career Development Fellowship (1143429). TCH is supported by an Australian NHMRC Senior Research Fellowship (1154607). JMT is supported by Evidence Partners Inc. JMG is supported by a Tier 1 Canada Research Chair in Health Knowledge Transfer and Uptake. MML is supported by The Ottawa Hospital Anaesthesia Alternate Funds Association and a Faculty of Medicine Junior Research Chair. TL is supported by funding from the National Eye Institute (UG1EY020522), National Institutes of Health, United States. LAM is supported by a National Institute for Health Research Doctoral Research Fellowship (DRF-2018-11-ST2-048). ACT is supported by a Tier 2 Canada Research Chair in Knowledge Synthesis. DM is supported in part by a University Research Chair, University of Ottawa. The funders had no role in considering the study design or in the collection, analysis, interpretation of data, writing of the report, or decision to submit the article for publication.

Competing interests: All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/conflicts-of-interest/ and declare: EL is head of research for the BMJ ; MJP is an editorial board member for PLOS Medicine ; ACT is an associate editor and MJP, TL, EMW, and DM are editorial board members for the Journal of Clinical Epidemiology ; DM and LAS were editors in chief, LS, JMT, and ACT are associate editors, and JG is an editorial board member for Systematic Reviews . None of these authors were involved in the peer review process or decision to publish. TCH has received personal fees from Elsevier outside the submitted work. EMW has received personal fees from the American Journal for Public Health , for which he is the editor for systematic reviews. VW is editor in chief of the Campbell Collaboration, which produces systematic reviews, and co-convenor of the Campbell and Cochrane equity methods group. DM is chair of the EQUATOR Network, IB is adjunct director of the French EQUATOR Centre and TCH is co-director of the Australasian EQUATOR Centre, which advocates for the use of reporting guidelines to improve the quality of reporting in research articles. JMT received salary from Evidence Partners, creator of DistillerSR software for systematic reviews; Evidence Partners was not involved in the design or outcomes of the statement, and the views expressed solely represent those of the author.

Provenance and peer review: Not commissioned; externally peer reviewed.

Patient and public involvement: Patients and the public were not involved in this methodological research. We plan to disseminate the research widely, including to community participants in evidence synthesis organisations.

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ .

  • Gurevitch J ,
  • Koricheva J ,
  • Nakagawa S ,
  • Liberati A ,
  • Tetzlaff J ,
  • Altman DG ,
  • PRISMA Group
  • Tricco AC ,
  • Sampson M ,
  • Shamseer L ,
  • Leoncini E ,
  • de Belvis G ,
  • Ricciardi W ,
  • Fowler AJ ,
  • Leclercq V ,
  • Beaudart C ,
  • Ajamieh S ,
  • Rabenda V ,
  • Tirelli E ,
  • O’Mara-Eves A ,
  • McNaught J ,
  • Ananiadou S
  • Marshall IJ ,
  • Noel-Storr A ,
  • Higgins JPT ,
  • Chandler J ,
  • McKenzie JE ,
  • López-López JA ,
  • Becker BJ ,
  • Campbell M ,
  • Sterne JAC ,
  • Savović J ,
  • Sterne JA ,
  • Hernán MA ,
  • Reeves BC ,
  • Whiting P ,
  • Higgins JP ,
  • ROBIS group
  • Hultcrantz M ,
  • Stewart L ,
  • Bossuyt PM ,
  • Flemming K ,
  • McInnes E ,
  • France EF ,
  • Cunningham M ,
  • Rethlefsen ML ,
  • Kirtley S ,
  • Waffenschmidt S ,
  • PRISMA-S Group
  • ↵ Higgins JPT, Thomas J, Chandler J, et al, eds. Cochrane Handbook for Systematic Reviews of Interventions : Version 6.0. Cochrane, 2019. Available from https://training.cochrane.org/handbook .
  • Dekkers OM ,
  • Vandenbroucke JP ,
  • Cevallos M ,
  • Renehan AG ,
  • ↵ Cooper H, Hedges LV, Valentine JV, eds. The Handbook of Research Synthesis and Meta-Analysis. Russell Sage Foundation, 2019.
  • IOM (Institute of Medicine)
  • PRISMA-P Group
  • Salanti G ,
  • Caldwell DM ,
  • Stewart LA ,
  • PRISMA-IPD Development Group
  • Zorzela L ,
  • Ioannidis JP ,
  • PRISMAHarms Group
  • McInnes MDF ,
  • Thombs BD ,
  • and the PRISMA-DTA Group
  • Beller EM ,
  • Glasziou PP ,
  • PRISMA for Abstracts Group
  • Mayo-Wilson E ,
  • Dickersin K ,
  • MUDS investigators
  • Stovold E ,
  • Beecher D ,
  • Noel-Storr A
  • McGuinness LA
  • Sarafoglou A ,
  • Boutron I ,
  • Giraudeau B ,
  • Porcher R ,
  • Chauvin A ,
  • Schulz KF ,
  • Schroter S ,
  • Stevens A ,
  • Weinstein E ,
  • Macleod MR ,
  • IICARus Collaboration
  • Kirkham JJ ,
  • Petticrew M ,
  • Tugwell P ,
  • PRISMA-Equity Bellagio group

guidelines in literature review

U.S. flag

An official website of the United States government

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

  • Publications
  • Account settings
  • My Bibliography
  • Collections
  • Citation manager

Save citation to file

Email citation, add to collections.

  • Create a new collection
  • Add to an existing collection

Add to My Bibliography

Your saved search, create a file for external citation management software, your rss feed.

  • Search in PubMed
  • Search in NLM Catalog
  • Add to Search

How to Do a Systematic Review: A Best Practice Guide for Conducting and Reporting Narrative Reviews, Meta-Analyses, and Meta-Syntheses

Affiliations.

  • 1 Behavioural Science Centre, Stirling Management School, University of Stirling, Stirling FK9 4LA, United Kingdom; email: [email protected].
  • 2 Department of Psychological and Behavioural Science, London School of Economics and Political Science, London WC2A 2AE, United Kingdom.
  • 3 Department of Statistics, Northwestern University, Evanston, Illinois 60208, USA; email: [email protected].
  • PMID: 30089228
  • DOI: 10.1146/annurev-psych-010418-102803

Systematic reviews are characterized by a methodical and replicable methodology and presentation. They involve a comprehensive search to locate all relevant published and unpublished work on a subject; a systematic integration of search results; and a critique of the extent, nature, and quality of evidence in relation to a particular research question. The best reviews synthesize studies to draw broad theoretical conclusions about what a literature means, linking theory to evidence and evidence to theory. This guide describes how to plan, conduct, organize, and present a systematic review of quantitative (meta-analysis) or qualitative (narrative review, meta-synthesis) information. We outline core standards and principles and describe commonly encountered problems. Although this guide targets psychological scientists, its high level of abstraction makes it potentially relevant to any subject area or discipline. We argue that systematic reviews are a key methodology for clarifying whether and how research findings replicate and for explaining possible inconsistencies, and we call for researchers to conduct systematic reviews to help elucidate whether there is a replication crisis.

Keywords: evidence; guide; meta-analysis; meta-synthesis; narrative; systematic review; theory.

PubMed Disclaimer

Similar articles

  • The future of Cochrane Neonatal. Soll RF, Ovelman C, McGuire W. Soll RF, et al. Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12. Early Hum Dev. 2020. PMID: 33036834
  • Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. Aromataris E, Fernandez R, Godfrey CM, Holly C, Khalil H, Tungpunkom P. Aromataris E, et al. Int J Evid Based Healthc. 2015 Sep;13(3):132-40. doi: 10.1097/XEB.0000000000000055. Int J Evid Based Healthc. 2015. PMID: 26360830
  • RAMESES publication standards: meta-narrative reviews. Wong G, Greenhalgh T, Westhorp G, Buckingham J, Pawson R. Wong G, et al. BMC Med. 2013 Jan 29;11:20. doi: 10.1186/1741-7015-11-20. BMC Med. 2013. PMID: 23360661 Free PMC article.
  • A Primer on Systematic Reviews and Meta-Analyses. Nguyen NH, Singh S. Nguyen NH, et al. Semin Liver Dis. 2018 May;38(2):103-111. doi: 10.1055/s-0038-1655776. Epub 2018 Jun 5. Semin Liver Dis. 2018. PMID: 29871017 Review.
  • Publication Bias and Nonreporting Found in Majority of Systematic Reviews and Meta-analyses in Anesthesiology Journals. Hedin RJ, Umberham BA, Detweiler BN, Kollmorgen L, Vassar M. Hedin RJ, et al. Anesth Analg. 2016 Oct;123(4):1018-25. doi: 10.1213/ANE.0000000000001452. Anesth Analg. 2016. PMID: 27537925 Review.
  • The Association between Emotional Intelligence and Prosocial Behaviors in Children and Adolescents: A Systematic Review and Meta-Analysis. Cao X, Chen J. Cao X, et al. J Youth Adolesc. 2024 Aug 28. doi: 10.1007/s10964-024-02062-y. Online ahead of print. J Youth Adolesc. 2024. PMID: 39198344
  • The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians. Martin C, Capilla-Lasheras P, Monaghan P, Burraco P. Martin C, et al. Proc Biol Sci. 2024 Aug;291(2029):20241536. doi: 10.1098/rspb.2024.1536. Epub 2024 Aug 28. Proc Biol Sci. 2024. PMID: 39191283 Free PMC article.
  • Target mechanisms of mindfulness-based programmes and practices: a scoping review. Maloney S, Kock M, Slaghekke Y, Radley L, Lopez-Montoyo A, Montero-Marin J, Kuyken W. Maloney S, et al. BMJ Ment Health. 2024 Aug 24;27(1):e300955. doi: 10.1136/bmjment-2023-300955. BMJ Ment Health. 2024. PMID: 39181568 Free PMC article. Review.
  • Bridging disciplines-key to success when implementing planetary health in medical training curricula. Malmqvist E, Oudin A. Malmqvist E, et al. Front Public Health. 2024 Aug 6;12:1454729. doi: 10.3389/fpubh.2024.1454729. eCollection 2024. Front Public Health. 2024. PMID: 39165783 Free PMC article. Review.
  • Strength of evidence for five happiness strategies. Puterman E, Zieff G, Stoner L. Puterman E, et al. Nat Hum Behav. 2024 Aug 12. doi: 10.1038/s41562-024-01954-0. Online ahead of print. Nat Hum Behav. 2024. PMID: 39134738 No abstract available.
  • Search in MeSH

LinkOut - more resources

Full text sources.

  • Ingenta plc
  • Ovid Technologies, Inc.

Other Literature Sources

  • scite Smart Citations

Miscellaneous

  • NCI CPTAC Assay Portal
  • Citation Manager

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

Banner

PSYC 210: Foundations of Psychology

  • Tips for Searching for Articles

What is a literature review?

Conducting a literature review, organizing a literature review, writing a literature review, helpful book.

  • Avoiding Plagiarism
  • Google Scholar

Profile Photo

A  literature review  is a compilation of the works published in a particular field of study or line of research, usually over a specific period of time, in the form of an in-depth, critical bibliographic essay or annotated list in which attention is drawn to the most significant works.

  • Summarizes and analyzes previous research relevant to a topic
  • Includes scholarly books and articles published in academic journals
  • Can be an specific scholarly paper or a section in a research paper

The objective of a Literature Review is to find previous published scholarly works relevant to an specific topic

  • Help gather ideas or information
  • Keep up to date in current trends and findings
  • Help develop new questions

A literature review is important because it:

  • Explains the background of research on a topic
  • Demonstrates why a topic is significant to a subject area
  • Helps focus your own research questions or problems
  • Discovers relationships between research studies/ideas
  • Suggests unexplored ideas or populations
  • Identifies major themes, concepts, and researchers on a topic
  • Tests assumptions; may help counter preconceived ideas and remove unconscious bias
  • Identifies critical gaps, points of disagreement, or potentially flawed methodology or theoretical approaches

Source: "What is a Literature Review?", Old Dominion University,  https://guides.lib.odu.edu/c.php?g=966167&p=6980532

1. Choose a topic. Define your research question. 

Your literature review should be guided by a central research question. It represents background and research developments related to a specific research question, interpreted, and analyzed by you in a synthesized way. 

  • Make sure your research question is not too broad or too narrow.
  • Write down terms that are related to your question for they will be useful for searches later. 

2. Decide on the scope of your review. 

How many studies do you need to look at? How comprehensive should it be? How many years should it cover? 

  • This may depend on your assignment.
  • Consider these things when planning your time for research. 

3. Select the databases you will use to conduct your searches. 

  • By Research Guide 

4. Conduct your searches and find the literature. 

  • Review the abstracts carefully - this will save you time!
  • Many databases will have a search history tab for you to return to for later.
  • Use bibliographies and references of research studies to locate others.
  • Use citation management software such as Zotero to keep track of your research citations. 

5. Review the literature. 

Some questions to help you analyze the research: 

  • What was the research question you are reviewing? What are the authors trying to discover? 
  • Was the research funded by a source that could influence the findings? 
  • What were the research methodologies? Analyze the literature review, samples and variables used, results, and conclusions. Does the research seem complete? Could it have been conducted more soundly? What further questions does it raise? 
  • If there are conflicted studies, why do you think that is? 
  • How are the authors viewed in the field? Are they experts or novices? Has the study been cited? 

Source: "Literature Review", University of West Florida,  https://libguides.uwf.edu/c.php?g=215113&p=5139469

A literature review is not a summary of the sources but a synthesis of the sources. It is made up of the topics the sources are discussing. Each section of the review is focused on a topic, and the relevant sources are discussed within the context of that topic. 

1. Select the most relevant material from the sources

  • Could be material that answers the question directly
  • Extract as a direct quote or paraphrase 

2. Arrange that material so you can focus on it apart from the source text itself

  • You are now working with fewer words/passages
  • Material is all in one place

3. Group similar points, themes, or topics together and label them 

  • The labels describe the points, themes, or topics that are the backbone of your paper’s structure

4. Order those points, themes, or topics as you will discuss them in the paper, and turn the labels into actual assertions

  • A sentence that makes a point that is directly related to your research question or thesis 

This is now the outline for your literature review. 

Source: "Organizing a Review of the Literature – The Basics", George Mason University Writing Center,  https://writingcenter.gmu.edu/writing-resources/research-based-writing/organizing-literature-reviews-the-basics

  • Literature Review Matrix Here is a template on how people tend to organize their thoughts. The matrix template is a good way to write out the key parts of each article and take notes. Downloads as an XLSX file.

The most common way that literature reviews are organized is by theme or author. Find a general pattern of structure for the review. When organizing the review, consider the following: 

  • the methodology 
  • the quality of the findings or conclusions
  • major strengths and weaknesses
  • any other important information

Writing Tips: 

  • Be selective - Select only the most important points in each source to highlight in the review. It should directly relate to the review's focus.
  • Use quotes sparingly.
  • Keep your own voice - Your voice (the writer's) should remain front and center. .   
  • Aim for one key figure/table per section to illustrate complex content, summarize a large body of relevant data, or describe the order of a process
  • Legend below image/figure and above table and always refer to them in text 

Source: "Composing your Literature Review", Florida A&M University,  https://library.famu.edu/c.php?g=577356&p=3982811

Cover Art

  • << Previous: Tips for Searching for Articles
  • Next: Citing Your Sources >>
  • Last Updated: Aug 21, 2024 3:43 PM
  • URL: https://infoguides.pepperdine.edu/PSYC210

Explore. Discover. Create.

Copyright ©  2022  Pepperdine University

  • UWF Libraries

Literature Review: Conducting & Writing

  • Sample Literature Reviews
  • Steps for Conducting a Lit Review
  • Finding "The Literature"
  • Organizing/Writing
  • APA Style This link opens in a new window
  • Chicago: Notes Bibliography This link opens in a new window
  • MLA Style This link opens in a new window

Sample Lit Reviews from Communication Arts

Have an exemplary literature review.

  • Literature Review Sample 1
  • Literature Review Sample 2
  • Literature Review Sample 3

Have you written a stellar literature review you care to share for teaching purposes?

Are you an instructor who has received an exemplary literature review and have permission from the student to post?

Please contact Britt McGowan at [email protected] for inclusion in this guide. All disciplines welcome and encouraged.

  • << Previous: MLA Style
  • Next: Get Help! >>
  • Last Updated: Aug 8, 2024 11:00 AM
  • URL: https://libguides.uwf.edu/litreview

American Psychological Association Logo

Literature review guidelines

Developed by James O'Neill with assistance from Ronald Levant, Rod Watts, Andrew Smiler, Michael Addis, and Stephen Wester.

General considerations

  • A good review should summarize the state of knowledge on a well-defined topic in the psychology of men and masculinity in concise and clear ways. This means that the review is written with exceptional clarity, cohesiveness, conciseness, and comprehensiveness.
  • A good review should describe in detail the systematic process or method that was used in doing the literature review. There are articulated ways to do "narrative reviews" just as there are ways of doing experiments or meta-analyses (Baumeister & Leary, 1997; Bem, 1995).

Essential elements for a review

  • Focus on an important, relevant, and operationally defined topic in the psychology of men and masculinity, and make a strong case for why a literature review of this topic is important.
  • Include a critical and inclusive review of previous theory related to the relevant topic. "Critical" means that the literature review reveals problems, contradictions, controversies, strengths, next steps, and potentials in the theories. "Inclusive" means that there is an active evaluation of all of the theory relevant to the topic.
  • Include a critical and inclusive review of previous empirical research related to the relevant topic.
  • Critically analyze the distinction between authors' interpretation of their data and the actual empirical evidence presented. A good review critically analyses how accurately previous authors have reported their findings and whether they have refrained from asserting conclusions not supported by data.
  • Discuss the methodological diversity of studies reported in the literature review and the implications of this diversity for new knowledge or future research.
  • Raise provocative and innovative questions on the topic not discussed before in the literature.
  • Write the review so that theoretical knowledge and empirical research is significantly advanced in the psychology of men and masculinity, and that there is an overall contribution to the field's theory, research, and clinical practice.
  • Include many "take home messages" (Sternberg, 1991) that generate new theories and empirical research.

Sections that might be included in a review

  • Provide a historical account or background of the development of the theory or research program reviewed.
  • Include persuasive arguments and articulated points of view on the topic from both theoretical and empirical perspectives.
  • Propose novel conceptualizations or theories based on reviews of previous theories and empirical research.
  • Propose new research paradigms or testable hypotheses that advance future research.
  • Propose new therapeutic paradigms or testable hypotheses that advance clinical practice/psychoeducational programming with men.
  • Address the frequent gap between reporting theory/research and interpreting the meaning of the theory and research.

It is not expected that reviews will be able to meet all of the above-listed criteria, but authors should meet many of them.

  • Bem, D. J. (1995). Writing a review article for Psychological Bulletin. Psychological Bulletin, 118 , 172–177.
  • Baumeister, R. F., & Leary, M. R. (1997). Writing narrative literature reviews. Review of General Psychology, 1 , 311–320.
  • Sternberg, R. J. (1991). Editorial. Psychological Bulletin, 109, 3–4.

More about this journal

  • Psychology of Men & Masculinities
  • Pricing and subscription info
  • Read sample articles
  • General call for papers
  • Call for papers: Advancements in research methods in the psychology of men and masculinities

Contact Journals

  • Open access
  • Published: 02 September 2024

The right care in the right place: a scoping review of digital health education and training for rural healthcare workers

  • Leanna Woods 1 , 2 ,
  • Priya Martin 3 ,
  • Johnson Khor 1 , 4 ,
  • Lauren Guthrie 1 &
  • Clair Sullivan 1 , 2 , 5  

BMC Health Services Research volume  24 , Article number:  1011 ( 2024 ) Cite this article

Metrics details

Digital health offers unprecedented opportunities to enhance health service delivery across vast geographic regions. However, these benefits can only be realized with effective capabilities and clinical leadership of the rural healthcare workforce. Little is known about how rural healthcare workers acquire skills in digital health, how digital health education or training programs are evaluated and the barriers and enablers for high quality digital health education and training.

To conduct a scoping review to identify and synthesize existing evidence on digital health education and training of the rural healthcare workforce.

Inclusion criteria

Sources that reported digital health and education or training in the healthcare workforce in any healthcare setting outside metropolitan areas.

We searched for published and unpublished studies written in English in the last decade to August 2023. The databases searched were PubMed, Embase, Scopus, CINAHL and Education Resources Information Centre. We also searched the grey literature (Google, Google Scholar), conducted citation searching and stakeholder engagement. The JBI Scoping Review methodology and PRISMA guidelines for scoping reviews were used.

Five articles met the eligibility criteria. Two case studies, one feasibility study, one micro-credential and one fellowship were described. The mode of delivery was commonly modular online learning. Only one article described an evaluation, and findings showed the train-the-trainer model was technically and pedagogically feasible and well received. A limited number of barriers and enablers for high quality education or training of the rural healthcare workforce were reported across macro (legal, regulatory, economic), meso (local health service and community) and micro (day-to-day practice) levels.

Conclusions

Upskilling rural healthcare workers in digital health appears rare. Current best practice points to flexible, blended training programs that are suitably embedded with interdisciplinary and collaborative rural healthcare improvement initiatives. Future work to advance the field could define rural health informatician career pathways, address concurrent rural workforce issues, and conduct training implementation evaluations.

Review registration number

Open Science Framework: https://doi.org/10.17605/OSF.IO/N2RMX .

Peer Review reports

Introduction

Globally, healthcare workers (HCWs) face multiple pressures simultaneously: increasing demand for care, co-morbidities and condition complexity, budget pressures, and rapid digital disruption [ 1 ]. The digital disruption in healthcare promises an unprecedented circumstance to improve outcomes and strengthen health systems [ 2 ]. However, this opportunity depends on a capable healthcare workforce with adequate skills and knowledge in data and emerging technologies [ 3 ]. HCW capability in digital health and clinical informatics is increasingly acknowledged as an essential component to the delivery of high-quality patient care [ 4 ]. Universities do not yet routinely teach these curricula in clinical degrees, and the capability gap in the current workforce is often filled by brief, reactive, and on-the-job training [ 5 ]. Sustainability of healthcare includes developing a skilled healthcare workforce educated and competent in digital health [ 6 ].

The rural healthcare workforce is faced with the location-based issues of resource constraints, workforce shortages, high staff turnover rates, stress, burnout, and an ageing workforce [ 7 ]. The World Health Organization has acknowledged in a recent report (2021) the complex challenge of shortage of healthcare workers globally in rural areas [ 7 ]. This report has acknowledged that the workforce density is lower than national averages in most of these areas. In places where there isn’t a national shortage, maldistribution of the workforce has been noted [ 7 ]. Digitally enabled models of care are well placed to enhance health service delivery across vast and distributed geographic regions. However, rural health service organizations require uplift to align with their metropolitan counterparts in workforce digital readiness [ 8 ]. Building digital health capability in rural settings is critical because higher digital health capability is associated with better outcomes, including the ability to maintain an accurate patient health record, track patient experience data, track the patient journey, and mitigate clinical risks [ 9 ]. Rurality is contributing to widening digital health inequities [ 10 ] with significant efforts required to adequately manage the rural digital divide [ 11 , 12 ]. Building digital capabilities of healthcare providers in rural and remote settings through education, training and support is needed [ 13 ].

Existing evidence on the education and training the rural healthcare workforce is limited. Firstly, while health science faculties are progressively integrating digital health into the undergraduate curricula for the future workforce [ 14 , 15 , 16 ], it is unclear how the education of current HCW is approached [ 14 ]. Despite global exemplars such as fellowship training for physicians [ 17 ], certification for nurses [ 18 ], and advanced education for clinical and non-clinical professionals [ 19 ], limited evidence of successful workforce programs to build digital health skills exist [ 4 ]. None focus on the rural healthcare setting.

Secondly, in literature reporting digital health in rural settings, there is a notable scarcity on workforce training programs. Existing studies focus on efficacy of delivered healthcare [ 20 , 21 ], workforce perceptions of digital health tool implementation [ 22 , 23 ] or are limited to training of specific interventions (e.g., clinical telehealth [ 24 ]). This review sought to explore the literature where these two gaps coexist, the intersection of digital health education and training and the rural healthcare workforce, and synthesize the available evidence on digital health education and training for the rural healthcare workforce.

Review question

The research questions for this review were:

What are the existing practices and approaches to digital health education and training for rural HCWs?

How has digital health education and training been evaluated following implementation?

What are the barriers and enablers for high quality digital health education and training in the rural healthcare workforce?

Participants

The review considered studies and reports on any members of the workforce in healthcare settings outside of metropolitan areas. The healthcare workforce refers to ‘all individuals who deliver or assist in the delivery of health services or support the operation of health care facilities’ [ 3 ]. All clinical (e.g., medical doctors, nurses, allied health professionals, pharmacists, Indigenous HCWs, pre-registration/qualification students undertaking placements in health care facilities) and non-clinical workers (e.g., administration, executive and management, clinical support, and volunteers) were considered regardless of professional body or government registration status. Patients, healthcare consumers, and the public were excluded.

The core concepts of digital health and training were combined in this review. Digital health and clinical informatics are often used interchangeably, and both were considered in this review. While digital health refers to the use of digital technologies for health [ 25 ], clinical informatics refers to more specialized practice of analyzing, designing, implementing and evaluating information and communication systems [ 26 ]. Specific digital health systems (e.g., IT infrastructure, telehealth, electronic medical records) were included. Training relates to the education or training initiatives (e.g., programs, curriculum, course) that build an individuals’ digital health capability to confidently use technologies to respond to the needs of consumers now and into the future [ 1 ]. Both education and training activities were considered. Education often refers to theoretical learning (e.g., by an academic institution, qualification), and training often teaches practical skills (e.g., employer-provided professional development, ‘just-in-time’ training) [ 3 , 24 ]. This review did not consider HCW education delivered at a distance through technologies (e.g., telesupervision for clinical skills training).

This review considered studies and reports from rural healthcare settings defined as outside metropolitan cities, inclusive of regional, rural, remote, and very remote settings. When the term ‘rural’ is used in this review, it refers to all areas outside major metropolitan cities as described by authors of individual studies and reports. All healthcare facilities across primary, secondary, and tertiary care settings were included in any country.

Types of sources

All research studies, irrespective of the study design, were considered. Reviews, conference abstracts and non-research sources (e.g., policy documents, program or course curriculum) were considered. The grey literature was included to capture reactionary training developed by rural health services that were not published as peer-reviewed research studies.

This review was conducted in accordance with the Joanna Briggs Institute (JBI) methodology for scoping reviews [ 27 ] and reported as per the Preferred Reporting of Systematic Reviews and Meta-analyses for scoping reviews (PRISMA-ScR) [ 28 ] (Additional file 1 ). The review protocol was registered in Open Science Framework [ https://doi.org/10.17605/OSF.IO/N2RMX ].

A scoping review approach was chosen over a systematic review to address a general, formative review question on this topic that is emerging in the literature and where the literature is complex and heterogenous [ 29 ]. An initial preliminary search of the topic in the academic databases, Cochrane Library, Open Science Framework and Prospero registry resulted in a very small number of relevant articles. It was determined that a broader search strategy and inclusion of non-research sources was required, consistent with the scoping review methodology [ 29 ]. Scoping review format is also well suited to the vast, diverse healthcare education topic across different disciplines, interventions and outcomes realised [ 30 ]. Mapping and synthesis across sources in this scoping review aims to inform research agendas and identify implications for policy and practice [ 31 ].

Deviations from the protocol

There were no deviations to the protocol.

Search strategy

The three phase JBI search process was followed. An initial limited search of PubMed was performed to identify keywords on the topic, followed by an analysis of the text words and index terms contained in the title and abstract. A subsequent preliminary search in Prospero registry, Cochrane Library and Open Science Framework informed the development of a full search strategy in PubMed. The search strategy, including all identified keyworks and index terms, was adapted for each included database and information source after refining the strategy with an information specialist. The reference lists of all included sources of evidence were screened for additional studies.

The review included only studies and reports in English (due to translation resourcing limitations) in the last 10 years (due to the relative novelty of the digital transformation of healthcare). The search was conducted in August 2023. The databases searched included PubMed, Scopus, Cumulative Index for Nursing and Allied Health Literature (CINAHL), Embase, and Education Resources Information Center (ERIC). Scopus was chosen over Web of Science as it provides 20% more coverage and the relative recency of articles indexed (publish date after 1995 [ 32 ]) was not a concern for our research question. The search for unpublished studies and grey literature included Google and Google Scholar, using a modified search strategy as required. In addition, national and international stakeholders ( n  = 29) from Asia, the Pacific Islands, Australia, USA and the UK known to have subject matter expertise on the topic were contacted via direct email. Stakeholders were asked to share any relevant work underway or otherwise undiscoverable using our scoping review methods. The full search strategy for each information source is provided in Additional file 2 .

Study selection

Following the search, identified articles were collated and uploaded into Covidence review software (Veritas Health Innovation Ltd; Melbourne, Australia) and duplicates removed. Two reviewers (among LW, JK and LG) then independently screened the title and abstract of each citation and selected studies that met the inclusion criteria. The full text articles were retrieved and uploaded into Covidence. These studies and reports were assessed independently by two reviewers (listed previously) for full assessment against the inclusion criteria. Any disagreements that arose between the reviewers at each stage of the selection process were resolved through discussion or with an additional reviewer (among LG and PM). Three meetings occurred to discuss any voting conflicts that occurred during title and abstract screening and full-text screening. Articles that did not satisfy the criteria were excluded with reasons for exclusion recorded. Search results and study selection process is presented in accordance to the PRISMA-ScR flow diagram (Fig. 1 ) [ 28 ]. Quality appraisal of selected studies was not conducted, consistent with scoping reviews methods [ 33 ].

figure 1

Search results and source selection and inclusion process

Data extraction

Extracted data included the specific details about the participants, concept, context, study methods and key findings relevant to each review question. Data was extracted by one reviewer (JK) and checked by a second reviewer (LW). Data were extracted using the data extraction tool developed and piloted by the team (Additional file 3 ).

Data synthesis and presentation

The characteristics of the included studies were analyzed and organized in tabular format, accompanied by a narrative summary. Results of each research question was presented under separate headings. The data analysis for research question three (barriers and enablers of high-quality digital health education and training) was enhanced. We adopted the socio-institutional framework described by Smith et al [ 34 ] and used in education research [ 35 ] to classify macro, meso, micro level enablers and barriers to help improve the generalizability of the synthesized insights and identify stakeholders that are able to influence change. Gaps and limitations of the current literature were discovered from the evidence with recommendations for policy, practice and future research provided.

Study inclusion

Database searching yielded 1005 articles and stakeholder engagement yielded two articles. After removing duplicates, 660 articles were screened for title and abstract, after which 29 articles underwent full text review. Of the 29 articles, 24 articles were excluded: the setting was metropolitan or otherwise inadequately described as non-metropolitan ( n  = 6); the intervention was not a training or education initiative for digital health or clinical informatics ( n  = 16), or the population was not rural healthcare workers ( n  = 2). In total, following full-text screening, five articles were included in the final review (Fig.  1 ).

Characteristics of included studies

Of the five included articles, three were academic publications including two case studies [ 36 , 37 ] and one feasibility study [ 38 ] (Table 1 ). The two articles identified through stakeholder engagement presented course summaries [ 39 , 40 ] where one described a micro-credential [ 40 ] and the other described a fellowship [ 39 ]. Most articles ( n  = 3) were published recently between 2021 and 2023 [ 38 , 39 , 40 ]. Healthcare workforce settings were distributed across the continents of the United States of America [ 36 ], Asia [ 37 ], Africa [ 38 ] and Australia [ 39 , 40 ], with no articles reporting a setting in the European continent. Further study characteristics are available in Table 1 .

Review findings

What are the existing approaches to digital health education and training for rural hcws.

Training and education programs were needed due to identified gaps in knowledge, skills and expertise to support healthcare delivery in rural contexts with digital health [ 36 , 37 , 38 ], [ 40 ]. One article reported the target learners as village doctors, who may have “limited training and inadequate medical knowledge, yet they are generally the mainstay of health services” [ 37 ]. The mode of teaching in the included studies were four modular online learning courses [ 36 , 37 , 38 ], [ 40 ] and one fellowship [ 39 ]. Of the four modular online learning courses, one was supplemented by a facilitator-led train-the-trainer model [ 38 ], informed by an academic framework [ 41 ], with cohort-based discussion via a social media platform. The second was a certification in the form of a self-paced micro-credential completed individually [ 40 ]. Of the four modular online learning courses, the number of modules ranged from three to eight and covered a variety of digital health topics including innovation, commercialization, bioinformatics, technology use, data and information, professionalism, implementation and evaluation. One had a particular focus on information and communication technology tool use [ 37 ] while another focused on remote consulting [ 38 ]. The mode of delivery of the fellowship was not reported in the article.

Four [ 36 , 37 , 39 , 40 ] of the five included articles did not report an evaluation. One article in rural Tanzania described the evaluation of the train-the-trainer digital health training program using a mixed-method design [ 38 ]: (1) questionnaire informed by Kirkpatrick’s model of evaluation to capture knowledge gained and perceived behavior change on a Likert scale, (2) qualitative interviews to explore training experiences and views of remote consulting, and (3) document analysis from texts, emails and training reports [ 38 ]. Of the tier 1 trainees (senior medical figure trainers who were trained to educate their peers) that completed the questionnaire ( n  = 10, 83%), nine (90%) recommended the training program and reported receiving relevant skills and applying learning to daily work, demonstrating satisfaction, learning and perceived behavior change [ 38 ]. Overall, the feasibility study confirmed that remotely delivered training supported by cascade training was technically and pedagogically feasible and well received in rural Tanzania [ 38 ].

What are the barriers and enablers for high quality digital health education and training of the rural healthcare workforce?

Reported enablers and barriers are presented using the macro, meso, micro framework [ 34 ] (Table 2 ).

This scoping review reflects the scarcity of reported digital health education and training programs in existence for rural HCWs globally. This review responds to the World Health Organization (WHO) recommendation to design and enable access to continuing education and professional development programs that meet the needs of rural HCWs [ 7 ], and the Sustainable Development Goal for inclusive and equitable quality education [ 42 ].

Concurrent challenges of people (workforce), setting (rural) and content (digital health) are reported in included articles alongside enablers and barriers to education and training programs. Included studies reported a shortage of doctors and specialists [ 36 ], lack of technical knowledge [ 36 ] (people); higher cost of delivering rural healthcare, high burden of illness [ 40 ], medically underserved population due to rural hospital closures [ 36 ] (setting); and limited use of digital health tools due to coordination challenges among non-government organisations [ 37 ] (content). These additional macro, meso and micro level factors are described by authors firstly as influencing the need for digital health programs in rural settings, and secondly, as contributing to the challenges of implementing effective programs. The rural health workforce challenges in digital health education and training reflect the broader workforce development issues experienced globally [ 7 ]. While this review sought to identify workforce development programs, the WHO model indicates the need for attractiveness, recruitment and retention to enable workforce performance (i.e., appropriate and competent multidisciplinary teams providing care) and health system performance (i.e., improving universal health coverage) [ 7 ].

In low-resource settings such as rural areas, education and training may not be prioritized among other competing workload demands. As the value of digital health transformations are realized for strengthening healthcare systems [ 25 , 43 ], the value of digital health education or training programs may become realized. This value was evidenced in the implementation of the teleconsulting training intervention in rural Tanzania [ 38 ] in rapid response to supporting care delivery during the COVID-19 pandemic period. With evaluations of programs largely absent from an already small number of programs globally, it will be important for future research to focus on implementation evaluation studies. As Table 2 presents only limited enablers and barriers, more evidence is needed to build on the findings from this scoping review to inform strategies for policy and practice.

The interdisciplinarity of digital health presents challenges and opportunities for nurturing digital health expertise across the rural healthcare workforce. Included articles largely described the target learners of education and training programs as clinicians, practitioners and healthcare workforce. Walden et al. further indicated that users of online content may extend beyond rural health clinicians to healthcare administrators, researchers and providers relevant to address the regulatory factors of clinical validation and implementation [ 36 ]. Therefore, for their program of work, the University of Arkansas for Medical Sciences identified and fostered collaboration with an interprofessional team of clinicians, researchers, informaticists, a bioethicist, lawyers, technology investment experts, and educators [ 36 ]. No articles in the review described education or training health informaticians or similar digital health leadership role types, yet building defined career pathways for health informaticians is recommended [ 4 ]. Existing pedagogy shows that the learning principles of interprofessional practice is grounded in understanding one’s own practice as well as the practice of other health professionals and remains aligned to the educational needs of specific professions [ 44 ] (i.e., medicine, nursing, pharmacy). Defining new career pathways for interdisciplinary leaders in digital health within a specific clinical context, like the ‘rural health informatician’, will be important to identify or define the (hidden) specialized workforce.

Local, informal organizational initiatives for digital health learning were discovered alongside formal education or training programs in included studies. Programs were often reported in articles alongside concurrent digital health implementation or healthcare improvement programs, sometimes referred to as ‘outreach’ [ 36 ] activities. These informal initiatives included special interest groups, in-person conferences, networking events, working groups [ 36 ] and seminars [ 37 ]. Current evidence from this scoping review suggests that the efficacy and sustainability of education or training programs are reliant on integrated approaches, like the train-the-trainer [ 38 ] or academic organization approach [ 36 ], that foster translational research for rural healthcare improvement. As illustrated by Walden et al., success in digital health is likely to require a foundational environment where technologies can be discussed, developed and deployed [ 36 ]. Success in rural digital health skills acquisition likely requires a similar, longitudinal and collaborative approach beyond the confines of an online course completed individually. Previous research shows us that blended learning, which merges face-to-face with online learning, translates to better knowledge outcomes [ 44 ]. Blended learning can also overcome the barrier of rural HCWs travelling large distances to attend face-to-face training that comes at a great cost to themselves and the work unit. A key recommendation to improve the digital health training program described by Downie et al. was more face-to-face time with trainers, from the perspective of both trainee and facilitator [ 38 ]. This, however, can only be realized with targeted planning and budgeting of such offerings by involved rural healthcare organizations.

The opportunities to advance digital health education and training for rural HCWs are presented across the macro, meso and micro levels in the socio-institutional framework, with suggested relevant stakeholders suited to actioning the recommendations (Table  3 ). While the context for this is likely to vary across the globe, these recommendations and stakeholders are expected to provide a starting point to initiate a dialogue that can influence change. These recommendations are not meant to be prescriptive or rigid, but rather meant to flag actionable solutions that can be contextualized for any given setting.

Strengths and limitations

It is possible that there is a greater number of published educational and training programs than those reported in this review (i.e., publication bias). To mitigate this, we used a scoping review methodology and stakeholder engagement activity to identify unpublished or emerging programs that answer the review question but may not be discoverable in the academic databases. The review is limited to articles available in the English language. The small number of programs, heterogeneity of programs and limited evaluation of programs significantly limit generalizability of findings. Due to data availability, the barriers and enablers findings summary contain an overrepresentation from a small number of studies limiting conclusions that can be drawn.

Digital health offers the best opportunity for innovative sustainable change to address critical issues in health and care in rural settings. Workforce education and training initiatives in rural healthcare settings are scarce, largely delivered via online training, and are rarely evaluated. Current best practice points to flexible, blended (online and face-to-face) training programs that are suitably embedded with interdisciplinary, collaborative rural healthcare improvement initiatives. More research will expand the evidence base to deliver high-quality digital health education to strengthen rural healthcare delivery. Future work to advance the field could define rural health informatician career pathways, address concurrent rural workforce issues, and conduct implementation evaluations.

Availability of data and materials

No datasets were generated or analysed during the current study.

Abbreviations

Cumulative Index for Nursing and Allied Health Literature

Education Resources Information Centre

Healthcare worker

Joanna Briggs Institute

Preferred Reporting of Systematic Reviews and Meta-analyses for scoping reviews

World Health Organization

Australian Digital Health Agency. The national digital health capability action plan. Australia: Australian Government; 2022. p. 36.

Google Scholar  

World Health Organization. Global strategy on digital health 2020–2025. Geneva: World Health Organization; 2021. p. 60.

Australian Digital Health Agency. National digital health workforce and education roadmap. Sydney; 2020.

Woods L, Janssen A, Robertson S, et al. The typing is on the wall: Australia’s healthcare future needs a digitally capable workforce. Aust Health Rev. September 2023;2023:25. https://doi.org/10.1071/AH23142 .

Article   Google Scholar  

Younge VL, Borycki EM, Kushniruk AW. On-the-job training of health professionals for electronic health record and electronic medical record use: A scoping review. Knowledge Management & E-Learning: An International Journal. 2015;7:436–69.

Thomas EE, Haydon HM, Mehrotra A, et al. Building on the momentum: sustaining telehealth beyond COVID-19. J Telemed Telecare. 2022;28:301–8.

Article   PubMed   Google Scholar  

World Health Organization. WHO guideline on health workforce development, attraction, recruitment and retention in rural and remote areas. 2021.

Woods L, Eden R, Pearce A, et al. Evaluating Digital Health Capability at Scale Using the Digital Health Indicator. Appl Clin Inform. 2022;13:991–1001. https://doi.org/10.1055/s-0042-1757554 .

Article   PubMed   PubMed Central   Google Scholar  

Woods L, Dendere R, Eden R, et al. Perceived Impact of Digital Health Maturity on Patient Experience, Population Health, Health Care Costs, and Provider Experience: Mixed Methods Case Study. J Med Internet Res. 2023;25: e45868. https://doi.org/10.2196/45868 .

Yao R, Zhang W, Evans R, et al. Inequities in health care services caused by the adoption of digital health technologies: scoping review. J Med Internet Res. 2022;24:e34144. https://doi.org/10.2196/34144 .

Clark CR, Akdas Y, Wilkins CH, et al. TechQuity is an imperative for health and technology business: Let’s work together to achieve it. J Am Med Inform Assoc. 2021;28:2013–6. https://doi.org/10.1093/jamia/ocab103 .

Esteban-Navarro M-Á, García-Madurga M-Á, Morte-Nadal T, et al. The rural digital divide in the face of the COVID-19 pandemic in Europe—recommendations from a scoping review. Informatics. 2020;7:54.  https://doi.org/10.3390/informatics7040054 .

Macklin S. Understanding the pathway to consumer centred healthcare information in rural and remote Queensland. Brisbane: The University of Queensland; 2022.

Aungst TD, Patel R. Integrating digital health into the curriculum—considerations on the current landscape and future developments. J Med Educ Curric Dev. 2020;7:2382120519901275.

Edirippulige S, Gong S, Hathurusinghe M, et al. Medical students’ perceptions and expectations regarding digital health education and training: a qualitative study. J Telemed Telecare. 2022;28:258–65.

Veikkolainen P, Tuovinen T, Jarva E, et al. eHealth competence building for future doctors and nurses–Attitudes and capabilities. Int J Med Informatics. 2023;169:104912.

American Medical Informatics Association. Informatics academic programs. 2022 https://amia.org/careers-certifications/informatics-academic-programs . Accessed 21 June 2022.

American Nurses Credentialing Center. Informatics nursing board certification examination. Maryland, USA2018, p. https://www.nursingworld.org/~490a495b/globalassets/certification/certification-specialty-pages/resources/test-content-outlines/427-tco-rds-2016-effective-date-march-2023-2018_100317.pdf .

Topol E. The topol review: preparing the healthcare workforce to deliver the digital future. United Kingdom: Health Education England NHS; 2019. p. 1–48.

McCleery J, Laverty J, Quinn TJ. Diagnostic test accuracy of telehealth assessment for dementia and mild cognitive impairment. Cochrane Database Syst Rev. 2021;7(7):CD013786.

PubMed   Google Scholar  

Janjua S, Carter D, Threapleton CJ, et al. Telehealth interventions: remote monitoring and consultations for people with chronic obstructive pulmonary disease (COPD). Cochrane database of systematic reviews; 2021.

Xyrichis A, Iliopoulou K, Mackintosh NJ, et al. Healthcare stakeholders’ perceptions and experiences of factors affecting the implementation of critical care telemedicine (CCT): qualitative evidence synthesis. Cochrane Database Syst Rev. 2021;2(2):CD012876.

Odendaal WA, Watkins JA, Leon N, et al. Health workers’ perceptions and experiences of using mHealth technologies to deliver primary healthcare services: a qualitative evidence synthesis. Cochrane Database Syst Rev. 2020;3(3):CD011942.

Edirippulige S, Armfield N. Education and training to support the use of clinical telehealth: A review of the literature. J Telemed Telecare. 2017;23:273–82. https://doi.org/10.1177/1357633x16632968 .

Article   CAS   PubMed   Google Scholar  

World Health Organization. Recommendations on digital interventions for health system strengthening. World Health Organization. 2019. 2020–2010.

Gardner RM, Overhage JM, Steen EB, et al. Core content for the subspecialty of clinical informatics. J Am Med Inform Assoc. 2009;16:153–7.

JBI. JBI manual for evidence synthesis. 2020.

Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169:467–73.

Peters MDJ, Marnie C, Tricco AC, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020;18(10):2119–26. https://doi.org/10.11124/jbies-20-00167 .

Shead DA, Olivier B. Traditional or digital health care education? JBI Evidence Synthesis. 2020;18:861–2.

Tricco AC, Lillie E, Zarin W, et al. A scoping review on the conduct and reporting of scoping reviews. BMC Med Res Methodol 2016; 16: 15. https://doi.org/10.1186/s12874-016-0116-4 .

Falagas ME, Pitsouni EI, Malietzis GA, et al. Comparison of PubMed, Scopus, web of science, and Google scholar: strengths and weaknesses. FASEB J. 2008;22:338–42.

Peters MD, Godfrey CM, Khalil H, et al. Guidance for conducting systematic scoping reviews. JBI Evid Implement. 2015;13:141–6.

Smith T, McNeil K, Mitchell R, et al. A study of macro-, meso-and micro-barriers and enablers affecting extended scopes of practice: the case of rural nurse practitioners in Australia. BMC Nurs. 2019;18:1–12.

Desai D, Mayne C, Bates H, et al. A rapid review of the barriers and enablers of medical student participation in research in health settings. 2022. https://doi.org/10.17605/OSF.IO/5XZWN .

Walden A, Kemp AS, Larson-Prior LJ, et al. Establishing a digital health platform in an academic medical center supporting rural communities. Journal of Clinical and Translational Science. 2020;4:384–8.

Mridha M and Islam M. To improve patient care & safety of rural patients empowering the village doctors. In: EMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017 2018, pp.502-505. Springer.

Downie A, Mashanya T, Chipwaza B, et al. Remote Consulting in Primary Health Care in Low-and Middle-Income Countries: Feasibility Study of an Online Training Program to Support Care Delivery During the COVID-19 Pandemic. JMIR Formative Research. 2022;6:e32964.

Australian College of Rural & Remote Medicine. Rural Generalist Curriculum - Fellowship. Brisbane, Australia: ACRRM; 2021. p. 174.

Northern Australia Regional Digital Health Collaborative and James Cook University (NARDHC and JCU). Digital Health for the Rural and Remote Health Workforce Micro-credential (Brochure). Townsville: JCU; 2023.

Mormina M, Pinder S. A conceptual framework for training of trainers (ToT) interventions in global health. Glob Health. 2018;14:1–11.

United Nations Department of Economic and Social Affairs Sustainable Development. Sustainable development goals. 2023. https://sdgs.un.org/goals . Accessed 20 Feb 2024

Woods L, Eden R, Canfell OJ, et al. Show me the money: how do we justify spending health care dollars on digital health? Med J Aust 2022 2022/12/12. https://doi.org/10.5694/mja2.51799 .

Dizon JMR. Educating future health professionals to keep pace with changing times. LWW, 2021, p. 2904–2905.

Download references

Acknowledgements

Not applicable.

No external funding.

Author information

Authors and affiliations.

Queensland Digital Health Centre, The University of Queensland, Brisbane, Australia

Leanna Woods, Johnson Khor, Lauren Guthrie & Clair Sullivan

Centre for Health Services Research, The University of Queensland, Brisbane, Australia

Leanna Woods & Clair Sullivan

Rural Clinical School, Faculty of Medicine, The University of Queensland, Toowoomba, Australia

Priya Martin

Ochsner Clinical School, Faculty of Medicine, The University of Queensland, Brisbane, Australia

Johnson Khor

Metro North Hospital and Health Service, Herston, Australia

Clair Sullivan

You can also search for this author in PubMed   Google Scholar

Contributions

LW, PM and CS designed the study. LW, PM, JK and LG acquired data; analyzed and interpreted results and drafted the manuscript and all subsequent drafts. CS read and contributed to manuscript drafts. All authors read and approved the final manuscript draft.

Corresponding author

Correspondence to Leanna Woods .

Ethics declarations

Ethics approval and consent to participate, consent for publication, competing interests.

The authors declare no competing interests.

Additional information

Publisher’s note.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

12913_2024_11313_moesm1_esm.docx.

Additional File 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Additional File 2. Full search strategy for each information source.

Additional file 3. data extraction instrument template., rights and permissions.

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ .

Reprints and permissions

About this article

Cite this article.

Woods, L., Martin, P., Khor, J. et al. The right care in the right place: a scoping review of digital health education and training for rural healthcare workers. BMC Health Serv Res 24 , 1011 (2024). https://doi.org/10.1186/s12913-024-11313-4

Download citation

Received : 13 March 2024

Accepted : 15 July 2024

Published : 02 September 2024

DOI : https://doi.org/10.1186/s12913-024-11313-4

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

  • Clinical informatics
  • Health informaticians
  • Digital health
  • Health personnel
  • Rural population
  • Rural health
  • Low-resource settings

BMC Health Services Research

ISSN: 1472-6963

guidelines in literature review

Log in using your username and password

  • Search More Search for this keyword Advanced search
  • Latest content
  • For authors
  • Browse by collection
  • BMJ Journals

You are here

  • Volume 14, Issue 8
  • Prevention and care of adult enterostomy with high output: a scoping review protocol
  • Article Text
  • Article info
  • Citation Tools
  • Rapid Responses
  • Article metrics

Download PDF

  • http://orcid.org/0009-0008-0113-2984 Ying Che 1 ,
  • Tianming Wang 2 ,
  • Caifeng Gao 3 ,
  • Fei Sun 1 ,
  • Shangke Li 4 ,
  • Zhanlin Luo 5
  • 1 Research Ward , Gansu Provincial Hospital , Lanzhou , China
  • 2 Gansu University Of Chinese Medicine , Lanzhou , China
  • 3 Department of radiotherapy , Gansu Provincial People's Hospital , Lanzhou , China
  • 4 Gansu Provincial Hospital , Lanzhou , Gansu , China
  • 5 Department of radiotherapy , Gansu Provincial Hospital , Lanzhou , Gansu , China
  • Correspondence to Professor Zhanlin Luo; lzl120606{at}126.com

Introduction The purpose of this protocol is to investigate the risk factors, critical evaluation contents and preventive measures of high-output enterostomy.

Methods and analysis This scoping review will follow the Joanna Briggs Institute guidelines for scoping reviews. PubMed, EMBASE, CINAHL, the Chinese Biological Literature Database and the Cochrane Library will be searched for relevant literature published from January 2015 to January 2024. The Grading of Recommendations, Assessment, Development and Evaluation and the Risk Of Bias In Non-randomised Studies of Interventions will be used to assess the reliability of the evidence.

Ethics and dissemination As this scoping review involves database searches for literature analysis, informed consent and ethical approval from patients will not be required. The findings will provide essential decision-making information for researchers, clinicians and ostomy nursing staff. The results of the review will be presented at a scientific conference and published in a peer-reviewed journal.

  • Nursing Care
  • Protocols & guidelines
  • WOUND MANAGEMENT

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/ .

https://doi.org/10.1136/bmjopen-2023-078602

Statistics from Altmetric.com

Request permissions.

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

STRENGTHS AND LIMITATIONS OF THIS STUDY

This protocol will strictly adhere to the Joanna Briggs Institute methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews.

The literature search will include only English and Chinese literature from the past 10 years, potentially limiting the comprehensiveness of the search. However, researchers will broaden the search scope based on the included literature and supplement it by searching grey literature.

The Grading of Recommendations, Assessment, Development and Evaluation and Risk Of Bias In Non-randomised Studies of Interventions tools will be used to grade the quality of the evidence obtained after quality evaluation, ensuring the scientific rigour of the research design and the appropriateness of evidence classification.

To reduce the risk of bias, researchers will triple-check the input data during the process of literature quality evaluation and evidence summarisation.

Introduction

In recent years, with the rapid development of living standards, people’s eating habits and lifestyles have undergone major changes, leading to a continuously increasing trend in the incidence and mortality of malignant tumours such as gastric cancer and colorectal cancer. 1 The treatment of colorectal cancer predominantly involves surgery, and the number of patients undergoing enterostomy is on the rise. 2 Enterostomy requires the removal of the cancerous end of the intestine, extraction of a section of the intestine through the abdominal incision, and its attachment to the abdominal wall skin to form a stoma. 3 As the anal sphincter loses its normal excretion function, patients must use a stoma bag to collect excreta postsurgery. In the USA, approximately 100 000 patients undergo enterostomy annually, with a current total of 1 million enterostomy patients. 4 Despite rapid advancements in surgical techniques, the incidence of high output in enterostomy patients ranges from 23.8% to 31.1% compared with other common surgical procedures. 5 6

Postoperative complications of enterostomy can be categorised into early and advanced complications based on the time of occurrence. Early complications refer to those occurring within the first 30 days postoperation. High output is a prevalent early complication of enterostomy. 7 Typically, the output from an enterostomy ranges from 500 to 2000 mL but varies based on the type of stoma, enteral feedings and other factors. A review of extensive literature reveals ambiguity in the normal output for different types of enterostomies; however, it is widely accepted that an output exceeding 1500 mL per day from a small bowel enterostomy is considered high. 8 Fluid losses postsurgery usually resolve within a few weeks due to adaptive changes in the remaining small intestine. In some patients, high-output enterostomy results from inadequate adaptation or other causes of diarrhoea, such as indigestible food intake, leading to significant water and electrolyte loss, and potentially causing complications like kidney function injury. 9 High output is also the most common reason affecting readmissions of enterostomy patients. 10 Moreover, the quality of life for patients with enterostomy is poor in the early stages due to insufficient knowledge about stoma care and influences such as psychological emotions. 11 Overall, the risk of postoperative complications after enterostomy is lifelong, with high output being a frequent complication. Specialist stoma nurses should proactively focus on complication prevention and provide guidance.

Currently, the literature on preventing high output has not received adequate attention, and there is no consensus to guide precise and effective nursing interventions for preventing high output in enterostomy patients. Monitoring of enterostomy discharge is also often overlooked by patients and clinical ostomy nurses. Additionally, the variable quality of relevant literature can waste medical resources and lead to misleading clinical practices.

Given these issues, it is urgent to determine a comprehensive and effective prevention programme for high output. The scoping review, based on evidence-based concepts, aims to help researchers understand the scope and characteristics of existing evidence and identify gaps in the evidence. Thus, the methods employed in this study were designed to retrieve, summarise and analyse relevant evidence on high output in enterostomy patients, providing an evidence-based foundation for clinical nurses, patients and caregivers to implement enterostomy care and reduce the incidence of high output.

Review questions

What are the risk factors for high output enterostomy?

What are the critical evaluation contents of high-output enterostomy?

What are the main interventions that can effectively prevent high-output enterostomy?

This scoping review will follow the Joanna Briggs Institute methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews. 12 13 The study is scheduled to commence in April 2024 and conclude in August 2024. This protocol has been registered with the OSF ( https://doi.org/10.17605/OSF.IO/UF9B7 ).

Patient and public involvement

No patients and the public were involved.

Inclusion criteria

The subjects are patients who have undergone enterostomy (including colostomy, ileostomy, cecostomy, jejunostomy, etc) after a pathological diagnosis of malignant diseases such as stomach and colorectal cancer. The patients are 18 years or older. Enterostomy in children is excluded due to factors such as the thin cuticle of the skin, crying and different ostomy bag management needs. Additionally, children undergoing enterostomy often have various congenital diseases, such as anal absence and Hirschsprung’s disease, which differ significantly from adult enterostomy. Finally, the rehabilitation outcomes for minor enterostomy patients depend on the effectiveness of care provided by primary caregivers, which is a further reason for their exclusion from this study.

Exclusion criteria

The subjects are patients undergoing urostomy.

Conference abstracts, animal experiments or preclinical trial studies and studies without specifying the type of stoma.

Studies where the full text is not available.

Studies with incomplete data and unsuccessful attempts to contact the original authors.

The objective of this scoping review is to search, select and extract evidence for the prevention and care of high-output enterostomy patients. According to the requirements of different databases, appropriate search strategies will be developed, and a literature search will be conducted. The data that meet the inclusion criteria will be analysed. The main contents include (1) risk factors for high-output enterostomy patients; (2) critical evaluation contents of high-output enterostomy, such as symptoms and signs of high output in enterostomy patients and (3) interventions that can effectively prevent and improve high output.

Types of studies

The literature types included in this study encompass randomised controlled trials (RCTs), non-RCTs, cohort studies, case–control studies, cross-sectional studies, observational studies and descriptive studies. Qualitative studies and systematic reviews will also be considered and published in either English or Chinese, from January 2015 to January 2024. This review will include studies on high-output enterostomy conducted in any country or region.

Search strategy

The search for studies related to the prevention of high output in adult enterostomy patients will be conducted through PubMed, EMBASE, CINAHL, the Chinese Biological Literature Database and the Cochrane Library. We will employ the following MeSH terms and/or free-text terms: surgical stomas, enterostomy, ostomy, stoma, ileostomy, jejunostomy, colostomy, high output, fast transit, diarrhoea, risk factor, association, relative risk, factor, influence, correlation, management, treatment, therapy and care.

Additionally, grey literature sources, such as Google Scholar, will be searched to ensure comprehensive evidence incorporation. Grey literature includes materials published by government departments, academic institutions and commercial industries that are non-profit, helping to avoid publication bias. The flow chart of the study diagram is presented in figure 1 , and the detailed search strategy is outlined in online supplemental appendix S1 .

Supplemental material

  • Download figure
  • Open in new tab
  • Download powerpoint

The flow diagram of the study selection.

Literature screening

The literature screening will be conducted independently and cross-checked by two reviewers (Che Y and Luo ZL). In the event of disagreements, decisions will be discussed in a group meeting. The reviewers will independently use EndNote V.X9 software to remove duplicate entries and initially exclude irrelevant literature by reviewing titles and abstracts. For literature retained after this initial screening, further exclusions will be made by reading the full text to ensure alignment with the study theme, such as research object consistency and intervention plans.

Data extraction and presentation

Two reviewers (Che Y and Luo ZL) will independently extract data, including (1) research design, title, author, year of publication, types of literature, country or region of publication, and publication languages; (2) baseline characteristics of participants: sample size, gender, age, type of enterostomy, characteristics of the research population; (3) intervention details: intervention measures, observation period and (4) primary outcomes: the incidence of high-output enterostomy, enterostomy output volume, the change of output and the factors contributing to high-output enterostomy. There will be no secondary outcome measures.

Strategy for data synthesis

The study design, baseline characteristics of participants and intervention details of this scoping review will be quantitatively summarised in table format. For the incidence of high output in enterostomy, enterostomy output volume, changes in output and factors contributing to high-output enterostomy will be presented in the form of frequency, percentage and descriptive summary.

Quality of evidence

The quality of evidence for outcome indicators will be assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. 14 The GRADE evaluation criteria include five grading factors: research limitations, inconsistency, indirectness, imprecision and publication bias. The evidence quality will be rated across four levels: high, moderate, low and very low. The default evidence quality for RCTs is high, with one grade reduction to moderate, two reductions to low and three to very low.

For cohort studies, case–control studies and other non-RCTs included in this review, the risk of bias will be assessed using the Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I) tool. 15 ROBINS-I tool divides bias into 7 domains with a total of 33 items: (1) confounding bias; (2) subject selection bias; (3) intervention classification bias; (4) intentional intervention deviation bias; (5) loss of data bias; (6) outcome measurement bias and (7) selective reporting bias. According to the evaluation results of each item, the researcher will make yes (Y), probably yes (PY), no (N), probably no (PN) and no information (NI) answers. ROBINS-I divided the evaluation results into five levels: low risk of bias, moderate risk of bias, high risk of bias, critical risk of bias and no information.

Ethics statements

Patient consent for publication.

Not applicable.

Ethics approval

Since the literature related to the research topic will be obtained by searching the database for analysis in this scoping review, informed consent and ethical approval of patients will not be required. The results of this study will provide decision-making information for researchers, clinicians, and other ostomy nursing staff. The results of the review will be presented at a scientific conference and published in a peer-reviewed journal.

  • Li H , et al
  • Fu L , et al
  • Takahashi H ,
  • Haraguchi N , et al
  • Sakamoto Y , et al
  • Babakhanlou R ,
  • Hita AG , et al
  • Lederhuber H ,
  • Massey LH ,
  • Kantola VE , et al
  • Nightingale JMD
  • Shinkwin M ,
  • van der Storm SL , et al
  • Dulskas A ,
  • Petrauskas V ,
  • Kuliavas J , et al
  • Peters MDJ ,
  • Godfrey C ,
  • McInerney P , et al
  • Tricco AC ,
  • Zarin W , et al
  • Mendoza Pinto C ,
  • García Carrasco M

Contributors All authors in the manuscript contributed substantially to the idea or design of the study and agreed to the manuscript’s publication; YC and SL: literature search and data extraction; YC and FS: quality assessment of systematic reviews and writing of papers; ZL: search literature and quality assessment of systematic reviews; TW and CG: search literature and quality assessment of systematic reviews; YC: design study and data extraction.

Funding This scoping review protocol was supported by Natural Science Foundation of Gansu Province, China (22JR5RA697).

Competing interests None declared.

Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

Provenance and peer review Not commissioned; externally peer reviewed.

Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

Read the full text or download the PDF:

  • Open access
  • Published: 31 August 2024

Incidence of post-extubation dysphagia among critical care patients undergoing orotracheal intubation: a systematic review and meta-analysis

  • Weixia Yu 1   na1 ,
  • Limi Dan 1   na1 ,
  • Jianzheng Cai 1 ,
  • Yuyu Wang 1 ,
  • Qingling Wang 1 ,
  • Yingying Zhang 1 &
  • Xin Wang 1  

European Journal of Medical Research volume  29 , Article number:  444 ( 2024 ) Cite this article

Metrics details

Post-extubation dysphagia (PED) emerges as a frequent complication following endotracheal intubation within the intensive care unit (ICU). PED has been strongly linked to adverse outcomes, including aspiration, pneumonia, malnutrition, heightened mortality rates, and prolonged hospitalization, resulting in escalated healthcare expenditures. Nevertheless, the reported incidence of PED varies substantially across the existing body of literature. Therefore, the principal objective of this review was to provide a comprehensive estimate of PED incidence in ICU patients undergoing orotracheal intubation.

We searched Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science, Technology Journal Database (VIP), and SinoMed databases from inception to August 2023. Two reviewers independently screened studies and extracted data. Subsequently, a random-effects model was employed for meta-statistical analysis utilizing the “meta prop” command within Stata SE version 15.0 to ascertain the incidence of PED. In addition, we performed subgroup analyses and meta-regression to elucidate potential sources of heterogeneity among the included studies.

Of 4144 studies, 30 studies were included in this review. The overall pooled incidence of PED was 36% (95% confidence interval [CI] 29–44%). Subgroup analyses unveiled that the pooled incidence of PED, stratified by assessment time (≤ 3 h, 4–6 h, ≤ 24 h, and ≤ 48 h), was as follows: 31.0% (95% CI 8.0–59.0%), 28% (95% CI 22.0–35.0%), 41% (95% CI 33.0–49.0%), and 49.0% (95% CI 34.0–63.0%), respectively. When sample size was 100 <  N  ≤ 300, the PED incidence was more close to the overall PED incidence. Meta-regression analysis highlighted that sample size, assessment time and mean intubation time constituted the source of heterogeneity among the included studies.

The incidence of PED was high among ICU patients who underwent orotracheal intubation. ICU professionals should raise awareness about PED. In the meantime, it is important to develop guidelines or consensus on the most appropriate PED assessment time and assessment tools to accurately assess the incidence of PED.

Graphical abstract

guidelines in literature review

Introduction

Mechanical ventilation is the most common technological support, being required by 20–40% of adult in ICU [ 1 ]. Orotracheal intubation is the primary way of mechanical ventilation in ICU, which can increase the risk of post-extubation dysphagia (PED) [ 2 , 3 ]. PED is any form of swallowing dysfunction that arises subsequent to extubation following endotracheal intubation, affecting the passage of food from the entrance to the stomach. The occurrence rate of PED within the ICU setting demonstrates considerable variation among different countries [ 4 ]. The incidence varied among countries, including 13.3–61.8% in the United States [ 5 , 6 ], 25.3–43.5% in France, and 23.2–56% in China [ 7 , 8 ], and the incidence ranging from 7 to 80% [ 9 , 10 ]. Significantly, PED standing out as a prominent complication encountered in this particular context. For instance, See et al. have elucidated that patients afflicted with PED face an 11-fold higher risk of aspiration compared to those without PED [ 11 ]. McIntyre et al. have underscored that patients afflicted with PED endure double the length of stay in the ICU and the overall hospitalization period when compared to patients without PED [ 10 ]. Furthermore, it is essential to note that PED emerged as an independent predictor of 28-day and 90-day mortality [ 12 ]. This high incidence of PED places an immense burden not only on patients but also on the broader healthcare system. Therefore, a systematic review and meta-analysis is necessary to explore the incidence of PED in ICU patients. A systematic review and meta-analysis conducted by McIntyre et al. reported that the incidence of PED was 41%, but the main outcomes of their partly included studies was aspiration [ 12 ]. Although aspiration and PED are closely related, not all aspiration is caused by dysphagia. The incidence of aspiration was 8.80%-88.00% in ICU [ 13 , 14 ], so the incidence of PED in that study may be overestimated. Moreover, there has been increasing literature on PED of ICU patients, and a new systematic review and meta-analysis is needed to obtain a more precise estimate of its incidence.

The incidence of PED may indeed vary depending on various covariates, including assessment time, mean intubation time, age and other relevant factors. First, there is no standard time for swallowing function assessment, which spans a range of intervals, including 3 h [ 6 , 9 , 12 ], 4–6 h [ 15 , 16 ], 24 h [ 17 , 18 , 19 ], 48 h [ 20 ], 7 days [ 21 ], and discharge [ 22 ], and the incidence of PED was 80% [ 9 ], 22.62% [ 15 ], 56.06% [ 18 ], and 35.91% [ 20 ], 22.06% [ 21 ], and 28.78% [ 22 ], respectively. Second, the PED is closely tied to the time of orotracheal intubation. Skoretz et al. have demonstrated that the overall incidence of PED in the ICU ranges from 3 to 4%. However, upon re-analysis of patients subjected to orotracheal intubation for more than 48 h, the PED incidence can surge as high as 51% [ 23 ]. Third, the choice of assessment tool to evaluate PED in ICU patients plays a pivotal role. These assessment tools may include Video-fluoroscopic Swallowing Study (VFSS), Fiberoptic Endoscopic Evaluation of Swallowing (FEES), Standardized Swallowing Assessment (SSA), Bedside Swallowing Evaluation (BSE), Gugging Swallowing Screen (GUSS), Post-Extubation Dysphagia Screening Tool (PEDS), Water Swallowing Test (WST) and other assessment tools. FEES and VFSS are considered the gold standards, with a detection rate of approximately 80% [ 9 ]. SSA and BSE exhibit detection rates of 22% and 62%, respectively [ 5 , 15 ]. Finally, age-related changes in laryngeal sensory and motor functions also influence PED risk [ 24 ]. Notably, there may not be a significant difference in the incidence of PED between elderly and young patients within the initial 48 h post-extubation. However, elderly patients exhibit a significantly slower rate of PED recovery compared to their younger counterparts over time (5.0 days vs 3.0 days; p  = 0.006) [ 5 ]. Therefore, it is necessary to explore the potential source of heterogeneity in the incidence of PED in ICU patients from such covariates.

The purpose of this study was to estimate the incidence of PED among ICU patients who underwent orotracheal intubation and investigate potential sources of heterogeneity through the application of subgroup analyses and meta-regression.

This systematic review and meta-analysis was conducted adhering to the guidelines outlined in the Joanna Briggs Institute (JBI) Reviewers’ Manual and followed the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement (PRISMA 2020) [ 25 ] (see Additional file 1: Table S1). In addition, it was registered with PROSPERO under the registration number CRD42022373300.

Eligibility criteria

The study’s eligibility criteria were established in accordance with the PICOS principle. Inclusion criteria as follows: population (P): adult patients (≥ 18 years old) admitted to the ICU who underwent orotracheal intubation. Exposure (E): undergoing orotracheal intubation. Outcome (O): PED. Study design (S): observational study (cohort, case–control, cross-sectional study). In studies where multiple articles were derived from the same sample, only the article providing the most detailed data was included. Patients at high risk of dysphagia (such as those with head and neck cancer, who have undergone head and neck surgery, patients receiving palliative care, esophageal dysfunction, stroke, esophageal cancer and Parkinson’s disease) were excluded. Studies were excluded if they exhibited incomplete original data or data that could not be extracted. Studied were also excluded if their sample sizes fell below 30 participants or the full text was inaccessible.

Data sources and search strategy

Our comprehensive search multiple databases, including Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, China Science and Technology Journal Database (VIP), and SinoMed, with the search period encompassing inception to August 18, 2023. Search language was Chinese and English. The limited number of studies retrieved initially, primarily attributed to the inclusion of the qualifier “ICU” in the initial search, prompted us to broaden the scope of our literature search. Consequently, we refined the search strategy by reducing the emphasis on “ICU” during the search process. After a series of preliminary searches, we finalized the search strategy, which combined subject headings and free-text terms while employing Boolean operators to enhance search precision. In addition, a manual hand-search of the reference lists of selected articles was carried out to identify any supplementary studies not originally identified through the electronic search. For a detailed presentation of our complete search strategies across all databases, please refer to Additional file 1: Table S2.

Quality evaluation

The evaluation of the risk of bias within the included studies was conducted by two trained investigators. Cross-sectional study was evaluated by the Agency for Healthcare Research and Quality (AHRQ) tool [ 26 ], which consisted of 11 items, resulting in a maximum score of 11. Scores falling within the ranges of 0–3, 4–7, and 8–11 corresponded to studies of poor, moderate, and high quality, respectively. Cohort study was evaluated by the Newcastle–Ottawa Scale (NOS) tool [ 27 ], which comprised three dimensions and eight items, allowing for a star rating ranging from 2 to 9 stars. In this case, 0–4, 5–6, and 7–9 stars were indicative of study of poor, moderate, and high quality, respectively. Any discrepancies or disagreements between the investigators were resolved through discussion, when necessary, consultation with a third expert specializing in evidence-based practice methodology.

Study selection and data extraction

Bibliographic records were systematically exported into the NoteExpress database to facilitate the screening process and the removal of duplicate citations. Initial screening, based on titles and abstracts, was conducted by two reviewers who possessed specialized training in evidence-based knowledge. To ascertain whether the studies satisfied the predefined inclusion and exclusion criteria, the full texts of potentially relevant articles were acquired. In the event of disagreements between the two reviewers, resolution was achieved through discussion or, when necessary, by enlisting the input of a third reviewer for arbitration.

After confirming the included studies, the two authors independently extracted data from the each paper, including the first author, year of publication, country, study design, ICU type, mean patient age, mean intubation time, assessment time, assessment tool, evaluator, sample size, and the PED event. Any disparities during the process of extracted data were addressed through thorough discussion and consensus-building among the reviewers.

The outcomes of this review were as follows: (1) incidence of PED in patients with orotracheal intubation in the ICU; (2) sources of heterogeneity of PED in patients with orotracheal intubation in ICU.

Statistical analyses

Meta-analysis was conducted using the ‘meta prop’ function from the meta package within STATA/SE (version 15.0, StataCorp, TX, USA). To approximate the normal distribution of the data, incidence estimates were transformed using the “Freeman-Tukey Double Arcsine Transformation”. Heterogeneity was assessed using the I 2 statistic, and pooled analyses of PED were executed employing a random-effects model in the presence of significant heterogeneity ( I 2  ≥ 50%), with fixed-effects models utilized when heterogeneity was non-significant. A significance level of P  < 0.05 was established for all analyses.

Subgroup analyses were undertaken to investigate the potential impact of various factors, including assessment tool (gold standard, SSA, GUSS, BSE, PEDS, WST, and other assessment tools), year of publication (2000–2010, 2011–2015, 2016–2020, 2021–2023), study design (cross-sectional study and cohort study), study quality (moderate quality and high quality), assessment time (≤ 3 h, 4–6 h, ≤ 24 h, ≤ 48 h, and after 48 h post-extubation), mean intubation time (≤ 24 h, 48 – 168 h, and > 168 h), mean patient age (≤ 44 years, 45–59 years, 60–74 years), evaluator (nurses, speech-language pathologist), ICU type (Trauma ICU, Cardiac surgery ICU, Mixed medical and surgical ICU), and sample size ( N  ≤ 100, 100 <  N  ≤ 200, 200 <  N  ≤ 300, N  > 300) on the pooled estimate. In instances where no source of heterogeneity was identified in the subgroup analyse, we conducted meta-regression to further pinpoint the origins of heterogeneity, focusing on assessment time, mean intubation time, mean age, assessment tool, sample size, evaluator, ICU type, study design, study quality and year of publication. Sensitivity analysis by the “leave-one-out method” was employed to evaluate the random-effects model’s stability of the pooled incidence of PED. Publication bias was assessed by funnel plot and “Trim and Full” method.

Certainty of the evidence

The level of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) [ 28 ]. This tool classifies the certainty of evidence into four levels: very low, low, moderate, and high. “High quality” suggests that the actual effect is approximate to the estimate of the effect. On the other hand, “Very low quality” suggests that there is very little confidence in the effect estimate and the reported estimate may be substantially different from what was measured. Two reviewers judged the following aspects: risk of bias, inconsistency, imprecision, indirect evidence, and publication bias. Disagreements were resolved by consensus with the third reviewer.

Study selection

Out of the 4144 studies initially identified, 1280 duplicate studies were removed, and an additional 2864 studies that were deemed irrelevant were excluded based on title and abstract screening. Subsequently, a thorough examination of the full text was conducted for the remaining 122 studies. A manual hand-search of the reference lists of selected articles was 5 studies. Finally, 30 studies were chosen as they met the predetermined inclusion criteria for this systematic review and meta-analysis. The study selection flowchart is shown in Fig.  1 .

figure 1

Flowchart of study selection

General characteristics of the included studies

The characteristics of the included studies are shown in Table  1 . The total sample size across these studies amounted to 6,228 participants. The earliest study in this review was conducted in 2003 [ 29 ], while the most recent study was conducted in 2023 [ 15 ], with 14 studies published after 2020. The study with the largest sample size was conducted by Schefold et al. [ 12 ], comprising 933 participants, while the study with the smallest sample size was carried out by Yılmaz et al. [ 19 ], including 40 participants. The methods employed to assess the incidence of PED exhibited variability among the studies. Specifically, one study employed VFSS [ 30 ], and four studies relied on FEES [ 9 , 29 , 31 , 32 ], and seven studies utilized SSA assessment tools [ 7 , 15 , 16 , 33 , 34 , 35 , 36 ]. Furthermore, six studies utilized BSE [ 5 , 10 , 17 , 37 , 38 , 39 ], two studies employed WST [ 12 , 40 ], two studies adopted PEDS [ 8 , 18 ], two studies utilized GUSS [ 19 , 41 ], and six studies employed other assessment tools [ 6 , 20 , 21 , 22 , 43 ,, 42 , 43 ] such as ASHA, FOIS, SSQ200, NPS-PED, MASA, and YSP.

Among all the studies, 23 studies recorded the assessment time for PED. Specifically, three studies assessed PED within ≤ 3 h post-extubation [ 6 , 9 , 12 ], four studies conducted assessments at 4–6 h post-extubation [ 15 , 16 , 33 , 36 ], nine studies assessed PED within ≤ 24 h post-extubation [ 7 , 8 , 17 , 18 , 19 , 31 , 34 , 40 , 41 ], three studies assessed PED within ≤ 48 h post-extubation [ 5 , 20 , 37 ], and four studies evaluated PED at > 24 h post-extubation [ 21 , 22 , 29 , 38 ]. In terms of study quality, eight of the included studies were categorized as high quality, while the remainder were deemed of moderate quality (see Additional 1: Tables S3, S4).

Meta-analysis results

Utilizing the random-effects model, the pooled incidence of PED was estimated to be 36% (95% CI 29.0%–44.0%, I 2  = 97.06%, p  < 0.001; Fig.  2 ), indicating a substantial degree of heterogeneity. Despite conducting additional subgroup analyses, the source of this high heterogeneity remained elusive. However, the results of the meta-regression analysis revealed that sample size ( p  < 0.001), assessment time ( p  = 0.027) and mean intubation time ( p  = 0.045) emerged as the significant factor contributing to the heterogeneity.

figure 2

Overall pooled incidence of PED in ICU

Subgroup analysis of incidence

The subgroup analyses yielded the following incidence rates of PED based on assessment time post-extubation: the incidence of PED within 3 h post-extubation was 31% (95% CI 8.0–59.0), 4–6 h was 28% (95% CI 22.0–35.0, I 2  = 78.56%, p  < 0.001), within 24 h was 41% (95% CI 33.0–49.0, I 2  = 88.99%, p  < 0.001), and within 48 h was 49%. In addition, the incidence of PED beyond 24 h post-extubation was 37% (95% CI 23.0–52.0, I 2  = 91.73%, p  < 0.001) (Additional file 1: Fig. S1). Furthermore, when analyzing studies based on sample size ( N ), the overall incidence of PED was found 51% (95% CI 39.0–63.0, I 2  = 87.11%, p  < 0.001) for studies with N  < 100 participants, 37% (95% CI 31.0–43.0, I 2  = 84.74%, p  < 0.001) for studies with 100 <  N  ≤ 200 participants, 32% (95% CI 20.0–46.0, I 2  = 97.16%, p  < 0.001) for studies with 200 <  N  ≤ 300 participants, and 16% (95% CI 8.0–26.0, I 2  = 97.07%, p  < 0.001) for studies with N  > 300 participants (see Additional file 1: Fig. S2). In addition, further analyses were conducted based on assessment tool, mean intubation time, mean age, ICU type, evaluator, publication year, study design and study quality (see Additional file 1: Figs. S3–S11).

Results of meta-regression analysis

In the meta-regression analysis, we examined PED assessment time, sample size, assessment tools, mean intubation time, mean age, ICU type, evaluator, publication year, study design and study quality as potential covariates to identify the source of heterogeneity (Table  2 ). The univariate meta-regression analysis revealed a statistically significant correlation between incidence and sample size, assessment time and mean intubation time. Bubble plots of meta-regression of covariates were shown in Additional (see Additional file 1: Figs. S12–S22).

Sensitivity analysis

Sensitivity analysis showed that the incidence of PED ranged from 29 to 44% (see Additional file 1: Fig. S23). The marginal variance between these results and the pooled incidence was minimal, suggesting that the result of the pooled incidence being stable and reliable.

Publication bias

In our study, publication bias was detected by the funnel plot (see Additional file 1: Fig. S24). We found that the adjusted effect size was similar to the original effect size ( p  < 0.01) (see Additional file 1: Fig. S25).

The certainty of evidence was very low for all comparisons performed according to the GRADE rating [ 28 ]. Thus, it can be considered that the certainty of the evidence regarding the incidence of PED in this review is very low (Table  3 ).

This systematic review and meta-analysis aimed to estimate the incidence of PED in ICU patients. The study revealed an overall incidence of PED in ICU patients who underwent orotracheal intubation to be 36.0%. This incidence rate was comparable to the incidence of dysphagia resulting from stroke (36.30%) [ 45 ] and aligned with the incidence of PED observed in ICU patients (36%) [ 46 ]. However, it was slightly lower than the 41% reported in the meta-analysis conducted by McIntyre et al. [ 4 ]. The incidence of PED among ICU patients who underwent orotracheal intubation was high, ICU medical professionals, especially nurses should raise awareness about PED. However, the included studies were characterized by diversity and heterogeneity in assessment time and assessment tools signaled the need for obtaining consensus on a range of issues, including assessment time and assessment tools appropriate for ICU.

Sample size

This review identified sample size as a significant source of heterogeneity ( p  < 0.001). Notably, the incidence of PED demonstrated a gradual decrease as the sample size of the studies increased. In larger scale studies, such as those conducted by McIntyre et al. and Schefold et al., simpler assessment tools are employed, allowing for quick completion [ 10 , 12 ]. However, the reliability and validity of some of these tools remain unverified. Conversely, certain studies are conducted by highly trained professionals using the gold standard for PED assessment [ 9 , 29 , 31 ], which, while more accurate, is also time-consuming and costly [ 47 ]. In addition, some ICU patients, due to their unstable conditions, are unable to complete the gold standard assessment, resulting in relatively smaller sample sizes for these studies.

In statistics, sample size is intricately linked to result stability, and the confidence intervals for subgroups with N  < 100 in this study exhibited a wider range, this might diminish the result precision and lead to larger deviations from the true value. However, as the sample size increased to 100 <  N  ≤ 300, the confidence intervals narrowed in comparison to other subgroups. Consequently, when sample size was 100 <  N  ≤ 300, the PED incidence rates were more close with the overall PED rate. According to the central limit theorem, if the sampling method remains consistent, results obtained from larger samples are more stable and closer to the true value [ 48 , 49 ]. It is worth noting that the confidence intervals for the subgroup with N  > 300 in this study were wider and demonstrated a larger divergence from the total PED incidence. Therefore, in future studies, careful consideration of the sample size, based on the detection rate of the assessment tool used, is advisable to ensure both the stability and reliability of the results.

Mean intubation time

This review identified mean intubation time as a significant source of heterogeneity ( p  = 0.045). Variances in mean intubation time among ICU patients undergoing orotracheal intubation can lead to differing degrees of mucosal damage in the oropharynx and larynx [ 2 , 50 ], thereby resulting in varying incidence rates of PED. For instance, Malandraki et al. have reported that prolonged intubation is associated with more than a 12-fold increased risk of moderate/severe dysphagia compared to shorter intubation durations, and this effect is particularly pronounced among elderly patients [ 51 ]. Moreover, studies have demonstrated that ICU patients with extended orotracheal intubation periods leading to PED also exhibit diminished tongue and lip strength, protracted oral food transportation, slower swallowing, and muscle weakness in swallowing-related muscles [ 24 , 46 ]. In view of these findings, ICU medical professionals should routinely evaluate the need for orotracheal intubation, strive to minimize the duration of mechanical ventilation.

PED assessment time

This review identified assessment time as a significant source of heterogeneity ( P  = 0.027). It is important to note that there are currently no established guidelines recommending the optimal timing for the initial assessment of PED in ICU patients who have undergone orotracheal intubation. Consequently, the assessment time varies widely across studies, resulting in PED incidence rates ranging from 28 to 49% among subgroups. Interestingly, the incidence of PED assessed within ≤ 3 h post-extubation appeared lower than that assessed within ≤ 24 h and ≤ 48 h post-extubation. This difference may be attributed to the study by Schefold et al., which featured a shorter intubation duration [ 12 ]. Therefore, the incidence of PED assessed within ≤ 3 h post-extubation in ICU patients with orotracheal intubation may be underestimated. Moreover, it is essential to highlight that some ICU patients, particularly those with severe illnesses and extended intubation time, may face challenges in complying with post-extubation instructions provided by healthcare personnel. Paradoxically, this group of patients is at a higher risk of developing PED, subsequently increasing their susceptibility to post-extubation pneumonia [ 11 ]. ICU professionals should evaluate swallowing function in patients post-extubation; early identification of patients at risk for PED to reduce complications. If PED is identified, nurses should follow-up assessments at multiple time to obtain a thorough comprehension of PED recovery trajectory among PED patients, which can serve as a foundation for determining the timing of clinical interventions accurately.

PED assessment tools

Despite the subgroup analyses and meta-regression results indicating that PED assessment tools did not contribute to the observed heterogeneity, it is important to acknowledge the wide array of assessment tools employed across the studies included in this review. The study’s findings revealed that the results of the GUSS and BSE assessments were most closely aligned with the gold standard screening results. In contrast, the PEDS assessment results tended to be higher than those derived from the gold standard assessment. Furthermore, the results of other assessment tools generally yielded lower incidence rates of PED, possibly attributable to variations in specificity or sensitivity. FEES and VFSS assessments are recognized for their meticulous scrutiny of patients’ swallowing processes, including the detection of food residue and aspiration, which may not be as comprehensively addressed by other assessment methods [ 51 ]. Assessment tools such as BSE, SSA, GUSS, WST, and other clinical methods do not provide direct visualization of the swallowing process. Instead, assessors rely on the observation of overt clinical symptoms during the patient’s initial food or water intake to judge the presence of PED. However, these methods may overlook occult aspiration in patients, potentially resulting in an underestimation of PED incidence. In contrast, PEDS, which primarily assesses patients based on their medical history and plumbing symptoms without screening for drinking or swallowing, may overestimate PED incidence. Considering the varying strengths and limitations of existing assessment tools, ICU professionals select appropriate PED assessment tool based on the characteristics of the critically ill patient. Early and rapid identification of PED, before the use of more complex and expensive assessment tools, minimizes the occurrence of complications in patients.

Strengths and weaknesses

In this study, we conducted a comprehensive analysis of the incidence of PED in ICU patients who underwent orotracheal intubation across various subgroups, revealing a notable degree of heterogeneity among the included studies. In our study, we have expanded the search as much as possible and included a total of 30 papers after screening, half of which were published after 2020. There are several limitations that should be considered when interpreting the results of this meta-analysis. First, there was varied heterogeneity between methodological of the study and estimates of prevalence that may question the appropriateness of calculating pooled prevalence estimates. However, in order to address this heterogeneity, we addressed the heterogeneity with applying a random-effect model and conducting subgroup analysis and meta-regression to explore three sources of heterogeneity. Second, the overall quality of evidence for the incidence of PED was rated as low according to GRADE. Higher quality original studies on the incidence of PED should be performed in the future. As a result, the findings should be interpreted with caution in such cases.

In conclusion, our systematic review and meta-analysis revealed a high incidence of PED among ICU patients who underwent orotracheal intubation. It is also worth noting that the incidence of PED in the ICU may be underestimated. It is expected to increase awareness about the issue of PED among ICU patients. It will be important to develop guidelines or consensus on the most appropriate PED assessment time and assessment tools to accurately assess the incidence of PED.

Relevance to clinical practice

Each year, a substantial number of critically ill patients, ranging from 13 to 20 million, necessitate endotracheal intubation to sustain their lives. Patients undergoing orotracheal intubation are at heightened risk of developing PED. PED has been linked to prolonged hospital and ICU length of stay, increased rates of pneumonia, and all-cause mortality. Early identification of high-risk patients by clinical nurses is critical for reduce patient burden and adverse outcomes.

Early and multiple times assessment: Future investigations should early assess PED in clinical practice, especially within 6 h post-extubation. Furthermore, we suggest for follow-up assessments at multiple time to obtain a thorough comprehension of PED incidence and the recovery trajectory among ICU patients who have undergone orotracheal intubation.

Assessment tool: Considering the varying strengths and limitations of existing assessment tools, ICU professionals should carefully evaluate the characteristics of critically ill patients and select appropriate assessment tools, before the use of more complex and expensive assessment tools.

Routinely evaluate the need for orotracheal intubation: Healthcare professionals should routinely evaluate the need for orotracheal intubation, strive to minimize the duration of mechanical ventilation.

Availability of data and materials

All data related to the present systematic review and meta-analysis are available from the original study corresponding author on reasonable request.

Abbreviations

Confidence interval

  • Intensive care unit

Post-extubation dysphagia

Sydney Swallow Questionnaire 200

Water swallowing test

Post-Extubation Dysphagia Screening Tool

Bedside swallow evaluation

The Yale swallow protocol

Mann Assessment of Swallowing Ability

American Speech-Language-Hearing Association

Video Fluoroscopic Swallowing Study

Fiberoptic endoscopic evaluation of swallowing

Gugging swallowing screen

Standardized Swallowing Assessment

Functional Oral Intake Scale

Nurse-performed screening for post-extubation dysphagia

Speech-language pathologists

Events of PED

Preferred Reporting Items for Systematic Reviews and Meta-analyses

International Prospective Register of Systematic Reviews

Wunsch H, Wagner J, Herlim M, Chong DH, Kramer AA, Halpern SD. ICU occupancy and mechanical ventilator use in the United States. Crit Care Med. 2013;41(12):2712–9.

Article   PubMed   Google Scholar  

Brodsky MB, Akst LM, Jedlanek E, Pandian V, Blackford B, Price C, Cole G, Mendez-Tellez PA, Hillel AT, Best SR, et al. Laryngeal injury and upper airway symptoms after endotracheal intubation during surgery: a systematic review and meta-analysis. Anesth Analg. 2021;132(4):1023–32.

Article   PubMed   PubMed Central   Google Scholar  

Brodsky MB, Chilukuri K, De I, Huang M, Needham DM. Coordination of pharyngeal and laryngeal swallowing events during single liquid swallows after oral endotracheal intubation. Am J Respir Crit Care Med. 2017;195:768–77.

Google Scholar  

McIntyre M, Doeltgen S, Dalton N, Koppa M, Chimunda T. Post-extubation dysphagia incidence in critically ill patients: a systematic review and meta-analysis. Aust Crit Care. 2021;34(1):67–75.

Tsai MH, Ku SC, Wang TG, Hsiao TY, Lee JJ, Chan DC, Huang GH, Chen C. Swallowing dysfunction following endotracheal intubation age matters. Medicine. 2016;95(24):e3871.

Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, et al. Evaluation of swallow function post-extubation: is it necessary to wait 24 hours? Ann Otol Rhinol Laryngol. 2019;128(7):619–24.

Zeng L, Song Y, Dong Y, Wu Q, Zhang L, Yu L, Gao L, Shi Y. Risk score for predicting dysphagia in patients after neurosurgery: a prospective observational trial. Front Neurol. 2021;12:605687.

Dan L, Yunfang C, Chengfen Y, Li T. Reliability and validity of the Chinese version of postextubation dysphagia screening tool for patients with mechanical ventilation. Tianjin J Nurs. 2022;30(2):161–5.

Troll C, Trapl-Grundschober M, Teuschl Y, Cerrito A, Compte MG, Siegemund M. A bedside swallowing screen for the identification of post-extubation dysphagia on the intensive care unit—validation of the Gugging Swallowing Screen (GUSS)—ICU. BMC Anesthesiol. 2023;23(1):122.

McInytre M, Doeltgen S, Shao C, Chimunda T. The incidence and clinical outcomes of postextubation dysphagia in a regional critical care setting. Aust Crit Care. 2022;35(2):107–12.

See KC, Peng SY, Phua J, Sum CL, Concepcion J. Nurse-performed screening for postextubation dysphagia: a retrospective cohort study in critically ill medical patients. Crit Care. 2016;20(1):326.

Schefold JC, Berger D, Zurcher P, Lensch M, Perren A, Jakob SM, Parviainen I, Takala J. Dysphagia in mechanically ventilated ICU patients (DYnAMICS): a prospective observational trial. Crit Care Med. 2017;45(12):2061–9.

Byun SE, Shon HC, Kim JW, Kim HK, Sim Y. Risk factors and prognostic implications of aspiration pneumonia in older hip fracture patients: a multicenter retrospective analysis. Geriatr Gerontol Int. 2019;19(2):119–23.

Jaillette E, Martin-Loeches I, Artigas A, Nseir S. Optimal care and design of the tracheal cuff in the critically ill patient. Ann Intensive Care. 2014;4(1):7.

Tang JY, Feng XQ, Huang XX, Zhang YP, Guo ZT, Chen L, Chen HT, Ying XX. Development and validation of a predictive model for patients with post-extubation dysphagia. World J Emerg Med. 2023;14(1):49–55.

Xia C, Ji J. The characteristics and predicators of post-extubation dysphagia in ICU patients with endotracheal intubation. Dysphagia. 2022;38:253.

Beduneau G, Souday V, Richard JC, Hamel JF, Carpentier D, Chretien JM, Bouchetemble P, Laccoureye L, Astier A, Tanguy V, et al. Persistent swallowing disorders after extubation in mechanically ventilated patients in ICU: a two-center prospective study. Ann Intensive Care. 2020;10(1):1–7.

Article   Google Scholar  

Johnson KL, Speirs L, Mitchell A, Przybyl H, Anderson D, Manos B, Schaenzer AT, Winchester K. Validation of a postextubation dysphagia screening tool for patients after prolonged endotracheal intubation. Am J Crit Care. 2018;27(2):89–96.

Yılmaz D, Mengi T, Sarı S. Post-extubation dysphagia and COVID-2019. Turkish J Neurol. 2021;27:21–5.

Oliveira A, Friche A, Salomão MS, Bougo GC, Vicente L. Predictive factors for oropharyngeal dysphagia after prolonged orotracheal intubation. Brazil J Otorhinolaryngol. 2018;84(6):722–8.

Yamada T, Ochiai R, Kotake Y. Changes in maximum tongue pressure and postoperative dysphagia in mechanically ventilated patients after cardiovascular surgery. Indian J Crit Care Med. 2022;26(12):1253–8.

Article   PubMed   PubMed Central   CAS   Google Scholar  

Brodsky MB, Huang M, Shanholtz C, Mendez-Tellez PA, Palmer JB, Colantuoni E, Needham DM. Recovery from dysphagia symptoms after oral endotracheal intubation in acute respiratory distress syndrome survivors. A 5-year longitudinal study. Ann Am Thorac Soc. 2017;14(3):376–83.

Skoretz SA, Yau TM, Ivanov J, Granton JT, Martino R. Dysphagia and associated risk factors following extubation in cardiovascular surgical patients. Dysphagia. 2014;29(6):647–54.

Park HS, Koo JH, Song SH. Association of post-extubation dysphagia with tongue weakness and somatosensory disturbance in non-neurologic critically ill patients. Ann Rehabil Med Arm. 2017;41(6):961–8.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Rev Esp Cardiol (Engl Ed). 2021;74(9):790–9.

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ Br Med J. 2011;343: d5928.

Lo CK, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014;14:45.

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ-Br Med J. 2008;336(7650):924–6.

El SA, Okada M, Bhat A, Pietrantoni C. Swallowing disorders post orotracheal intubation in the elderly. Intensive Care Med. 2003;29(9):1451–5.

Yang WJ, Park E, Min YS, Huh JW, Kim AR, Oh HM, Nam TW, Jung TD. Association between clinical risk factors and severity of dysphagia after extubation based on a videofluoroscopic swallowing study. Korean J Intern Med. 2020;35(1):79.

Megarbane B, Hong TB, Kania R, Herman P, Baud FJ. Early laryngeal injury and complications because of endotracheal intubation in acutely poisoned patients: a prospective observational study. Clin Toxicol. 2010;48(4):331–6.

Scheel R, Pisegna JM, McNally E, Noordzij JP, Langmore SE. Endoscopic assessment of swallowing after prolonged intubation in the ICU setting. Ann Otol Rhinol Laryngol. 2016;125(1):43–52.

Fan GUO, Mingming WANG, Shengqiang ZOU. Analysis of risk factors and establishment of prediction model for post-extubation swallowing dysfunction in ICU patients with endotracheal intubation. Chin Nurs Res. 2020;34(19):3424–8.

Yaqian W: Localization and evaluation of reliability and validity of GuSS-ICU bedside swallowing screening tool. Master: Huzhou University; 2020.

Yun D, Yuan Z, Yanli Y. Risk factors and nursing strategies of the occurrences of acquired swallowing disorders after ICU patients treated with oral tracheal intubation and extubation. Med Equip. 2021;34(1):20–2.

JinTian Y. Study on the recovery of swallowing function and the real experience of patients with acquired swallowing disorder after cardiac surgery. Master: Nanjing University; 2020.

de Medeiros GC, Sassi FC, Mangilli LD, Zilberstein B, de Andrade C. Clinical dysphagia risk predictors after prolonged orotracheal intubation. Clinics. 2014;69(1):8–14.

Kwok AM, Davis JW, Cagle KM, Sue LP, Kaups KL. Post-extubation dysphagia in trauma patients: it’s hard to swallow. Am J Surg. 2013;206(6):924–7 ( 927–928 ).

Barker J, Martino R, Reichardt B, Hickey EJ, Ralph-Edwards A. Incidence and impact of dysphagia in patients receiving prolonged endotracheal intubation after cardiac surgery. Can J Surg. 2009;52(2):119–24.

PubMed   PubMed Central   Google Scholar  

Bordon A, Bokhari R, Sperry J, Testa D, Feinstein A, Ghaemmaghami V. Swallowing dysfunction after prolonged intubation: analysis of risk factors in trauma patients. Am J Surg. 2011;202(6):679–82.

Limin Z. The application of gugging swallowing screenin post-extubation swallowing dysfunction assessment after long-term intubation. Master. Tianjin Medical University; 2016.

Omura K, Komine A, Yanagigawa M, Chiba N, Osada M. Frequency and outcome of post-extubation dysphagia using nurse-performed swallowing screening protocol. Nurs Crit Care. 2019;24(2):70–5.

Regala M, Marvin S, Ehlenbach WJ. Association between postextubation dysphagia and long-term mortality among critically ill older adults. J Am Geriatr Soc. 2019;67(9):1895–901.

Meng PP, Zhang SC, Han C, Wang Q, Bai GT, Yue SW. The occurrence rate of swallowing disorders after stroke patients in Asia: a PRISMA-compliant systematic review and meta-analysis. J Stroke Cerebrovasc Dis Off J Nat Stroke Assoc. 2020;29(10): 105113.

Yingli H, Mengxin C, Donglei S. Incidence and influencing factors of post-extubation dysphagia among patients with mechanical ventilation: a meta-analysis. Chin J Modern Nurs. 2019;25(17):2158–63.

Spronk PE, Spronk LEJ, Egerod I, McGaughey J, McRae J, Rose L, Brodsky MB, Brodsky MB, Rose L, Lut J, et al. Dysphagia in intensive care evaluation (DICE): an international cross-sectional survey. Dysphagia. 2022;37(6):1451–60.

Pourhoseingholi MA, Vahedi M, Rahimzadeh M. Sample size calculation in medical studies. Gastroenterol Hepatol Bed Bench. 2013;6(1):14–7.

Faber J, Fonseca LM. How sample size influences research outcomes. Dental Press J Orthod. 2014;19(4):27–9.

Zuercher P, Moret CS, Dziewas R, Schefold JC. Dysphagia in the intensive care unit: epidemiology, mechanisms, and clinical management. Crit Care. 2019;23(1):103.

Malandraki GA, Markaki V, Georgopoulos VC, Psychogios L, Nanas S. Postextubation dysphagia in critical patients: a first report from the largest step-down intensive care unit in Greece. Am J Speech Lang Pathol. 2016;25(2):150–6.

Ambika RS, Datta B, Manjula BV, Warawantkar UV, Thomas AM. Fiberoptic endoscopic evaluation of swallow (FEES) in intensive care unit patients post extubation. Indian J Otolaryngol Head Neck Surg. 2019;71(2):266–70.

Article   PubMed   CAS   Google Scholar  

Download references

No funding.

Author information

Weixia Yu and Limi Dan contributed as the co-first authors.

Authors and Affiliations

Department of Nursing, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China

Weixia Yu, Limi Dan, Jianzheng Cai, Yuyu Wang, Qingling Wang, Yingying Zhang & Xin Wang

You can also search for this author in PubMed   Google Scholar

Contributions

Weixia Yu, Limi Dan, Jianzheng Cai, and Yuyu Wang developed the original concept of this systematic review and meta-analysis. Weixia Yu, Limi Dan, Jianzheng Cai and Yuyu Wang contributed to the screening of eligible studies, data extraction, and data synthesis. Weixia Yu, Limi Dan, Jianzheng Cai, Yuyu Wang and Qingling Wang drafted the first version of the manuscript. Yingying Zhang, Qingling Wang and Xin Wang prepared the tables and figures. All the authors have edited and contributed for intellectual content. All the authors read and approved the final manuscript and take public responsibility for it.

Corresponding authors

Correspondence to Jianzheng Cai or Yuyu Wang .

Ethics declarations

Ethics approval and consent to participate.

Not applicable.

Consent for publication

Competing interests.

The authors declare that they have no competing interests.

Additional information

Publisher's note.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

40001_2024_2024_moesm1_esm.docx.

Additional file 1: Table S1. PRISMA 2020 Checklist. Table S2. Search strategy. Table S3. Quality evaluation results of the cohort studies. Table S4. Quality evaluation results of the cross-sectional study. Fig. S1. Subgroup analysis of the incidence of PED by assessment time. Fig. S2. Subgroup analysis of the incidence of PED by sample size. Fig. S3. Incidence of PED by assessment tool. Fig. S4. Incidence of PED by mean intubation time. Fig. S5 Incidence of PED by mean age. Fig. S6. Incidence of PED by ICU type. Fig. S7. Incidence of PED by evaluator. Fig. S8. Incidence of PED by year of publication. Fig. S9. Incidence of PED by study design. Fig. S10. Incidence of PED by quality of cohort study. Fig. S11. Incidence of PED by quality of Cross-sectional study. Fig. S12. Bubble plot of meta-regression result for evaluate time as a covariate. Fig. S13. Bubble plot of meta-regression result for sample size as a covariate. Fig. S14. Bubble plot of meta-regression result for assessment tool as a covariate. Fig. S15. Bubble plot of meta-regression result for mean intubation time as a covariate. Fig. S16. Bubble plot of meta-regression result for mean age as a covariate. Fig. S17. Bubble plot of meta-regression result for ICU type as a covariate. Fig. S18. Bubble plot of meta-regression result for evaluator as a covariate. Fig. S19. Bubble plot of meta-regression result for year of publication as a covariate. Fig. S20. Bubble plot of meta-regression result for study design as a covariate. Fig. S21. Bubble plot of meta-regression result for quality of cohort study as a covariate. Fig. S22. Bubble plot of meta-regression result for quality of cross-sectional study as a covariate. Fig. S23. Sensitivity analysis of PED. Fig. S24. Publication bias assessment plot. Fig. S25. Publication bias assessment plot. “Trim and Full test” method.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ .

Reprints and permissions

About this article

Cite this article.

Yu, W., Dan, L., Cai, J. et al. Incidence of post-extubation dysphagia among critical care patients undergoing orotracheal intubation: a systematic review and meta-analysis. Eur J Med Res 29 , 444 (2024). https://doi.org/10.1186/s40001-024-02024-x

Download citation

Received : 19 December 2023

Accepted : 12 August 2024

Published : 31 August 2024

DOI : https://doi.org/10.1186/s40001-024-02024-x

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

  • Orotracheal intubation
  • Post-extubation
  • Systematic review
  • Meta-analysis

European Journal of Medical Research

ISSN: 2047-783X

guidelines in literature review

Information

  • Author Services

Initiatives

You are accessing a machine-readable page. In order to be human-readable, please install an RSS reader.

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess .

Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.

Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive positive feedback from the reviewers.

Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.

Original Submission Date Received: .

  • Active Journals
  • Find a Journal
  • Proceedings Series
  • For Authors
  • For Reviewers
  • For Editors
  • For Librarians
  • For Publishers
  • For Societies
  • For Conference Organizers
  • Open Access Policy
  • Institutional Open Access Program
  • Special Issues Guidelines
  • Editorial Process
  • Research and Publication Ethics
  • Article Processing Charges
  • Testimonials
  • Preprints.org
  • SciProfiles
  • Encyclopedia

environments-logo

Article Menu

guidelines in literature review

  • Subscribe SciFeed
  • Recommended Articles
  • Google Scholar
  • on Google Scholar
  • Table of Contents

Find support for a specific problem in the support section of our website.

Please let us know what you think of our products and services.

Visit our dedicated information section to learn more about MDPI.

JSmol Viewer

Impacts of pfas exposure on neurodevelopment: a comprehensive literature review.

guidelines in literature review

1. Introduction

2. materials and methods, 2.1. data sourcing, 2.2. exposure assessment, 2.3. outcomes, 2.4. covariates, 2.5. data extraction, 3.1. the intelligence quotient (iq), 3.2. attention-deficit hyperactivity disorder (adhd), 3.3. autism spectrum disorder (asd), 4. discussion, 5. conclusions, author contributions, conflicts of interest.

  • Morris-Rosendahl, D.J.; Crocq, M.A. Neurodevelopmental disorders—The history and future of a diagnostic concept. Dialogues Clin. Neurosci. 2020 , 22 , 65–72. [ Google Scholar ] [ CrossRef ]
  • Graf, W.D.; Kekatpure, M.V.; Kosofsky, B.E. Prenatal-onset neurodevelopmental disorders secondary to toxins, nutritional deficiencies, and maternal illness. Handb. Clin. Neurol. 2013 , 111 , 143–159. [ Google Scholar ]
  • Ijomone, O.M.; Olung, N.F.; Akingbade, G.T.; Okoh, C.O.A.; Aschner, M. Environmental influence on neurodevelopmental disorders: Potential association of heavy metal exposure and autism. J. Trace Elem. Med. Biol. 2020 , 62 , 126638. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Landrigan, P.J.; Lambertini, L.; Birnbaum, L.S. A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ. Health Perspect. 2012 , 120 , a258–a260. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Grandjean, P.; Landrigan, P.J. Developmental neurotoxicity of industrial chemicals. Lancet 2006 , 368 , 2167–2178. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Giordano, G.; Costa, L.G. Developmental neurotoxicity: Some old and new issues. ISRN Toxicol. 2012 , 2012 , 814795. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Makris, S.L.; Raffaele, K.; Allen, S.; Bowers, W.J.; Hass, U.; Alleva, E.; Calamandrei, G.; Sheets, L.; Amcoff, P.; Delrue, N.; et al. A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426. Environ. Health Perspect. 2009 , 117 , 17–25. [ Google Scholar ] [ CrossRef ]
  • Panieri, E.; Baralic, K.; Djukic-Cosic, D.; Buha Djordjevic, A.; Saso, L. PFAS Molecules: A Major Concern for the Human Health and the Environment. Toxics 2022 , 10 , 44. [ Google Scholar ] [ CrossRef ]
  • Di Nisio, A.; Pannella, M.; Vogiatzis, S.; Sut, S.; Dall’Acqua, S.; Santa Rocca, M.; Antonini, A.; Porzionato, A.; De Caro, R.; Bortolozzi, M.; et al. Toni and C. Foresta. Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals. Environ. Int. 2022 , 158 , 106982. [ Google Scholar ] [ CrossRef ]
  • Sunderland, E.M.; Hu, X.C.; Dassuncao, C.; Tokranov, A.K.; Wagner, C.C.; Allen, J.G. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects. J. Expo. Sci. Environ. Epidemiol. 2019 , 29 , 131–147. [ Google Scholar ] [ CrossRef ]
  • Spratlen, M.J.; Perera, F.P.; Lederman, S.A.; Rauh, V.A.; Robinson, M.; Kannan, K.; Trasande, L.; Herbstman, J. The association between prenatal exposure to perfluoroalkyl substances and childhood neurodevelopment. Environ. Pollut. 2020 , 263 Pt B , 114444. [ Google Scholar ] [ CrossRef ]
  • Trudel, D.; Horowitz, L.; Wormuth, M.; Scheringer, M.; Cousins, I.T.; Hungerbühler, K. Estimating consumer exposure to PFOS and PFOA. Risk Anal. 2008 , 28 , 251–269. [ Google Scholar ] [ CrossRef ]
  • Death, C.; Bell, C.; Champness, D.; Milne, C.; Reichman, S.; Hagen, T. Per-and polyfluoroalkyl substances (PFAS) in livestock and game species: A review. Sci. Total Environ. 2021 , 774 , 144795. [ Google Scholar ] [ CrossRef ]
  • Ericson, I.M.; Nadal, B.; van Bavel, G.; Lindstrom, J.L. Domingo. Levels of perfluorochemicals in water samples from Catalonia, Spain: Is drinking water a significant contribution to human exposure? Environ. Sci. Pollut. Res. Int. 2008 , 15 , 614–619. [ Google Scholar ] [ CrossRef ]
  • Banzhaf, S.; Filipovic, M.; Lewis, J.; Sparrenbom, C.J.; Barthel, R. A review of contamination of surface-, ground-, and drinking water in Sweden by perfluoroalkyl and polyfluoroalkyl substances (PFASs). Ambio 2017 , 46 , 335–346. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Domingo, J.L.; Nadal, M. Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature. Environ. Res. 2019 , 177 , 108648. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Cousins, I.T.; DeWitt, J.C.; Glüge, J.; Goldenman, G.; Herzke, D.; Lohmann, R.; Ng, C.A.; Scheringer, M.; Wang, Z. The high persistence of PFAS is sufficient for their management as a chemical class. Environ. Sci. Process. Impacts 2020 , 22 , 2307–2312. [ Google Scholar ] [ CrossRef ]
  • Cui, Q.; Pan, Y.; Wang, J.; Liu, H.; Yao, B.; Dai, J. Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones. Environ. Pollut. 2020 , 266 Pt 2 , 115330. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Gardener, H.; Sun, Q.; Grandjean, P. PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes. Environ. Res. 2021 , 192 , 110287. [ Google Scholar ] [ CrossRef ]
  • Stein, C.R.; McGovern, K.J.; Pajak, A.M.; Maglione, P.J.; Wolff, M.S. Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12–19 y: National Health and Nutrition Examination Survey. Pediatr. Res. 2016 , 79 , 348–357. [ Google Scholar ] [ CrossRef ]
  • Papadopoulou, E.; Stratakis, N.; Basagaña, X.; Brantsæter, A.L.; Casas, M.; Fossati, S.; Gražulevičienė, R.; Haug, L.S.; Heude, B.; Maitre, L.; et al. Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts. Environ. Int. 2021 , 157 , 106853. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Alderete, T.L.; Jin, R.; Walker, D.I.; Valvi, D.; Chen, Z.; Jones, D.P.; Peng, C.; Gilliland, F.D.; Berhane, K.; Conti, D.V.; et al. Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis. Environ. Int. 2019 , 126 , 445–453. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Chen, Z.; Yang, T.; Walker, D.I.; Thomas, D.C.; Qiu, C.; Chatzi, L.; Alderete, T.L.; Kim, J.S.; Conti, D.V.; Breton, C.V.; et al. Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults. Environ. Int. 2020 , 145 , 106091. [ Google Scholar ] [ CrossRef ]
  • Fan, Y.; Li, X.; Xu, Q.; Zhang, Y.; Yang, X.; Han, X.; Du, G.; Xia, Y.; Wang, X.; Lu, C. Serum albumin mediates the effect of multiple per- and polyfluoroalkyl substances on serum lipid levels. Environ. Pollut. 2020 , 266 Pt 2 , 115138. [ Google Scholar ] [ CrossRef ]
  • Blomberg, A.J.; Shih, Y.-H.; Messerlian, C.; Jørgensen, L.H.; Weihe, P.; Grandjean, P. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ. Res. 2021 , 200 , 111400. [ Google Scholar ] [ CrossRef ]
  • Ojo, A.F.; Xia, Q.; Peng, C.; Ng, J.C. Evaluation of the individual and combined toxicity of perfluoroalkyl substances to human liver cells using biomarkers of oxidative stress. Chemosphere 2021 , 281 , 130808. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Lind, P.M.; Salihovic, S.; van Bavel, B.; Lind, L. Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery atherosclerosis. Environ. Res. 2017 , 152 , 157–164. [ Google Scholar ] [ CrossRef ]
  • Bjorke-Monsen, A.-L.; Varsi, K.; Averina, M.; Brox, J.; Huber, S. Perfluoroalkyl substances (PFASs) and mercury in never-pregnant women of fertile age: Association with fish consumption and unfavorable lipid profile. BMJ Nutr. Prev. Health 2020 , 3 , 277–284. [ Google Scholar ] [ CrossRef ]
  • Carstens, K.E.; Freudenrich, T.; Wallace, K.; Choo, S.; Carpenter, A.; Smeltz, M.; Clifton, M.S.; Henderson, W.M.; Richard, A.M.; Patlewicz, G.; et al. Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity. Chem. Res. Toxicol. 2023 , 36 , 402–419. [ Google Scholar ] [ CrossRef ]
  • Chen, N.; Li, J.; Li, D.; Yang, Y.; He, D. Chronic exposure to perfluorooctane sulfonate induces behavior defects and neurotoxicity through oxidative damages, in vivo and in vitro. PLoS ONE 2014 , 9 , 113453. [ Google Scholar ] [ CrossRef ]
  • Oh, J.; Shin, H.-M.; Kannan, K.; Busgang, S.A.; Schmidt, R.J.; Schweitzer, J.B.; Hertz-Picciotto, I.; Bennett, D.H. Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study. Environ. Res. 2022 , 215 Pt 2 , 114322. [ Google Scholar ] [ CrossRef ]
  • Yao, H.; Fu, Y.; Weng, X.; Zeng, Z.; Tan, Y.; Wu, X.; Zeng, H.; Yang, Z.; Li, Y.; Liang, H.; et al. The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis. Int. J. Environ. Res. Public Health 2023 , 20 , 1668. [ Google Scholar ] [ CrossRef ]
  • Rock, K.D.; Patisaul, H.B. Environmental Mechanisms of Neurodevelopmental Toxicity. Curr. Environ. Health Rep. 2018 , 5 , 145–157. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Costa, L.G.; Cole, T.B.; Dao, K.; Chang, Y.-C.; Garrick, J.M. Developmental impact of air pollution on brain function. Neurochem. Int. 2019 , 131 , 104580. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Hamm, M.P.; Cherry, N.M.; Chan, E.; Martin, J.W.; Burstyn, I. Maternal exposure to perfluorinated acids and fetal growth. J. Expo. Sci. Environ. Epidemiol. 2010 , 20 , 589–597. [ Google Scholar ] [ CrossRef ]
  • Szilagyi, J.T.; Avula, V.; Fry, R.C. Perfluoroalkyl Substances (PFAS) and Their Effects on the Placenta, Pregnancy, and Child Development: A Potential Mechanistic Role for Placental Peroxisome Proliferator-Activated Receptors (PPARs). Curr. Environ. Health Rep. 2020 , 7 , 222–230. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Erinc, A.; Davis, M.B.; Padmanabhan, V.; Langen, E.; Goodrich, J.M. Considering environmental exposures to per- and polyfluoroalkyl substances (PFAS) as risk factors for hypertensive disorders of pregnancy. Environ. Res. 2021 , 197 , 111113. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Blake, B.E.; Fenton, S.E. Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects. Toxicology 2020 , 443 , 152565. [ Google Scholar ] [ CrossRef ]
  • Liu, D.; Yan, S.; Liu, Y.; Chen, Q.; Ren, S. Association of prenatal exposure to perfluorinated and polyfluoroalkyl substances with childhood neurodevelopment: A systematic review and meta-analysis. Ecotoxicol. Environ. Saf. 2024 , 271 , 115939. [ Google Scholar ] [ CrossRef ]
  • McAdam, J.; Bell, E.M. Determinants of maternal and neonatal PFAS concentrations: A review. Environ. Health 2023 , 22 , 41. [ Google Scholar ] [ CrossRef ]
  • Cai, D.; Li, Q.-Q.; Chu, C.; Wang, S.-Z.; Tang, Y.-T.; Appleton, A.A.; Qiu, R.-L.; Yang, B.-Y.; Hu, L.-W.; Dong, G.-H.; et al. High trans-placental transfer of perfluoroalkyl substances alternatives in the matched maternal-cord blood serum: Evidence from a birth cohort study. Sci. Total Environ. 2020 , 705 , 135885. [ Google Scholar ] [ CrossRef ]
  • Gützkow, K.B.; Haug, L.S.; Thomsen, C.; Sabaredzovic, A.; Becher, G.; Brunborg, G. Placental transfer of perfluorinated compounds is selective—A Norwegian Mother and Child sub-cohort study. Int. J. Hyg. Environ. Health 2012 , 215 , 216–219. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Bloom, M.S.; Varde, M.; Newman, R.B. Environmental toxicants and placental function. Best Pract. Res. Clin. Obstet. Gynaecol. 2022 , 85 Pt B , 105–120. [ Google Scholar ] [ CrossRef ]
  • Liu, Y.; Li, A.; Buchanan, S.; Liu, W. Exposure characteristics for congeners, isomers, and enantiomers of perfluoroalkyl substances in mothers and infants. Environ. Int. 2020 , 144 , 106012. [ Google Scholar ] [ CrossRef ]
  • Brantsæter, A.; Whitworth, K.; Ydersbond, T.; Haug, L.; Haugen, M.; Knutsen, H.; Thomsen, C.; Meltzer, H.; Becher, G.; Sabaredzovic, A.; et al. Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women. Environ. Int. 2013 , 54 , 74–84. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Liew, Z.; Goudarzi, H.; Oulhote, Y. Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes. Curr. Environ. Health Rep. 2018 , 5 , 1–19. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Gao, X.-X.; Zuo, Q.-L.; Fu, X.-H.; Song, L.-L.; Cen, M.-Q.; Wu, J. Association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort. Environ. Res. 2023 , 236 Pt 2 , 116812. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Mullin, A.P.; Gokhale, A.; Moreno-De-Luca, A.; Sanyal, S.; Waddington, J.L.; Faundez, V. Neurodevelopmental disorders: Mechanisms and boundary definitions from genomes, interactomes and proteomes. Transl. Psychiatry 2013 , 3 , 329. [ Google Scholar ] [ CrossRef ]
  • Lewis, R.C.; Johns, L.E.; Meeker, J.D. Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012. Int. J. Environ. Res. Public Health 2015 , 12 , 6098–6114. [ Google Scholar ] [ CrossRef ]
  • Da Silva, B.F.; Ahmadireskety, A.; Aristizabal-Henao, J.J.; Bowden, J.A. A rapid and simple method to quantify per- and polyfluoroalkyl substances (PFAS) in plasma and serum using 96-well plates. MethodsX 2020 , 7 , 101111. [ Google Scholar ] [ CrossRef ]
  • Marra, V.; Abballe, A.; Dellatte, E.; Iacovella, N.; Ingelido, A.M.; De Felip, E. A Simple and Rapid Method for Quantitative HPLC MS/MS Determination of Selected Perfluorocarboxylic Acids and Perfluorosulfonates in Human Serum. Int. J. Anal. Chem. 2020 , 2020 , 8878618. [ Google Scholar ] [ CrossRef ]
  • Henn, B.C.; Bellinger, D.C.; Hopkins, M.R.; Coull, B.A.; Ettinger, A.S.; Jim, R.; Hatley, E.; Christiani, D.C.; Wright, R.O. Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site. Environ. Health Perspect. 2017 , 125 , 067020. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Gansler, D.A.; Varvaris, M.; Schretlen, D.J. The use of neuropsychological tests to assess intelligence. Clin. Neuropsychol. 2017 , 31 , 1073–1086. [ Google Scholar ] [ CrossRef ]
  • Smelror, R.E.; Ueland, T. Cognitive functioning in early-onset psychosis. In Adolescent Psychosis ; Elsevier: Amsterdam, The Netherlands, 2023; Volume 13, pp. 127–152. [ Google Scholar ]
  • Chatham, C.H.; Taylor, K.I.; Charman, T.; D’Ardhuy, X.L.; Eule, E.; Fedele, A.; Hardan, A.Y.; Loth, E.; Murtagh, L.; Rubido, M.d.V.; et al. Adaptive behavior in autism: Minimal clinically important differences on the Vineland-II. Autism Res. 2018 , 11 , 270–283. [ Google Scholar ] [ CrossRef ]
  • Burns, T.G.; King, T.Z.; Spencer, K.S. Mullen scales of early learning: The utility in assessing children diagnosed with autism spectrum disorders, cerebral palsy, and epilepsy. Appl. Neuropsychol. Child 2013 , 2 , 33–42. [ Google Scholar ] [ CrossRef ]
  • Tsujii, N.; Usami, M.; Naya, N.; Tsuji, T.; Mishima, H.; Horie, J.; Fujiwara, M.; Iida, J. Efficacy and Safety of Medication for Attention-Deficit Hyperactivity Disorder in Children and Adolescents with Common Comorbidities: A Systematic Review. Neurol. Ther. 2021 , 10 , 499–522. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Biederman, J.; DiSalvo, M.; Vaudreuil, C.; Wozniak, J.; Uchida, M.; Woodworth, K.Y.; Green, A.; Farrell, A.; Faraone, S.V. The child behavior checklist can aid in characterizing suspected comorbid psychopathology in clinically referred youth with ADHD. J. Psychiatr. Res. 2021 , 138 , 477–484. [ Google Scholar ] [ CrossRef ]
  • Goodman, C.V.; Till, C.; Green, R.; El-Sabbagh, J.; Arbuckle, T.E.; Hornung, R.; Lanphear, B.; Seguin, J.R.; Booij, L.; Fisher, M.; et al. Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort. Neurotoxicol. Teratol. 2023 , 98 , 107181. [ Google Scholar ] [ CrossRef ]
  • Beck, I.H.; Bilenberg, N.; Möller, S.; Nielsen, F.; Grandjean, P.; Højsager, F.D.; Halldorsson, T.I.; Nielsen, C.; Jensen, T.K. Association Between Prenatal and Early Postnatal Exposure to Perfluoroalkyl Substances and IQ Score in 7-Year-Old Children From the Odense Child Cohort. Am. J. Epidemiol. 2023 , 192 , 1522–1535. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Vuong, A.M.; Webster, G.M.; Yolton, K.; Calafat, A.M.; Muckle, G.; Lanphear, B.P.; Chen, A. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and neurobehavior in US children through 8 years of age: The HOME study. Environ. Res. 2021 , 195 , 110825. [ Google Scholar ] [ CrossRef ]
  • Wang, H.; Luo, F.; Zhang, Y.; Yang, X.; Zhang, S.; Zhang, J.; Tian, Y.; Zheng, L. Prenatal exposure to perfluoroalkyl substances and child intelligence quotient: Evidence from the Shanghai birth cohort. Environ. Int. 2023 , 174 , 107912. [ Google Scholar ] [ CrossRef ]
  • Liew, Z.; Ritz, B.; Bach, C.C.; Asarnow, R.F.; Bech, B.H.; Nohr, E.A.; Bossi, R.; Henriksen, T.B.; Bonefeld-Jørgensen, E.C.; Olsen, J. Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort. Environ. Health Perspect. 2018 , 126 , 067004. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Wang, Y.; Rogan, W.J.; Chen, H.-Y.; Chen, P.-C.; Su, P.-H.; Chen, H.-Y.; Wang, S.-L. Prenatal exposure to perfluroalkyl substances and children’‘s’ IQ: The Taiwan maternal and infant cohort study. Int. J. Hyg. Environ. Health 2015 , 218 , 639–644. [ Google Scholar ] [ CrossRef ]
  • Harris, M.H.; Oken, E.; Rifas-Shiman, S.L.; Calafat, A.M.; Ye, X.; Bellinger, D.C.; Webster, T.F.; White, R.F.; Sagiv, S.K. Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition. Environ. Int. 2018 , 115 , 358–369. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Skogheim, T.S.; Villanger, G.D.; Weyde, K.V.F.; Engel, S.M.; Surén, P.; Øie, M.G.; Skogan, A.H.; Biele, G.; Zeiner, P.; Øvergaard, K.R.; et al. Prenatal exposure to perfluoroalkyl substances and associations with symptoms of attention-deficit/hyperactivity disorder and cognitive functions in preschool children. Int. J. Hyg. Environ. Health 2020 , 223 , 80–92. [ Google Scholar ] [ CrossRef ]
  • Zhang, B.; Wang, Z.; Zhang, J.; Dai, Y.; Ding, J.; Guo, J.; Qi, X.; Wu, C.; Zhou, Z. Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study. Environ. Int. 2024 , 187 , 108720. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Bünger, A.; Grieder, S.; Schweizer, F.; Grob, A. The comparability of intelligence test results: Group- and individual-level comparisons of seven intelligence tests. J. Sch. Psychol. 2021 , 88 , 101–117. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Vuong, A.M.; Yolton, K.; Xie, C.; Dietrich, K.N.; Braun, J.M.; Webster, G.M.; Calafat, A.M.; Lanphear, B.P.; Chen, A. Prenatal and childhood exposure to poly- and perfluoroalkyl substances (PFAS) and cognitive development in children at age 8 years. Environ. Res. 2019 , 172 , 242–248. [ Google Scholar ] [ CrossRef ]
  • Forns, J.; Verner, M.-A.; Iszatt, N.; Nowack, N.; Bach, C.C.; Vrijheid, M.; Costa, O.; Andiarena, A.; Sovcikova, E.; Høyer, B.B.; et al. Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies. Environ. Health Perspect. 2020 , 128 , 57002. [ Google Scholar ] [ CrossRef ]
  • Dalsager, L.; Jensen, T.K.; Nielsen, F.; Grandjean, P.; Bilenberg, N.; Andersen, H.R. No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 2(1/2) and 5 years in children from the Odense Child Cohort. Neurotoxicol. Teratol. 2021 , 88 , 107031. [ Google Scholar ] [ CrossRef ]
  • Kim, J.I.; Kim, B.-N.; Lee, Y.A.; Shin, C.H.; Hong, Y.-C.; Døssing, L.D.; Hildebrandt, G.; Lim, Y.-H. Association between early-childhood exposure to perfluoroalkyl substances and ADHD symptoms: A prospective cohort study. Sci. Total Environ. 2023 , 879 , 163081. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Liew, Z.; Ritz, B.; von Ehrenstein, O.S.; Bech, B.H.; Nohr, E.A.; Fei, C.; Bossi, R.; Henriksen, T.B.; Bonefeld-Jørgensen, E.C.; Olsen, J. Attention deficit/hyperactivity disorder and childhood autism in association with prenatal exposure to perfluoroalkyl substances: A nested case-control study in the Danish National Birth Cohort. Environ. Health Perspect. 2015 , 123 , 367–373. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Skogheim, T.S.; Weyde, K.V.F.; Aase, H.; Engel, S.M.; Surén, P.; Øie, M.G.; Biele, G.; Reichborn-Kjennerud, T.; Brantsæter, A.L.; Haug, L.S.; et al. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and associations with attention-deficit/hyperactivity disorder and autism spectrum disorder in children. Environ. Res. 2021 , 202 , 111692. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Itoh, S.; Yamazaki, K.; Suyama, S.; Ikeda-Araki, A.; Miyashita, C.; Bamai, Y.A.; Kobayashi, S.; Masuda, H.; Yamaguchi, T.; Goudarzi, H.; et al. The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study. Environ. Int. 2022 , 159 , 107026. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Quaak, I.; De Cock, M.; De Boer, M.; Lamoree, P.; Leonards, P.; Van de Bor, M. Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children. Int. J. Environ. Res. Public. Health 2016 , 13 , 511. [ Google Scholar ] [ CrossRef ]
  • Oh, J.; Bennett, D.H.; Calafat, A.M.; Tancredi, D.; Roa, D.L.; Schmidt, R.J.; Hertz-Picciotto, I.; Shin, H.-M. Prenatal exposure to per- and polyfluoroalkyl substances in association with autism spectrum disorder in the MARBLES study. Environ. Int. 2021 , 147 , 106328. [ Google Scholar ] [ CrossRef ]
  • Choi, J.W.; Oh, J.; Bennett, D.H.; Calafat, A.M.; Schmidt, R.J.; Shin, H.-M. Prenatal exposure to per- and polyfluoroalkyl substances and child behavioral problems. Environ. Res. 2024 , 251 Pt 1 , 118511. [ Google Scholar ] [ CrossRef ]
  • Shin, H.-M.; Bennett, D.H.; Calafat, A.M.; Tancredi, D.; Hertz-Picciotto, I. Modeled prenatal exposure to per- and polyfluoroalkyl substances in association with child autism spectrum disorder: A case-control study. Environ. Res. 2020 , 186 , 109514. [ Google Scholar ] [ CrossRef ]
  • Lyall, K.; Yau, V.M.; Hansen, R.; Kharrazi, M.; Yoshida, C.K.; Calafat, A.M.; Windham, G.; Croen, L.A. Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability. Environ. Health Perspect. 2018 , 126 , 017001. [ Google Scholar ] [ CrossRef ]
  • Hoadley, L.; Watters, M.; Rogers, R.; Werner, L.S.; Markiewicz, K.V.; Forrester, T.; McLanahan, E.D. Public health evaluation of PFAS exposures and breastfeeding: A systematic literature review. Toxicol. Sci. 2023 , 194 , 121–137. [ Google Scholar ] [ CrossRef ]
  • Mamsen, L.S.; Björvang, R.D.; Mucs, D.; Vinnars, M.-T.; Papadogiannakis, N.; Lindh, C.H.; Andersen, C.Y.; Damdimopoulou, P. Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies. Environ. Int. 2019 , 124 , 482–492. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Hanssen, L.; Dudarev, A.A.; Huber, S.; Odland, J.; Nieboer, E.; Sandanger, T.M. Partition of perfluoroalkyl substances (PFASs) in whole blood and plasma, assessed in maternal and umbilical cord samples from inhabitants of arctic Russia and Uzbekistan. Sci. Total Environ. 2013 , 447 , 430–437. [ Google Scholar ] [ CrossRef ]
  • Chen, F.; Yin, S.; Kelly, B.C.; Liu, W. Isomer-Specific Transplacental Transfer of Perfluoroalkyl Acids: Results from a Survey of Paired Maternal, Cord Sera, and Placentas. Environ. Sci. Technol. 2017 , 51 , 5756–5763. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Macheka-Tendenguwo, L.R.; Olowoyo, J.O.; Mugivhisa, L.L.; Abafe, O.A. Per- and polyfluoroalkyl substances in human breast milk and current analytical methods. Environ. Sci. Pollut. Res. Int. 2018 , 25 , 36064–36086. [ Google Scholar ] [ CrossRef ]
  • Timmermann, A.; Avenbuan, O.N.; Romano, M.E.; Braun, J.M.; Tolstrup, J.S.; Vandenberg, L.N.; Fenton, S.E. Per- and Polyfluoroalkyl Substances and Breastfeeding as a Vulnerable Function: A Systematic Review of Epidemiological Studies. Toxics 2023 , 11 , 325. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Jian, J.-M.; Chen, D.; Han, F.-J.; Guo, Y.; Zeng, L.; Lu, X.; Wang, F. A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs). Sci. Total Environ. 2018 , 636 , 1058–1069. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Ragnarsdottir, O.; Abdallah, M.A.; Harrad, S. Dermal uptake: An important pathway of human exposure to perfluoroalkyl substances? Environ. Pollut. 2022 , 307 , 119478. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Lin, C.-Y.; Lin, L.-Y.; Wen, T.-W.; Lien, G.-W.; Chien, K.-L.; Hsu, S.H.; Liao, C.-C.; Sung, F.-C.; Chen, P.-C.; Su, T.-C. Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults. Int. J. Cardiol. 2013 , 168 , 3309–3316. [ Google Scholar ] [ CrossRef ]
  • Grandjean, P.; Andersen, E.W.; Budtz-Jørgensen, E.; Nielsen, F.; Mølbak, K.; Weihe, P.; Heilmann, C. Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA 2012 , 307 , 391–397. [ Google Scholar ] [ CrossRef ]
  • Granum, B.; Haug, L.S.; Namork, E.; Stølevik, S.B.; Thomsen, C.; Aaberge, I.S.; van Loveren, H.; Løvik, M.; Nygaard, U.C. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. J. Immunotoxicol. 2013 , 10 , 373–379. [ Google Scholar ] [ CrossRef ]
  • White, S.S.; Stanko, J.P.; Kato, K.; Calafat, A.M.; Hines, E.P.; Fenton, S.E. Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice. Environ. Health Perspect. 2011 , 119 , 1070–1076. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Yang, C.; Tan, Y.S.; Harkema, J.R.; Haslam, S.Z. Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains. Reprod. Toxicol. 2009 , 27 , 299–306. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Lopez-Espinosa, M.-J.; Mondal, D.; Armstrong, B.; Bloom, M.S.; Fletcher, T. Thyroid function and perfluoroalkyl acids in children living near a chemical plant. Environ. Health Perspect. 2012 , 120 , 1036–1041. [ Google Scholar ] [ CrossRef ]
  • Tsai, M.-S.; Lin, C.-C.; Chen, M.-H.; Hsieh, W.-S.; Chen, P.-C. Perfluoroalkyl substances and thyroid hormones in cord blood. Environ. Pollut. 2017 , 222 , 543–548. [ Google Scholar ] [ CrossRef ]
  • Lin, C.-Y.; Wen, L.-L.; Lin, L.-Y.; Wen, T.-W.; Lien, G.-W.; Hsu, S.H.; Chien, K.-L.; Liao, C.-C.; Sung, F.-C.; Chen, P.-C.; et al. The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. J. Hazard. Mater. 2013 , 244–245 , 637–644. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Kataria, A.; Trachtman, H.; Malaga-Dieguez, L.; Trasande, L. Association between perfluoroalkyl acids and kidney function in a cross-sectional study of adolescents. Environ. Health 2015 , 14 , 89. [ Google Scholar ] [ CrossRef ]
  • Qin, X.-D.; Qian, Z.; Vaughn, M.G.; Huang, J.; Ward, P.; Zeng, X.-W.; Zhou, Y.; Zhu, Y.; Yuan, P.; Li, M.; et al. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environ. Pollut. 2016 , 212 , 519–524. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Fei, C.; McLaughlin, J.K.; Lipworth, L.; Olsen, J. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ. Health Perspect. 2008 , 116 , 1391–1395. [ Google Scholar ] [ CrossRef ]
  • Goudarzi, H.; Nakajima, S.; Ikeno, T.; Sasaki, S.; Kobayashi, S.; Miyashita, C.; Ito, S.; Araki, A.; Nakazawa, H.; Kishi, R. Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study. Sci. Total Environ. 2016 , 541 , 1002–1010. [ Google Scholar ] [ CrossRef ]
  • Stein, C.R.; Savitz, D.A.; Bellinger, D.C. Perfluorooctanoate and neuropsychological outcomes in children. Epidemiology 2013 , 24 , 590–599. [ Google Scholar ] [ CrossRef ]
  • Parenti, I.; Rabaneda, L.G.; Schoen, H.; Novarino, G. Neurodevelopmental Disorders: From Genetics to Functional Pathways. Trends Neurosci. 2020 , 43 , 608–621. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Antolini, G.; Colizzi, M. Where Do Neurodevelopmental Disorders Go? Casting the Eye Away from Childhood towards Adulthood. Healthcare 2023 , 11 , 1015. [ Google Scholar ] [ CrossRef ]
  • Bragg, M.; Chavarro, J.E.; Hamra, G.B.; Hart, J.E.; Tabb, L.P.; Weisskopf, M.G.; Volk, H.E.; Lyall, K. Prenatal Diet as a Modifier of Environmental Risk Factors for Autism and Related Neurodevelopmental Outcomes. Curr. Environ. Health Rep. 2022 , 9 , 324–338. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Brabhukumr, A.; Malhi, P.; Ravindra, K.; Lakshmi, P. Exposure to household air pollution during first 3 years of life and IQ level among 6–8-year-old children in India- A cross-sectional study. Sci. Total Environ. 2020 , 709 , 135110. [ Google Scholar ] [ CrossRef ]
  • Carroll, J.B. Psychometrics, intelligence, and public perception. Intelligence 1997 , 24 , 25–52. [ Google Scholar ] [ CrossRef ]
  • Iqubal, A.; Ahmed, M.; Ahmad, S.; Sahoo, C.R.; Iqubal, M.K.; Haque, S.E. Environmental neurotoxic pollutants: Review. Environ. Sci. Pollut. Res. 2020 , 27 , 41175–41198. [ Google Scholar ] [ CrossRef ]
  • Thapar, A.; Cooper, M. Attention deficit hyperactivity disorder. Lancet 2016 , 387 , 1240–1250. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Koutsoklenis, A.; Honkasilta, J. ADHD in the DSM-5-TR: What has changed and what has not. Front. Psychiatry 2022 , 13 , 1064141. [ Google Scholar ] [ CrossRef ]
  • Association, A.P. Diagnostic and Statistical Manual of Mental Disorders ; American Psychiatric Association: Washington, DC, USA, 2000. [ Google Scholar ]
  • Wang, L.; Wang, B.; Wu, C.; Wang, J.; Sun, M. Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy. Int. J. Mol. Sci. 2023 , 24 , 1819. [ Google Scholar ] [ CrossRef ]
  • Hirota, T.; King, B.H. Autism Spectrum Disorder: A Review. JAMA 2023 , 329 , 157–168. [ Google Scholar ] [ CrossRef ]
  • Rosen, T.E.; Mazefsky, C.A.; Vasa, R.A.; Lerner, M.D. Co-occurring psychiatric conditions in autism spectrum disorder. Int. Rev. Psychiatry 2018 , 30 , 40–61. [ Google Scholar ] [ CrossRef ] [ PubMed ]

Click here to enlarge figure

First Author/Year/CountryDesignSample SizeAge of ChildrenPFASSample/
Measuring Method
Exposure MeasureTest Type and IndicatorAdjustment of CovariatesConclusion
Carly V Goodman/2023/Canada [ ]Cohort Studyn = 522Between 3 and 4PFOA, PFOS, and PFHxSPlasma/
UHPLC–MS/MS
PFOA: 1.68 (1.10–2.50), PFOS: 4.97 (3.20–6.20), PFHxS: 1.09 (0.67–1.60) (µg/L)Wechsler Preschool and Primary Scale of Intelligence, Third Edition (WPPSI-III), composite full-scale IQ (FSIQ), performance IQ (PIQ), and verbal IQ (VIQ) scoresGestational week of blood sampling, maternal age, pre-pregnancy BMI, country of birth (Canadian born, foreign born), maternal level of education (trade school diploma or lower, bachelor’s degree or higher), parity (0, 1, 2+), maternal smoking during pregnancy (current smoker, former smoker, never smoked), study site, and the Home Observation Measurement of the Environment (HOME) score, a continuous measure of the quality of the child’s home environmentEach doubling of PFHxS levels corresponded to a reduction of 2.0 points (95% CI: −3.6, −0.5) in FSIQ and 2.9 points (95% CI: −4.7, −1.1) in PIQ in males. However, in females, PFHxS showed no association with FSIQ or PIQ. PFOA and PFOS were also linked to lower PIQ scores in males (PFOA: B = −2.8, 95% CI: −4.9, −0.7; PFOS: B = −2.6, 95% CI: −4.8, −0.5), while in females, they were slightly positively associated with PIQ, but not FSIQ
Iben Have Beck/2023/Denmark [ ]Cohort Studyn = 9677 years oldPFOS, PFOA, PFHxS, PFNA, and PFDASerum/
LC–MS
PFOS: 4.61 (3.08–7.08), PFOA: 2.48 (1.58–3.49), PFHxS: 0.33 (0.21–0.50), PFNA: 0.57 (0.40–0.78), PFDA: 0.18 (0.13–0.24) (ng/mL)Abbreviated version of the Danish WISC-V, Full-Scale Intelligence Quotient (FSIQ) score, and Verbal Comprehension Index (VCI) scoreMaternal educational level, BMI, and sexPFOS and PFNA exposure and FSIQ remained significant, with β coefficients of −1.7 (95% CI: −3.0, −0.3) and −1.7 (95% CI: −3.0, −0.4)
Ann M Vuong/2019/United States [ ]Cohort Studyn = 2213 and 8 years oldPFOA, PFOS, PFHxS, and PFNASerum/
HPLC–MS/MS
PFOA: 2.4, PFOA: 3.9, PFHxS: 1.4, PFNA: 0.8 (ng/mL)Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) and Full Scale IQ (FSIQ)Maternal sociodemographic, behavioral factors, and biological measurements of environmental chemicalFindings do not support that PFAS are adversely associated with cognitive function
Hui Wang/2023/China [ ]Cohort Studyn = 20314 years oldPFOA, PFOS, PFNA, PFUA, PFDA, PFHxS, PFBS, PFDoA, PFHpA, and PFOSAPlasma/
HPLC–MS/MS
PFOA: 13.12 (9.36–15.50), PFOS: 11.3 (6.66–13.68), PFNA: 2.05 (1.27–2.49), PFDA: 2.16 (1.18–2.67), PFHxS: 0.62 (0.42–0.69) (ng/mL)Wechsler Preschool and Primary Scales of Intelligence-Fourth Edition (WPPSI-IV)Maternal age at delivery, maternal educational level, maternal pre-pregnancy body mass index, parity, maternal folic acid intake during pregnancy, maternal place of birth, maternal active/passive smoking status during pregnancy, maternal freshwater fish intake during pregnancy, and self-reported economic statusNo significant associations between ln-transformed nine individual PFAS and child full scale IQ (FSIQ) or subscale IQ after adjusting for potential confounders
Zeyan Liew/2018/Norway [ ]Cohort Studyn = 15925 years oldPFOS, PFOA, PFHxS, PFNA, PFHpS, PFDA, and PFOSAPlasma/
LC–MS/MS
PFOS: 28.10 (21.60–35.80), PFOA: 4.28 (3.51–5.49), PFHxS: 1.07 (0.76–1.38), PFNA: 0.46 (0.36–0.57), PFHpS: 0.37 (0.27–0.49), PFDA: 0.17 (0.14–0.22), PFOSA: 2.32 (1.38–4.16) (ng/mL)Wechsler Primary and Preschool Scales of Intelligence–Revised (WPPSI-R)Maternal age at delivery, parity, maternal IQ, socioeconomic status, maternal smoking during pregnancy, maternal alcohol consumption during pregnancy, maternal prepregnancy BMI, child’s sexThere is no reliable evidence establishing a connection between prenatal exposure to PFAS and IQ scores in children at the age of five
Yan Wang/2015/United States [ ]Cohort Studyn = 1205 years oldPFHxS, PFOA, PFOS, PFNA, PFDeA, PFUnDA, PFDoDA, PFHpA, and PFHxASerum/
HPLC–MS/MS
PFHxS: 0.45 (0.35–0.57), PFOA: 2.00 (1.72–2.33), PFOS: 11.5 (10.2–13.07), PFNA: 1.33 (1.12–1.59), PFDeA: 0.39 (0.34–0.44), PFUnDA: 3.05 (2.37–3.94), PFDoDA: 0.29 (0.25–0.34) (ng/mL)Full-Scale Intelligence Quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ)Maternal age, maternal education, previous live births, family income, and maternal fish consumption during pregnancyExposure to two types of long-chain PFAS during pregnancy has been linked to lower IQ scores in children
Maria H Harris/2018/United States [ ]Cohort Studyn = 12263 years oldPFOA, PFOS, PFHxS, PFNA, MeFOSAA, and PFDeAPlasma/
HPLC–MS/MS
PFOA: 4.4 (3.1–6.0), PFOS: 6.2 (4.2–9.7), PFHxS: 1.9 (1.2–3.4), PFNA: 1.5 (1.1–2.3), MeFOSAA: 0.3 (<LOD −0.6), PFDeA: 0.3 (0.2–0.5) (ng/mL)Peabody Picture Vocabulary Test (PPVT-III), Wide Range Assessment of Visual Motor Abilities (WRAVMA), Kaufman Brief Intelligence Test (KBIT-2), and Visual Memory Index of the Wide Range Assessment of Memory and Learning (WRAML2)Child sex, age at cognitive testing, maternal race/ethnicity, age, maternal and paternal education, socioeconomic status and maternal intelligence scoresPrenatal PFAS were associated with both better and worse cognitive scores
Miranda J. Spratlen/2020/United States [ ]Cohort Studyn = 110Children ages 3–7 yearsPFOS, PFOA, PFHxS, PFNA, PFDS, PFBS, PFOSA, PFHxA, PFHpA, PFDA, PFUnDA, and PFDoDAPlasma/
HPLC–MS/MS
PFOS: 6.27 (1.05, 33.7), PFOA: 2.37 (0.18, 8.14), PFNA: 0.45 (<LOQ, 10.3), PFHxS: 0.69 (<LOQ, 15.8), PFDS: 0.13 (<LOQ, 0.64) (ng/mL)Bayley Scales of Infant Development (BSID-II), Mental Development Index (MDI), Psychomotor Development Index (PDI), and Wechsler Preschool and Primary Scale of Intelligence (WPPSI)Maternal age; material hardship during pregnancy; pre-pregnancy BMI; maternal IQ; maternal race; maternal education; home smoking exposure; marital status; parity; child’s gestational age at birth; exact child age on test date; child’s sex; maternal demoralization score; and child breastfeeding historyFindings on prenatal PFAS exposure and child neurodevelopment are inconsistent
Thea S. Skogheim/2020/Norway [ ]Longitudinal Prospective Studyn = 9443.5 years oldPFOA, PFNA, PFDA, PFUnDA, PFHxS, PFHpS, and PFOSPlasma/
LC–MS/MS
PFOA: 2.50 (1.77–3.21), PFNA: 0.41 (0.29–0.53), PFDA: 0.15 (0.10–0.23), PFUnDA: 0.22 (0.14–0.32), PFHxS: 0.65 (0.46–0.88), PFHpS: 0.15 (0.10–0.20), PFOS: 11.51 (8.77–14.84) (ng/mL)The Preschool Age Psychiatric Assessment interview, Child Development Inventory and Stanford–Binet (5th revision)Maternal age, maternal education, maternal fish intake, parity, maternal ADHD symptoms, child sex, premature birth, birth weight, maternal BMI, maternal smoking, maternal alcohol consumption, maternal anxiety/depression and maternal iodine intakeNo consistent evidence to conclude that prenatal exposure to PFAS are associated with cognitive dysfunctions in preschool children aged three and a half years
Boya Zhang/2024/China [ ]Cohort Studyn = 3277 years oldPFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFBS, PFHxS, PFHpS, PFOS, PFDS, and PFOSASerum/
UHPLC–MS/MS
PFHpA: 0.27 (0.23–0.30), PFOA: 3.51 (3.29–3.75), PFNA: 0.32 (0.28–0.36), PFDA: 0.86 (0.76–0.96), PFUnDA: 0.61 (0.57–0.65), PFDoDA: 0.13 (0.12–0.14), PFBS: 0.08 (0.07–0.09), PFHxS: 0.09 (0.08–0.10), PFHpS: 0.06 (0.05–0.07), PFOS: 2.10 (1.98–2.22) (ng/mL)Wechsler Intelligence Scale for Children-Chinese Revised (WISC-CR)Maternal age at delivery, parity, maternal educational level, child’s sex, annual household income, pet ownership, changes in marital status, pre-pregnancy BMIIncreased prenatal exposure to PFAS negatively affected the IQ of school-aged children
First Author/Year/CountryDesignSample SizeAge of ChildrenPFASSample/Measuring MethodExposure MeasureTest Type and IndicatorAdjustment of CovariatesConclusion
Joan Forns/2020/Norway [ ]Cross-Sectional Studyn = 5183, 6, 12, and 24 months of agePFOS and PFOASerum/
HPLC–MS/MS
PFOS: 20.19 (4.1–87.3), PFOA: 1.83 (0.5–5.1) (ng/mL)Attention Syndrome Scale of the Child Behavior Checklist (CBCL-ADHD), Hyperactivity/Inattention Problems subscale of the Strengths and Difficulties Questionnaire (SDQ-Hyperactivity/Inattention), and ADHD Criteria of Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (ADHD-DSM-IV)Maternal prepregnancy body mass index, maternal age at delivery, maternal education, maternal smoking during pregnancy, maternal parity, duration of total breastfeeding, and child sexExposure to PFOS or PFOA early in life was not linked to ADHD during childhood, with odds ratios (ORs) varying between 0.96 (95% CI: 0.87, 1.06) and 1.02 (95% CI: 0.93, 1.11). Analysis using stratified models indicates that the impact of PFAS may vary based on the child’s sex and the mother’s level of education
Louise Dalsager/2021/Denmark [ ]Cohort Studyn = 11382.5–5 years oldPFHxS, PFOS, PFOA, PFNA, and PFDASerum/
LC–MS/MS
PFOS: 4.65 (11.22), PFOA: 2.43 (6.40), PFHxS: 0.32 (0.81), PFNA: 0.58 (1.24), PFDA: 0.18 (0.37), Median (95th percentile) (ng/mL)Child Behavior Checklist 1.5–5Parity, maternal educational level, parental psychiatric diagnosis, child sexNo correlation has been found between PFAS levels in mothers or children and symptoms of ADHD
Johanna Inhyang Kim/2023/South Korea [ ]Prospective Cohort Studyn = 5212, 4, and 8 years oldPFOA, PFNA, PFDA, PFUnDA, PFHxS, and PFOSSerum/
HPLC–MS/MS
PFOA: 3.61 (1.91–6.72), PFNA: 0.99 (0.45–2.96), PFDA: 0.34 (0.12–0.94), PFUnDA: 0.45 (0.17–0.94), PFHxS: 1.01 (0.54–1.95), PFOS: 3.94 (1.80–7.47) (ng/mLADHD Rating Scale IV (ARS) Mother’s age during pregnancy, mother’s educational attainment, father’s educational background, socioeconomic conditions, maternal smoking during pregnancy, use of assisted reproductive technologies, maternal stress levels during pregnancyPFAS exposure at age 2 was associated with ADHD development at age 8
Ann M Vuong/2021/United States [ ]Cohort Studyn = 2405 and 8 years oldPFOA, PFHxS, PDNA, and PFOSSerum/
HPLC–MS/MS
PFOA: 5.3 (1.7), PFOS: 12.8 (1.7), PFHxS: 1.5 (0.8), PFNA: 0.90 (1.5), mean (SD) (ng/mL)The Behavioral Assessment System for Children-2 (BASC-2) and the Diagnostic Interview Schedule for Children–Young Child (DISC-YC) were used to evaluate ADHD symptoms and diagnostic criteriaMaternal age, race/ethnicity, education, family income, ln-maternal serum cotinine (ng/mL), maternal depression, marital status, maternal IQ, parity, and child sexPFOS and PFNA were consistently linked to hyperactive-impulsive ADHD traits across two validated assessment tools
Thea S. Skogheim/2021/Norway [ ]Cohort Studyn = 8213 years oldPFOA, PFNA, PFDA, PFUnDA, PFHxS, PFHpS, and PFOSPlasma/
LC–MS/MS
PFOA: 2.46 (3.46–2.86), PFNA: 0.42 (0.20–0.49), PFDA: 0.19 (0.15–0.23) (ng/mL)Adult ADHD Self-Report Scale (ASRS screener)Child sex, birth weight, and small for gestational age (SGA); maternal age at delivery, education, parity, pre-pregnancy body mass index (BMI, kg/m ), self-reported smoking and alcohol intake during pregnancy, as well as FFQ-based estimates of seafood (g/day), and dietary iodine intake (μg/day)Several PFAS (PFUnDA, PFDA, and PFOS) were inversely associated with odds of ADHD and/or ASD
Sachiko Itoh/2022/Japan [ ]Prospective Cohort Studyn = 7708 years oldPFHxS, PFOS, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFTrDA, and PFTeDAPlasma/
UHPLC–MS/MS
PFHxS: 0.32 (0.22–0.41), PFOS: 6.66 (4.92–8.31), PFOA: 2.48 (1.50–3.00), PFNA: 1.16 (0.79–1.38), PFDA: 0.53 (0.34–0.62), PFUnDA: 1.37 (0.73–1.73), PFDoDA: 0.18 (0.12–0.23), PFTrDA: 0.35 (0.24–0.44) (ng/mL)ADHD Rating Scale (ADHD-RS)Age of the mother at delivery, number of previous pregnancies, level of education, body mass index before pregnancy, alcohol consumption during pregnancy, smoking habits during pregnancy, and the sex of the childHigher the maternal PFAS levels, lower the risk of ADHD symptoms at 8 y of age
Ilona Quaak/2016/The Netherlands [ ]Cohort Studyn = 7618 monthsPFOA, PFOS, PFHxS, PFHpS, PFNA, PFDA, and PFUnDAPlasma/
LC–MS/MS
PFOA: 905.6 (437.1), PFOS: 1583.6 (648.3), PFHxS: 140.0 (69.2), PFHpS: 35.6 (21.3), PFNA: 140.0 (61.8), PFDA: 52.2 (20.9), PFUnDA: 32.05 (11.9), Mean (SD) (ng/L)Child Behavior Checklist 1.5–5 (CBCL)Family history, educational level, smoking, alcohol use and illicit drug use during pregnancyPrenatal exposure to PFAS showed no significant associations with ADHD scores
Thea S. Skogheim/2020/Norway [ ]Cohort Studyn = 9443.5 years oldPFHpS, PFOS, PFHxS, PFOA, PFDA, PFUnDA, and PFNAPlasma/
LC–MS/MS
PFOA: 2.61 (1.77–3.21), PFNA: 0.45 (0.29–0.53), PFDA: 0.19 (0.10–0.23), PFUnDA: 0.25 (0.05–0.32), PFHxS: 0.79 (0.46–0.88), PFHpS: 0.16 (0.10–0.20), PFOS: 12.32 (8.77–14.84), (ng/mL)The Preschool Age Psychiatric Assessment interview, Child Development Inventory and Stanford–Binet (5th revision)Maternal age, maternal education, maternal fish intake, parity, maternal ADHD symptoms, child sex, premature birth, birth weight, maternal BMI, maternal smoking, maternal alcohol consumption, maternal anxiety/depression and maternal iodine intakeConsistent evidence was not found to link prenatal PFAS exposure with ADHD symptoms or cognitive impairments in preschool children around three and a half years old
Zeyan Liew/2015/United States [ ]Cohort Studyn = 220Average 10.7 years oldPFOS, PFOA, PFHxS, PFHpS, PFNA, and PFDAPlasma/
LC–MS/MS
PFOS: 26.80 (19.20, 35.00), PFOA: 4.06 (3.08, 5.50), PFHxS: 0.84 (0.61, 1.15), PFHpS: 0.30 (0.20, 0.40), PFNA: 0.42 (0.34, 0.52), PFDA: 0.15 (0.11, 0.20), (ng/mL)ICD-10 codes F90.0Maternal age at delivery, socioeconomic status, maternal smoking, alcohol drinking during pregnancy, mother’s self-reported psychiatric illnesses, child’s birth year, child’s sexEvidence does not consistently support a link between prenatal PFAS exposure and an increased risk of ADHD
First Author/Year/CountryDesignSample SizeAge of ChildrenPFASSample/Measuring MethodExposure MeasureTest Type and IndicatorAdjustment of CovariatesConclusion
Thea S. Skogheim/2021/Norway [ ]Cohort Studyn = 4003 years oldPFOA, PFNA, PFDA, PFUnDA, PFHxS, PFHpS, and PFOSPlasma/
LC–MS/MS
PFOA: 2.46 (3.46–2.86), PFNA: 0.42 (0.20–0.49), PFDA: 0.19 (0.15–0.23) (ng/mL)Diagnoses of “pervasive developmental disorders” were identified using ICD-10 codes F84.0, F84.1, F84.5, F84.8, or F84.9Child’s sex, birth weight, and status as small for gestational age (SGA); maternal age at delivery, education level, number of previous births, pre-pregnancy body mass index (BMI, kg/m ), self-reported smoking and alcohol consumption during pregnancy, as well as estimates of seafood intake (g/day) and dietary iodine intake (μg/day) based on a food frequency questionnaire (FFQ).An increased risk of Autism Spectrum Disorder (ASD) was observed in the second quartile of PFOA exposure [OR = 1.71 (95% CI: 1.20, 2.45)]. Conversely, PFUnDA, PFDA, and PFOS were associated with a reduced likelihood of ADHD, and the overall PFAS mixture showed a decreased risk of ASD [OR = 0.76 (95% CI: 0.64, 0.90)].
Jiwon Oh/2022/United States [ ]Case–control Studyn = 5512–5 years oldPFOS, PFHxS, PFNA, PFDA, PFPeA, PFUnDA, PFBS, PFHxA, MeFOSAA, and EtFOSAASerum/
HPLC–MS/MS
PFOA: 2.20 (0.91, 6.30), PFOS: 2.01 (0.81, 8.01), PFHxS: 0.59 (0.20, 3.05), PFNA: 0.71 (0.26, 2.49), PFDA: 0.14 (0.06, 0.49), PFPeA: 0.51 (0.20, 1.33), PFHpA: 0.23 (0.03, 1.00), PFUnDA: 0.03 (<LOD, 0.13), PFBS: <LOD (<LOD, 0.10), PFHxA: <LOD (<LOD, 0.43), MeFOSAA: 0.10 (<LOD, 1.56), EtFOSAA: <LOD (<LOD, 0.06) (ng/mL)Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) are combined to generate an Early Learning Composite (Composite) scoreChild’s sex, age at sampling, recruitment regional center; sampling year; gestational age at delivery, maternal factors, parity, breastfeeding duration, race/ethnicity, and socioeconomic status.PFOA was linked to higher odds of ASD, with an odds ratio (OR) of 1.99 per log ng/mL increase (95% CI: 1.20, 3.29). PFHpA also showed increased odds of ASD with an OR of 1.61 (95% CI: 1.21, 2.13). Conversely, perfluoroundecanoic acid (PFUnDA) was associated with lower odds of ASD, showing an OR of 0.43 (95% CI: 0.26, 0.69). Additionally, mixtures of PFAS were associated with increased odds of ASD, with an average OR of 1.57 and a range from the 5th to 95th percentile of 1.16 to 2.13.
Jiwon Oh/2021/United States [ ]Cohort Studyn = 573 years oldPFOA, PFOS, PFHxS, PFNA, PFDA, PFUnDA, PFDoDA, MeFOSAA, and EtFOSAASerum/
Reverse-Phase LC–MS/MS
PFOA: 0.9 (0.3–2.3), PFOS: 3.0 (1.1–6.8), PFHxS 0.4 (0.2–1.6), PFNA 0.5 (0.2–1.0), PFDA 0.1 (<LOD −0.4), PFUnDA 0.1 (<LOD −0.3), PFDoDA: <LOD (<LOD −0.1), MeFOSAA: 0.1 (<LOD −0.8), EtFOSAA <LOD (<LOD-<LOD) (ng/mL)Autism Diagnostic Observation Schedule (ADOS) and Mullen Scales of Early Learning (MSEL)Child’s sex, birth year, maternal vitamin intake in the first month of pregnancy, maternal education, and homeownership.PFOA and PFNA were positively associated with ASD risk, with relative risks (RR) of 1.20 (95% CI: 0.90, 1.61) and 1.24 (95% CI: 0.91, 1.69), respectively, for each 2-fold increase in concentration. In contrast, PFHxS was negatively associated with ASD risk, showing an RR of 0.88 (95% CI: 0.77, 1.01).
Jeong Weon Choi/2024/United States [ ]Cohort Studyn = 2803 years oldPFHxS, PFOS, PFOA, PFNA, and PFDASerum/
Reverse-Phase LC–MS/MS
PFHxS: 0.45 (0.2–1.60), PFOS: 2.93 (1.10–7.00), PFOA: 0.87 (0.35–2.10), PFNA: 0.48 (0.20–1.00), PFDA 0.14 (<LOD −0.40) (ng/mL)Autism Diagnostic Observation Schedule and Mullen Scales of Early Mullen Scales of Early LearningChild sex, child age at assessment, year of birth, gestational age at delivery, maternal age at delivery, parity, maternal pre-pregnancy BMI, maternal race/ethnicity, maternal education, breastfeeding duration, homeownership, maternal smoking status during pregnancy, and child ASD outcome group.PFOS, PFNA, and PFDA were associated with several behavioral problems among children diagnosed with ASD.
Hyeong-Moo Shin/2020/United States [ ]Case–control Studyn = 2392–5 years oldPFOA, PFOS, PFHxS, and PFNAPlasma/
Reverse-Phase HPLC–MS/MS
PFOA: 1.07 (0.37–3.40), PFOS: 3.10 (1.08–10.03), PFHxS: 0.50 (0.20–1.63), PFNA: 0.50 (<LOD −1.23) (ng/mL)Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedules-Generic (ADOS-G)Age and sex of the child at the time of assessment, year of birth, regional center of recruitment, number of previous pregnancies, gestational age at birth, maternal race/ethnicity, place of maternal birth, mother’s age at delivery, maternal BMI before pregnancy, vitamin intake around conception, duration of breastfeeding.Increases in PFHxS and PFOS levels were tentatively connected to a higher risk of ASD diagnosis in children. For each nanogram per milliliter increase, PFHxS had an odds ratio of 1.46 (95% CI: 0.98, 2.18) and PFOS had an odds ratio of 1.03 (95% CI: 0.99, 1.08).
Kristen Lyall/2018/United States [ ]Case–control Studen = 55315–19 weeks gestational ageEt-PFOSA, Me-PFOSA, PFDeA, PFHxS, PFNA, PFOA, PFOS, PFOSASerum/
Negative-ion Turbo Ion Spray–tandem mass spectrometry
Et-PFOSA: 0.68 (0.63, 0.73), Me-PFOSA: 1.14 (1.07, 1.23), PFDeA: 0.17 (0.16, 0.18), PFHxS: 1.39 (1.29, 1.49), PFNA: 0.60 (0.57, 0.63), PFOA: 3.58 (3.41, 3.76), PFOS: 17.5 (16.8, 18.3), PFOSA: 0.11 (0.10, 0.11) (ng/mL)Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV-TR) criteriaChild sex, month and year of birth, maternal age, country of maternal birth, maternal race/ethnicity, parity, and maternal education.While most PFAS prenatal concentrations were not significantly linked to ASD, notable inverse associations were observed for perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS). Specifically, the adjusted odds ratios for the highest versus lowest quartiles were 0.62 (95% CI: 0.41, 0.93) for PFOA and 0.64 (95% CI: 0.43, 0.97) for PFOS.
The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

Currie, S.D.; Wang, J.-S.; Tang, L. Impacts of PFAS Exposure on Neurodevelopment: A Comprehensive Literature Review. Environments 2024 , 11 , 188. https://doi.org/10.3390/environments11090188

Currie SD, Wang J-S, Tang L. Impacts of PFAS Exposure on Neurodevelopment: A Comprehensive Literature Review. Environments . 2024; 11(9):188. https://doi.org/10.3390/environments11090188

Currie, Seth D., Jia-Sheng Wang, and Lili Tang. 2024. "Impacts of PFAS Exposure on Neurodevelopment: A Comprehensive Literature Review" Environments 11, no. 9: 188. https://doi.org/10.3390/environments11090188

Article Metrics

Article access statistics, further information, mdpi initiatives, follow mdpi.

MDPI

Subscribe to receive issue release notifications and newsletters from MDPI journals

IMAGES

  1. How to write a literature review: Tips, Format and Significance

    guidelines in literature review

  2. Literature Review Guidelines

    guidelines in literature review

  3. 50 Smart Literature Review Templates (APA) ᐅ TemplateLab

    guidelines in literature review

  4. 39 Best Literature Review Examples (Guide & Samples)

    guidelines in literature review

  5. Guidelines For Writing A Literature Review

    guidelines in literature review

  6. The Importance of Literature Review in Scientific Research Writing

    guidelines in literature review

VIDEO

  1. Introduction to Literature Review, Systematic Review, and Meta-analysis

  2. Literature Review Process (With Example)

  3. Literature review: Supporting your claim

  4. Literature Review for Research Paper

  5. EDUA630 Assignment 3 Solution with complete guidelines by MALIK HAFEEZ

  6. PRISMA Guidelines| Systematic review

COMMENTS

  1. Writing a Literature Review

    Writing a Literature Review. A literature review is a document or section of a document that collects key sources on a topic and discusses those sources in conversation with each other (also called synthesis). The lit review is an important genre in many disciplines, not just literature (i.e., the study of works of literature such as novels and ...

  2. How to Write a Literature Review

    Examples of literature reviews. Step 1 - Search for relevant literature. Step 2 - Evaluate and select sources. Step 3 - Identify themes, debates, and gaps. Step 4 - Outline your literature review's structure. Step 5 - Write your literature review.

  3. Ten Simple Rules for Writing a Literature Review

    A diversity of feedback perspectives on a literature review can help identify where the consensus view stands in the landscape of the current scientific understanding of an issue . Rule 9: Include Your Own Relevant Research, but Be Objective ... (2005) Writing integrative literature reviews: guidelines and examples. Human Res Develop Rev 4: 356 ...

  4. How To Write A Literature Review

    1. Outline and identify the purpose of a literature review. As a first step on how to write a literature review, you must know what the research question or topic is and what shape you want your literature review to take. Ensure you understand the research topic inside out, or else seek clarifications.

  5. Write a Literature Review

    Literature reviews take time. Here is some general information to know before you start. VIDEO -- This video is a great overview of the entire process. (2020; North Carolina State University Libraries) --The transcript is included. --This is for everyone; ignore the mention of "graduate students". --9.5 minutes, and every second is important.

  6. Literature Review: The What, Why and How-to Guide

    Example: Predictors and Outcomes of U.S. Quality Maternity Leave: A Review and Conceptual Framework: 10.1177/08948453211037398 ; Systematic review: "The authors of a systematic review use a specific procedure to search the research literature, select the studies to include in their review, and critically evaluate the studies they find." (p. 139).

  7. How to write a superb literature review

    The best proposals are timely and clearly explain why readers should pay attention to the proposed topic. It is not enough for a review to be a summary of the latest growth in the literature: the ...

  8. What is a Literature Review?

    A literature review is a survey of scholarly sources on a specific topic. It provides an overview of current knowledge, allowing you to identify relevant theories, methods, and gaps in the existing research. There are five key steps to writing a literature review: Search for relevant literature. Evaluate sources. Identify themes, debates and gaps.

  9. Writing a literature review

    How to write a literature review in 6 steps. How do you write a good literature review? This step-by-step guide on how to write an excellent literature review covers all aspects of planning and writing literature reviews for academic papers and theses.

  10. 5. The Literature Review

    A literature review may consist of simply a summary of key sources, but in the social sciences, a literature review usually has an organizational pattern and combines both summary and synthesis, often within specific conceptual categories.A summary is a recap of the important information of the source, but a synthesis is a re-organization, or a reshuffling, of that information in a way that ...

  11. Steps in Conducting a Literature Review

    A literature review is an integrated analysis-- not just a summary-- of scholarly writings and other relevant evidence related directly to your research question.That is, it represents a synthesis of the evidence that provides background information on your topic and shows a association between the evidence and your research question.

  12. Literature review as a research methodology: An overview and guidelines

    As mentioned previously, there are a number of existing guidelines for literature reviews. Depending on the methodology needed to achieve the purpose of the review, all types can be helpful and appropriate to reach a specific goal (for examples, please see Table 1).These approaches can be qualitative, quantitative, or have a mixed design depending on the phase of the review.

  13. Writing a literature review

    A formal literature review is an evidence-based, in-depth analysis of a subject. There are many reasons for writing one and these will influence the length and style of your review, but in essence a literature review is a critical appraisal of the current collective knowledge on a subject. Rather than just being an exhaustive list of all that ...

  14. PDF Writing an Effective Literature Review

    he simplest thing of all—structure. Everything you write has three components: a beginning, a middle and an e. d and each serves a different purpose. In practice, this means your review will have an introduction, a main body where you review the literature an. a conclusion where you tie things up.

  15. PDF Instructions and Guidelines for Writing a Literature Review

    tu. e review: Abstract, Body, Concluding Remarks, References;3. Use fo. t. imes New Roman, font size 11 and a line spacing of 1. 5; 4. Total length of document should not exc. ed. 15 pages;5. Typical number of references listed 100-150;6. Submit your review in a fo. mat that can be edited by the reviewer.

  16. Guidance on Conducting a Systematic Literature Review

    Literature reviews establish the foundation of academic inquires. However, in the planning field, we lack rigorous systematic reviews. In this article, through a systematic search on the methodology of literature review, we categorize a typology of literature reviews, discuss steps in conducting a systematic literature review, and provide suggestions on how to enhance rigor in literature ...

  17. PDF Instructions and Guidelines for Writing a Literature Review

    advisor and discuss your literature review topic and how to format your review. 1. On the cover page list your name + student number, the title of your literature review, the research group you're in, and the date on which your literature review is submitted; 2. Format of your literature review: Abstract, Body, Concluding Remarks, References; 3.

  18. Literature Review Guidelines

    Your literature review will demonstrate your familiarity with your topic's secondary literature. GUIDELINES FOR A LITERATURE REVIEW: 1) LENGTH: 8-10 pages of text for Senior Theses (485) (consult with your professor for other classes), with either footnotes or endnotes and with a works-consulted bibliography.

  19. Ten Simple Rules for Writing a Literature Review

    Literature reviews are in great demand in most scientific fields. Their need stems from the ever-increasing output of scientific publications .For example, compared to 1991, in 2008 three, eight, and forty times more papers were indexed in Web of Science on malaria, obesity, and biodiversity, respectively .Given such mountains of papers, scientists cannot be expected to examine in detail every ...

  20. Getting started

    What is a literature review? Definition: A literature review is a systematic examination and synthesis of existing scholarly research on a specific topic or subject. Purpose: It serves to provide a comprehensive overview of the current state of knowledge within a particular field. Analysis: Involves critically evaluating and summarizing key findings, methodologies, and debates found in ...

  21. The PRISMA 2020 statement: an updated guideline for reporting ...

    The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, published in 2009, was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found. Over the past decade, advances in systematic review methodology and terminology have necessitated an update to the guideline. The PRISMA 2020 statement ...

  22. How to Do a Systematic Review: A Best Practice Guide for ...

    The best reviews synthesize studies to draw broad theoretical conclusions about what a literature means, linking theory to evidence and evidence to theory. This guide describes how to plan, conduct, organize, and present a systematic review of quantitative (meta-analysis) or qualitative (narrative review, meta-synthesis) information.

  23. Tips for Writing a Literature Review

    A literature review is a compilation of the works published in a particular field of study or line of research, usually over a specific period of time, in the form of an in-depth, critical bibliographic essay or annotated list in which attention is drawn to the most significant works.. Summarizes and analyzes previous research relevant to a topic ...

  24. Literature Review: Conducting & Writing

    Steps for Conducting a Lit Review; Finding "The Literature" Organizing/Writing; APA Style This link opens in a new window; Chicago: Notes Bibliography This link opens in a new window; MLA Style This link opens in a new window; Sample Literature Reviews. Sample Lit Reviews from Communication Arts; Have an exemplary literature review? Get Help!

  25. Literature review guidelines

    Literature review guidelines. Developed by James O'Neill with assistance from Ronald Levant, Rod Watts, Andrew Smiler, Michael Addis, and Stephen Wester. General considerations. A good review should summarize the state of knowledge on a well-defined topic in the psychology of men and masculinity in concise and clear ways. This means that the ...

  26. The right care in the right place: a scoping review of digital health

    A scoping review approach was chosen over a systematic review to address a general, formative review question on this topic that is emerging in the literature and where the literature is complex and heterogenous . An initial preliminary search of the topic in the academic databases, Cochrane Library, Open Science Framework and Prospero registry ...

  27. Prevention and care of adult enterostomy with high output: a scoping

    Introduction The purpose of this protocol is to investigate the risk factors, critical evaluation contents and preventive measures of high-output enterostomy. Methods and analysis This scoping review will follow the Joanna Briggs Institute guidelines for scoping reviews. PubMed, EMBASE, CINAHL, the Chinese Biological Literature Database and the Cochrane Library will be searched for relevant ...

  28. Fertility-sparing treatment and follow-up in patients with cervical

    A systematic, unbiased literature review, which represents a cornerstone for developing evidence-based guidelines, was carried out by an experienced methodologist using MEDLINE (appendix p 4). Literature published between Jan 1, 2003, and June 1, 2023, was reviewed and critically appraised.

  29. Incidence of post-extubation dysphagia among critical care patients

    This systematic review and meta-analysis was conducted adhering to the guidelines outlined in the Joanna Briggs Institute (JBI) Reviewers' Manual and followed the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement (PRISMA 2020) [] (see Additional file 1: Table S1).In addition, it was registered with PROSPERO under the registration number ...

  30. Environments

    Neurodevelopmental disorders (NDDs) encompass a range of conditions that begin during the developmental stage and cause deficits that lead to disruptions in normal functioning. One class of chemicals that is of increasing concern for neurodevelopmental disorders is made up of per- and polyfluoroalkyl substances (PFAS). In this comprehensive literature review, we investigated data from ...