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Grants & funding.

The National Institutes of Health is the largest public funder of biomedical research in the world. In fiscal year 2022, NIH invested most of its $45 billion appropriations in research seeking to enhance life, and to reduce illness and disability. NIH-funded research has led to breakthroughs and new treatments helping people live longer, healthier lives, and building the research foundation that drives discovery.

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NIH’s central resource for grants and funding information.

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Find Funding

NIH offers funding for many types of grants, contracts, and even programs that help repay loans for researchers.

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Grant applications and associated documents (e.g., reference letters) are due by 5:00 PM local time of application organization on the specified due date.

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Instructions for submitting a grant application to NIH and other Public Health Service agencies.

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By accepting a grant award, recipients agree to comply with the requirements in the NIH Grants Policy Statement unless the notice of award states otherwise.

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News, updates, and blog posts on NIH extramural grant policies, processes, events, and resources.

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Explore opportunities at NIH for research and development contract funding.

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The NIH Loan Repayment Programs repay up to $50,000 annually of a researcher’s qualified educational debt in return for a commitment to engage in NIH mission-relevant research.

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We fund research to improve life, health and wellbeing through new knowledge and understanding.

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Research to inform and accelerate interventions that reduce the impact of infectious diseases. 

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Research to better understand anxiety, depression and psychosis and develop new ways to intervene earlier. 

Funding opportunities

We’re spending £16 billion in the decade to 2032 on a range of activities to enable discoveries and advance solutions for urgent health challenges. Our funding covers a broad scope of research, including physical and social sciences, clinical research and humanities.  

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Common Fund Programs with Open Funding Opportunities

This page last reviewed on September 10, 2024

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NIGMS Funding Opportunities for Research Funding

The following list provides links to announcements regarding NIGMS-supported funding opportunities related to the Institute's various research initiatives, as published in the online NIH Guide for Grants and Contracts .

Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) (R24 - Clinical Trial Not Allowed)

• Mechanism : R24
• Release Date : Aug. 12, 2024
• Expiration Date : Jan. 28, 2027

B-INSPIRE: Research on Behavioral Interventions that Promote Careers in the Biomedical Research Enterprise (R01 - Clinical Trial Not Allowed)

• Mechanism : R01
• Release Date : Jun. 27, 2024
• Expiration Date : Oct. 15, 2026

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)

• Mechanism : R15
• Release Date : May 08, 2024
• Expiration Date : May 08, 2027

Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)

• Mechanism : R16
• Release Date : Mar. 14, 2024
• Expiration Date : Jan. 08, 2027

Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)

Nih support for conferences and scientific meetings (parent r13 clinical trial not allowed).

• Mechanism : R13
• Release Date : Mar. 06, 2024

Single Source: The NIGMS Human Genetic Cell Repository (U42 - Clinical Trial Not Allowed)

• Mechanism : U42
• Release Date : Dec. 15, 2023
• Expiration Date : Jun. 11, 2026

Assessment of Climate at Institutions (ACt) Award (RC2 - Clinical Trial Not Allowed)

• Mechanism : RC2
• Release Date : Dec. 07, 2023
• Expiration Date : Feb. 21, 2026

Native American Research Centers for Health (NARCH) Planning Grants (R34 - Clinical Trial Not Allowed)

• Mechanism : R34
• Release Date : Nov. 28, 2023
• Expiration Date : Jul. 09, 2026

Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (U24 Clinical Trial Not Allowed)

• Mechanism : U24
• Release Date : Aug. 30, 2023
• Expiration Date : Jan. 26, 2026

IDeA Clinical and Translational Research Network (CTR-N) Award (P50 - Clinical Trial Optional)

• Mechanism : P50
• Release Date : Aug. 29, 2023
• Expiration Date : Oct. 10, 2025

IDeA Clinical and Translational Research Development (CTR-D) Award (P20-Clinical Trial Optional)

• Mechanism : P20

Limited Competition: Centers of Biomedical Research Excellence (COBRE) (Phase 3) - Transitional Centers (P30 Clinical Trial Optional)

• Mechanism : P30
• Release Date : Jul. 11, 2023
• Expiration Date : Oct. 01, 2025

Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional)

• Mechanism : S06
• Release Date : Jun. 02, 2023
• Expiration Date : Aug. 08, 2026

Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 - Clinical Trial Optional)

• Mechanism : R35
• Release Date : Apr. 24, 2023
• Expiration Date : Feb. 04, 2026

STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed)

• Mechanism : UC2
• Release Date : Apr. 19, 2023
• Expiration Date : Sep. 19, 2025

Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)

• Mechanism : S10
• Release Date : Mar. 21, 2023
• Expiration Date : Jun. 03, 2025

Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional)

• Release Date : Mar. 16, 2023
• Expiration Date : May 08, 2026

Biomedical Technology Optimization and Dissemination Center (BTOD)(RM1-Clinical Trial Not Allowed)

• Mechanism : RM1
• Release Date : Mar. 07, 2023
• Expiration Date : Jan. 28, 2026

IDeA Networks of Biomedical Research Excellence (INBRE) (P20 Clinical Trial Optional)

• Release Date : Feb. 10, 2023
• Expiration Date : May 23, 2025

Collaborative Program Grant for Multidisciplinary Teams (RM1 - Clinical Trial Optional)

• Release Date : Feb. 03, 2023

Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)

• Release Date : Jan. 30, 2023
• Expiration Date : Jan. 08, 2026

Limited Competition: Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) (P20 - Clinical Trial Optional)

• Release Date : Dec. 20, 2022
• Expiration Date : May 29, 2025

Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional)

• Release Date : Sep. 14, 2022
• Expiration Date : Jan. 31, 2025

Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)

• Release Date : May 24, 2022
• Expiration Date : May 17, 2025

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)

• Mechanism : UG3/UH3
• Release Date : May 09, 2022
• Expiration Date : Oct. 18, 2024

Limited Competition: NIGMS Mature Synchrotron Resources for Structural Biology (P30 - Clinical Trial Not Allowed)

• Release Date : Apr. 19, 2022
• Expiration Date : Oct. 11, 2024

Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)

• Mechanism : R21
• Release Date : Mar. 21, 2022
• Expiration Date : May 08, 2025

Focused Technology Research and Development (R01 Clinical Trial Not Allowed)

Research project grant (parent r01 clinical trial required).

• Release Date : May 05, 2020
• Expiration Date : Jan. 08, 2025

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

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OPTIMIZE YOUR IMPACT

We are a non-profit consultancy that helps foundations and trusts that invest in medical research to optimize their impact, by providing expert scientific advice, world-class review committees, and professional grants management. We have been developing high-impact biomedical research funding programs that accelerate medical discoveries and advance public health since 1957 as The Medical Foundation at HRiA.

Who we serve:

Are you a big picture thinker concerned mainly with end results? Or do you like to be part of the process and stay involved in decision-making along the way? We serve clients with diverse working styles and levels of engagement, to meet their needs for high quality strategic planning and program management. Clients and partners have included private family foundations, bank trusts, and individual donors.

Research & strategic planning

Are you interested in exploring a new strategy to drive progress in biomedical research or do you have an existing strategy that you’d like to update hria explores the funding landscape for investment and provides planning services for grant programs, so that your funds generate optimal impact..

Making a meaningful impact requires understanding the research landscape and targeting investments to unmet needs. We work with clients to (1) understand and explore topic areas of potential interest, to (2) develop strategic priorities and funding initiatives that match the scale of their planned investments, and to (3) implement methods to measure investment impact going forward. Client areas of interest range from specific diseases, to the career trajectories of investigators, to diversity and equity in research topics and career pathways. We draw on our decades of experience in biomedical research grantmaking, our professional staff of scientific advisors, and our extensive network of active researchers and experts in academia and biotechnology. We empower our clients with the information they need to build the foundation for the launch of a new funding initiative, or to strengthen an existing one.

Our research and planning process begins with a Landscape Scan. We collect and synthesize information to describe the research environment, in order to prevent duplication of efforts and to identify gaps and opportunities. Landscape scans typically include:

• Literature review to synthesize findings from scientific studies to identify opportunities and strategies
• Quantitative and qualitative analysis of the current research funding landscape, including government and private investments in research
• Interviews and surveys of stakeholders including scientific experts, academic administrators, major funders, and researchers likely to be eligible for the awards.

Program design

Do you seek to design a biomedical research funding initiative to implement your strategic vision hria collaborates with our partners and clients to design funding initiatives and grant programs that align with your vision, mission, and strategy..

The pace of research innovation has accelerated dramatically in recent years, due to unprecedented technological and computational advances. We specialize in finding new and emerging opportunities in the rapidly evolving research landscape, and in developing funding initiatives that are uniquely innovative. We excel at identifying creative, cutting-edge strategies to support researchers and drive meaningful progress. We actively maintain a broad and deep understanding of the current research funding landscape, and work with our clients to ensure their investments are differentiated in a way that will add value in this context.

Program management

Are you looking for an experienced partner to implement your vision in biomedical research grantmaking hria provides grantmaking advisory and implementation services to execute your investment vision..

While the research funding ecosystem is large, game-changing approaches to research funding often start small. We help our clients pilot new ways to tackle both emerging and long-standing gaps and unmet needs in biomedical research. On behalf of our clients we manage biomedical research programs supporting postdoctoral fellows, junior faculty, and individual research scientists. We build Scientific Review Committees and recruit world-class scientists to impartially review and recommend researchers and research projects for funding. Each year, more than 100 internationally recognized scientists and physicians from across the United States and Europe serve as scientific advisors to our clients’ programs. Our management of grant programs and commitment to scientific rigor is reflected in the thousands of former award recipients whose research has impacted their fields.

Learning & evaluation

Do you seek rigorous and innovative ways to assess the impact of your philanthropic investments are you looking for opportunities to iterate to improve the impact of your investment hria evaluates the impact of your investments using rigorous methods to determine the impact of funding initiatives..

We evaluate the impact of existing investments in biomedical research using quantitative and qualitative methods and provide recommendations to maximize impact moving forward. While each evaluation is customized to the needs of the client, we typically start with an articulation of how the program is expected to make a difference in the world. Based on this, we identify key evaluation questions and measurable indicators of success to help answer these questions. We collect data from relevant sources such as progress reports, the scientific literature, funding records, and surveys and interviews with stakeholders such as awardees, experts and review committee members, clinicians, key academic administrators, and other funders, in order to assess if the program is on track to meet its goals. In some cases we also conduct an updated scan of the research landscape, to determine if the program is still solving the right problem, and synthesize this information with the findings of the program evaluation in order to develop recommendations.

In cases where the research landscape and/or context of the program have evolved, we identify the most pressing current issues, gaps, and opportunities in this funding area, and suggest options to deploy an investment to address them. In situations where the central problem the program addresses remains critical, we suggest ways to improve the program in order to solve that problem faster or better.

We encourage clients to measure their impact prospectively. To support this work we develop customized learning agendas that use logic models to develop customized evaluation plans with specific, measurable short- and long-term outcomes, and strategies to collect data prospectively moving forward.

Research capacity building

Do you have a strong existing program and a desire to invest more broadly to support its aims are you considering add-on investments such as scientific convenings, mentoring programs, training in science communication, and initiatives to increase the number of researchers from demographic groups currently underrepresented in biomedical research hria builds the capacity of grant recipients to make a difference by facilitating diverse forms of support to grantees including scientific convenings, networking events, communications training, and initiatives to increase diversity and inclusion in science..

We develop and implement a diverse range of programmatic enhancements, in order to address the specific needs and gaps in specific sectors and to increase our clients’ investment impact. Our capacity building initiatives include:

• Fostering collaboration and networking within a scientific community through scientific convenings,
• Supporting junior researchers with mentoring opportunities tailored to their career stage and needs,
• Improving the communication of science within and outside of the scientific community by providing tools and training to help researchers enhance their scientific communication and presentation skills,
• Increasing the number of researchers from demographic groups currently underrepresented in biomedical research through targeted strategies including coaching and support in preparing proposals, mentoring opportunities, and the redesign of grant program materials and processes to elicit strong proposals from these groups,
• Exploring and developing partnerships with other funders, businesses, and the public sector to advance the client’s mission, and
• Strengthening the research infrastructure by creating investment opportunities focused on scientific resource development, including large scale data collection and the development and dissemination of tools and techniques.

Open Funding Opportunities

Charles h. hood foundation child health research awards program, postdoctoral fellowship awards, charles a. king trust postdoctoral research fellowship program, charles a. king trust postdoctoral research fellowship program – basic and preclinical science, charles a. king trust postdoctoral research fellowship program – clinical and implementation research, robert e. leet and clara guthrie patterson trust mentored research award, the hilda and preston davis foundation awards program for eating disorders research: senior postdoctoral fellows, junior faculty awards, smith family awards program for excellence in biomedical research, smith family foundation: odyssey award, the hilda and preston davis foundation awards program for eating disorders research: junior faculty, research awards, alagille syndrome accelerator award, deborah munroe noonan memorial research fund, dr. ralph and marian falk medical research trust – catalyst awards program, dr. ralph and marian falk medical research trust – transformational awards program, edward n. and della l. thome memorial foundation awards program in age-related macular degeneration research, edward n. and della l. thome memorial foundation awards program in alzheimer’s disease drug discovery research, harold s. geneen charitable trust awards program for coronary heart disease research, jeffress trust awards program in research advancing health equity, privacy overview.

Research Opportunities

There are NIH programs that help to prepare the skilled, creative, and diverse biomedical research workforce of tomorrow. This page contains information on how to find funding opportunities, an overview on the grants process, and interactive guides on research career pathways. 

NIH Funding

Grants process overview & how to apply, other research funding portals.

One way to identify the types of grants for which you are eligible to apply is by choosing your career path . NIH has programs to support stages from undergraduate to established investigator.

You can also search for opportunities based on each type of program. These include individual programs you apply for directly and institutional programs that your institution may participate in to support groups of students with research and career development opportunities.

NIH understands that a diverse, inclusive workforce is critical to achieving the goals of turning discovery into health. NIH is deeply committed to advancing diversity and inclusion and provides various opportunities tailored to underrepresented groups. Learn more here .

Interactive guides created by the Division of Biomedical Research Workforce (DBRW) describe NIH programs and provide links to support training and career development of biomedical scientists:

• Physician-Scientist Infographic
• Veterinarian-Scientist Infographic
• Dentist-Scientist Infographic
• Research Scientist Infographic

Funding opportunities are located throughout the DBRW website. The ones below represent just a snapshot of opportunities that are specific to the promotion, advancement, and retention of women in biomedical research careers. You are encouraged to contact your Institute or Center (IC) to find information on current opportunities.

NIH provides programs to investigators at various stages and backgrounds to assist in the support of a research project, as well as mentoring and training aimed at advancing the diversity and preparedness of the biomedical research workforce. NIH supplements are awarded to existing grants and serve different purposes.

Some examples of NIH’s supplement programs available for individuals are:

• Research Supplements to Promote Re-Entry, Re-integration into, and Re-training in Health-Related Research Careers (Admin Supp - Clinical Trial Not Allowed) (NOT-OD-23-170)
• Primary Caregiver Technical Assistance Supplements (PCTAS) (Admin Supp Clinical Trial Optional)
• Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) (PA-23-189)
• Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) (PA-21-345)
• Notice of Special Interest: Administrative Supplements to Promote Research Continuity and Retention of NIH Mentored Career Development (K) Award Recipients and Scholars ( NOT-OD-23-031 )
• Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards ( NOT-OD-23-032 )

Individual programs also provide independent research support during the transition from one career stage to another in order to help awardees launch independent research careers.

• BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)
• Individual Predoctoral to Postdoctoral Fellow Transition Award (F99/K00)

More established investigators looking to develop programs that pay it forward and provide training and career opportunities, NIH has myriad Research Education Program (R25) grants—which support research education activities that complement or enhance the training of early-stage investigators—such as:

• Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)
• NIH Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP-ENDURE) (R25 Clinical Trial Not Allowed)
• Providing Research Education Experiences to Enhance Diversity in the Next Generation of Substance Abuse and Addiction Scientists (R25 - Clinical Trials Not Allowed)
• Short-Term Research Education Program to Increase Diversity in Health-Related Research (R25 Clinical Trial Not Allowed)

There are also funding opportunities that are designed to protect and retain women in biomedical careers.

• Interventions Designed to Change the Culture to Mitigate or Eliminate Sexual Harassment in the Biomedical Research Enterprise

Lastly, NIH provides other institutional opportunities to connect well-established investigators with earlier-stage investigators with shared research interests for additional mentoring, training, and career development opportunities.

• Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) (K12 Clinical Trial Optional)
• Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) (K99/R00 and UE5)

• Doris Duke Fellowships for the Promotion of Child Well-Being : The fellowships are designed to identify and develop leaders who conduct practice- and policy-relevant research that enhances child development and improves the Nation’s ability to prevent all forms of child maltreatment.
• Graduate Women in Science (GWIS) National Fellowship Program : The GWIS National Fellowship Program helps increase knowledge in the natural sciences and encourages academic and professional careers in the sciences by women. 
• Hanna H. Gray Fellows Program : The goal of this program, from the Howard Hughes Medical Institute (HHMI), is to recruit and retain individuals from gender, racial, ethnic, and other groups underrepresented in the life sciences, including those individuals from disadvantaged backgrounds. Through their successful careers, HHMI Hanna Gray Fellows will become leaders in academic research and inspire future generations of scientists from America’s diverse talent pool.
• L’Oréal USA For Women in Science Fellowship : This program awards five women postdoctoral scientists annually with grants of $60,000 each for their contributions in science, technology, engineering, and math (STEM) fields and commitment to serving as role models for younger generations. 
• Research Professional
• Funding Institutional (Elsevier)
• ResearchGate (only open to U.S.-based members)

Page last updated on October 31, 2023

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Biomedical Research Funding

An Endocrine Society Position Statement

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INTRODUCTION

A half century of investment by the United States Federal Government in biomedical research has dramatically advanced the health and improved the lives of the American people. Funding for the National Institutes of Health (NIH) specifically has had a significant impact on the United States’ global preeminence and development of a biomedical research enterprise that is unrivaled throughout the world. Biomedical research entails understanding how the body works and investigating what happens in human disease. A vital field of study for maintaining human health is endocrinology, which involves the investigation of hormones and the role they play in the body’s daily function. This includes research to help us understand how changes in hormones contribute to disease. Basic and clinical endocrine scientists funded by NIH conduct research that leads to the development of treatments for endocrine disorders and diseases including diabetes, some cancers, obesity, thyroid disorders, and infertility. These conditions affect millions of people in the US and create a significant health and economic burden on society. The development and discovery of treatments for diabetes, obesity, cancer, cardiovascular disease and others are available today thanks to NIH funding.

The NIH is comprised of 27 institutes and centers and annually invests more than $35 billion in extramural research funded throughout the country. 1 More than 80% of the NIH’s funding is awarded through over 55,000 competitive grants to more than 300,000 researchers at over 2,500 universities, medical schools, and other research institutions around the United States and throughout the world. 2 There is no single NIH institute focused on endocrine research. Instead, clinical and basic endocrine-related research is supported though at least 18 different NIH institutes and centers such as the National Institute of Diabetes and Digestive and Kidney Disease, National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Cancer Institute, and National Institute of Environmental Health Sciences.

Federally funded biomedical research is supported primarily through appropriations to the NIH and provides opportunities to conduct foundational and translational research that is not performed in the private sector or other government agencies. The United States Congress has historically shown bipartisan support for biomedical research by increasing the NIH budget. From 1998 to 2003, the Congress committed to double the budget of the NIH from $13.6 billion to $27.3 billion. However, this was followed by a period of stagnant growth for the agency. Then, from Fiscal Year (FY) 2016-FY 2023, the NIH saw funding increases each year with bipartisan support, with the FY 2023 budget reaching $47.5 billion. 3 Despite this support, NIH funding is not keeping pace with inflation as FY 2024 appropriated funds for NIH have not achieved considerable growth in real terms relative to FY 2003 funding levels. 1 Without funding increases that account for inflation or investment in real growth in the biomedical research enterprise, the opportunities to discover lifechanging cures and treatments will drastically decrease.

CONSIDERATIONS

Since the doubling of its budget, the NIH has typically received annual funding increases at or below the rate of biomedical inflation; consequently, the purchasing power of NIH funding initially peaked in FY 2003 and steadily declined for more than a decade until more substantial funding increases began in FY 2016. However, the FY 2022 purchasing power was still only 0.6% greater than the FY 2003 level. 3 As a result, the NIH budget cannot sufficiently fund many of the highly meritorious research grants received from investigators and scored highly during peer review. While the total number of awards funded by NIH has recovered due to recent increases in the NIH budget, success rates of being awarded a grant are close to the lowest they have ever been. At present, roughly one in five projects are supported. 4

Not only does the low success rate affect the number of scientists who are able to continue their research and discover new treatments and cures, it also has a significant impact on the United States economy. Policymakers need to understand the positive impact that research programs have on the health and economy of the country.

Increased longevity and improved quality of life

Federally funded endocrine-related research has resulted in significant advances in the prevention and treatment of some of the nation’s most prevalent diseases at a fraction of what it would cost to manage these conditions. For instance, NIH-funded studies have found that in post-menopausal women, one of the best predictors of fracture is bone mineral density of the hip. This finding resulted in a better method for identifying those at risk for osteoporosis, which in turn prevents expensive and debilitating fractures that cost $17 billion annually in direct care. 5 Another impact of NIH research is focused on the management of Type 1 diabetes (T1D), which affects 1.6 million adults in the US.   People with T1D cannot make insulin and must rely on external sources of insulin to survive.   Monitoring insulin levels and when and how much to dose can be complicated for users, particularly children. To address this, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) within the NIH funded researchers developed a device known as a “bionic pancreas”, which uses next-generation technology to automatically deliver insulin to those with T1D. 6 Not only is the bionic pancreas more effective at maintaining blood glucose levels, it is also easier to use and leads to improved quality of life. This was made possible not only through funding of this project, but also through sizeable investments in basic research in the decades prior to establish the mechanism of how T1D leads to dysregulation of blood glucose levels. Additionally, studies conducted by the NIH have found that with intensive lifestyle intervention, a patient’s risk of getting type 2 diabetes can be reduced by 58%, and that the drug metformin can reduce the development of diabetes by 31%. 7 These interventions in improve quality of life for those living with diabetes and reduce associated health care costs. Diabetes affects 11% of the entire US population, and $1 out of every $4 in US health care costs is spent on care for people with diabetes. 8 However, if funding levels for biomedical research do not keep pace with inflation, breakthroughs in medical care to address this need will never be realized.

Impact on the national, regional, and local economy

Funding for biomedical research fuels the local, regional, and national economy. For every $1 invested in NIH funding, there is a $2.46 return on investment. This means that the $37.81 billion awarded to NIH scientists in FY 23 lead to $92.89 billion in economic activity. 1 NIH funding supports basic, translational, and clinical science, ensuring that the discoveries made in the laboratory translate to treatment options for patients suffering from debilitating and life-threatening diseases. Advances in treatment also reduce the health care costs of our nation. As the population of the United States ages, the incidence of costly, chronic conditions such as diabetes, obesity, cardiovascular disease and cancer, will significantly increase. To save the country billions in healthcare costs, additional investment in biomedical research will be needed. Studies on the effectiveness of investing in research has identified significant savings on health care: for instance, treatments that delay or prevent diabetic retinopathy save the country $1.6 billion a year, 9 and prevention programs that reduce the risk of developing type 2 diabetes can result in a net savings to Medicare of $2 billion over 10 years. 10

In addition to the impact that research has on spending on health care for the nation’s citizens, research funding also has a positive impact on local economies by supporting the development of new, high-paying jobs. FY 2023 NIH funding created over 400,000 jobs in the US. 1 In Los Angeles, each dollar of taxpayer investment received by the University of California Los Angeles, generates $21 in economic activity, resulting in a $16.6 billion impact on the region. 11 The jobs created by federal dollars directly impact those conducting   research, and also support staff who operate “core” research facilities that provide specialized resources for numerous labs, administer grant submission and compliance at universities, and many others that directly or indirectly support the research enterprise. Without federal research funding, the revenue injected into local and regional economies would be lost, significantly impacting not only those individuals directly involved in research, but also affecting industries that depend on downstream revenue.

Global competitiveness and leadership in science and the economy

Bolstering research funding is imperative for the success of the US biomedical research enterprise and leadership in the global economy. US R&D expenditures relative to the global share of R&D has declined over nineteen years from 37.1% in 2000 to 27.3% in 2019. 12 As the amount of federal research funding remains flat or begins to decline, so do the opportunities for the US to maintain its leadership and competitiveness in R&D globally. A decline in funding can translate to a depletion of America’s pool of scientific talent, thereby reducing the US’s ability to drive discoveries and innovation in all sectors of the economy.

A survey conducted by Research!America revealed that public sentiment supports federal funding of research as 73% of Americans feel it is very important for the US to be a leader in medical and health research. 13 61% say current spending on research to prevent, cure, and treat disease is not enough. 14 In fact, 63% of Americans say they are willing to pay more in taxes in support of health research. 15 These survey data highlight the need for policymakers to prioritize investments in research to maintain the country’s global leadership.

• The Endocrine Society is deeply concerned about the future of biomedical research in the United States without sustained support from the federal government.
• The Endocrine Society strongly supports increased federal funding for biomedical research to provide the additional resources needed to enable scientists to address the burgeoning scientific opportunities, identify better treatments, find cures for diseases, and maintain the country’s status as the preeminent research enterprise.
• The Endocrine Society recommends the National Institutes of Health receive funding of at least $51.303 billion in FY 2025.
• The Endocrine Society recommends funding for the Advanced Research Projects Agency for Health (ARPA-H) be separate from NIH base funding.
• The Endocrine Society endorses the funding recommendations from the Federation of American Societies for Experimental Biology (FASEB) for other agencies that support biomedical research.
• 2022 Update: NIH’s Role in Sustaining the U.S. Economy. United for Medical Research. https://unitedformedicalresearch.org/annual-economic-report/ . Updated in 2022. Accessed March 8, 2023.
• Overview of FY 2023 Executive Summary. Office of Budget, National Institutes of Health. https://officeofbudget.od.nih.gov/pdfs/FY23/br/Overview%20of%20FY%202023%20Executive%20Summary.pdf . Updated in 2022. Accessed March 8, 2023
• National Institutes of Health (NIH) Funding: FY 1996-FY 2023. Congressional Research Service. https://sgp.fas.org/crs/misc/R43341.pdf. Updated May 20 , 2022. Accessed March 8, 2022.
• Success Rates: R01-Equivalent and Research Project Grants. NIH Data Book, NIH RePORT. https://report.nih.gov/nihdatabook/category/10 . Updated in 2022. Accessed March 8, 2022.
• Tran O, Silverman S, Xu X, Bonafede M, Fox K, McDermott M, Gandra S. Long-term direct and indirect economic burden associated with osteoporotic fracture in US postmenopausal women. Osteoporos Int. 2021 Jun;32(6):1195-1205. doi: 10.1007/s00198-020-05769-3. Epub 2021 Jan 7. Erratum in: Osteoporos Int. 2022 Aug;33(8):1835. PMID: 33411007; PMCID: PMC8128807.
• Bionic Pancreas Simplifies Management of Type 1 Diabetes. NIH Research Matters, National Institutes of Health. https://www.nih.gov/news-events/nih-research-matters/bionic-pancreas-simplifies-management-type-1-diabetes . Updated October 18, 2022. Accessed March 10, 2023.
• About the National DPP. National Diabetes Prevention Program, Centers for Disease Control and Prevention. https://www.cdc.gov/diabetes/prevention/about.htm . Updated on December 27, 2022. Accessed March 8, 2023.
• American Diabetes Association. Economic costs of diabetes in the US in 2017. Diabetes Care. 2018;41(5):917–928.
• Medical Research: Saving Lives, Reducing the Cost of Health Care, Powering the Economy. Research!America. http://www.researchamerica.org/sites/default/files/uploads/ EconomicFactSheet.pdf. Created November 9, 2012. Accessed May 11, 2017.
• Thorpe, K. and Z. Yang. Enrolling People with Prediabetes Ages 60-64 in a Proven Weight Loss Program Could Save Medicare $7 billion or More. Health Affairs. September 2011.
• Systemwide Economic, Fiscal, and Social Impact Analysis. The University of California. https://universityofcalifornia.edu/sites/default/files/economic-impact-report-2021.pdf . Updated January 2021. Accessed March 8, 2023.
• The State of U.S. Science and Engineering 2022. U.S. and Global Research and Development. Science & Engineering Indicators, NSF. https://ncses.nsf.gov/pubs/nsb20221/u-s-and-global-research-and-development . Updated January 2022. Accessed March 28, 2024.
• January National Survey. Research!America. https://www.researchamerica.org/wp-content/uploads/2024/02/January-2024-National-Survey-Release.pdf . Updated in February 2024. Accessed March 28, 2024.
• America Speaks! Poll Data Summary, Research! America. https://www.researchamerica.org/wp-content/uploads/2022/09/PollDataSummary_vol20.pdf . Updated in 2020. Accessed March 8. 2023.
• America Speaks! Poll Data Summary, Research! America. https://www.researchamerica.org/wp-content/uploads/2023/05/America-Speaks-Poll-Data-Summary-Volume-23.pdf Updated in 2023. Accessed March 28. 2024.

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