= 20%
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Please note you do not have access to teaching notes, using monte carlo simulation to refine emergency logistics response models: a case study.
International Journal of Physical Distribution & Logistics Management
ISSN : 0960-0035
Article publication date: 7 September 2010
The purpose of this paper is to provide a framework for the development of emergency logistics response models. The proposition of a conceptual framework is in itself not sufficient and simulation models are further needed in order to help emergency logistics decision makers in refining their preparedness planning process.
The paper presents a framework proposition with illustrative case study.
The use of simulation modelling can help enhance the reliability and validity of developed emergency response model.
The emergency response model outcomes are still based on simulated outputs and would still need to be validated in a real‐life environment. Proposing a new or revised emergency logistics response model is not sufficient. Developed logistics response models need to be further validated and simulation modelling can help enhance validity.
Emergency logistics decision makers can make better informed decisions based on simulation model output and can further refine their decision‐making capability.
The paper posits the contribution of simulation modelling as part of the framework for developing and refining emergency logistics response.
Banomyong, R. and Sopadang, A. (2010), "Using Monte Carlo simulation to refine emergency logistics response models: a case study", International Journal of Physical Distribution & Logistics Management , Vol. 40 No. 8/9, pp. 709-721. https://doi.org/10.1108/09600031011079346
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2014, European J. of Industrial Engineering
… of the INFORMS conference, Seattle, WA
Transportation Research Board 93rd Annual Meeting
Reza Faturechi
In the event of an unnoticed man-made or natural disaster, city and metropolitan areas are required to deliver prophylactic medications or emergency relief supplies to their entire residents within a restricted time window via previously selected points of dispensing (PODs). Inventory of such supplements at PODs should not reach the negative stock at any times. Medical inventory management; thus, can be formulated as Inventory Slack Routing Problems (ISRPs), which are known to be NP-Hard. Solution algorithm developed herein is based on three phases: routing and scheduling of supply vehicles to PODs and defining delivery quantities to each POD. Heuristic approaches are proposed for the first two phases, results of which are employed in the third phase to obtain the exact delivery quantities. The proposed algorithms are later tested on county public health departments in the state of Maryland facing emergency situation that requires dispense of one type of prophylactic medicine to its entire population. The proposed approach outperforms the existing methods in terms of the delivery slack as well as its generic applicability in different conditions (geographical location of the depot and PODs, resource availability…). Modifications and detailed comparison with earlier methodologies are provided and followed by sensitivity analyses guiding decision makers towards an efficient and essential investment in public health section.
Jyotirmoy Dalal
Annals of Operations Research
Ediz Ekinci
Logistics planning in emergency situations involves dispatching commodities (e.g., medical materials and personnel, specialised rescue equipment and rescue teams, food, etc.) to distribution centres in affected areas as soon as possible so that relief operations are accelerated. In this study, a planning model that is to be integrated into a natural disaster logistics Decision Support System is developed. The model addresses the dynamic time-dependent transportation problem that needs to be solved repetitively at given time intervals during ongoing aid delivery. The model regenerates plans incorporating new requests for aid materials, new supplies and transportation means that become available during the current planning time horizon. The plan indicates the optimal mixed pick up and delivery schedules for vehicles within the considered planning time horizon as well as the optimal quantities and types of loads picked up and delivered on these routes. In emergency logistics context, supply is available in limited quantities at the current time period and on specified future dates. Commodity demand is known with certainty at the current date, but can be forecasted for future dates. Unlike commercial environments, vehicles do not have to return to depots, because the next time the plan is re-generated, a node receiving commodities may become a depot or a former depot may have no supplies at all. As a result, there are no closed loop tours, and vehicles wait at their last stop until they receive the next order from the logistics coordination centre. Hence, dispatch orders for vehicles consist of sets of “broken” routes that are generated in response to time-dependent supply/demand. The mathematical model describes a setting that is considerably different than the conventional vehicle routing problem. In fact, the problem is a hybrid that integrates the multi-commodity network flow problem and the vehicle routing problem. In this setting, vehicles are also treated as commodities. The model is readily decomposed into two multi-commodity network flow problems, the first one being linear (for conventional commodities) and the second integer (for vehicle flows). In the solution approach, these sub-models are coupled with relaxed arc capacity constraints using Lagrangean relaxation. The convergence of the proposed algorithm is tested on small test instances as well as on an earthquake scenario of realistic size.
International Journal of Engineering Technologies and Management Research
INTERNATIONAL JOURNAL OF ENGINEERING TECHNOLOGIES AND MANAGEMENT RESEARCH I J E T M R JOURNAL
Emergency response preparedness increases disaster resilience and mitigates its possible impacts, mostly in public health emergencies. Prompt activation of these response plans and rapid optimization of delivery models and are essential for effective management of emergencies and disaster. In this paper, existing computational models and algorithms for routing deliveries and logistics during public health emergencies are identified. An overview of recent developments of optimization models and contributions, with emphasis on their applications in situations of uncertainties and unreliability, as obtainable in low-resource countries, is presented. Specific recent improvements in biologically-inspired and intelligent algorithms, genetic algorithms, and artificial immune systems techniques are surveyed. The research gaps are identified, and suggestions for potential future research concentrations are proffered.
Computers & Industrial Engineering
Fernando Ordóñez
Alistair Clark
This paper discusses the practical aspects and resulting insights of the results of a two-stage mathematical network flow model to help make the decisions required to get humanitarian aid quickly to needy recipients as part of a disaster relief operation. The aim of model is to plan where to best place aid inventory in preparation for possible disasters, and to make fast decisions about how best to channel aid to recipients as fast as possible. Humanitarian supply chains differ from commercial supply chains in their greater urgency of response and in the poor quality of data and increased uncertainty about important inputs such as transportation resources, aid availability, and the suddenness and degree of "demand". The context is usually more chaotic with poor information feedback and a multiplicity of decision-makers in different aid organizations. The model attempts to handle this complexity by incorporating practical decisions, such as pre-allocation of emergency goods...
Vismayam Sud
A B S T R A C T Since the 1950s, the number of natural and man-made disasters has increased exponentially and the facility location problem has become the preferred approach for dealing with emergency humanitarian logistical problems. To deal with this challenge, an exact algorithm and a heuristic algorithm have been combined as the main approach to solving this problem. Owing to the importance that an exact algorithm holds with regard to enhancing emergency humanitarian logistical facility location problems, this paper aims to conduct a survey on the facility location problems that are related to emergency humanitarian logistics based on both data modeling types and problem types and to examine the pre-and post-disaster situations with respect to facility location, such as the location of distribution centers, warehouses, shelters, debris removal sites and medical centers. The survey will examine the four main problems highlighted in the literature review: deterministic facility location problems, dynamic facility location problems, stochastic facility location problems, and robust facility location problems. For each problem, facility location type, data modeling type, disaster type, decisions, objectives, constraints, and solution methods will be evaluated and real-world applications and case studies will then be presented. Finally, research gaps will be identified and be addressed in further research studies to develop more effective disaster relief operations.
Operational Research
Vasilis Koutras
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Uncertain Supply Chain Management
Reza Tavakkoli-Moghaddam
International Journal of Industrial Engineering Computations
Ahmad Makui
International Journal of Production Economics
Disaster Prevention and Management
Jerry D VanVactor, DHA
Transportation Research Procedia
Simona Mancini
Transportation Research Part E: Logistics and …
Jiuh-Biing Sheu
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M. Fakhrzad
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Eduardo Pérez
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Matthieu Lauras
Operations and Supply Chain Management: An International Journal
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Vedat Verter
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European Journal of Operational Research
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Naim Kapucu
Transportation Research Record
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Emmanuel BIZIMANA
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Nur Budi Mulyono
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Emergency logistics facilities location dual-objective modeling in uncertain environments.
2. literature review, 2.1. concept of emergency logistics, 2.2. emergency logistics research methodology, 2.3. risk metrics applications, 3. problem formulation, 3.1. problem description.
4. stochastic programming model, tsp model for emergency logistics facility location based on risk preference, 5. robust optimization model, 5.1. robust model for emergency logistics facility location based on box uncertainty set, 5.2. robust model for emergency logistics facility location based on polyhedral uncertainty set, 6. numerical analysis, 6.1. numerical example, 6.1.1. pre-locating of emergency logistics facilities, 6.1.2. parameters of model, 6.2. analysis of location results in defined environments, 6.2.1. comparative analysis of single target results, 6.2.2. comparative analysis of dual objective results, 6.2.3. sensitivity analysis of transportation costs, 6.3. analysis of location results in uncertain environments, 6.3.1. location results for stochastic programming models, 6.3.2. location results for robust optimization models, 6.3.3. sensitivity analysis of parameters in uncertainty models, 6.3.4. comparative analysis of uncertainty optimization methods, 6.4. management insights, 7. conclusions, author contributions, institutional review board statement, informed consent statement, data availability statement, acknowledgments, conflicts of interest.
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Author | Multi-Objective | Problem | Uncertainty | Method | ||||
---|---|---|---|---|---|---|---|---|
Huang et al. [ ] | √ | √ | √ | EVIA | ||||
Liu et al. [ ] | -constraint method | |||||||
Sun et al. [ ] | √ | √ | Gurobi | |||||
Ghasemi et al. [ ] | √ | √ | √ | √ | NSGAII | |||
Paul and Zhang [ ] | √ | √ | √ | Cplex | ||||
Oksuz and Satoglu [ ] | √ | √ | √ | Cplex | ||||
Aydin [ ] | √ | √ | Cplex | |||||
Manopiniwes and Irohara [ ] | √ | √ | √ | √ | Matlab | |||
Li et al. [ ] | √ | √ | √ | √ | √ | Matlab | ||
Ke [ ] | √ | √ | Gurobi | |||||
Du et al. [ ] | √ | √ | Algorithm and Cplex | |||||
Barbarosoglu and Arda [ ] | √ | √ | Cplex | |||||
Paul and MacDonald [ ] | √ | √ | √ | √ | EV | |||
Paul and Wang [ ] | √ | √ | √ | Cplex | ||||
Shen et al. [ ] | √ | √ | √ | Cplex | ||||
Jin and Xia [ ] | √ | √ | Gurobi | |||||
Qu and Li [ ] | √ | √ | Cplex | |||||
Ji and Ma [ ] | √ | √ | Matlab | |||||
Miller and Ruszczyński [ ] | √ | √ | DA | |||||
Wang [ ] | √ | √ | √ | √ | LRA | |||
Xu et al. [ ] | √ | √ | Matlab | |||||
Das et al. [ ] | √ | √ | √ | Gurobi | ||||
Najafi [ ] | √ | √ | SMSRM | |||||
Ni et al. [ ] | √ | √ | √ | BDA | ||||
Balcik and Yanikoglu [ ] | √ | √ | √ | TSHA | ||||
Our paper | √ | √ | √ | √ | √ | √ | √ | Gurobi |
Alternative | ||||||
---|---|---|---|---|---|---|
Chengdu | 240 | 0.3 | 80 | 260 | 180 | 40 |
Deyang | 180 | 0.25 | 60 | 340 | 230 | 50 |
Mianyang | 180 | 0.25 | 60 | 400 | 260 | 65 |
Guangyuan | 180 | 0.25 | 60 | 480 | 310 | 80 |
Meishan | 150 | 0.2 | 50 | 340 | 230 | 50 |
Ziyang | 150 | 0.2 | 50 | 340 | 230 | 50 |
Suining | 150 | 0.2 | 50 | 400 | 260 | 65 |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang | Suining |
---|---|---|---|---|---|---|---|
Wenchuan County | 144 | 162 | 198 | 328 | 202 | 225 | 297 |
Beichuan County | 215 | 134 | 92 | 231 | 223 | 207 | 187 |
Mianzhu | 116 | 35 | 60 | 221 | 180 | 180 | 185 |
Qingchuan County | 300 | 218 | 174 | 92 | 389 | 353 | 313 |
Mao County | 183 | 114 | 122 | 288 | 242 | 256 | 270 |
Dujiangyan | 71 | 105 | 123 | 290 | 130 | 169 | 226 |
Pingwu County | 293 | 212 | 160 | 167 | 360 | 347 | 302 |
Pengzhou | 69 | 74 | 95 | 261 | 135 | 140 | 195 |
Santai County | 138 | 106 | 72 | 222 | 207 | 160 | 99 |
Lezhi County | 115 | 150 | 185 | 332 | 141 | 58 | 83 |
Zhongjiang County | 97 | 39 | 59 | 235 | 165 | 120 | 141 |
Renshou County | 78 | 152 | 200 | 367 | 34 | 65 | 179 |
Zitong County | 201 | 122 | 60 | 150 | 268 | 258 | 194 |
Yanting County | 174 | 135 | 126 | 222 | 243 | 196 | 94 |
Hongya County | 123 | 208 | 255 | 438 | 63 | 139 | 253 |
Ya’an City | 131 | 210 | 248 | 421 | 101 | 177 | 294 |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang | Suining |
---|---|---|---|---|---|---|---|
Wenchuan County | 3.6 | 4.1 | 5 | 8.2 | 5.1 | 5.6 | 7.4 |
Beichuan County | 5.4 | 3.4 | 2.3 | 5.8 | 5.6 | 5.2 | 4.7 |
Mianzhu | 2.9 | 0.9 | 1.5 | 5.5 | 4.5 | 4.5 | 4.6 |
Qingchuan County | 7.5 | 5.5 | 4.4 | 2.3 | 9.7 | 8.8 | 7.8 |
Mao County | 4.6 | 2.9 | 3.1 | 7.2 | 6.1 | 6.4 | 6.8 |
Dujiangyan | 1.8 | 2.6 | 3.1 | 7.3 | 3.3 | 4.2 | 5.7 |
Pingwu County | 7.3 | 5.3 | 4 | 4.2 | 9 | 8.7 | 7.6 |
Pengzhou | 1.7 | 1.9 | 2.4 | 6.5 | 3.4 | 3.5 | 4.9 |
Santai County | 3.5 | 2.7 | 1.8 | 5.6 | 5.2 | 4 | 2.5 |
Lezhi County | 2.9 | 3.8 | 4.6 | 8.3 | 3.5 | 1.5 | 2.1 |
Zhongjiang County | 2.4 | 1 | 1.5 | 5.9 | 4.1 | 3 | 3.5 |
Renshou County | 2 | 3.8 | 5 | 9.2 | 0.9 | 1.6 | 4.5 |
Zitong County | 5 | 3.1 | 1.5 | 3.8 | 6.7 | 6.5 | 4.9 |
Yanting County | 4.4 | 3.4 | 3.2 | 5.6 | 6.1 | 4.9 | 2.4 |
Hongya County | 3.1 | 5.2 | 6.4 | 11 | 1.6 | 3.5 | 6.3 |
Ya’an City | 3.3 | 5.3 | 6.2 | 10.5 | 2.5 | 4.4 | 7.4 |
Cities/Towns | Demand | Cities/Towns | Demand |
---|---|---|---|
Wenchuan County | 8 | Santai County | 20 |
Beichuan County | 10 | Lezhi County | 10 |
Mianzhu | 20 | Zhongjiang County | 20 |
Qingchuan County | 8 | Renshou County | 20 |
Mao County | 10 | Zitong County | 8 |
Dujiangyan | 25 | Yanting County | 10 |
Pingwu County | 10 | Hongya County | 12 |
Pengzhou | 15 | Ya’an City | 20 |
Alternative Locations | Chengdu | Deyang | Mianyang | Meishan |
---|---|---|---|---|
Wenchuan County | 8 | |||
Beichuan County | 10 | |||
Mianzhu | 20 | |||
Qingchuan County | 8 | |||
Mao County | 10 | |||
Dujiangyan | 25 | |||
Pingwu County | 10 | |||
Pengzhou | 15 | |||
Santai County | 6 | 14 | ||
Lezhi County | 10 | |||
Zhongjiang County | 20 | |||
Renshou County | 20 | |||
Zitong County | 8 | |||
Yanting County | 10 | |||
Hongya County | 12 | |||
Ya’an City | 2 | 18 |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang | Suining |
---|---|---|---|---|---|---|---|
Wenchuan County | 8 | ||||||
Beichuan County | 10 | ||||||
Mianzhu | 20 | ||||||
Qingchuan County | 8 | ||||||
Mao County | 10 | ||||||
Dujiangyan | 25 | ||||||
Pingwu County | 10 | ||||||
Pengzhou | 15 | ||||||
Santai County | 20 | ||||||
Lezhi County | 10 | ||||||
Zhongjiang County | 20 | ||||||
Renshou County | 8 | ||||||
Zitong County | 10 | ||||||
Yanting County | 10 | ||||||
Hongya County | 12 | ||||||
Ya’an City | 20 |
Cost Weight | Time Weight | Locating and Dispatching | Emergency Transport |
---|---|---|---|
0.1 | 0.9 | 228.75 | 33.2 |
0.2 | 0.8 | 208.45 | 33.8 |
0.3 | 0.7 | 189.46 | 35.4 |
0.4 | 0.6 | 166.35 | 37.7 |
0.5 | 0.5 | 166.35 | 37.7 |
Cost Weighting | Transport Cost | Locating and Dispatching | Emergency Transport |
---|---|---|---|
0.3 | 0.0014 | 139.79 | 37.7 |
0.3 | 0.0021 | 176.71 | 36.4 |
0.3 | 0.0028 | 189.45 | 35.4 |
0.3 | 0.0035 | 220.77 | 33.8 |
0.3 | 0.0042 | 233.07 | 33.8 |
Road Conditions | Demand Scenarios | ||
---|---|---|---|
(0.25) | (0.15) | (0.1) | |
(0.15) | (0.09) | (0.06) | |
(0.1) | (0.06) | (0.04) |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang |
---|---|---|---|---|---|---|
Wenchuan County | 10 | |||||
Beichuan County | 12 | |||||
Mianzhu | 24 | |||||
Qingchuan County | 10 | |||||
Mao County | 12 | |||||
Dujiangyan | 29 | |||||
Pingwu County | 12 | |||||
Pengzhou | 18 | |||||
Santai County | 24 | |||||
Lezhi County | 12 | |||||
Zhongjiang County | 24 | |||||
Renshou County | 24 | |||||
Zitong County | 10 | |||||
Yanting County | 12 | |||||
Hongya County | 14 | |||||
Ya’an City | 24 |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang |
---|---|---|---|---|---|---|
Wenchuan County | 10 | |||||
Beichuan County | 12 | |||||
Mianzhu | 24 | |||||
Qingchuan County | 10 | |||||
Mao County | 12 | |||||
Dujiangyan | 29 | |||||
Pingwu County | 12 | |||||
Pengzhou | 18 | |||||
Santai County | 24 | |||||
Lezhi County | 12 | |||||
Zhongjiang County | 24 | |||||
Renshou County | 24 | |||||
Zitong County | 10 | |||||
Yanting County | 12 | |||||
Hongya County | 14 | |||||
Ya’an City | 24 |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang | Suining |
---|---|---|---|---|---|---|---|
Wenchuan County | 12 | ||||||
Beichuan County | 15 | ||||||
Mianzhu | 30 | ||||||
Qingchuan County | 12 | ||||||
Mao County | 15 | ||||||
Dujiangyan | 38 | ||||||
Pingwu County | 15 | ||||||
Pengzhou | 23 | ||||||
Santai County | 30 | ||||||
Lezhi County | 15 | ||||||
Zhongjiang County | 30 | ||||||
Renshou County | 30 | ||||||
Zitong County | |||||||
Yanting County | 12 | 15 | |||||
Hongya County | 18 | ||||||
Ya’an City | 30 |
Alternative Locations | Chengdu | Deyang | Mianyang | Guangyuan | Meishan | Ziyang | Suining |
---|---|---|---|---|---|---|---|
Wenchuan County | 11 | ||||||
Beichuan County | 13 | ||||||
Mianzhu | 27 | ||||||
Qingchuan County | 11 | ||||||
Mao County | 13 | ||||||
Dujiangyan | 35 | ||||||
Pingwu County | 13 | ||||||
Pengzhou | 20 | ||||||
Santai County | 27 | ||||||
Lezhi County | 13 | ||||||
Zhongjiang County | 27 | ||||||
Renshou County | 27 | ||||||
Zitong County | 11 | ||||||
Yanting County | 13 | ||||||
Hongya County | 15 | ||||||
Ya’an City | 27 |
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Xu, F.; Ma, Y.; Liu, C.; Ji, Y. Emergency Logistics Facilities Location Dual-Objective Modeling in Uncertain Environments. Sustainability 2024 , 16 , 1361. https://doi.org/10.3390/su16041361
Xu F, Ma Y, Liu C, Ji Y. Emergency Logistics Facilities Location Dual-Objective Modeling in Uncertain Environments. Sustainability . 2024; 16(4):1361. https://doi.org/10.3390/su16041361
Xu, Fang, Yifan Ma, Chang Liu, and Ying Ji. 2024. "Emergency Logistics Facilities Location Dual-Objective Modeling in Uncertain Environments" Sustainability 16, no. 4: 1361. https://doi.org/10.3390/su16041361
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Yellow fever (YF) is a mosquito-borne disease with no specific treatment. The burden of YF was much reduced around the world in the 1950s, but many mosquito control programs were allowed to lapse thereafter, and the World Health Organization (WHO) has been warning for decades that explosive outbreaks of urban YF were likely. YF resurged and spread widely in urban Angola in late 2015, then to Kenya, China, and the Democratic Republic of the Congo (DRC). The existing WHO YF vaccine stockpile was insufficient, and WHO proposed using a fractional dose (one-fifth of that previously used) against the spreading epidemic. We used mathematical modeling to assess the impact of potentially reduced vaccine efficacy with fractional dosing on the infection attack rate. Our rapid risk assessment model showed that the proposed WHO dose-sparing strategy for the YF vaccination campaign in Kinshasa would be robust and effective and would prevent many more infections than using the available vaccine at standard dosage, even with a large margin for error in case fivefold fractional-dose vaccine efficacy turned out to be lower than expected. WHO implemented the strategy in August 2016, and subsequent studies found it to be a viable control strategy, with possible implications for other situations of vaccine shortage.
Learning Track Note: This chapter appears in Learning Tracks: Biostatistics
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This chapter should enable readers to understand and discuss:
Why WHO warned against cutting mosquito control programs when the incidence of yellow fever (YF) dropped around the world.
The basis of the proposal to provide one-fifth of the normally recommended YF vaccine dose in response to a 2016 YF outbreak in Central Africa.
How a dose-sparing immunization regimen could reduce the infection rate even if the smaller dose is less effective in preventing infection and disease.
The mathematical modeling used by the authors to assess the impact of potentially reduced vaccine efficacy with fractional dosing on the YF infection attack rate.
How the conclusions of the modeling study were applied in urban Kinshasa.
Conference recommendations for further research on the efficacy of fractional doses in outbreaks.
Yellow fever (YF) is a mosquito-borne disease with no specific treatment (WHO 2019b ). During the 1950s, mass vaccination and intensive mosquito-control programs largely eliminated YF, except in sub-Saharan Africa and sporadic hotspots in South America. However, as the burden of YF subsided, many mosquito control programs were dismantled. The World Health Organization (WHO) has been warning for decades that such policy failure, together with changes in demography, land use patterns, and international air travel, would set the stage for explosive outbreaks of urban YF.
Dose-sparing yellow fever vaccination campaign underway near Kinshasa. (Courtesy of WHO/E. Photo: Soteras Jalil)
This premonition was realized when YF resurged and spread widely in urban Angola in late 2015 (Chan 2016 ). By May 2016, more than 2500 suspected cases, including 301 deaths, had been reported from all 18 provinces of Angola. Cases had been exported to Kenya, China, and the Democratic Republic of the Congo (DRC), and the risk of further international spread was escalating. Although WHO maintained a YF vaccine stockpile of about six million doses for emergency use in reactive campaigns, the stockpile was intended for responding to sylvatic spillovers and was therefore insufficient in size for controlling sustained urban outbreaks. Facing severe shortages of YF vaccines, WHO proposed dose fractionation for an emergency YF vaccination campaign in August 2016 to vaccinate eight million people in Kinshasa, three million in anterior Angola, and 4.3 million along the DRC-Angola corridor (Schnirring 2016 ).
Although empirical evidence suggested that a fivefold fractional dose was not inferior to a standard dose in terms of safety and immunogenicity (largely due to the excess of infectious viral particles in routine YF vaccine batches) (Visser 2019 ), it was not known whether equal immunogenicity implies equal vaccine efficacy (VE) for YF vaccines. To strengthen the evidence base for the public health benefit of dose fractionation of YF vaccines, we used mathematical modeling to assess the impact of reduced VE in fractional dose vaccines on the infection attack rate (IAR), defined as the proportion of the population infected over the course of an epidemic (Wu et al. 2016 ). Such an assessment would be particularly useful if the pathogen was not highly transmissible (e.g., the basic reproductive number R 0 of influenza is below 2 (Riley et al. 2007 )) because even if dose fractionation reduced VE, the resulting higher vaccine coverage (VC) might confer higher herd immunity, in which case the number of infections could be significantly reduced by the indirect effect of large-scale vaccination. However, the transmissibility of YF in urban settings had never been adequately characterized before due to limited data, and hence the importance of herd immunity for YF vaccination was unknown. As such, the first step of our study was to estimate the R 0 of YF in urban settings by analyzing the epidemic curve of YF in Luanda, Angola. We found that in the absence of interventions, the R 0 of YF was around 5–7, which suggested that the intrinsic transmissibility of YF was not low. Therefore, the herd effect would not likely be substantial unless the immunization coverage (VC x VE) was close to the control threshold \( 1-\frac{1}{R_0} \) .
Let VE( n ) and IAR( n ) be the VE and IAR under n-fold dose fractionation. We assumed that vaccine action was all-or-nothing, i.e., vaccines provided 100% protection against infection in a proportion VE( n ) of vaccinees and no protection in the remainder. Under this assumption,
where V was the vaccine coverage achievable with standard-dose vaccines, and S 0 and I 0 were the initial proportion of population that were susceptible and infectious. This simple model indicated that n-fold dose fractionation reduced IAR if and only if \( \mathrm{VE}(n)>\frac{\mathrm{VE}(1)}{n} \) regardless of the transmissibility of the pathogen and pre-existing population immunity.
Having established the minimum requirement on VE( n ) for n-fold dose fractionation to be non-inferior, we then considered VE(5) = 1, 0.9, 0.6 and 0.3 and compared the IAR when vaccines were administered in standard dose only versus according to the fivefold dose-fractionation proposed by the WHO for its vaccination campaign in Kinshasa. We parameterized the population demographics and pre-campaign vaccine coverage in the model using (1) the age distribution of Angola and Kinshasa from the World Factbook (CIA 2020 ); (2) the annual routine immunization coverage among children aged 12–23 months between 1997 and 2015 from WHO/United Nations Children’s Fund (UNICEF) immunization estimates (WHO 2019a ); and (3) vaccine coverage conferred by the emergency vaccination of around one million people in Kinshasa during May–June 2016. We estimated that the dose-sparing strategy would avert 7.1, 7.1, 5.4, and 1.3 million infections if R 0 = 4, and around 7.9, 7.9, 4.0 and 1.0 million infections if R 0 = 8–12. These figures were based on the assumption of a sustained epidemic, such that transmission declined when the population of susceptible hosts was depleted.
In conclusion, our rapid risk assessment model, shared via preprint in May 2016, showed that the proposed WHO dose-sparing strategy for the YF vaccination campaign in Kinshasa, DRC, would be a robust and effective strategy for reducing infection attack rate; it would prevent many more infections than using the vaccine at standard dosage, even with a large margin for error in case fivefold fractional-dose vaccine efficacy turned out to be lower than expected. WHO formally recommended the dose-fractionation strategy in July 2016 (WHO 2016a ), and it was implemented in August 2016 (◘ Fig. 1 ), during which nearly 7.5 million residents of urban Kinshasa received fivefold fractional dose vaccines and nearly 0.5 million children under two and pregnant women received standard dose vaccines, achieving an estimated 98% coverage of the target population (WHO 2016b ). In June 2017, WHO published an addendum to its 2013 position paper on YF vaccine stating, “As a dose-sparing strategy, a fractional YF vaccine dose meeting the WHO minimum requirement for potency is expected to be equivalent to a standard YF vaccine dose with respect to safety, immunogenicity, and effectiveness” (WHO 2013 , 2017c ). Research conferences in 2017 and 2019 drew on several clinical studies that supported the efficacy of fractional doses in outbreak circumstances, while recommending further research on the duration of immunity and potential need for booster doses (WHO 2017a , 2020 ; Casey et al. 2019 ).
Here, mathematical modeling (► Chaps. 24 and 25 ) provided insights into the tradeoffs between individual-level vaccine efficacy and population-level herd immunity conferred by dose-sparing strategies. This approach bears relevance for questions of dose-sparing for other vaccines, e.g., inactivated polio vaccine (WHO 2017b ), as well as dose-spacing approaches, for example with coronavirus disease 2019 (COVID-19) vaccines (Kadire et al. 2021 ; Tuite et al. 2021 ). With respect to the latter, delaying the administration of the second dose of a two-dose vaccine regimen has been implemented in some countries as a means to accelerate population coverage with the first dose, at the potential, uncertain cost of lower and/or waning efficacy during the time between when the second dose would be administered under the standard regimen and the second injection under the dose-spacing regimen. In principle, if during this period the average vaccine efficacy of the first dose remains above one-half of the vaccine efficacy following the second dose, then a dose-spacing regimen may reduce the infection attack rate.
During the 1950s, mass vaccination and intensive mosquito-control programs largely eliminated YF except in sub-Saharan Africa and sporadic hotspots in South America. As the burden of YF subsided, WHO warned against dismantling many mosquito control programs. Why?
Following YF’s resurgence and spread in urban Angola in late 2015, cases were exported to Kenya, China, and the DRC, escalating the risk of further international spread. What prompted WHO to consider a fivefold fractional vaccine dose for an emergency YF vaccination campaign in August 2016?
The transmissibility of YF in urban settings had never been adequately characterized, so the importance of herd immunity in YF was also largely unknown. Briefly summarize the mathematical modeling used by the authors to assess the potential impact of vaccine efficacy being reduced by an uncertain amount by fractional dosing.
Briefly state the conclusions of this study and their application in urban Kinshasa.
Research conferences in 2017 and 2019 drew on several clinical studies that supported the efficacy of fractional doses in outbreak circumstances. What were some recommendations for further research?
The mathematical modeling of this study provided insights into the tradeoffs between individual-level vaccine efficacy and population-level herd immunity conferred by dose-sparing strategies. Beside YF, this approach also bears relevance for questions of dose-sparing for inactivated polio vaccine and dose-spacing for COVID-19 vaccines. How could a dose-spacing regimen reduce the infection attack rate?
Casey R, Harris J, Ahuka-Mundeke S, Dixon M, Kizito G, Nsele P, et al. Immunogenicity of fractional-dose vaccine during a yellow fever outbreak—final report. N Engl J Med. 2019;381(5):444–54. https://doi.org/10.1056/NEJMoa1710430 .
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Wu, J.T., Peak, C.M. (2024). 25.1 Case Study: Modeling Fractional-Dose Emergency Vaccination Campaigns for Yellow Fever. In: Sorenson, R.A. (eds) Principles and Practice of Emergency Research Response. Springer, Cham. https://doi.org/10.1007/978-3-031-48408-7_38
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Emergency evacuation studies how to displace people from dangerous areas to safe places. In OR, the evacuation problem is mainly formulated as a network design and network flow control problem with the objective of improving the efficiency of emergency evacuation. ... [23,86], and may inadequate in the case of general emergency logistics. We ...
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Request PDF | Designing a large-scale emergency logistics network - A case study for Kentucky | During a medical emergency in the USA, critical medical supplies such as medications, vaccines ...
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European J. Industrial Engineering, Vol. 8, No. 4, 2014 Designing a large-scale emergency logistics network - a case study for Kentucky Umut Rıfat Tuzkaya* Department of Industrial Engineering, Yildiz Technical University, Istanbul 34349, Turkey E-mail: [email protected] *Corresponding author Sunderesh S. Heragu and Gerald W. Evans ...
During a medical emergency in the USA, critical medical supplies such as medications, vaccines, gloves, masks and ventilators, are delivered to one location within each state. The state and local governments are responsible for delivering the supplies from this location, called the receiving, staging and storage (RSS) site to the points of dispense (PODs). The supplies can be sent from the RSS ...
emergency logistics network, and must be completed within ... The case study consists on earthquake disaster occurred in Taiwan on September 1999. It caused 2455 death in total, more than 8000 injuries, with 38,935 homes destroyed [7]. The affected areas are located in Taichung and Nantou Counties, central Taiwan. ...
Young and Peterson (Citation 2014) analysed the challenges of EL and suggested the need to add supply chain management to EL, Peterson, Young, and Gordon (Citation 2016) demonstrated through a series of case studies that supply chain theory can optimise the management of emergency logistics. ELSC is a dynamic strategic alliance led by the ...
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25.1 Case Study: Modeling Fractional-Dose Emergency Vaccination Campaigns for Yellow Fever. Chapter; Open Access; First Online: 31 August 2024; pp 687-691 ... C.M. (2024). 25.1 Case Study: Modeling Fractional-Dose Emergency Vaccination Campaigns for Yellow Fever. In: Sorenson, R.A. (eds) Principles and Practice of Emergency Research Response ...
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