Recurrent distressing dreams (content and/or affect related)
Dissociative reaction (acting or feeling as if event is recurring)
Intense or prolonged psychological distress to cues
Noticeable physiological reactions to cues
Box 1 describes the nature of the traumatic event(s) required by DSM-5 (diagnostic and statistical manual of mental disorders, fifth edition) 14 for diagnosis and the proposed criteria by ICD-11 (international classification of diseases, 11th revision). 17 Some events such as bullying, divorce, death of a pet, and learning about a diagnosis of cancer in a close family member are not deemed extreme enough to precipitate PTSD. However, they can result in almost identical symptoms and raise questions about the validity of the definitions for traumatic events. 18
Dsm-5 criteria[14].
DSM-5 lists the 20 symptoms required for PTSD to be diagnosed, 14 separated into four groups (table). All symptoms must be associated with the traumatic event. In the proposed criteria by ICD-11, 17 PTSD will be diagnosed according to six criteria (table). To reflect the heterogeneity of PTSD, ICD-11 will introduce a new complex PTSD diagnosis (table). This requires satisfaction of the criteria for PTSD plus symptoms of mood dysregulation, negative self concept, and persistent difficulty in sustaining relationships and feeling close to others. Service users may meet the diagnostic criteria in one system but not in the other owing to the differences. 19
Psychological interventions.
Psychological interventions have been evaluated after traumas concerning a single incident, such as a road traffic crash and physical or sexual assaults. Meta-analyses show that brief, trauma focused, cognitive behavioural interventions can reduce the severity of symptoms when the intervention is targeted at those with early symptoms. 20 21 However, non-targeted interventions (including psychoeducation, psychological debriefing, individual and group counselling, cognitive behavioural therapy (CBT) based programmes, and collaborative care based approaches) are largely ineffective. 22 23 24 25
No robust evidence supports the use of drug interventions. 26
Evidence to support routine intervention after traumatic events involving many people (for example, terrorist attacks and natural disasters) is lacking. However, some evidence suggests that high levels of social support are perceived as protective. 27 Consensus guidelines recommend supportive, practical, and pragmatic input but avoidance of formal clinical interventions unless indicated. 28 29 30
Psychological therapy.
Clinical guidelines recommend trauma focused psychological therapies based on evidence from systematic reviews and meta-analyses. 31 32 33 Individual trauma focused CBT and eye movement desensitisation and reprocessing (EMDR) (box 2) have been found to be equally effective. 34
Exposure therapy.
Group trauma focused CBT is also effective, but fewer studies have focused on this method. 35 Non-trauma focused CBT—including components such as grounding techniques to manage flashbacks (for example, focusing on the here and now by describing items in a room), relaxation training (for example, controlled breathing and progressive muscle relaxation), positive thinking and self talk (for example, repeating positive phrases such as “I can deal with this”)—has been found to be superior to waiting list control groups and has shown similar efficacy to trauma focused CBT and EMDR immediately after treatment, but this is not maintained at follow-up. 34 Non-trauma focused CBT offers a valid alternative to trauma focused therapy if the latter is poorly tolerated, contraindicated, or unavailable. It is unclear whether specific therapies are more or less effective for particular subgroups or trauma types. 36 37
Research on interventions for more complex presentations of PTSD is limited. 38 Evidence suggests that phased approaches may be beneficial for more complex presentations of PTSD. 39 Phase based approaches target problems such as affect dysregulation, dissociation, and somatic symptoms to promote adaptive coping, a sense of safety, and stabilisation before undertaking any trauma focused intervention.
Guided self help interventions for depression and anxiety disorders are being used as an alternative to face to face therapy as these interventions offer enhanced access to cost effective treatment. 40 Some evidence suggests that internet based guided self help therapies effectively alleviate the symptoms of traumatic stress, but randomised controlled trials (RCTs) have historically been limited to subsyndromal populations. 41 42 More recent evidence supports the efficacy of guided self help for people meeting diagnostic criteria for PTSD, 43 44 45 but no head to head trials have compared guided self help with trauma focused psychological therapy administered by a therapist.
The National Institute for Health and Care Excellence and World Health Organization recommend drug treatment second to trauma focused therapy. 33 46 The effect sizes for drug treatments compared with placebo are inferior to those reported for psychological treatments with a trauma focus over waiting list or treatment as usual controls. 33 47 Effect sizes with drug treatment are similar to those observed from use of antidepressants for depression compared with placebo. 48 A recent systematic review and meta-analysis found statistically significant evidence (when at least two RCTs were available) of reduction in severity of PTSD symptoms for four drugs (fluoxetine, paroxetine, sertraline, and venlafaxine) versus placebo. 47 In single RCTs, amitriptyline, {"type":"entrez-nucleotide","attrs":{"text":"GR205171","term_id":"238470896","term_text":"GR205171"}} GR205171 (a neurokinin-1 antagonist), mirtazapine, and phenelzine have shown superiority over placebo in reducing the symptoms of PTSD.
In an RCT the α 1 adrenoceptor antagonist prazosin was found to reduce nightmares in veterans with PTSD, 49 and a further RCT in veterans showed reduction in overall symptom severity. 50 This suggests a possible role for α 1 adrenoceptor blockers in PTSD, although further research is needed. Olanzapine, in contrast with another antipsychotic, risperidone, has been shown to accentuate the effects of antidepressants when resistance to treatment is encountered. 51 52
Evidence to support the use of pharmacotherapy combined with psychological therapy over either treatment method separately is insufficient. 53
PTSD is associated with depression, anxiety disorders, and drug and alcohol use disorders. Little evidence exists for the effectiveness of psychological interventions for PTSD with comorbid substance use disorders. Some evidence suggests that trauma focused CBT can be effective with concomitant interventions to stabilise drug or alcohol use, but treatment effects are not as large as for PTSD in the absence of drug or alcohol misuse. 54
Few longitudinal follow-up studies have been done of PTSD, but for many patients PTSD is severe and enduring. 5 There is, however, good evidence that patients may benefit from treatment even when the symptoms have been present for many years. 34
Several experimental studies provide hope that better or alternative ways to prevent and treat PTSD are on the way. Simple visuospatial tasks such as playing a computer game shortly after a traumatic experience reduce re-experiencing. 55 For established PTSD, interest in using drugs to augment psychological therapy is increasing. The results of a recent RCT of the psychedelic 3,4-methylenedioxymethylamphetamine with psychotherapy for treatment resistant PTSD have been promising. 56 57 These approaches remain in their infancy, and further well designed clinical studies are required to determine if they will live up to their early promise.
Sarah Cosgrove is a former patient with PTSD and a representative of the public in Cardiff University’s Traumatic Stress Research Group. Sarah is a coauthor of the paper and provides an account of her experiences in the patient’s perspective box.
I was diagnosed with PTSD in November 2013 in the aftermath of a violent assault. From the time of the attack to the case coming to court, I had support from police and victim services enabling me to face my assailant in court with courage and conviction.
But in the weeks after the judicial process had concluded, I started to unravel. Naturally a glass half full sort of person, I slid into a state of great anxiety, frightened to be alone, scared to be in a group, reluctant to go out, and terrified of staying at home. I knew something was very wrong. I had gone from being confident and outgoing, to not being able to sleep, being tearful, and experiencing episodes of unparalleled low mood. My GP immediately diagnosed PTSD. Being able to put a label on what I was going through was so helpful—it meant that there was something wrong.
Fortunately, I was offered the chance to participate in a trial of a guided self help programme for sufferers of PTSD. This enabled me to both confront my experience and desensitise it, and within a few months I felt stronger than I had ever been. The programme has given me a coping strategy to employ whenever I get negative thoughts or flashbacks. It may have saved my life; at the very least it got me back to the person I used to be.
Information for healthcare professionals.
Contributors: JB, CL, and NR planned, conducted reviews, and drafted the article. SC drafted the patient’s perspective box and commented on and amended the initial draft. All authors reviewed and agreed the final draft. JB is the guarantor.
Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following: JB, CL, and NR have undertaken systematic reviews, meta-analyses, randomised controlled trials, and other research in the specialty of traumatic stress, some of which is referred to in the manuscript. JB, CL, and NR are members of a research team that developed a web based guided self help programme to treat PTSD. The programme is likely to be marketed in the future. Royalties will be payable to Cardiff University, with a proportion of these being shared with the research team in line with Cardiff University’s rules.
Provenance and peer review: Commissioned; externally peer reviewed.
Cite this as: BMJ 2015;351:h6161
COMMENTS
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