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In our November 2024 issue
Programmable RNA condensates, DNA Computing, Thermal metasurfaces, Transition metal oxide cathodes, Coupled nanopores, the DELIVER framework—translating nanomedicines to the clinic and more...
Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications
This Review presents a path to strategically overcoming extracellular vesicle heterogeneity and assay standardization, and offers solutions for realizing the clinical translation of extracellular vesicles for diagnostics and nanotherapeutics.
- Randy P. Carney
- Rachel R. Mizenko
- Steven C. George
Designing nanotheranostics with machine learning
This Review explores how machine learning approaches can drive progress in nanotheranostics.
- Xiaoyuan Chen
A translational framework to DELIVER nanomedicines to the clinic
The authors propose a framework to be followed during preclinical investigation of nanomedicines to increase their translatability potential.
- Christine J. Allen
- Hélder A. Santos
Bottom-up synthetic immunology
This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.
- Kerstin Göpfrich
- Michael Platten
- Oliver T. Fackler
Current issue
Silk protein connecting water and nanofabrication.
- Sunghwan Kim
DNA origami force probes illuminate T cell receptor forces at the immune synapse
- Tram Thi Hong Le
- Byoung Choul Kim
A photo-controlled charge regulator improves cancer theranostics
Bolometric detection of josephson radiation.
- Bayan Karimi
- Gorm Ole Steffensen
- Jukka P. Pekola
Announcements
Focus: 2D Semiconductors
Two-dimensional (2D) materials show great potential for pushing semiconductor device performance and functionality. In this Focus, we highlight advances in 2D semiconductors, leveraging nanoscale insights for materials growth, novel devices, boosted performance, and integrated systems.
Nature Conference: CO2 Conversion by Renewable Energy
Reducing atmospheric CO2 levels is one of the grand global challenges of our generation. This conference will bring together scientists and engineers, drawing inspiration from both physical and life sciences, with the shared goal of utilizing renewable energy and CO2 as feedstocks for a sustainable future. The sessions will range from fundamental mechanistic understanding to practical devices.
Nature Nano Talks
In 2020 and 2021, Nature Nanotechnology hosted several panel discussions on exciting topics in nanotechnology. See the recordings here.
Nature Nanotechnology is a Transformative Journal ; authors can publish using the traditional publishing route OR via immediate gold Open Access.
Our Open Access option complies with funder and institutional requirements .
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Latest Research articles
A cascade X-ray energy converting approach toward radio-afterglow cancer theranostics
Here, the authors present the design, molecular assembly and mechanistic insights into an organic, biomarker-activatable radiotheranostic nanoprobe for image-guided precision cancer radiotherapy with sensitivity up to a depth of 15 cm in thick tissues.
Layer-dependent evolution of electronic structures and correlations in rhombohedral multilayer graphene
By using scanning tunnelling microscopy and spectroscopy, researchers observe layer-dependent electronic correlations in rhombohedral graphene multilayers at 77 K, revealing the layer-enhanced low-energy flat bands and interlayer interactions.
- Yue-Ying Zhou
- Long-Jing Yin
Full on-device manipulation of olefin metathesis for precise manufacturing
Single-molecule electrical detections clarify both productive and hidden degenerate pathways of ring-closing metathesis, and enable precise on-device synthesis of a single polymer with single-monomer-insertion-event resolution.
- Xuefeng Guo
Fully integrated multi-mode optoelectronic memristor array for diversified in-sensor computing
This study reports a fully integrated 128 × 8 optoelectronic memristor array with Si complementary metal–oxide–semiconductor circuits, featuring configurable multi-mode functionality. It demonstrates diversified in-sensor computing tasks and consumes 20 times less energy than GPUs.
- Xiangpeng Liang
- Huaqiang Wu
Engineering modular and tunable single-molecule sensors by decoupling sensing from signal output
The study presents a modular DNA origami-based single-molecule nanosensor that separates sensing from the signal output. It achieves high fluorescence resonance energy transfer contrast and enables tuning of the response window for improved sensor specificity, multiplexing and logic sensing.
- Lennart Grabenhorst
- Martina Pfeiffer
- Viktorija Glembockyte
Targeted intervention in nerve–cancer crosstalk enhances pancreatic cancer chemotherapy
This study presents the development of nanodrugs based on bacterial-derived outer membrane vesicles for targeted intervention in nerve–cancer crosstalk, which efficiently enhances pancreatic cancer chemotherapy.
- Jingjie Liu
Latest Reviews & Analysis
Organic radio-afterglow nanoprobes for cancer theranostics
Leveraging X-rays to induce prolonged luminescence (radio-afterglow) and radiodynamic effects from typically inorganic optical agents enables diagnosis and therapy at light-inaccessible tissue depths. Now, a cascade X-ray energy conversion approach is developed to increase the intrinsically low X-ray conversion efficiency of organic molecules for the construction of radio-afterglow nanoprobes for cancer theranostics.
Unravelling topological states in quantum spin chains
Scanning tunnelling microscopy experiments enable the realization of artificially built topological quantum magnets with titanium atoms and graphene goblets.
- Deung-Jang Choi
- Dario Bercioux
Small structural changes in siloxane-based lipidoids improve tissue-specific mRNA delivery
From a single library of siloxane-based lipidoids, siloxane-incorporated lipid nanoparticles (SiLNPs) involving minor alterations in lipid chemistry yield tissue-specific mRNA delivery to the liver, lung, or spleen. Upon enhanced intracellular delivery, these SiLNPs show clinical promise for protein replacement therapies, regenerative medicine, and CRISPR–Cas-based gene editing applications.
The amphiphilic silk fibroin is a natural surfactant. It influences interface interactions and enables wetting hydrophobic surfaces with aqueous solutions. This offers a sustainable route for fabricating water-processed nanodevices without prior surface modification.
Energy-efficient magnetization manipulation using picosecond current pulses
Playing electron ping-pong with the excited states of a single molecule.
- Harry Mönig
3D printed photonic crystals with a complete bandgap in the visible range
News & comment.
The climate crisis is a call for action for nanotechnology
The Nano4EARTH challenge, launched by the National Nanotechnology Initiative in the United States, has identified four strategic areas where nanotechnology can make the most impact in addressing the climate crisis.
Nanotechnology solutions for the climate crisis
Climate change is one of humankind’s biggest challenges, leading to more frequent and intense climate extremes, including heatwaves, wildfires, hurricanes, ocean acidification, and increased extinction rates. Nanotechnology already plays an important role in decarbonizing critical processes. Still, despite the technical advances seen in the last decades, the International Energy Agency has identified many sectors that are not on track to achieve the global climate mitigation goals by 2030. Here, a multi-stakeholder group of nanoscientists from the public, private, and philanthropic sectors discuss four high-potential application spaces where nanotechnologies could accelerate progress: batteries and energy storage; catalysis; coatings, lubricants, membranes, and other interface technology; and capture of greenhouse gases. This Comment highlights opportunities and current gaps for those working to minimize the climate crisis and provides a framework for the nanotechnology community to answer the call to action on this global issue.
- Maria Fernanda Campa
- Craig M. Brown
- James A. Warren
Nanomedicine pioneers awarded the Kavli Prize
The 2024 Kavli Prize in Nanoscience is awarded to three nanomedicine pioneers who laid the foundation of controlled release, biomedical imaging and diagnostics.
Competing light extraction strategies in perovskite light-emitting diodes
Light extraction is a key factor determining the efficiency of light-emitting diodes. This becomes more pronounced in high-refractive-index perovskite light-emitting diodes according to the ray-optics model. Photon recycling and microcavity effect are important ways to break through the ray-optics efficiency limit. However, these two effects are competing, that is, strategies to optimize them are mutually exclusive. For a breakthrough in efficiency, we should favour one of them and inhibit the other.
- Guanding Mei
- Xiao Wei Sun
Reimagining computing with 2D semiconductors
We present a Focus issue on how the research community is continually pushing the device performance boundaries of 2D transistors and explore the pivotal role that these devices play in the future computing landscape.
The gap between academic research on proton exchange membrane water electrolysers and industrial demands
Driven by carbon neutral targets, proton exchange membrane water electrolysis is becoming a hot technology due to its capability to convert fluctuating power into green hydrogen. Unfortunately, despite tremendous resources invested in fundamental research, only very few research outcomes have successfully translated into the development of industrial-scale electrolysers.
- Hua Bing Tao
- Nanfeng Zheng
Trending - Altmetric
Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation
Mechanochemistry-mediated colloidal liquid metals for electronic device cooling at kilowatt levels
Revealing the degradation pathways of layered Li-rich oxide cathodes
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