Research articles
Molecular mechanism of ige-mediated fcεri activation.
- Mengying Chen
Long-term lineage commitment in hematopoietic stem cell gene therapy
- Andrea Calabria
- Giulio Spinozzi
- Eugenio Montini
Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation
The bacterial anti-phage toxin–antitoxin–chaperone defence system CmdTAC senses capsid proteins via CmdC, enabling dissociation from the CmdTAC complex of the RNA ADP-ribosyltransferase CmdT, which targets single-stranded RNAs, inhibiting viral replication.
- Christopher N. Vassallo
- Christopher R. Doering
- Michael T. Laub
Large-scale medieval urbanism traced by UAV–lidar in highland Central Asia
Pairing of very-high-resolution surface modelling with semiautomated feature detection produces a detailed plan of monumental fortifications and architecture spanning 120 ha at Tugunbulak, Uzbekistan, demonstrating one of the largest highland urban constellations in premodern Central Asia.
- Michael D. Frachetti
- Jack Berner
Bureaucrat incentives reduce crop burning and child mortality in South Asia
Around 1.8–2.7 deaths per 1,000 births (4.4–6.6% of the average child mortality) could be prevented in Pakistan and India if bureaucrats control crop burning across all areas of their jurisdiction as they do in places where fires would pollute their own district.
- Gemma Dipoppa
- Saad Gulzar
Selection bias obfuscates the discovery of fast radio burst sources
The chances of detecting fast radio bursts from a galaxy may be affected by its inclination angle, showing a potential selection bias in determining the sources of the bursts.
- Mohit Bhardwaj
Global influence of soil texture on ecosystem water limitation
Through their effects on soil hydraulic properties, soil texture and sand content are shown to have broad implications for the terrestrial water cycle and carbon sink, and specific implications for vital ecosystems that are vulnerable to drought, especially with changing climate.
- F. J. P. Wankmüller
- A. Carminati
Scalable watermarking for identifying large language model outputs
A scheme for watermarking the text generated by large language models shows high text quality preservation and detection accuracy and low latency, and is feasible in large-scale-production settings.
- Sumanth Dathathri
- Abigail See
- Pushmeet Kohli
Machine-guided design of cell-type-targeting cis -regulatory elements
A generalizable framework to prospectively engineer cis -regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
- Sager J. Gosai
- Rodrigo I. Castro
- Ryan Tewhey
A transcriptomic hourglass in brown algae
Similar to other eukaryotes, brown algae exhibit transcriptome conservation that is consistent with the molecular hourglass model during differentiation in embryonic development.
- Jaruwatana Sodai Lotharukpong
- Susana M. Coelho
Carbon dioxide capture from open air using covalent organic frameworks
A polyamine-functionalized covalent organic framework, COF-999, can be used as a material for direct air capture of CO 2 from open air.
- Tianqiong Ma
- Omar M. Yaghi
Coral photosymbiosis on Mid-Devonian reefs
Nitrogen isotope evidence of Mid-Devonian photosymbiotic associations in certain types of corals suggests that autotrophic and heterotrophic corals co-existed on extinct reefs, as today, but in warmer oceans, indicating the current warming rate, not temperature, is causing coral bleaching.
- Jonathan Jung
- Simon F. Zoppe
- Alfredo Martínez-García
Chromatin remodelling drives immune cell–fibroblast communication in heart failure
Conditional deletion of the transcriptional co-activator Brd4 in infiltrating Cx3cr1 + mouse macrophages ameliorates heart failure and substantially reduces fibroblast activation.
- Michael Alexanian
- Arun Padmanabhan
- Deepak Srivastava
The black hole low-mass X-ray binary V404 Cygni is part of a wide triple
Analysis of the black hole low-mass X-ray binary V404 Cygni shows that it is part of a wide hierarchical triple whose configuration provides evidence that some black holes form with nearly no natal kick.
- Kevin B. Burdge
- Kareem El-Badry
- Andrew Vanderburg
Parallel molecular data storage by printing epigenetic bits on DNA
We present a DNA self-assembly based molecular data writing strategy to enable parallel movable-type printing for scalable DNA storage.
- Cheng Zhang
Nuclear release of eIF1 restricts start-codon selection during mitosis
Transcriptome-wide profiling studies in mammalian cells show that the stringency of start-codon selection is increased during mitosis, and that this is regulated by nuclear eIF1 to preserve mitotic arrest physiology.
- Kehui Xiang
- Iain M. Cheeseman
Transgelin 2 guards T cell lipid metabolism and antitumour function
Together with the fatty-acid-binding protein FABP5, the cytoskeletal organizer TAGLN2 is an essential factor for fatty acid uptake, mitochondrial respiration and anticancer function in CD8 + T cells.
- Sung-Min Hwang
- Deepika Awasthi
- Juan R. Cubillos-Ruiz
Differentiation fate of a stem-like CD4 T cell controls immunity to cancer
A population of tumour-specific PD1 + TCF1 + CD4 T cells in tumour-draining lymph nodes is capable of self-renewal and differentiation into CD4 effector cells, thereby controlling CD8 T cell activity.
- Maria A. Cardenas
- Nataliya Prokhnevska
- Haydn T. Kissick
Neural crest lineage in the protovertebrate model Ciona
In the tunicate Ciona , we show that pigment cell lineage also produces neural progenitor cells that form regions of the juvenile nervous system after metamorphosis, suggesting that neural crest cell multipotency precedes the emergence of vertebrates.
- Lauren G. Todorov
- Kouhei Oonuma
- Laurence A. Lemaire
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin
Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
- Adrianna M. Turner
- Glen P. Carter
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HBR’s Most-Read Research Articles of 2021
by Dagny Dukach
Summary .
As the workplace rapidly transforms in the wake of the pandemic, social movements, and more, a fundamental question remains: How can we ensure we’re making work better — for employees, organizations, and society at large?
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